NO972406L - Bis-orto-substituerte benzoylguanidiner, fremgangsmåte for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikamenter inneholdende forbindelsene - Google Patents
Bis-orto-substituerte benzoylguanidiner, fremgangsmåte for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikamenter inneholdende forbindelseneInfo
- Publication number
- NO972406L NO972406L NO972406A NO972406A NO972406L NO 972406 L NO972406 L NO 972406L NO 972406 A NO972406 A NO 972406A NO 972406 A NO972406 A NO 972406A NO 972406 L NO972406 L NO 972406L
- Authority
- NO
- Norway
- Prior art keywords
- bis
- compounds
- processes
- atomicr
- alkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 206010061216 Infarction Diseases 0.000 abstract 2
- 230000007574 infarction Effects 0.000 abstract 2
- 230000000302 ischemic effect Effects 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000003293 cardioprotective effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Bis-orio-substituerte benzoylguanidiner, k a r a k t c r i ved formel I R(1) s e r t (I). N. ^NH, hvor substituentene kan ha flere betydninger og f eks. kan R(l), R(2)og R(3) uavhengig av hverandre bety R(10)-SOa-, hvor a er null, 1 eller 2 og R(10) Leks. kan bety alkyl med 1, 2, 3, 4, 5, 6. 7 eller 8 C-atomcr, eller R(l), R(2) og R(3) kan fcks. uavhengig av hverandre bety hydrogen. F, Cl. OI I, CN, CF3, alkyl med 1,2,3 eller C-atomcr, R(4) og R(5) kan likeledes ha flere betydninger og blant annt, uavhengig av hverandre, bcly alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1, 2, 3 eller 4 C-atomcr, OH, F, Cl, DN cllcr -CF3. Disse forbindelsene cr egnede som antiarytmiske legemidler med kardio- bcskyttcndc komponenter for infarkt-profylaksc og infarkt-bchandling saml for be- handling av angina pectoris. De inhiberer også prc\cnti\l de patofyslologiske prosessene ved opptreden av ischcmisk induserte skader, spesiell ved utlesningen av ischcmisk induserte hjertearytmier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19621319A DE19621319A1 (de) | 1996-05-28 | 1996-05-28 | Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO972406D0 NO972406D0 (no) | 1997-05-27 |
| NO972406L true NO972406L (no) | 1997-12-01 |
Family
ID=7795458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO972406A NO972406L (no) | 1996-05-28 | 1997-05-27 | Bis-orto-substituerte benzoylguanidiner, fremgangsmåte for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikamenter inneholdende forbindelsene |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0810207A1 (no) |
| JP (1) | JPH1081662A (no) |
| KR (1) | KR970074756A (no) |
| CN (1) | CN1170716A (no) |
| AR (1) | AR007497A1 (no) |
| AU (1) | AU2359897A (no) |
| BR (1) | BR9703326A (no) |
| CA (1) | CA2206198A1 (no) |
| CZ (1) | CZ161697A3 (no) |
| DE (1) | DE19621319A1 (no) |
| HR (1) | HRP970293A2 (no) |
| HU (1) | HUP9700953A3 (no) |
| ID (1) | ID16988A (no) |
| IL (1) | IL120908A0 (no) |
| NO (1) | NO972406L (no) |
| NZ (1) | NZ314900A (no) |
| PL (1) | PL318722A1 (no) |
| SK (1) | SK66497A3 (no) |
| TR (1) | TR199700423A2 (no) |
| ZA (1) | ZA974607B (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19859727A1 (de) | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
| DE10001879A1 (de) * | 2000-01-19 | 2001-07-19 | Aventis Pharma Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| MXPA05007572A (es) | 2003-01-17 | 2005-11-17 | Threshold Pharmaceuticals Inc | Tratamiento de hiperplasia prostatica benigna. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0556673B1 (de) * | 1992-02-15 | 1997-09-17 | Hoechst Aktiengesellschaft | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4318756A1 (de) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4328869A1 (de) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4417004A1 (de) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4422685A1 (de) * | 1994-06-29 | 1996-01-04 | Hoechst Ag | Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4432106A1 (de) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung |
| DE4432101A1 (de) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Aminosäure-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1996
- 1996-05-28 DE DE19621319A patent/DE19621319A1/de not_active Withdrawn
-
1997
- 1997-02-28 PL PL97318722A patent/PL318722A1/xx unknown
- 1997-05-15 EP EP97107903A patent/EP0810207A1/de not_active Withdrawn
- 1997-05-26 AR ARP970102237A patent/AR007497A1/es unknown
- 1997-05-26 TR TR97/00423A patent/TR199700423A2/xx unknown
- 1997-05-26 CN CN97113032A patent/CN1170716A/zh active Pending
- 1997-05-26 IL IL12090897A patent/IL120908A0/xx unknown
- 1997-05-26 SK SK664-97A patent/SK66497A3/sk unknown
- 1997-05-26 CZ CZ971616A patent/CZ161697A3/cs unknown
- 1997-05-26 AU AU23598/97A patent/AU2359897A/en not_active Abandoned
- 1997-05-26 NZ NZ314900A patent/NZ314900A/en unknown
- 1997-05-27 NO NO972406A patent/NO972406L/no unknown
- 1997-05-27 CA CA002206198A patent/CA2206198A1/en not_active Abandoned
- 1997-05-27 JP JP9136223A patent/JPH1081662A/ja active Pending
- 1997-05-27 HU HU9700953A patent/HUP9700953A3/hu unknown
- 1997-05-27 HR HR19621319.3A patent/HRP970293A2/xx not_active Application Discontinuation
- 1997-05-27 ZA ZA9704607A patent/ZA974607B/xx unknown
- 1997-05-28 ID IDP971812A patent/ID16988A/id unknown
- 1997-05-28 BR BR9703326A patent/BR9703326A/pt not_active Application Discontinuation
- 1997-05-28 KR KR1019970021105A patent/KR970074756A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2206198A1 (en) | 1997-11-28 |
| NO972406D0 (no) | 1997-05-27 |
| MX9703871A (es) | 1997-11-29 |
| HU9700953D0 (en) | 1997-07-28 |
| ZA974607B (en) | 1997-11-28 |
| KR970074756A (ko) | 1997-12-10 |
| AR007497A1 (es) | 1999-11-10 |
| SK66497A3 (en) | 1997-12-10 |
| BR9703326A (pt) | 1998-09-22 |
| JPH1081662A (ja) | 1998-03-31 |
| AU2359897A (en) | 1997-12-04 |
| NZ314900A (en) | 1998-02-26 |
| HUP9700953A3 (en) | 1998-04-28 |
| ID16988A (id) | 1997-11-27 |
| CZ161697A3 (cs) | 1998-06-17 |
| DE19621319A1 (de) | 1997-12-04 |
| HRP970293A2 (en) | 1998-04-30 |
| IL120908A0 (en) | 1997-09-30 |
| PL318722A1 (en) | 1997-12-08 |
| TR199700423A2 (xx) | 1997-12-21 |
| HUP9700953A2 (hu) | 1998-03-02 |
| EP0810207A1 (de) | 1997-12-03 |
| CN1170716A (zh) | 1998-01-21 |
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