[go: up one dir, main page]

MX9704094A - Benzoil-guanidinas sustituidas en orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents

Benzoil-guanidinas sustituidas en orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Info

Publication number
MX9704094A
MX9704094A MX9704094A MX9704094A MX9704094A MX 9704094 A MX9704094 A MX 9704094A MX 9704094 A MX9704094 A MX 9704094A MX 9704094 A MX9704094 A MX 9704094A MX 9704094 A MX9704094 A MX 9704094A
Authority
MX
Mexico
Prior art keywords
medicament
orto
guanidines
well
utilization
Prior art date
Application number
MX9704094A
Other languages
English (en)
Inventor
Andreas Weichert
Joachim Brendel
Heinz-Werner Kleemann
Hans Jochen Lang
Jan-Robert Schwark
Udo Albus
Wolfgang Scholz
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MX9704094A publication Critical patent/MX9704094A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

Las benzoil-guanidinas sustituidas en orto de la formula (I): en las que R(1) hasta R(5) tiene los significados indicados en las reivindicaciones, son adecuados como medicamentos antiarrítmicos con una componente cardioprotectora para la profilaxis y el tratamiento del infarto así como para el tratamiento de la angina de pecho. Éstas inhiben también de modo preventivo los procesos patofisiologicos al formarse lesiones inducidas por isquemias, especialmente en el caso de la provocacion de arritmias cardíacas inducidas por isquemias.
MX9704094A 1996-06-04 1997-06-03 Benzoil-guanidinas sustituidas en orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. MX9704094A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19622370A DE19622370A1 (de) 1996-06-04 1996-06-04 Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
MX9704094A true MX9704094A (es) 1997-12-31

Family

ID=7796095

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704094A MX9704094A (es) 1996-06-04 1997-06-03 Benzoil-guanidinas sustituidas en orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Country Status (29)

Country Link
US (1) US6011063A (es)
EP (1) EP0811610B1 (es)
JP (1) JP4101904B2 (es)
KR (1) KR980002019A (es)
CN (1) CN1064956C (es)
AR (1) AR008761A1 (es)
AT (1) ATE209630T1 (es)
AU (1) AU723665B2 (es)
BR (1) BR9703440A (es)
CA (1) CA2206758C (es)
CZ (1) CZ289411B6 (es)
DE (2) DE19622370A1 (es)
DK (1) DK0811610T3 (es)
ES (1) ES2166487T3 (es)
HR (1) HRP970304B1 (es)
HU (1) HUP9700989A3 (es)
ID (1) ID17038A (es)
IL (1) IL120988A0 (es)
MX (1) MX9704094A (es)
NO (1) NO310188B1 (es)
NZ (1) NZ314973A (es)
PL (1) PL185757B1 (es)
PT (1) PT811610E (es)
RU (1) RU2214397C2 (es)
SI (1) SI0811610T1 (es)
SK (1) SK282628B6 (es)
TR (1) TR199700453A2 (es)
TW (1) TW429243B (es)
ZA (1) ZA974869B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410563B1 (en) 1999-12-22 2002-06-25 Merck Frosst Canada & Co. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
US6639077B2 (en) 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
MY123585A (en) 2000-03-23 2006-05-31 Merck Canada Inc Tri-aryl-substituted-ethane pde4 inhibitors.
AU6196201A (en) 2000-05-25 2001-12-03 Merck Frosst Canada Inc Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
US6740666B2 (en) 2000-12-20 2004-05-25 Merck & Co., Inc. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
CA2447765C (en) 2001-05-24 2011-01-25 Merck Frosst Canada & Co./Merck Frosst Canada & Cie 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors
JO2311B1 (en) 2001-08-29 2005-09-12 ميرك فروست كندا ليمتد Alkyl inhibitors Ariel phosphodiesterase-4
WO2003077918A1 (en) 2002-03-12 2003-09-25 Merck & Co., Inc. Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
GB0916163D0 (en) * 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DE59403818D1 (de) * 1993-02-20 1997-10-02 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
DE4318756A1 (de) * 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4327244A1 (de) * 1993-08-13 1995-02-16 Hoechst Ag Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4422685A1 (de) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
JPH1067731A (ja) 1998-03-10
NZ314973A (en) 1998-09-24
PL320327A1 (en) 1997-12-08
CZ169697A3 (en) 1997-12-17
HRP970304A2 (en) 1998-04-30
ES2166487T3 (es) 2002-04-16
ZA974869B (en) 1997-12-04
EP0811610B1 (de) 2001-11-28
TW429243B (en) 2001-04-11
HRP970304B1 (en) 2002-10-31
SK69697A3 (en) 1998-01-14
AR008761A1 (es) 2000-02-23
CA2206758A1 (en) 1997-12-04
AU2465097A (en) 1997-12-11
HUP9700989A3 (en) 1998-04-28
PL185757B1 (pl) 2003-07-31
US6011063A (en) 2000-01-04
DK0811610T3 (da) 2002-03-25
IL120988A0 (en) 1997-11-20
DE59705495D1 (de) 2002-01-10
ID17038A (id) 1997-12-04
HU9700989D0 (en) 1997-07-28
TR199700453A2 (xx) 1997-12-21
HUP9700989A2 (en) 1997-12-29
NO972527D0 (no) 1997-06-03
EP0811610A1 (de) 1997-12-10
NO310188B1 (no) 2001-06-05
ATE209630T1 (de) 2001-12-15
BR9703440A (pt) 1998-09-29
RU2214397C2 (ru) 2003-10-20
CA2206758C (en) 2007-08-14
CN1064956C (zh) 2001-04-25
JP4101904B2 (ja) 2008-06-18
NO972527L (no) 1997-12-05
SK282628B6 (sk) 2002-10-08
CZ289411B6 (cs) 2002-01-16
CN1175572A (zh) 1998-03-11
SI0811610T1 (en) 2002-04-30
PT811610E (pt) 2002-05-31
DE19622370A1 (de) 1997-12-11
KR980002019A (ko) 1998-03-30
AU723665B2 (en) 2000-08-31

Similar Documents

Publication Publication Date Title
YU24402A (sh) 2'-supstituisani 1,1'-bifenil-2-karbonamidi, postupak za njihovu proizvodnju, njihova primena kao leka kao i farmaceutski preparati koji sadrže ta jedinjenja
CA2070388A1 (en) Antihypertensive compositions and use thereof
IL72354A0 (en) Imidazolium salts,processes for the preparation thereof and pharmaceutical compositions containing the same
CA2257448A1 (en) Pyridyl alkene- and pyridyl alkine-acid amides as cytostatics and immunosuppressives
CA2183972A1 (en) Oxazolidinone derivatives and pharmaceutical compositions containing them
CA2244785A1 (en) Pentafluorobenzenesulfonamides and analogs
YU42503A (sh) Arilovani furan-1 tiofen-amidi-karbonske kiseline sa blokirajućim dejstvom kalijumovog kanala
YU88801A (sh) Indalinom supstituisan benzolkarbonamid, postupak za njegovu proizvodnju, njegova prrimena kao medikamenata kao i farmaceutski preparati koji ga sadrže
CA2014008A1 (en) Benzimidazoles, medicaments containing these compounds and processes for their preparation
CA2361998A1 (en) Aromatic heterocyclic compounds as anti-inflammatory agents
CA2215013A1 (en) N-substituted indol-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action
MY121708A (en) Five- membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic and medicament comprising them
KR950031059A (ko) 골다공증 치료용 약제학적 조성물
MX9704094A (es) Benzoil-guanidinas sustituidas en orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.
CA2206366A1 (en) Substituted 2-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
MX9603300A (es) Derivados de la 4-sulfonilbenzoilguanidina o la 4-sulfinilbenzoilguanidina.
TW200407290A (en) Pentafluorosulfanylbenzoylguanidines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
CA2062779A1 (en) Sterilizing gas composition comprising monochlorotetrafluorethane and ethylene oxide
PT1427417E (pt) Derivados de 6, 7-di-hidroxitetra-hidroisoquinolina substituída em 3 para utilização como agentes antibacterianos
MX9701163A (es) Guanidinas de acidos tiofenilalquenilcarboxilicos sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.
CA2248300A1 (en) Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament, and pharmaceutical preparations comprising them
WO2000003994A3 (de) Imidazolderivate mit biphenylsulfonylsubstitution, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
MX9605538A (es) Benzoil-guanidinas sustituidas con sulfonilamino, procedimiento para su preparacion, su empleo como medicamento o para diagnostico, asi como el medicamento que las contiene.
ZA963046B (en) Antiarrhythmic and cardioprotective substituted indenoylguanidines
WO1992009574A3 (en) Poly-aminopyrrolecarboxamido derivatives, processes for their preparation and pharmaceutical compositions containing them