NZ187376A - N-cyano-n-(2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n-alkynyl guanidines intermediates pharmaceutical compositions - Google Patents

N-cyano-n-(2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n-alkynyl guanidines intermediates pharmaceutical compositions

Info

Publication number: NZ187376A
Authority: NZ; New Zealand
Prior art keywords: guanidines; methylthio; imidazolyl; intermediates; alkynyl
Prior art date: 1977-06-03

Application number

NZ187376A

Other languages

English (en)

Inventor

R R Crenshaw

G M Luke

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-03

Filing date

1978-05-25

Publication date

1981-05-29

1977-11-07 Priority claimed from US05/848,959 external-priority patent/US4112234A/en

1978-05-25 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1981-05-29 Publication of NZ187376A publication Critical patent/NZ187376A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NZ187376A 1977-06-03 1978-05-25 N-cyano-n-(2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n-alkynyl guanidines intermediates pharmaceutical compositions NZ187376A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US80300977A	1977-06-03	1977-06-03
US82679677A	1977-08-22	1977-08-22
US05/848,959 US4112234A (en)	1977-08-22	1977-11-07	Imidazolylmethylthioethyl alkynyl guanidines

Publications (1)

Publication Number	Publication Date
NZ187376A true NZ187376A (en)	1981-05-29

Family

ID=27419995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ187376A NZ187376A (en)	1977-06-03	1978-05-25	N-cyano-n-(2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n-alkynyl guanidines intermediates pharmaceutical compositions

Country Status (26)

Country	Link
JP (1)	JPS543067A (fr)
AR (2)	AR222797A1 (fr)
CA (1)	CA1110251A (fr)
CH (2)	CH641167A5 (fr)
CY (3)	CY1231A (fr)
DD (1)	DD140038A5 (fr)
DE (1)	DE2824066A1 (fr)
DK (1)	DK243178A (fr)
ES (3)	ES470474A1 (fr)
FI (1)	FI69069C (fr)
FR (2)	FR2401143A1 (fr)
GB (3)	GB1598628A (fr)
GR (1)	GR73860B (fr)
HK (3)	HK38284A (fr)
HU (1)	HU186766B (fr)
IE (1)	IE47543B1 (fr)
IL (1)	IL54819A (fr)
KE (1)	KE3373A (fr)
LU (1)	LU79725A1 (fr)
MY (3)	MY8500451A (fr)
NL (1)	NL7805935A (fr)
NO (3)	NO152214C (fr)
NZ (1)	NZ187376A (fr)
SE (3)	SE443784B (fr)
SG (1)	SG8584G (fr)
YU (4)	YU129778A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS568352A (en) *	1979-07-03	1981-01-28	Shionogi & Co Ltd	Aminoalkylvenzene derivative
US4339439A (en) *	1981-01-19	1982-07-13	Bristol-Myers Company	Pharmaceutical methods and compositions
JPS6018010U (ja) *	1983-07-18	1985-02-07	日産自動車株式会社	車両用空気調和装置の温度調整機構
JPS60113211U (ja) *	1984-01-06	1985-07-31	松下電器産業株式会社	自動車用空気調和装置
ES2007948A6 (es) *	1988-07-06	1989-07-01	Vinas Lab	Procedimiento para la obtencion de derivados propargilguanidicos.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4024271A (en) *	1971-03-09	1977-05-17	Smith Kline & French Laboratories Limited	Pharmacologically active guanidine compounds
GB1338169A (en) *	1971-03-09	1973-11-21	Smith Kline French Lab	Ureas thioureas and guanidines
GB1397436A (en) *	1972-09-05	1975-06-11	Smith Kline French Lab	Heterocyclic n-cyanoguinidines
GB1531221A (en) *	1974-09-02	1978-11-08	Smith Kline French Lab	Process for preparing guanidine derivatives
GB1531231A (en) *	1974-09-02	1978-11-08	Smith Kline French Lab	Process for the production of cyanoguanidine derivatives
GB1533380A (en) *	1974-09-02	1978-11-22	Smith Kline French Lab	Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines

1978
- 1978-05-25 NZ NZ187376A patent/NZ187376A/xx unknown
- 1978-05-25 CA CA304,045A patent/CA1110251A/fr not_active Expired
- 1978-05-26 CY CY1231A patent/CY1231A/en unknown
- 1978-05-26 GB GB23611/78A patent/GB1598628A/en not_active Expired
- 1978-05-26 CY CY1229A patent/CY1229A/en unknown
- 1978-05-26 GB GB18923/80A patent/GB1598630A/en not_active Expired
- 1978-05-26 GB GB27637/79A patent/GB1598629A/en not_active Expired
- 1978-05-26 CY CY1230A patent/CY1230A/en unknown
- 1978-05-29 GR GR56374A patent/GR73860B/el unknown
- 1978-05-29 LU LU79725A patent/LU79725A1/fr unknown
- 1978-05-31 IL IL54819A patent/IL54819A/xx unknown
- 1978-05-31 DK DK243178A patent/DK243178A/da not_active Application Discontinuation
- 1978-05-31 YU YU01297/78A patent/YU129778A/xx unknown
- 1978-05-31 NL NL7805935A patent/NL7805935A/xx not_active Application Discontinuation
- 1978-05-31 AR AR272401A patent/AR222797A1/es active
- 1978-05-31 FI FI781737A patent/FI69069C/fi not_active IP Right Cessation
- 1978-06-01 DE DE19782824066 patent/DE2824066A1/de not_active Withdrawn
- 1978-06-02 IE IE1112/78A patent/IE47543B1/en unknown
- 1978-06-02 ES ES470474A patent/ES470474A1/es not_active Expired
- 1978-06-02 HU HU811135A patent/HU186766B/hu unknown
- 1978-06-02 JP JP6590078A patent/JPS543067A/ja active Granted
- 1978-06-02 NO NO781928A patent/NO152214C/no unknown
- 1978-06-02 FR FR7816601A patent/FR2401143A1/fr active Granted
- 1978-06-02 CH CH609278A patent/CH641167A5/de not_active IP Right Cessation
- 1978-06-02 SE SE7806525A patent/SE443784B/sv unknown
- 1978-06-05 DD DD78205794A patent/DD140038A5/de unknown
1979
- 1979-03-01 ES ES478202A patent/ES478202A1/es not_active Expired
- 1979-03-01 ES ES478203A patent/ES478203A1/es not_active Expired
- 1979-03-05 YU YU530/79A patent/YU41620B/xx unknown
- 1979-05-16 NO NO791637A patent/NO791637L/no unknown
- 1979-10-26 AR AR278645A patent/AR222503A1/es active
- 1979-11-23 FR FR7928943A patent/FR2436138A1/fr active Granted
1982
- 1982-09-27 YU YU2155/82A patent/YU40625B/xx unknown
- 1982-09-27 YU YU2154/82A patent/YU40624B/xx unknown
1983
- 1983-09-12 NO NO833255A patent/NO151824C/no unknown
- 1983-10-07 CH CH549283A patent/CH644591A5/de not_active IP Right Cessation
1984
- 1984-01-30 SG SG85/84A patent/SG8584G/en unknown
- 1984-02-10 KE KE3373A patent/KE3373A/xx unknown
- 1984-03-16 SE SE8401492A patent/SE8401492D0/xx not_active Application Discontinuation
- 1984-03-16 SE SE8401491A patent/SE8401491L/xx not_active Application Discontinuation
- 1984-05-03 HK HK382/84A patent/HK38284A/xx unknown
- 1984-05-03 HK HK380/84A patent/HK38084A/xx unknown
- 1984-05-03 HK HK381/84A patent/HK38184A/xx unknown
1985
- 1985-12-30 MY MY451/85A patent/MY8500451A/xx unknown
- 1985-12-30 MY MY452/85A patent/MY8500452A/xx unknown
- 1985-12-30 MY MY453/85A patent/MY8500453A/xx unknown

Also Published As

Publication number	Publication date
JPS543067A (en)	1979-01-11
HK38284A (en)	1984-05-11
SE8401492L (sv)	1984-03-16
DE2824066A1 (de)	1978-12-14
YU215582A (en)	1983-02-28
IL54819A (en)	1983-03-31
MY8500452A (en)	1985-12-31
FR2436138B1 (fr)	1982-12-03
NO151824B (no)	1985-03-04
AR222503A1 (es)	1981-05-29
CY1231A (en)	1984-06-29
SG8584G (en)	1985-02-08
HU186766B (en)	1985-09-30
YU41620B (en)	1987-12-31
YU53079A (en)	1983-09-30
YU40625B (en)	1986-02-28
MY8500453A (en)	1985-12-31
FI69069C (fi)	1985-12-10
GR73860B (fr)	1984-05-08
YU129778A (en)	1983-02-28
GB1598628A (en)	1981-09-23
SE8401492D0 (sv)	1984-03-16
FI69069B (fi)	1985-08-30
IE781112L (en)	1978-12-03
FI781737A7 (fi)	1978-12-04
ES478203A1 (es)	1979-06-01
NO833255L (no)	1978-12-05
CY1230A (en)	1984-06-29
CH644591A5 (en)	1984-08-15
FR2401143B1 (fr)	1981-12-11
FR2436138A1 (fr)	1980-04-11
FR2401143A1 (fr)	1979-03-23
KE3373A (en)	1984-03-23
GB1598629A (en)	1981-09-23
SE8401491D0 (sv)	1984-03-16
YU40624B (en)	1986-02-28
YU215482A (en)	1983-02-28
ES470474A1 (es)	1979-09-01
NO152214B (no)	1985-05-13
HK38084A (en)	1984-05-11
SE8401491L (sv)	1984-03-16
NO791637L (no)	1978-12-05
NO152214C (no)	1985-08-28
AR222797A1 (es)	1981-06-30
GB1598630A (en)	1981-09-23
IL54819A0 (en)	1978-07-31
SE443784B (sv)	1986-03-10
JPS5639313B2 (fr)	1981-09-11
CH641167A5 (en)	1984-02-15
HK38184A (en)	1984-05-11
NO781928L (no)	1978-12-05
LU79725A1 (fr)	1979-02-02
SE7806525L (sv)	1978-12-04
NL7805935A (nl)	1978-12-05
CA1110251A (fr)	1981-10-06
IE47543B1 (en)	1984-04-18
CY1229A (en)	1984-06-29
MY8500451A (en)	1985-12-31
DK243178A (da)	1978-12-04
NO151824C (no)	1985-06-12
DD140038A5 (de)	1980-02-06
ES478202A1 (es)	1979-06-01

Publication	Publication Date	Title
ZA784899B (en)	1979-09-26	Herbicidal compositions containing pyrimidine derivatives
SG34985G (en)	1985-11-15	Pharmaceutical compositions
GB2003028B (en)	1982-02-03	Pharmaceutical compositions
SE7808336L (sv)	1979-02-04	Kataforetiskt avsettningsbar beleggningskomposition
EP0002259A3 (en)	1979-06-27	Hydantoin derivatives and salts thereof, their synthesis and intermediates, and pharmaceutical formulations
AR223313A1 (es)	1981-08-14	Composicion herbicida para formulaciones en polvo humectable
DE2862482D1 (en)	1987-01-08	Use of alpha-polyolefin compositions for extrusion
IT7869316A0 (it)	1978-10-05	Procedimento per la preparazione di composti imidazolici particolarmente utili come psicofarmaci
IT1107212B (it)	1985-11-25	Composizioni di impiego zootecnico
GB2058818B (en)	1982-11-10	Spray adhesive compositions
NZ187376A (en)	1981-05-29	N-cyano-n-(2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n-alkynyl guanidines intermediates pharmaceutical compositions
DE2861638D1 (en)	1982-03-25	Hydantoin derivatives and salts thereof, their synthesis and intermediates, and pharmaceutical formulations
JPS5458730A (en)	1979-05-11	Coating composition for construction
NZ186334A (en)	1980-05-08	Oxadiazolopyrimidines:pharmaceutical compositions
NZ187852A (en)	1981-03-16	Acylamido-3-cephem -4-carboxylic acids pharmaceutical compositions intermediates
IT1158883B (it)	1987-02-25	Procedimento per monoalchilazione di di-idrossibenzoli
GB2008408B (en)	1982-03-17	Pharmaceutical compositions
NZ190862A (en)	1981-11-19	N-(3-phenylpropyl)-2-hydroxy-2-phenylethlamines pharmaceutical compositions intermediates
IT7849555A0 (it)	1978-05-25	Procedimento per la preparazione di trialogenuri di stagno monoidrocarbile
JPS5443237A (en)	1979-04-05	Composition for coating
IT7826443A0 (it)	1978-08-03	Composti di ammido-acrilati per composizioni di rivestimento induribili mediante radiazioni.
ZA7812B (en)	1978-10-25	Pharmaceutical compositions
HK31982A (en)	1982-07-16	Applicator for creasse-setting compositions
IL54687A0 (en)	1978-07-31	Pharmaceutical compositions comprising nitroimidazoles
IL56755A0 (en)	1979-05-31	Sex stimulant compositions comprising phenethylamine derivatives