NO972841L - Aryl- og heteroaryl-sulfonamidderivater, deres fremstilling og anvendelse som endotelinantagonister - Google Patents

Aryl- og heteroaryl-sulfonamidderivater, deres fremstilling og anvendelse som endotelinantagonister

Info

Publication number: NO972841L
Authority: NO; Norway
Prior art keywords: signifies; alkyl; phenyl; heterocyclyl; substituted phenyl
Prior art date: 1994-12-20

Application number

NO972841A

Other languages

English (en)

Other versions

NO972841D0 (no

NO308297B1 (no

Inventor

Volker Breu

Kasper Burri

Jean-Marie Cassal

Martine Clozel

Georges Hirth

Bernd-Michael Loeffler

Marcel Mueller

Werner Neidhart

Henri Ramuz

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-20

Filing date

1997-06-19

Publication date

1997-08-18

1997-06-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1997-06-19 Publication of NO972841D0 publication Critical patent/NO972841D0/no

1997-08-18 Publication of NO972841L publication Critical patent/NO972841L/no

2000-08-28 Publication of NO308297B1 publication Critical patent/NO308297B1/no

Links

-1 heteroaryl sulfonamide Chemical class 0.000 title abstract 4
102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title 1
125000003118 aryl group Chemical class 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 9
125000000623 heterocyclic group Chemical group 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
101100516572 Caenorhabditis elegans nhr-8 gene Proteins 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
206010002383 Angina Pectoris Diseases 0.000 abstract 1
102000010180 Endothelin receptor Human genes 0.000 abstract 1
108050001739 Endothelin receptor Proteins 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
206010047163 Vasospasm Diseases 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO972841A 1994-12-20 1997-06-19 Aryl- og heteroaryl-sulfonamidderivater, og deres anvendelse for fremstilling av medikamenter NO308297B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH383894		1994-12-20
CH307995		1995-10-31
PCT/EP1995/004762 WO1996019455A1 (en)	1994-12-20	1995-12-04	Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists

Publications (3)

Publication Number	Publication Date
NO972841D0 NO972841D0 (no)	1997-06-19
NO972841L true NO972841L (no)	1997-08-18
NO308297B1 NO308297B1 (no)	2000-08-28

Family

ID=31189207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO972841A NO308297B1 (no)	1994-12-20	1997-06-19	Aryl- og heteroaryl-sulfonamidderivater, og deres anvendelse for fremstilling av medikamenter

Country Status (25)

Country	Link
US (2)	US5962682A (no)
EP (1)	EP0799206B1 (no)
JP (1)	JP2930731B2 (no)
KR (1)	KR100432843B1 (no)
CN (1)	CN1136192C (no)
AT (1)	ATE223899T1 (no)
AU (1)	AU695255B2 (no)
BR (1)	BR9510533A (no)
CA (1)	CA2208011A1 (no)
CZ (1)	CZ289090B6 (no)
DE (1)	DE69528198T2 (no)
DK (1)	DK0799206T3 (no)
ES (1)	ES2180664T3 (no)
FI (1)	FI116622B (no)
HU (1)	HUT77307A (no)
IL (1)	IL116410A (no)
MA (1)	MA23745A1 (no)
MX (1)	MX9704588A (no)
MY (1)	MY113214A (no)
NO (1)	NO308297B1 (no)
NZ (1)	NZ297774A (no)
PT (1)	PT799206E (no)
RU (1)	RU2163598C2 (no)
TW (1)	TW474920B (no)
WO (1)	WO1996019455A1 (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5962490A (en)	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6613804B2 (en)	1993-05-20	2003-09-02	Encysive Pharmaceuticals, Inc.	Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6376523B1 (en)	1994-05-20	2002-04-23	Texas Biotechnology Corporation	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6342610B2 (en)	1993-05-20	2002-01-29	Texas Biotechnology Corp.	N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6541498B2 (en)	1993-05-20	2003-04-01	Texas Biotechnology	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
JP2930731B2 (ja) *	1994-12-20	1999-08-03	エフ・ホフマン−ラロシュアーゲー	アリール−及びヘテロアリール−スルホンアミド誘導体、その製造法及びエンドセリンアンタゴニストとしてのその用途
US5977117A (en)	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5804585A (en)	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US6653331B2 (en) *	1996-07-03	2003-11-25	Pharmacia & Upjohn Company	Targeted drug delivery using sulfonamide derivatives
NZ336898A (en)	1997-04-28	2001-10-26	Texas Biotechnology Corp	Sulfonamides for treatment of endothelin-mediated disorders
US5783705A (en)	1997-04-28	1998-07-21	Texas Biotechnology Corporation	Process of preparing alkali metal salys of hydrophobic sulfonamides
US6191170B1 (en) *	1998-01-13	2001-02-20	Tularik Inc.	Benzenesulfonamides and benzamides as therapeutic agents
CA2315614C (en)	1999-07-29	2004-11-02	Pfizer Inc.	Pyrazoles
CA2389479A1 (en) *	1999-12-22	2001-06-28	Christoph Boss	Butyne diol derivatives
CN1414965A (zh)	1999-12-31	2003-04-30	德州生物科技公司	调整内皮肽活性的磺酰胺及其衍生物
US6387915B2 (en)	2000-05-31	2002-05-14	Pfizer Inc.	Isoxazole-sulfonamide endothelin antagonists
US6670362B2 (en)	2000-09-20	2003-12-30	Pfizer Inc.	Pyridazine endothelin antagonists
SE0102764D0 (sv)	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
DE60231729D1 (de) *	2001-09-27	2009-05-07	Univ Liege	Hren und verwendung
NZ541234A (en) *	2002-12-20	2008-06-30	Amgen Inc	Asthma and allergic inflammation modulators
WO2004074438A2 (en) *	2003-02-14	2004-09-02	Smithkline Beecham Corporation	Ccr8 antagonists
WO2004073619A2 (en) *	2003-02-14	2004-09-02	Smithkline Beecham Corporation	Ccr8 antagonists
JP4651714B2 (ja)	2005-07-09	2011-03-16	アストラゼネカアクチボラグ	糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
EA201001029A1 (ru) *	2007-12-19	2011-06-30	Амген Инк.	Производные фенилуксусной кислоты в качестве модуляторов процесса воспаления
WO2010015623A1 (en) *	2008-08-05	2010-02-11	Farmaprojects, S. A.	Process for the preparation of endothelin receptor antagonists
AR076221A1 (es)	2009-04-09	2011-05-26	Astrazeneca Ab	Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
CN110092743B (zh) *	2018-01-30	2022-03-15	中国医学科学院药物研究所	苯甲酰胺类化合物及其制备方法、用途和药物组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1521932A (en) *	1976-03-08	1978-08-16	Labaz	Sulphonamide derivatives and process for preparing the same
GB8708233D0 (en) *	1987-04-07	1987-05-13	Smith Kline French Lab	Pharmaceutically active compounds
ATE167473T1 (de) *	1990-08-20	1998-07-15	Eisai Co Ltd	Sulfonamid-derivate
RU2083567C1 (ru) *	1991-04-25	1997-07-10	Ф.Хоффманн-Ля Рош Аг	Производные арилсульфонамида или их соли и фармацевтическая композиция, проявляющая ангиопротекторное, антигипертензивное и вазоспазмолитическое, в частности противоишемическое, действие
TW270116B (no) *	1991-04-25	1996-02-11	Hoffmann La Roche
RU2086544C1 (ru) *	1991-06-13	1997-08-10	Хоффманн-Ля Рош АГ	Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
NZ247440A (en) *	1992-05-06	1995-04-27	Squibb & Sons Inc	Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
TW287160B (no) *	1992-12-10	1996-10-01	Hoffmann La Roche
IL111959A (en) *	1993-12-17	2000-07-16	Tanabe Seiyaku Co	N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
GB9504854D0 (en) *	1994-03-31	1995-04-26	Zeneca Ltd	Nitrogen derivatives
JP2930731B2 (ja) *	1994-12-20	1999-08-03	エフ・ホフマン−ラロシュアーゲー	アリール−及びヘテロアリール−スルホンアミド誘導体、その製造法及びエンドセリンアンタゴニストとしてのその用途

1995
- 1995-12-04 JP JP8519459A patent/JP2930731B2/ja not_active Expired - Fee Related
- 1995-12-04 KR KR1019970704136A patent/KR100432843B1/ko not_active Expired - Fee Related
- 1995-12-04 US US08/860,985 patent/US5962682A/en not_active Expired - Fee Related
- 1995-12-04 DE DE69528198T patent/DE69528198T2/de not_active Expired - Fee Related
- 1995-12-04 RU RU97112144/04A patent/RU2163598C2/ru active
- 1995-12-04 HU HU9701811A patent/HUT77307A/hu unknown
- 1995-12-04 EP EP95941660A patent/EP0799206B1/en not_active Expired - Lifetime
- 1995-12-04 PT PT95941660T patent/PT799206E/pt unknown
- 1995-12-04 NZ NZ297774A patent/NZ297774A/xx unknown
- 1995-12-04 AT AT95941660T patent/ATE223899T1/de not_active IP Right Cessation
- 1995-12-04 ES ES95941660T patent/ES2180664T3/es not_active Expired - Lifetime
- 1995-12-04 DK DK95941660T patent/DK0799206T3/da active
- 1995-12-04 CN CNB951969595A patent/CN1136192C/zh not_active Expired - Fee Related
- 1995-12-04 BR BR9510533A patent/BR9510533A/pt not_active IP Right Cessation
- 1995-12-04 WO PCT/EP1995/004762 patent/WO1996019455A1/en not_active Ceased
- 1995-12-04 CZ CZ19971873A patent/CZ289090B6/cs not_active IP Right Cessation
- 1995-12-04 AU AU43016/96A patent/AU695255B2/en not_active Ceased
- 1995-12-04 CA CA002208011A patent/CA2208011A1/en not_active Abandoned
- 1995-12-06 TW TW084113009A patent/TW474920B/zh active
- 1995-12-15 IL IL11641095A patent/IL116410A/xx not_active IP Right Cessation
- 1995-12-15 MA MA24096A patent/MA23745A1/fr unknown
- 1995-12-18 MY MYPI95003929A patent/MY113214A/en unknown
1997
- 1997-06-18 FI FI972629A patent/FI116622B/fi not_active IP Right Cessation
- 1997-06-19 MX MX9704588A patent/MX9704588A/es not_active IP Right Cessation
- 1997-06-19 NO NO972841A patent/NO308297B1/no not_active IP Right Cessation
1999
- 1999-03-05 US US09/263,034 patent/US6133442A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI972629A0 (fi)	1997-06-18
FI116622B (fi)	2006-01-13
BR9510533A (pt)	1998-07-14
WO1996019455A1 (en)	1996-06-27
EP0799206B1 (en)	2002-09-11
CZ187397A3 (en)	1997-09-17
IL116410A0 (en)	1996-03-31
TW474920B (en)	2002-02-01
US6133442A (en)	2000-10-17
DE69528198T2 (de)	2003-07-31
NO972841D0 (no)	1997-06-19
NZ297774A (en)	1998-10-28
AU695255B2 (en)	1998-08-13
MY113214A (en)	2001-12-31
ATE223899T1 (de)	2002-09-15
CN1170405A (zh)	1998-01-14
HUT77307A (hu)	1998-03-30
FI972629A7 (fi)	1997-06-18
KR100432843B1 (ko)	2004-10-14
JPH10500997A (ja)	1998-01-27
US5962682A (en)	1999-10-05
CA2208011A1 (en)	1996-06-27
JP2930731B2 (ja)	1999-08-03
EP0799206A1 (en)	1997-10-08
DK0799206T3 (da)	2003-01-27
AU4301696A (en)	1996-07-10
RU2163598C2 (ru)	2001-02-27
CN1136192C (zh)	2004-01-28
NO308297B1 (no)	2000-08-28
MX9704588A (es)	1998-07-31
MA23745A1 (fr)	1996-07-01
PT799206E (pt)	2003-01-31
CZ289090B6 (cs)	2001-10-17
ES2180664T3 (es)	2003-02-16
IL116410A (en)	2000-08-13
DE69528198D1 (de)	2002-10-17

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ATE265453T1 (de)	2004-05-15	Diketopiperazinderivate als thrombininhibitoren
PE20040557A1 (es)	2004-10-01	Amidas de acidos 2-heteroarilcarboxilicos
CO5040060A1 (es)	2001-05-29	Derivados de n-bencilazolio

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