NO972406L - Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compounds - Google Patents
Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compoundsInfo
- Publication number
- NO972406L NO972406L NO972406A NO972406A NO972406L NO 972406 L NO972406 L NO 972406L NO 972406 A NO972406 A NO 972406A NO 972406 A NO972406 A NO 972406A NO 972406 L NO972406 L NO 972406L
- Authority
- NO
- Norway
- Prior art keywords
- bis
- compounds
- processes
- atomicr
- alkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 206010061216 Infarction Diseases 0.000 abstract 2
- 230000007574 infarction Effects 0.000 abstract 2
- 230000000302 ischemic effect Effects 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000003293 cardioprotective effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Bis-orio-substituerte benzoylguanidiner, k a r a k t c r i ved formel I R(1) s e r t (I). N. ^NH, hvor substituentene kan ha flere betydninger og f eks. kan R(l), R(2)og R(3) uavhengig av hverandre bety R(10)-SOa-, hvor a er null, 1 eller 2 og R(10) Leks. kan bety alkyl med 1, 2, 3, 4, 5, 6. 7 eller 8 C-atomcr, eller R(l), R(2) og R(3) kan fcks. uavhengig av hverandre bety hydrogen. F, Cl. OI I, CN, CF3, alkyl med 1,2,3 eller C-atomcr, R(4) og R(5) kan likeledes ha flere betydninger og blant annt, uavhengig av hverandre, bcly alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1, 2, 3 eller 4 C-atomcr, OH, F, Cl, DN cllcr -CF3. Disse forbindelsene cr egnede som antiarytmiske legemidler med kardio- bcskyttcndc komponenter for infarkt-profylaksc og infarkt-bchandling saml for be- handling av angina pectoris. De inhiberer også prc\cnti\l de patofyslologiske prosessene ved opptreden av ischcmisk induserte skader, spesiell ved utlesningen av ischcmisk induserte hjertearytmier.Bis-orio-substituted benzoylguanidines, k a r a k t c r i by formula I R (1) s e r t (I). N. ^ NH, where the substituents may have several meanings and e.g. for example, R (1), R (2) and R (3) can independently mean R (10) -SOa, where a is zero, 1 or 2 and R (10) Ex. may be alkyl of 1, 2, 3, 4, 5, 6. 7 or 8 C atomicr, or R (1), R (2) and R (3) may be obtained. independently means hydrogen. F, Cl. OI I, CN, CF 3, alkyl of 1,2,3 or C atomicr, R (4) and R (5) can also have several meanings and among others, independently, bcly alkyl of 1,2,3 or 4 C atoms, alkoxy of 1, 2, 3 or 4 C atomicr, OH, F, Cl, DN cllcr -CF3. These compounds are useful as antiarrhythmic drugs with cardioprotective components for infarct prophylaxis and infarct drug collection for the treatment of angina pectoris. They also inhibit precisely the pathophyslological processes in the occurrence of ischemic-induced damage, especially in the reading of ischemic-induced cardiac arrhythmias.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19621319A DE19621319A1 (en) | 1996-05-28 | 1996-05-28 | Bis-ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent and medicament containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO972406D0 NO972406D0 (en) | 1997-05-27 |
| NO972406L true NO972406L (en) | 1997-12-01 |
Family
ID=7795458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO972406A NO972406L (en) | 1996-05-28 | 1997-05-27 | Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compounds |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0810207A1 (en) |
| JP (1) | JPH1081662A (en) |
| KR (1) | KR970074756A (en) |
| CN (1) | CN1170716A (en) |
| AR (1) | AR007497A1 (en) |
| AU (1) | AU2359897A (en) |
| BR (1) | BR9703326A (en) |
| CA (1) | CA2206198A1 (en) |
| CZ (1) | CZ161697A3 (en) |
| DE (1) | DE19621319A1 (en) |
| HR (1) | HRP970293A2 (en) |
| HU (1) | HUP9700953A3 (en) |
| ID (1) | ID16988A (en) |
| IL (1) | IL120908A0 (en) |
| NO (1) | NO972406L (en) |
| NZ (1) | NZ314900A (en) |
| PL (1) | PL318722A1 (en) |
| SK (1) | SK66497A3 (en) |
| TR (1) | TR199700423A2 (en) |
| ZA (1) | ZA974607B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19859727A1 (en) | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | The use of inhibitors of the sodium-hydrogen exchanger for the manufacture of a medicament for the prevention of age-related organ dysfunctions, age-related illnesses for the prolongation of life |
| DE10001879A1 (en) * | 2000-01-19 | 2001-07-19 | Aventis Pharma Gmbh | New benzoylguanidine derivatives are Na+/H+ exchange inhibitors useful for the treatment and prevention of e.g. ischemic disorders, infarction, arrhythmia, angina pectoris and stroke |
| JP2006518343A (en) | 2003-01-17 | 2006-08-10 | スレッシュオールド ファーマシューティカルズ， インコーポレイテッド | Treatment of benign prostatic hyperplasia using energy depleting factors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59307360D1 (en) * | 1992-02-15 | 1997-10-23 | Hoechst Ag | Ortho-substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them |
| DE4318756A1 (en) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them |
| DE4328869A1 (en) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
| DE4417004A1 (en) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
| DE4422685A1 (en) * | 1994-06-29 | 1996-01-04 | Hoechst Ag | Ortho-amino-substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them |
| DE4432101A1 (en) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Amino acid-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
| DE4432106A1 (en) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Heterocyclic N-oxide-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic, medicament containing them and intermediates for their preparation |
-
1996
- 1996-05-28 DE DE19621319A patent/DE19621319A1/en not_active Withdrawn
-
1997
- 1997-02-28 PL PL97318722A patent/PL318722A1/en unknown
- 1997-05-15 EP EP97107903A patent/EP0810207A1/en not_active Withdrawn
- 1997-05-26 CN CN97113032A patent/CN1170716A/en active Pending
- 1997-05-26 AR ARP970102237A patent/AR007497A1/en unknown
- 1997-05-26 IL IL12090897A patent/IL120908A0/en unknown
- 1997-05-26 CZ CZ971616A patent/CZ161697A3/en unknown
- 1997-05-26 AU AU23598/97A patent/AU2359897A/en not_active Abandoned
- 1997-05-26 SK SK664-97A patent/SK66497A3/en unknown
- 1997-05-26 TR TR97/00423A patent/TR199700423A2/en unknown
- 1997-05-26 NZ NZ314900A patent/NZ314900A/en unknown
- 1997-05-27 HR HR19621319.3A patent/HRP970293A2/en not_active Application Discontinuation
- 1997-05-27 NO NO972406A patent/NO972406L/en unknown
- 1997-05-27 CA CA002206198A patent/CA2206198A1/en not_active Abandoned
- 1997-05-27 HU HU9700953A patent/HUP9700953A3/en unknown
- 1997-05-27 ZA ZA9704607A patent/ZA974607B/en unknown
- 1997-05-27 JP JP9136223A patent/JPH1081662A/en active Pending
- 1997-05-28 ID IDP971812A patent/ID16988A/en unknown
- 1997-05-28 KR KR1019970021105A patent/KR970074756A/en not_active Withdrawn
- 1997-05-28 BR BR9703326A patent/BR9703326A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR970074756A (en) | 1997-12-10 |
| CN1170716A (en) | 1998-01-21 |
| ID16988A (en) | 1997-11-27 |
| AR007497A1 (en) | 1999-11-10 |
| EP0810207A1 (en) | 1997-12-03 |
| SK66497A3 (en) | 1997-12-10 |
| BR9703326A (en) | 1998-09-22 |
| CA2206198A1 (en) | 1997-11-28 |
| NO972406D0 (en) | 1997-05-27 |
| DE19621319A1 (en) | 1997-12-04 |
| AU2359897A (en) | 1997-12-04 |
| ZA974607B (en) | 1997-11-28 |
| NZ314900A (en) | 1998-02-26 |
| HUP9700953A2 (en) | 1998-03-02 |
| TR199700423A2 (en) | 1997-12-21 |
| JPH1081662A (en) | 1998-03-31 |
| CZ161697A3 (en) | 1998-06-17 |
| HUP9700953A3 (en) | 1998-04-28 |
| MX9703871A (en) | 1997-11-29 |
| HRP970293A2 (en) | 1998-04-30 |
| IL120908A0 (en) | 1997-09-30 |
| HU9700953D0 (en) | 1997-07-28 |
| PL318722A1 (en) | 1997-12-08 |
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