NO986024D0 - Substituerte 3,5-difenyl-1,2,4-triazoler og deres anvendelse som farmas÷yti - Google Patents
Substituerte 3,5-difenyl-1,2,4-triazoler og deres anvendelse som farmas÷ytiInfo
- Publication number
- NO986024D0 NO986024D0 NO986024A NO986024A NO986024D0 NO 986024 D0 NO986024 D0 NO 986024D0 NO 986024 A NO986024 A NO 986024A NO 986024 A NO986024 A NO 986024A NO 986024 D0 NO986024 D0 NO 986024D0
- Authority
- NO
- Norway
- Prior art keywords
- triazoles
- diphenyl
- pharmaceutical
- substituted
- Prior art date
Links
- KPKQWXGFEKRQQA-UHFFFAOYSA-N 3,5-diphenyl-1h-1,2,4-triazole Chemical class C1=CC=CC=C1C1=NNC(C=2C=CC=CC=2)=N1 KPKQWXGFEKRQQA-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH159396 | 1996-06-25 | ||
| PCT/EP1997/003315 WO1997049395A1 (en) | 1996-06-25 | 1997-06-24 | Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO986024D0 true NO986024D0 (no) | 1998-12-21 |
| NO986024L NO986024L (no) | 1998-12-21 |
| NO317180B1 NO317180B1 (no) | 2004-09-06 |
Family
ID=4214048
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19986024A NO317180B1 (no) | 1996-06-25 | 1998-12-21 | Substituerte 3,5-difenyl-1,2,4-triazoler og deres anvendelse som farmasoytiske metallchelatorer |
| NO2006017C NO2006017I2 (no) | 1996-06-25 | 2006-11-30 | 4-[3,5-bis(2-hydroksifenyl)-[1,2,4]triazol-l-yl]benzosyre(Deferasirox) |
| NO2018014C NO2018014I2 (no) | 1996-06-25 | 2018-04-17 | Deferasirox eller et farmasøytisk akseptabelt salt derav |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2006017C NO2006017I2 (no) | 1996-06-25 | 2006-11-30 | 4-[3,5-bis(2-hydroksifenyl)-[1,2,4]triazol-l-yl]benzosyre(Deferasirox) |
| NO2018014C NO2018014I2 (no) | 1996-06-25 | 2018-04-17 | Deferasirox eller et farmasøytisk akseptabelt salt derav |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US6465504B1 (no) |
| EP (1) | EP0914118B1 (no) |
| JP (1) | JP3541042B2 (no) |
| KR (1) | KR100616378B1 (no) |
| CN (1) | CN1146415C (no) |
| AP (1) | AP1127A (no) |
| AR (1) | AR007479A1 (no) |
| AT (1) | ATE226435T1 (no) |
| AU (1) | AU718037B2 (no) |
| BG (1) | BG64248B1 (no) |
| BR (1) | BR9709973A (no) |
| CA (1) | CA2255951C (no) |
| CY (2) | CY2429B1 (no) |
| CZ (1) | CZ291470B6 (no) |
| DE (3) | DE69716602T2 (no) |
| DK (1) | DK0914118T3 (no) |
| ES (1) | ES2187785T3 (no) |
| FR (1) | FR06C0049I2 (no) |
| GE (1) | GEP20084355B (no) |
| HU (1) | HU226232B1 (no) |
| IL (1) | IL127212A0 (no) |
| LT (1) | LTC0914118I2 (no) |
| LU (1) | LU91291I2 (no) |
| MY (1) | MY129541A (no) |
| NL (1) | NL300248I2 (no) |
| NO (3) | NO317180B1 (no) |
| NZ (1) | NZ333308A (no) |
| OA (1) | OA10946A (no) |
| PL (1) | PL194758B1 (no) |
| PT (1) | PT914118E (no) |
| RU (1) | RU2208010C2 (no) |
| SI (1) | SI0914118T1 (no) |
| SK (1) | SK284319B6 (no) |
| TR (1) | TR199802693T2 (no) |
| TW (1) | TW533205B (no) |
| WO (1) | WO1997049395A1 (no) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6677487B2 (en) | 2001-08-30 | 2004-01-13 | Pharmacia Corporation | α-haloenamine reagents |
| GB0126618D0 (en) * | 2001-11-06 | 2002-01-02 | Novartis Ag | Organic compounds |
| ES2192494B1 (es) * | 2002-03-27 | 2005-02-16 | Consejo Superior De Investigaciones Cientificas | Derivados de 1,2,4-triazol con propiedades cannabinoides. |
| US8829198B2 (en) * | 2007-10-31 | 2014-09-09 | Proteotech Inc | Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies |
| GB0223978D0 (en) * | 2002-10-15 | 2002-11-20 | Novartis Ag | Organic compound |
| MY142651A (en) * | 2003-03-18 | 2010-12-15 | Merck Sharp & Dohme | Biaryl substituted triazoles as sodium channel blockers |
| US20050008699A1 (en) * | 2003-07-11 | 2005-01-13 | Fred Wehling | Effervescent glucosamine composition |
| KR20060123739A (ko) * | 2003-11-10 | 2006-12-04 | 머크 앤드 캄파니 인코포레이티드 | 나트륨 채널 차단제로서의 치환된 트리아졸 |
| EP1696917A1 (en) * | 2003-12-19 | 2006-09-06 | Novartis AG | COMBINATION OF (a) N-{5- [4-(4-METHYL-PIPERAZINO-METHYL) -BENZOYLAMIDO] -2METHYLPHENYL]-4-(3-PYRIDYL)-2-PYRIMIDINE-AMINE AND (b) AT LEAST ONE HYPUSINATION INHIBITOR AND THE USE THEREOF |
| GB0408078D0 (en) * | 2004-04-08 | 2004-05-12 | Novartis Ag | Organic compounds |
| WO2005115379A2 (en) * | 2004-05-24 | 2005-12-08 | New York University | Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux |
| US9737511B2 (en) * | 2004-05-24 | 2017-08-22 | Geoffrey C. GURTNER | Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux |
| US20080114001A1 (en) * | 2005-01-28 | 2008-05-15 | Manley Paul W | Use of Pyrimidylaminobenzamides for the Treatment of Diseases that Respond to Modulation of Tie-2 Kinase Activity |
| JP2008530043A (ja) * | 2005-02-10 | 2008-08-07 | ノバルティス アクチエンゲゼルシャフト | 薬剤処分の改善法 |
| AU2006252718B2 (en) * | 2005-05-31 | 2010-04-15 | Novartis Ag | Treatment of liver diseases in which iron plays a role in pathogenesis |
| US20080311194A1 (en) * | 2005-10-19 | 2008-12-18 | Florian Battung | Dispersible Tablets Comprising Deferasirox |
| WO2007051773A1 (en) * | 2005-11-01 | 2007-05-10 | Novartis Ag | Method of scintigraphy |
| CN101415691B (zh) * | 2006-02-03 | 2011-12-14 | 大正制药株式会社 | 三唑衍生物 |
| EP2026800A1 (en) * | 2006-05-09 | 2009-02-25 | Novartis AG | Combination comprising an iron chelator and an anti-neoplastic agent and use thereof |
| US20110105575A1 (en) * | 2006-05-23 | 2011-05-05 | Hanspeter Nick | Method of treatment of hereditary hemochromatosis |
| CL2007002026A1 (es) | 2006-07-13 | 2008-06-06 | Los Angeles Biomed Res Inst | Composicion que comprende al menos un compuesto quelante de hierro y al menos un agente antifungico; y metodo para el tratamiento o prevencion de una condicion fungica. |
| US20100004303A1 (en) * | 2006-08-04 | 2010-01-07 | Novartis Ag | Treatment of endocrine dysfunction using iron chelators |
| RU2339625C2 (ru) * | 2006-11-02 | 2008-11-27 | Российский химико-технологический университет (РХТУ им. Д.И. Менделеева) | ЗАМЕЩЕННЫЕ N-[ω-АЗОЛ-1-ИЛ)АЛКИЛ]БЕНЗОЛСУЛЬФАМИДЫ В КАЧЕСТВЕ СРЕДСТВ С АНТИАГРЕГАЦИОННОЙ АКТИВНОСТЬЮ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
| KR20090085081A (ko) * | 2006-11-29 | 2009-08-06 | 노파르티스 아게 | 데페라시록스 (icl670a)의 다형체 형태 |
| EP1927591A1 (en) * | 2006-11-29 | 2008-06-04 | Novartis AG | Polymorphic Forms of Deferasirox (ICL670) |
| US20080262060A1 (en) * | 2007-01-29 | 2008-10-23 | Toth Zoltan G | Crystalline forms of Deferasirox |
| RU2009146126A (ru) * | 2007-05-14 | 2011-06-20 | Новартис АГ (CH) | Применение хелаторов железа для лечения инфаркта миокарда |
| EP1994930A1 (en) * | 2007-05-22 | 2008-11-26 | Novartis AG | Triazol compounds for treating biofilm formation |
| WO2009016359A1 (en) * | 2007-07-27 | 2009-02-05 | Pliva Hrvatska D.O.O. | New forms of deferasirox |
| US20090082412A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched deferasirox |
| EP2062572A1 (en) | 2007-11-19 | 2009-05-27 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical compositions |
| CZ301873B6 (cs) * | 2008-01-30 | 2010-07-14 | Farmak, A. S. | Zpusob prípravy kyseliny 4-[3,5-bis(2-hydroxyfenyl)-[1,2,4]triazol-1-yl]benzoové |
| WO2009106824A2 (en) * | 2008-02-25 | 2009-09-03 | Cipla Limited | Pharmaceutical formulations |
| WO2009111611A2 (en) | 2008-03-05 | 2009-09-11 | Proteotech Inc. | Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes |
| US20110097413A1 (en) * | 2008-04-21 | 2011-04-28 | Actavis Group Ptc Ehf | Solid state forms of deferasirox salts and process for the preparation thereof |
| US20110171138A1 (en) * | 2008-06-02 | 2011-07-14 | Actavis Group Ptc Ehf | Substantially pure deferasirox and processes for the preparation thereof |
| JPWO2010032489A1 (ja) | 2008-09-22 | 2012-02-09 | 国立大学法人旭川医科大学 | 鉄キレート剤及びその製造方法、並びに鉄イオンの定量・捕捉方法 |
| US10098857B2 (en) | 2008-10-10 | 2018-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds |
| WO2010092419A1 (en) | 2009-02-12 | 2010-08-19 | Assistance Publique - Hopitaux De Paris | Combined treatment of multiple sclerosis |
| US20120093828A1 (en) | 2009-03-19 | 2012-04-19 | Ibrahim Ashraf S | Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases |
| IT1398770B1 (it) * | 2009-07-22 | 2013-03-18 | Bellacchio | Oligonucleotidi attivabili mediante l'appaiamento con sequenze di acidi nucleici e loro uso |
| WO2011021218A2 (en) * | 2009-08-12 | 2011-02-24 | Msn Laboratories Limited | Process for the preparation of 4-[3,5-bis(2-hydroxyphenyl)-1h-1,2,4-triazol-1-yl]-benzoic acid and its amine salts |
| MX2012006434A (es) * | 2009-12-07 | 2012-07-30 | Mapi Pharma Ltd | Procesos para la preparacion de deferasirox, y polimorfos de deferasirox. |
| US8703203B2 (en) | 2010-07-08 | 2014-04-22 | Ratiopharm Gmbh | Oral dosage form of deferasirox |
| WO2012025935A2 (en) | 2010-08-25 | 2012-03-01 | Ramamohan Rao Davuluri | A process for the preparation of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one and its use for preparation of 4-[3, 5-bis (2-hydroxyphenyl)-1h-1, 2, 4-triazol-1-yl] benzoic acid |
| MY165826A (en) * | 2010-10-01 | 2018-05-17 | Cipla Ltd | Pharmaceutical composition |
| WO2012069946A1 (en) * | 2010-11-24 | 2012-05-31 | Alembic Pharmaceuticals Limited | Process for the preparation of deferasirox |
| WO2012096183A1 (ja) | 2011-01-14 | 2012-07-19 | 株式会社ダステック | 高分子鉄キレート剤 |
| WO2013053927A1 (en) | 2011-10-14 | 2013-04-18 | Photocure Asa | Photodynamic diagnosis of abnormalities of the epithelial lining of the oesophagus with the means of a 5-ala ester |
| EP2779956A1 (en) | 2011-10-14 | 2014-09-24 | Photocure ASA | Stent |
| US8822464B2 (en) | 2011-11-28 | 2014-09-02 | Boehringer Ingelheim International Gmbh | N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
| US8741892B2 (en) | 2011-12-05 | 2014-06-03 | Boehringer Ingelheim International Gmbh | Compounds |
| US8642774B2 (en) * | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
| US8846948B2 (en) | 2011-12-13 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Compounds |
| US8796467B2 (en) | 2011-12-13 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Compounds |
| US8716277B2 (en) | 2011-12-14 | 2014-05-06 | Boehringer Ingelheim International Gmbh | Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity |
| US8937176B2 (en) | 2011-12-14 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Compounds |
| US8883789B2 (en) | 2011-12-14 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
| US8889677B2 (en) | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
| EP2964659B1 (en) * | 2013-03-06 | 2017-08-09 | Biocon Limited | Process for the preparation of deferasirox |
| MY170303A (en) | 2013-03-08 | 2019-07-17 | Novartis Ag | Oral formulations of deferasirox |
| HK1215191A1 (zh) * | 2013-05-10 | 2016-08-19 | Cipla Limited | 低剂量医药组合物 |
| DE102013217390A1 (de) | 2013-09-02 | 2015-03-05 | Henkel Ag & Co. Kgaa | Wasch- und Reinigungsmittel mit verbesserter Leistung |
| CN103454370B (zh) * | 2013-09-11 | 2014-12-24 | 中美华世通生物医药科技(武汉)有限公司 | 一种利用hplc测定原料药中苯肼类化合物残留的方法 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| LT3116909T (lt) | 2014-03-14 | 2020-02-10 | Novartis Ag | Antikūno molekulės prieš lag-3 ir jų panaudojimas |
| TR201909052T4 (tr) | 2014-05-20 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Deferasiroks içeren suda dağılabilen tablet formülasyonu. |
| EP2987482A1 (en) | 2014-08-22 | 2016-02-24 | Santa Farma Ilaç Sanayi A.S. | Soluble and dispersible pharamaceutical deferasirox formulation |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| JP6877339B2 (ja) | 2014-10-14 | 2021-05-26 | ノバルティス アーゲー | Pd−l1に対する抗体分子およびその使用 |
| WO2016100882A1 (en) | 2014-12-19 | 2016-06-23 | Novartis Ag | Combination therapies |
| KR20160088965A (ko) | 2015-01-16 | 2016-07-27 | 대원제약주식회사 | 데페라시록스를 함유하는 현탁제 |
| JP6692826B2 (ja) | 2015-03-10 | 2020-05-13 | アドゥロ バイオテック,インク. | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達の活性化のための組成物及び方法 |
| CN104817538A (zh) * | 2015-03-13 | 2015-08-05 | 东南大学 | 去铁斯诺-他克林金属离子鳌合剂及其药物用途 |
| WO2016167729A1 (en) | 2015-04-16 | 2016-10-20 | Öğün Yusuf Toktamiş | Dispersible tablets comprising deferasirox |
| EP3095443A1 (en) | 2015-05-21 | 2016-11-23 | Abdi Ibrahim Ilac Sanayi ve Ticaret A.S. | Pharmaceutical composition comprising deferasirox |
| WO2016203488A1 (en) * | 2015-06-16 | 2016-12-22 | Havaldar Freddy H | Preparation of novel deferasirox analogues for antimalarial activity |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| EP3964528A1 (en) | 2015-07-29 | 2022-03-09 | Novartis AG | Combination therapies comprising antibody molecules to lag-3 |
| WO2017019896A1 (en) | 2015-07-29 | 2017-02-02 | Novartis Ag | Combination therapies comprising antibody molecules to pd-1 |
| KR101695970B1 (ko) | 2015-07-31 | 2017-01-13 | 건일제약 주식회사 | 데페라시록스 함유 산제 및 그 제조방법 |
| CN106554770B (zh) * | 2015-09-29 | 2018-10-19 | 杭州杜易科技有限公司 | 一种三唑衍生物金属离子荧光探针及其制备方法和应用 |
| CA3002418C (en) | 2015-10-23 | 2023-10-03 | Vifor (International) Ag | Novel ferroportin inhibitors |
| EP4424322A3 (en) | 2015-12-17 | 2025-04-16 | Novartis AG | Antibody molecules to pd-1 and uses thereof |
| EP3429562A1 (en) | 2016-03-17 | 2019-01-23 | Lupin Limited | Compositions of deferasirox |
| WO2018009466A1 (en) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| WO2018059922A1 (en) | 2016-09-30 | 2018-04-05 | Synthon B.V. | Pharmaceutical composition comprising deferasirox |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| CZ2017255A3 (cs) | 2017-05-04 | 2018-11-14 | Zentiva, K.S. | Filmem potažené tablety Deferasiroxu |
| WO2018208242A1 (en) | 2017-05-10 | 2018-11-15 | İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi | Formulation of deferasirox tablet for oral suspension composition with better processability |
| EP3642240A1 (en) | 2017-06-22 | 2020-04-29 | Novartis AG | Antibody molecules to cd73 and uses thereof |
| US11331288B2 (en) | 2017-09-14 | 2022-05-17 | The Board Of Trustees Of The Leland Stanford Junior University | Conditioning irradiated tissue for increasing vascularity |
| EP3489692A1 (de) | 2017-11-28 | 2019-05-29 | Siemens Healthcare Diagnostics Products GmbH | Prothrombinzeit-reagenz enthaltend einen eisenchelator |
| TR201722910A2 (tr) | 2017-12-29 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Deferasi̇roks i̇çeren suda dağilabi̇len tablet formülasyonlari |
| KR20190110771A (ko) | 2018-03-21 | 2019-10-01 | 주식회사 한국팜비오 | 데페라시록스를 함유하는 소형 분산성 정제 |
| CN108727287B (zh) * | 2018-05-10 | 2020-10-27 | 东南大学 | 1,2,4-三唑类化合物及其盐和应用 |
| TWI869346B (zh) | 2018-05-30 | 2025-01-11 | 瑞士商諾華公司 | Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法 |
| GR1009592B (el) * | 2018-07-03 | 2019-09-11 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα που περιλαμβανει εναν χηλικο παραγοντα συμπλεκτικο του σιδηρου και μεθοδος για την παρασκευη αυτου |
| KR20200113116A (ko) | 2019-03-22 | 2020-10-06 | 주식회사 한국팜비오 | 데페라시록스를 포함하는 필름코팅정제 |
| TW202102478A (zh) | 2019-04-01 | 2021-01-16 | 瑞士商威佛(國際)股份有限公司 | 新穎的鐵螯合物 |
| CN114502590A (zh) | 2019-09-18 | 2022-05-13 | 诺华股份有限公司 | Entpd2抗体、组合疗法、以及使用这些抗体和组合疗法的方法 |
| IT202000000922A1 (it) | 2020-01-20 | 2021-07-20 | Cage Chemicals S R L | Complessi di ferro e relativi sali come agenti di contrasto per MRI |
| US11155547B1 (en) * | 2020-06-18 | 2021-10-26 | Alterity Therapeutics Limited | Compounds for and methods of treating diseases |
| WO2022186809A1 (en) | 2021-03-05 | 2022-09-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | The film coated tablet comprising deferasirox |
| CN114276305B (zh) * | 2021-12-28 | 2023-11-17 | 中山大学 | 一种三取代苯基-1,2,4-三氮唑衍生物及其制备和治疗神经元损伤的应用 |
| CN114478410B (zh) * | 2022-03-31 | 2022-11-29 | 中山大学 | 一种二取代苯基-1,2,4-三氮唑衍生物及其制备和应用 |
| CN114591254B (zh) * | 2022-03-31 | 2023-10-13 | 中山大学 | 一种3,5-二取代苯基-1,2,4-三氮唑衍生物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH388252A (de) | 1963-01-24 | 1964-11-14 | Geigy Ag J R | Verfahren zum Schützen von Textilmaterial gegen Lichtschädigung |
| DE2628152C2 (de) | 1976-06-23 | 1985-03-28 | Bayer Ag, 5090 Leverkusen | Fungizide und nematizide Mittel |
| US4528196A (en) * | 1981-02-23 | 1985-07-09 | The United States Of America As Represented By The Department Of Health And Human Services | Chelating agents for the treatment of iron overload |
| SU1280851A1 (ru) * | 1983-07-08 | 1996-05-27 | Ростовский государственный университет | 1-фенил-3-алкил-5-(o-оксифенил)-1,2,4-триазолы, обладающие транквилизирующим и антигипоксическим действием, и 1-фенил-3-н-бутил-5-(о-оксифенил)-1,2,4-триазол, обладающий транквилизирующим, антигипоксическим и анальгетическим действием |
| GB8429307D0 (en) | 1984-11-20 | 1984-12-27 | Shell Int Research | Heterocyclic herbicides |
| IL84331A0 (en) * | 1987-11-02 | 1988-04-29 | Yissum Res Dev Co | Pyridoxyl hydrazone derivatives and pharmaceutical compositions containing the same |
| US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
| DE4320801A1 (de) * | 1993-06-23 | 1995-01-05 | Fahlberg List Pharma Gmbh | 2-Hydroxyphenylsubstituierte 1,2,4-Triazole und 1,2,4-Oxadiazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel |
-
1997
- 1997-06-23 TW TW086108750A patent/TW533205B/zh not_active IP Right Cessation
- 1997-06-23 MY MYPI97002822A patent/MY129541A/en unknown
- 1997-06-24 PL PL330119A patent/PL194758B1/pl unknown
- 1997-06-24 TR TR1998/02693T patent/TR199802693T2/xx unknown
- 1997-06-24 SI SI9730462T patent/SI0914118T1/xx unknown
- 1997-06-24 HU HU9903111A patent/HU226232B1/hu active Protection Beyond IP Right Term
- 1997-06-24 CN CNB971958319A patent/CN1146415C/zh not_active Expired - Lifetime
- 1997-06-24 NZ NZ333308A patent/NZ333308A/xx not_active IP Right Cessation
- 1997-06-24 DK DK97928269T patent/DK0914118T3/da active
- 1997-06-24 CZ CZ19984272A patent/CZ291470B6/cs not_active IP Right Cessation
- 1997-06-24 JP JP50234898A patent/JP3541042B2/ja not_active Expired - Lifetime
- 1997-06-24 KR KR1020057017800A patent/KR100616378B1/ko not_active Expired - Lifetime
- 1997-06-24 AU AU32629/97A patent/AU718037B2/en not_active Expired
- 1997-06-24 DE DE69716602T patent/DE69716602T2/de not_active Expired - Lifetime
- 1997-06-24 BR BR9709973A patent/BR9709973A/pt not_active IP Right Cessation
- 1997-06-24 SK SK1785-98A patent/SK284319B6/sk active Protection Beyond IP Right Term
- 1997-06-24 AP APAP/P/1998/001407A patent/AP1127A/en active
- 1997-06-24 WO PCT/EP1997/003315 patent/WO1997049395A1/en not_active Ceased
- 1997-06-24 ES ES97928269T patent/ES2187785T3/es not_active Expired - Lifetime
- 1997-06-24 IL IL12721297A patent/IL127212A0/xx active Protection Beyond IP Right Term
- 1997-06-24 RU RU99101050/04A patent/RU2208010C2/ru active Protection Beyond IP Right Term
- 1997-06-24 EP EP97928269A patent/EP0914118B1/en not_active Expired - Lifetime
- 1997-06-24 DE DE1997616602 patent/DE122007000020I1/de active Pending
- 1997-06-24 PT PT97928269T patent/PT914118E/pt unknown
- 1997-06-24 AT AT97928269T patent/ATE226435T1/de active
- 1997-06-24 CA CA002255951A patent/CA2255951C/en not_active Expired - Lifetime
- 1997-06-24 DE DE122007000020C patent/DE122007000020I2/de active Active
- 1997-06-25 AR ARP970102792A patent/AR007479A1/es active IP Right Grant
-
1998
- 1998-12-08 BG BG103003A patent/BG64248B1/bg unknown
- 1998-12-21 NO NO19986024A patent/NO317180B1/no not_active IP Right Cessation
- 1998-12-24 OA OA9800247A patent/OA10946A/en unknown
-
2000
- 2000-10-30 US US09/699,765 patent/US6465504B1/en not_active Expired - Lifetime
-
2002
- 2002-09-23 US US10/252,899 patent/US6596750B2/en not_active Expired - Lifetime
-
2003
- 2003-05-29 US US10/447,922 patent/US6723742B2/en not_active Expired - Lifetime
-
2004
- 2004-02-27 CY CY0400016A patent/CY2429B1/xx unknown
-
2006
- 2006-11-27 NL NL300248C patent/NL300248I2/nl unknown
- 2006-11-29 LU LU91291C patent/LU91291I2/fr unknown
- 2006-11-30 NO NO2006017C patent/NO2006017I2/no unknown
- 2006-12-26 FR FR06C0049C patent/FR06C0049I2/fr active Active
-
2007
- 2007-01-16 LT LTPA2007001C patent/LTC0914118I2/lt unknown
- 2007-02-09 CY CY2007005C patent/CY2007005I2/el unknown
- 2007-09-14 GE GEAP200710266A patent/GEP20084355B/en unknown
-
2018
- 2018-04-17 NO NO2018014C patent/NO2018014I2/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO986024D0 (no) | Substituerte 3,5-difenyl-1,2,4-triazoler og deres anvendelse som farmas÷yti | |
| NO991815D0 (no) | Oksadiazoler, fremgangsmÕter for deres fremstilling og deres anvendelse som medikamenter | |
| DK0906292T3 (da) | Triazolylmercaptider og deres anvendelse som mikrobicider | |
| NO993619D0 (no) | Titandioksid, fremstilling og anvendelse derav | |
| IS1989B (is) | Kristallað form 4-[5-metýl-3-fenýlísoxasól-4-ýl] bensensúlfonamíðs | |
| NO306401B1 (no) | Oksazolidindionderivater, farmasöytisk preparat inneholdende slike derivater, og deres anvendelse | |
| DK0832061T3 (da) | Benzamidderivater og anvendelse deraf som vasopressin-antagonister | |
| NO986023D0 (no) | Vannbaserte farmas÷ytiske preparater | |
| NO993003L (no) | Sulfonamid-derivater, fremgangsmÕte for deres fremstilling og deres anvendelse som medikamenter | |
| DK1019358T3 (da) | 3,3-diarylpropylaminer, deres anvendelse og fremstilling | |
| DK0770059T3 (da) | Substituerede benzamidiner, deres fremstilling og deres anvendelse som lægemidler | |
| NO962952L (no) | 1,2,4-oksadiazolderivater og deres anvendelse som parasitticider for dyr | |
| NO307510B1 (no) | Bicykliske aromatiske forbindelser, deres anvendelse og farmasøytiske og kosmetiske preparater derav | |
| DK0873308T3 (da) | O-Carbamoyl-phenylalaninol-forbindelser og deres farmaceutisk anvendelige salte | |
| NO962477D0 (no) | Benzamidderivater, deres fremstilling og deres terapautiske anvendelse | |
| DK0835254T3 (da) | Oxazolidinonderivater, deres fremstilling og deres terapeutiske anvendelse | |
| NO20001288L (no) | Substituerte 1,2,3,4,5,6-heksahydro-2,6-metano-3-benzazocin- 10-oler, fremgangsmõte for fremstilling derav og anvendelse som legemiddel | |
| NO954763D0 (no) | Piperidinderivater, deres fremstilling og anvendelse | |
| EE9800209A (et) | Antiglükokortikoidne ravimaine | |
| DK0811593T3 (da) | 1,4-diaryl-2-flour-2-buten som insektcider og acaricider | |
| NO308213B1 (no) | Substituerte indanylidinacetylguanidiner, deres anvendelse og medikamenter inneholdende forbindelsene | |
| NO980471L (no) | Benzensulfonamidderivater, fremstilling derav og terapautiske anvendelser derav | |
| NO20000066D0 (no) | 6-pyrrolidin-2-ylpyrindin-derivater, deres fremstilling og deres farmasoeytiske anvendelse | |
| DE69230590D1 (de) | Mittel gegen fettleibigkeit | |
| DE68906245D1 (de) | Therapeutisches mittel gegen aids. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SPCF | Filing of supplementary protection certificate |
Free format text: PRODUCT NAME: EXJADE; NAT. REG. NO/DATE: EU1063561-1 20060920; FIRST REG. NO/DATE: EU , EU/1/06/356/001-006 20060831 Spc suppl protection certif: 2006017 Filing date: 20061130 |
|
| SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: EXJADE; NAT. REG. NO/DATE: EU1063561-1 20060920; FIRST REG. NO/DATE: EU , EU/1/06/356/001-006 20060831 Spc suppl protection certif: 2006017 Filing date: 20061130 Extension date: 20210828 |
|
| MK1K | Patent expired | ||
| SPCK | Change in the validity period of an spc |
Free format text: PRODUCT NAME: DEFERASIROX ELLER ET FARMASOEYTISK AKSEPTABELT SALT DERAV; THE CERTIFICATE IS VALID EVEN: 2021.08.31 (AMENDED IN ACCORDANCE WITH SECTION 84) Spc suppl protection certif: 2006017 Filing date: 20061130 |
|
| SPCE | Application to extend a supplementary protection certificate (spc) |
Free format text: PRODUCT NAME: DEFERASIROX ELLER ET FARMASOEYTISK AKSEPTABELT SALT DERAV; NAT. REG. NO/DATE: NO , EU/1063561-1 20060828; FIRST REG. NO/DATE: EU , EU/1063561-1 20060920 Spc suppl protection certif: 2018014 Filing date: 20180417 |
|
| SPCH | Extension of a supplementary protection certificate (spc) granted |
Free format text: PRODUCT NAME: DEFERASIROX ELLER ET FARMASOEYTISK AKSEPTABELT SALT DERAV; NAT. REG. NO/DATE: NO , EU/1063561-1 20060828; FIRST REG. NO/DATE: EU , EU/1063561-1 20060920 Spc suppl protection certif: 2018014 Filing date: 20180417 Extension date: 20220228 |
|
| SPCX | Expiry of an spc |
Free format text: PRODUCT NAME: DEFERASIROX OR A PHARMACEUTICAL ACCEPTABLE SALT HENCE Spc suppl protection certif: 2006017 Effective date: 20210828 |
|
| SPCX | Expiry of an spc |
Spc suppl protection certif: 2018014 |