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NO992732L - Parasitticidale forbindelser - Google Patents

Parasitticidale forbindelser

Info

Publication number
NO992732L
NO992732L NO992732A NO992732A NO992732L NO 992732 L NO992732 L NO 992732L NO 992732 A NO992732 A NO 992732A NO 992732 A NO992732 A NO 992732A NO 992732 L NO992732 L NO 992732L
Authority
NO
Norway
Prior art keywords
parasiticidal compounds
parasiticidal
compounds
Prior art date
Application number
NO992732A
Other languages
English (en)
Other versions
NO992732D0 (no
NO313518B1 (no
Inventor
Bernard Joseph Banks
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625290.3A external-priority patent/GB9625290D0/en
Priority claimed from GBGB9702235.4A external-priority patent/GB9702235D0/en
Priority claimed from GBGB9712045.5A external-priority patent/GB9712045D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of NO992732D0 publication Critical patent/NO992732D0/no
Publication of NO992732L publication Critical patent/NO992732L/no
Publication of NO313518B1 publication Critical patent/NO313518B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
NO19992732A 1996-12-05 1999-06-04 Parasitticidale forbindelser NO313518B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9625290.3A GB9625290D0 (en) 1996-12-05 1996-12-05 Parasiticidal agents
GBGB9702235.4A GB9702235D0 (en) 1997-02-04 1997-02-04 Parasiticidal agents
GBGB9712045.5A GB9712045D0 (en) 1997-06-10 1997-06-10 Parasiticidal agents
PCT/EP1997/006697 WO1998024767A1 (en) 1996-12-05 1997-11-25 Parasiticidal pyrazoles

Publications (3)

Publication Number Publication Date
NO992732D0 NO992732D0 (no) 1999-06-04
NO992732L true NO992732L (no) 1999-08-05
NO313518B1 NO313518B1 (no) 2002-10-14

Family

ID=27268619

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19992732A NO313518B1 (no) 1996-12-05 1999-06-04 Parasitticidale forbindelser
NO992736A NO992736D0 (no) 1996-12-05 1999-06-04 Ikke oppgitt

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO992736A NO992736D0 (no) 1996-12-05 1999-06-04 Ikke oppgitt

Country Status (39)

Country Link
US (2) US6075043A (no)
EP (1) EP0946515B1 (no)
JP (2) JP3950483B2 (no)
KR (1) KR100354311B1 (no)
CN (1) CN1106386C (no)
AR (1) AR013879A1 (no)
AT (1) ATE233736T1 (no)
AU (1) AU720705B2 (no)
BG (1) BG64127B1 (no)
BR (1) BR9713565A (no)
CA (1) CA2273951C (no)
CO (1) CO5031251A1 (no)
CZ (1) CZ295295B6 (no)
DE (1) DE69719547T2 (no)
DK (1) DK0946515T3 (no)
DZ (1) DZ2360A1 (no)
EA (1) EA002278B1 (no)
ES (1) ES2191870T3 (no)
HR (1) HRP970663B1 (no)
HU (1) HUP0000544A3 (no)
ID (1) ID21556A (no)
IL (1) IL129866A (no)
IS (1) IS1982B (no)
MA (1) MA24414A1 (no)
MY (1) MY117021A (no)
NO (2) NO313518B1 (no)
NZ (1) NZ335611A (no)
OA (1) OA11055A (no)
PA (1) PA8442101A1 (no)
PE (1) PE20199A1 (no)
PL (1) PL190926B1 (no)
PT (1) PT946515E (no)
RS (1) RS49720B (no)
SK (1) SK285203B6 (no)
TN (1) TNSN97197A1 (no)
TW (1) TW524667B (no)
UA (1) UA60321C2 (no)
UY (2) UY24798A1 (no)
WO (1) WO1998024767A1 (no)

Families Citing this family (37)

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TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
GB9801851D0 (en) * 1998-01-29 1998-03-25 Pfizer Ltd Parasiticidal agents
GB9810354D0 (en) * 1998-05-14 1998-07-15 Pfizer Ltd Heterocycles
GB9811050D0 (en) * 1998-05-22 1998-07-22 Pfizer Ltd Pyrazoles
AR021608A1 (es) * 1998-12-11 2002-07-31 Merial Ltd Represion de artropodos en animales
US6531501B1 (en) 1998-12-11 2003-03-11 Aventis Cropscience, S.A. Control of arthropods in animals
GB9916052D0 (en) * 1999-07-08 1999-09-08 Pfizer Ltd Anthelmintic compositions
WO2001040195A2 (en) 1999-12-02 2001-06-07 Aventis Cropscience S.A. Control of arthropods in animals
AU2003218758A1 (en) * 2002-03-14 2003-09-22 Syngenta Participations Ag Derivatives of 1-phenyl-3-phenylpyrazole as herbicides
CH697663B1 (de) * 2003-01-07 2009-01-15 Lanxess Deutschland Gmbh Pyrazolylalkine.
WO2005023773A1 (en) * 2003-09-04 2005-03-17 Pfizer Limited Process for the preparation of substituted aryl pyrazoles
US7514464B2 (en) * 2003-12-18 2009-04-07 Pfizer Limited Substituted arylpyrazoles
GB0329314D0 (en) * 2003-12-18 2004-01-21 Pfizer Ltd Substituted arylpyrazoles
CA2560510C (en) 2004-03-18 2009-10-13 Pfizer Inc. N-(1-arylpyrazol-4yl) sulfonamides and their use as parasiticides
US20070149464A1 (en) * 2005-06-15 2007-06-28 Pfizer Inc. Combination
CN101228134A (zh) 2005-06-15 2008-07-23 辉瑞有限公司 用作杀寄生虫剂的取代芳基吡唑
US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
US20080176865A1 (en) * 2005-06-15 2008-07-24 Pfizer Limited Substituted arylpyrazoles
US20080146643A1 (en) * 2005-06-15 2008-06-19 Pfizer Limited Combination
CA2614282A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
EP1783114A1 (en) * 2005-11-03 2007-05-09 Novartis AG N-(hetero)aryl indole derivatives as pesticides
DE102006061537A1 (de) * 2006-12-27 2008-07-03 Bayer Healthcare Ag Mittel zur Bekämpfung von Parasiten an Tieren
DE102006061538A1 (de) 2006-12-27 2008-07-03 Bayer Healthcare Ag Kombinationsprodukt zur Bekämpfung von Parasiten an Tieren
JP2013523805A (ja) 2010-04-08 2013-06-17 ゾエティス・エルエルシー 殺虫剤および殺ダニ剤としての置換3,5−ジフェニル−イソオキサゾリン誘導体
CN103270036B (zh) 2010-08-05 2015-11-25 佐蒂斯有限责任公司 作为抗寄生物剂的异噁唑啉衍生物
BR112013006686A2 (pt) 2010-09-24 2017-11-14 Zoetis Llc isoxazolina oximas como agentes antiparasitários
WO2012120399A1 (en) 2011-03-10 2012-09-13 Pfizer Inc. Spirocyclic isoxazoline derivatives as antiparasitic agents
WO2012127347A1 (en) 2011-03-22 2012-09-27 Pfizer Inc. Isoxazoline derivatives as antiparasitic agents
ES2609005T3 (es) 2011-06-30 2017-04-18 Agente para combatir parásitos en animales
BR112014018650A8 (pt) 2012-02-03 2017-07-11 Zoetis Llc Derivados azetidina de dihidrofurano como agentes antiparasitários
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
MX336431B (es) 2012-05-09 2016-01-18 Zoetis Services Llc Derivados de azetidina como agentes antiparasitarios.
MX363173B (es) 2012-12-12 2019-03-12 Zoetis Services Llc Composiciones inyectables de fenilpirazol.
MX2020001525A (es) 2017-08-24 2020-03-20 Novo Nordisk As Composiciones de peptido similar al glucagon tipo 1 (glp-1) y sus usos.
CN111116478B (zh) * 2019-12-18 2021-10-26 浙江金伯士药业有限公司 一种兽用抗生素维吉霉素中间体的制备方法
IL294521A (en) 2020-02-18 2022-09-01 Novo Nordisk As glp-1 compounds and their uses
CN115894374A (zh) * 2023-02-16 2023-04-04 广州佳途科技股份有限公司 一种氟甲腈的制备方法及其应用

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DE2658725A1 (de) * 1976-12-24 1978-07-06 Bayer Ag Mittel zur bekaempfung von tierischen ektoparasiten mit stark ausgepraegter residualwirkung
US4479968A (en) 1980-10-17 1984-10-30 The Wellcome Foundation Ltd. Control of ectoparasitic infestations of pigs
GB2086302A (en) * 1980-10-24 1982-05-12 Bone Cravens Ltd Prefill Valve System
US5547974A (en) * 1985-12-20 1996-08-20 Rhone-Poulenc Agriculture Ltd. Derivatives of N-phenylpyrazoles
GB8531485D0 (en) * 1985-12-20 1986-02-05 May & Baker Ltd Compositions of matter
US5232940A (en) * 1985-12-20 1993-08-03 Hatton Leslie R Derivatives of N-phenylpyrazoles
GB8713768D0 (en) * 1987-06-12 1987-07-15 May & Baker Ltd Compositions of matter
GB8713769D0 (en) * 1987-06-12 1987-07-15 May & Baker Ltd Compositions of matter
GB8613914D0 (en) * 1986-06-07 1986-07-09 Coopers Animal Health Liquid formulations
ATE65013T1 (de) * 1986-12-05 1991-07-15 Ciba Geigy Ag Ektoparasitizide nicht-waessrige pour-onfl¨ssigformulierung.
DE3706993A1 (de) * 1987-03-05 1988-09-15 Bayer Ag 5-amino-3-halogenalkyl-1-aryl-pyrazole
SE455750B (sv) 1987-06-11 1988-08-01 Ericsson Telefon Ab L M Digitalt tidsmultiplext mobiltelefonisystem med ett effektivt utnyttjande av varje tidsram
GB9120641D0 (en) * 1991-09-27 1991-11-06 Ici Plc Heterocyclic compounds
ZA94170B (en) * 1993-01-20 1995-03-15 Soltec Res Pty Ltd Ectoparasiticidal formulation
AUPM437194A0 (en) * 1994-03-11 1994-03-31 Commonwealth Scientific And Industrial Research Organisation Pesticide formulation
WO1997007202A1 (en) 1995-08-11 1997-02-27 Novo Nordisk A/S Novel lipolytic enzymes
GB9601128D0 (en) * 1995-08-11 1996-03-20 Pfizer Ltd Parasiticidal compounds
JPH0987111A (ja) * 1995-09-27 1997-03-31 Sumitomo Chem Co Ltd 害虫駆除用毒餌剤
FR2739255B1 (fr) * 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
ES2191076T3 (es) * 1995-12-19 2003-09-01 Bayer Cropscience Sa Nuevos derivados de 1-aril-pirazol y su empleo como plaguicidas.
GR1002899B (el) * 1996-03-29 1998-05-11 Rhone Merieux Περιλαιμιο κατα ψυλλων και κροτωνων για σκυλους και γατες, με βαση ν-φαινυλπυραζολη
IE80657B1 (en) * 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
GR970100096A (el) * 1996-03-29 1997-11-28 Merial Εξωτερικη διαταξη κατα των παρασιτων για βοοειδη με βαση τη ν-φαινυλπυραζολη, ειδικα σκουλαρικια.
IE970215A1 (en) * 1996-03-29 1997-10-08 Rhone Merieux Direct pour-on skin solution for antiparasitic use in cattle¹and sheep
TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
US7100379B2 (en) * 2003-08-14 2006-09-05 Samsung Electronics Co., Ltd. Water supply control apparatus and method for ice maker

Also Published As

Publication number Publication date
IL129866A (en) 2004-05-12
TW524667B (en) 2003-03-21
HUP0000544A2 (hu) 2000-06-28
EP0946515B1 (en) 2003-03-05
DE69719547T2 (de) 2003-10-02
NO992736D0 (no) 1999-06-04
WO1998024767A1 (en) 1998-06-11
ATE233736T1 (de) 2003-03-15
CZ295295B6 (cs) 2005-06-15
IL129866A0 (en) 2000-02-29
NO992732D0 (no) 1999-06-04
UY24923A1 (es) 1998-09-01
HK1029111A1 (en) 2001-03-23
OA11055A (en) 2002-03-07
KR100354311B1 (ko) 2002-09-28
CZ195199A3 (cs) 2000-08-16
PT946515E (pt) 2003-06-30
IS5050A (is) 1999-05-11
JP3950483B2 (ja) 2007-08-01
UY24798A1 (es) 2000-09-29
US6268509B1 (en) 2001-07-31
NO313518B1 (no) 2002-10-14
MY117021A (en) 2004-04-30
DK0946515T3 (da) 2003-07-14
US6075043A (en) 2000-06-13
JP2000505812A (ja) 2000-05-16
TNSN97197A1 (fr) 2005-03-15
SK285203B6 (sk) 2006-08-03
PA8442101A1 (es) 2000-05-24
CN1106386C (zh) 2003-04-23
CN1258282A (zh) 2000-06-28
SK74099A3 (en) 2001-02-12
ES2191870T3 (es) 2003-09-16
KR20000057432A (ko) 2000-09-15
DZ2360A1 (fr) 2002-12-28
BG64127B1 (bg) 2004-01-30
DE69719547D1 (de) 2003-04-10
HUP0000544A3 (en) 2002-01-28
AR013879A1 (es) 2001-01-31
NZ335611A (en) 2001-01-26
HRP970663A2 (en) 1998-10-31
CA2273951A1 (en) 1998-06-11
IS1982B (is) 2005-01-14
EA199900447A1 (ru) 2000-02-28
YU25299A (sh) 2002-10-18
EA002278B1 (ru) 2002-02-28
HRP970663B1 (en) 2003-10-31
PL333922A1 (en) 2000-01-31
UA60321C2 (uk) 2003-10-15
AU5485998A (en) 1998-06-29
EP0946515A1 (en) 1999-10-06
CA2273951C (en) 2003-04-01
AU720705B2 (en) 2000-06-08
PL190926B1 (pl) 2006-02-28
JP2007211016A (ja) 2007-08-23
PE20199A1 (es) 1999-03-05
MA24414A1 (fr) 1998-07-01
BG103454A (en) 2000-01-31
BR9713565A (pt) 2000-03-14
CO5031251A1 (es) 2001-04-27
RS49720B (sr) 2007-12-31
ID21556A (id) 1999-06-24

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: ZOETIS LLC, US

MM1K Lapsed by not paying the annual fees