NO975496D0 - Isotiazoloner - Google Patents

Isotiazoloner

Info

Publication number: NO975496D0
Authority: NO; Norway
Prior art keywords: isothiazolones
Prior art date: 1995-05-31

Application number

NO975496A

Other languages

English (en)

Other versions

NO975496L (no

Inventor

Gary Louis Bolton

John Michael Domagala

Edward Faith Elslager

Rocco Dean Gogliotti

Terri Stoeber Purchase

Joseph Peter Sanchez

Bharat Kalidas Trivedi

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-31

Filing date

1997-11-28

Publication date

1997-11-28

1997-11-28 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1997-11-28 Publication of NO975496D0 publication Critical patent/NO975496D0/no

1998-01-22 Publication of NO975496L publication Critical patent/NO975496L/no

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO975496A 1995-05-31 1997-11-28 Isotiazoloner NO975496L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/456,149 US5620997A (en)	1995-05-31	1995-05-31	Isothiazolones
PCT/US1996/005821 WO1996038144A1 (en)	1995-05-31	1996-04-26	Isothiazolones

Publications (2)

Publication Number	Publication Date
NO975496D0 true NO975496D0 (no)	1997-11-28
NO975496L NO975496L (no)	1998-01-22

Family

ID=23811632

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO975496A NO975496L (no)	1995-05-31	1997-11-28	Isotiazoloner

Country Status (37)

Country	Link
US (4)	US5620997A (no)
EP (1)	EP0828488B1 (no)
JP (1)	JP2002502353A (no)
KR (2)	KR19990022132A (no)
CN (1)	CN1114402C (no)
AR (1)	AR002740A1 (no)
AT (1)	ATE232385T1 (no)
AU (1)	AU723233B2 (no)
BG (1)	BG62792B1 (no)
CA (1)	CA2218253A1 (no)
CO (1)	CO4700292A1 (no)
CZ (1)	CZ373997A3 (no)
DE (1)	DE69626203T2 (no)
DK (1)	DK0828488T3 (no)
EA (1)	EA000898B1 (no)
EE (1)	EE9700287A (no)
ES (1)	ES2192224T3 (no)
GE (1)	GEP20012375B (no)
GT (1)	GT199600026A (no)
HN (1)	HN1996000017A (no)
HR (1)	HRP960216B1 (no)
HU (1)	HUP9900917A3 (no)
IL (1)	IL117859A (no)
MX (1)	MX9707948A (no)
MY (1)	MY118452A (no)
NO (1)	NO975496L (no)
NZ (1)	NZ307023A (no)
OA (1)	OA10745A (no)
PE (1)	PE55097A1 (no)
PL (1)	PL323683A1 (no)
PT (1)	PT828488E (no)
SK (1)	SK162297A3 (no)
SV (2)	SV1996000026A (no)
TW (1)	TW418206B (no)
UY (1)	UY24244A1 (no)
WO (1)	WO1996038144A1 (no)
ZA (1)	ZA964441B (no)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6001863A (en) *	1996-11-26	1999-12-14	Warner-Lambert Company	Isothiazolones
US6706729B1 (en)	1998-06-19	2004-03-16	The United States Of America As Represented By The Department Of Health And Human Services	Thiolesters and uses thereof
DE69932820D1 (de) *	1998-06-19	2006-09-28	Us Health	Thiolester und ihre anwendungen
CA2344309A1 (en)	1998-09-17	2000-03-23	Scott A. Biller	Method for treating diabetes employing an ap2 inhibitor and combination
GB9917408D0 (en)	1999-07-23	1999-09-22	Smithkline Beecham Plc	Compounds
GB9917406D0 (en)	1999-07-23	1999-09-22	Smithkline Beecham Plc	Compounds
TW591031B (en) *	2000-02-29	2004-06-11	Takeda Chemical Industries Ltd	Thienopyridine derivatives, their production and use
US6395767B2 (en)	2000-03-10	2002-05-28	Bristol-Myers Squibb Company	Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
US6432433B1 (en)	2000-06-05	2002-08-13	Isp Investments Inc.	Liquid biocidal composition of a formaldehyde adduct and an isothiazolone and method of use
NZ523749A (en)	2000-07-26	2005-03-24	Smithkline Beecham P	Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0101577D0 (en)	2001-01-22	2001-03-07	Smithkline Beecham Plc	Compounds
DE60209343T2 (de)	2001-04-11	2006-10-26	Bristol-Myers Squibb Co.	Aminosäurekomplexe von c-arylglycosiden zur behandlung von diabetes und verfahren
HRP20040343A2 (en)	2001-10-18	2005-08-31	Bristol-Myers Squibb Company	Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
US7238671B2 (en)	2001-10-18	2007-07-03	Bristol-Myers Squibb Company	Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
US6984645B2 (en)	2001-11-16	2006-01-10	Bristol-Myers Squibb Company	Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
AU2002367173A1 (en) *	2001-12-21	2003-07-15	Achillion Pharmaceuticals, Inc.	Antifungal compositions
US7101676B2 (en) *	2002-01-11	2006-09-05	Douglas Buechter	Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA
EP1470125A1 (en)	2002-01-29	2004-10-27	Glaxo Group Limited	Aminopiperidine derivatives
MXPA04007611A (es) *	2002-02-08	2005-05-27	Hoffmann La Roche	Metodo para tratar y prevenir perdida osea.
GB0208223D0 (en) *	2002-04-10	2002-05-22	Celltech R&D Ltd	Chemical compounds
US7057046B2 (en)	2002-05-20	2006-06-06	Bristol-Myers Squibb Company	Lactam glycogen phosphorylase inhibitors and method of use
DE60332856D1 (de)	2002-10-23	2010-07-15	Bristol Myers Squibb Co	Auf glycinnitril basierende hemmer der dipeptidylpeptidase iv
US7098235B2 (en)	2002-11-14	2006-08-29	Bristol-Myers Squibb Co.	Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
TW200504021A (en)	2003-01-24	2005-02-01	Bristol Myers Squibb Co	Substituted anilide ligands for the thyroid receptor
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US6995183B2 (en)	2003-08-01	2006-02-07	Bristol Myers Squibb Company	Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
US7371759B2 (en)	2003-09-25	2008-05-13	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
WO2005047297A1 (en)	2003-11-12	2005-05-26	Phenomix Corporation	Heterocyclic boronic acid compounds
US7420059B2 (en)	2003-11-20	2008-09-02	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
CN102010382A (zh) *	2003-12-29	2011-04-13	塞普拉科公司	苯并[d]异噁唑-3-醇DAAO抑制剂
PL380887A1 (pl) *	2003-12-29	2007-04-02	Sepracor Inc.	Pirolowe i pirazolowe inhibitory DAAO
TW200611704A (en)	2004-07-02	2006-04-16	Bristol Myers Squibb Co	Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US7534763B2 (en)	2004-07-02	2009-05-19	Bristol-Myers Squibb Company	Sustained release GLP-1 receptor modulators
US7145040B2 (en)	2004-07-02	2006-12-05	Bristol-Myers Squibb Co.	Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
EP1778220A1 (en)	2004-07-12	2007-05-02	Phenomix Corporation	Constrained cyano compounds
AR051446A1 (es)	2004-09-23	2007-01-17	Bristol Myers Squibb Co	Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
US7635699B2 (en)	2004-12-29	2009-12-22	Bristol-Myers Squibb Company	Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7589088B2 (en)	2004-12-29	2009-09-15	Bristol-Myers Squibb Company	Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7317024B2 (en)	2005-01-13	2008-01-08	Bristol-Myers Squibb Co.	Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2527337A1 (en)	2005-04-14	2012-11-28	Bristol-Myers Squibb Company	Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
BRPI0611388A2 (pt) *	2005-05-04	2010-09-08	Hoffmann La Roche	compostos antivirais heterocìclicos, uso dos mesmos e composição farmacêutica
US7521557B2 (en)	2005-05-20	2009-04-21	Bristol-Myers Squibb Company	Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
US7888381B2 (en)	2005-06-14	2011-02-15	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
CA2614282A1 (en)	2005-07-06	2007-01-11	Sepracor Inc.	Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
EP1943215A2 (en)	2005-10-31	2008-07-16	Brystol-Myers Squibb Company	Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase iv and methods
US7464565B2 (en) *	2005-11-29	2008-12-16	Maytag Corporation	Rapid temperature change device for a refrigerator
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
AU2007205114B2 (en)	2006-01-06	2012-11-08	Sunovion Pharmaceuticals Inc.	Cycloalkylamines as monoamine reuptake inhibitors
CA2636275C (en) *	2006-01-06	2013-02-12	Sepracor Inc.	Tetralone-based monoamine reuptake inhibitors
AU2007233041B2 (en)	2006-03-31	2013-05-02	Sepracor Inc.	Preparation of chiral amides and amines
EP2019679B1 (en)	2006-05-23	2018-06-20	Theracos, Inc.	Glucose transport inhibitors and methods of use
WO2007139589A1 (en)	2006-05-26	2007-12-06	Bristol-Myers Squibb Company	Sustained release glp-1 receptor modulators
US7919598B2 (en)	2006-06-28	2011-04-05	Bristol-Myers Squibb Company	Crystal structures of SGLT2 inhibitors and processes for preparing same
US7579370B2 (en) *	2006-06-30	2009-08-25	Sepracor Inc.	Fused heterocycles
US7884124B2 (en) *	2006-06-30	2011-02-08	Sepracor Inc.	Fluoro-substituted inhibitors of D-amino acid oxidase
US7727978B2 (en)	2006-08-24	2010-06-01	Bristol-Myers Squibb Company	Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
US20080082066A1 (en) *	2006-10-02	2008-04-03	Weyerhaeuser Co.	Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP2089355A2 (en)	2006-11-01	2009-08-19	Brystol-Myers Squibb Company	Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
WO2008057857A1 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
US7902252B2 (en) *	2007-01-18	2011-03-08	Sepracor, Inc.	Inhibitors of D-amino acid oxidase
US20090099248A1 (en) *	2007-01-18	2009-04-16	Sepracor Inc.	Inhibitors of d-amino acid oxidase
AR065809A1 (es)	2007-03-22	2009-07-01	Bristol Myers Squibb Co	Formulaciones farmaceuticas que contienen un inhibidor sglt2
US8546394B2 (en)	2007-04-17	2013-10-01	Bristol-Myers Squibb Company	Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors
PE20090696A1 (es)	2007-04-20	2009-06-20	Bristol Myers Squibb Co	Formas cristalinas de saxagliptina y procesos para preparar las mismas
EP2152707B1 (en)	2007-05-04	2012-06-20	Bristol-Myers Squibb Company	[6,5]-bicyclic gpr119 g protein-coupled receptor agonists
ES2388967T3 (es)	2007-05-04	2012-10-22	Bristol-Myers Squibb Company	Agonistas [6,6]- y [6,7]-bicíclicos del receptor GPR119 acoplado a la proteína G
CA2687764A1 (en) *	2007-05-25	2008-12-04	Vertex Pharmaceuticals Incorporated	Ion channel modulators and methods of use
AU2008259841B2 (en)	2007-05-31	2015-02-05	Sunovion Pharmaceuticals Inc.	Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
JP5318867B2 (ja)	2007-07-17	2013-10-16	ブリストル−マイヤーズスクイブカンパニー	ピリドンｇｐｒ１１９ｇタンパク質共役受容体アゴニスト
ES2408384T3 (es)	2007-07-27	2013-06-20	Bristol-Myers Squibb Company	Nuevos activadores de glucoquinasa y procedimientos de uso de los mismos
BRPI0815708B8 (pt)	2007-08-23	2021-05-25	Theracos Sub Llc	composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condição
US8309730B2 (en)	2007-11-01	2012-11-13	Bristol-Myers Squibb Company	Nonsteroidal compounds useful as modulators of glucocorticoid receptor AP-1 and/or NF-kappab acitivity and use thereof
KR20100108337A (ko) *	2007-11-15	2010-10-06	베링거 인겔하임 인터내셔날 게엠베하	사람 면역결핍 바이러스 복제의 억제제
CA2705338A1 (en) *	2007-11-16	2009-05-22	Boehringer Ingelheim International Gmbh	Inhibitors of human immunodeficiency virus replication
RU2509773C2 (ru)	2008-07-15	2014-03-20	Теракос, Инк.	Дейтерированные бензилбензольные производные и способы применения
TW201006821A (en)	2008-07-16	2010-02-16	Bristol Myers Squibb Co	Pyridone and pyridazone analogues as GPR119 modulators
US20100120740A1 (en) *	2008-08-07	2010-05-13	Sepracor Inc.	Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110034434A1 (en) *	2009-08-07	2011-02-10	Sepracor Inc.	Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2011060255A1 (en)	2009-11-13	2011-05-19	Bristol-Myers Squibb Company	Reduced mass metformin formulations
CA2780939C (en)	2009-11-13	2018-06-12	Bristol-Myers Squibb Company	Bilayer tablet formulations
CN102740839B (zh)	2009-11-13	2015-05-06	阿斯利康(瑞典)有限公司	立即释放片剂
TWI562775B (en)	2010-03-02	2016-12-21	Lexicon Pharmaceuticals Inc	Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
US20110257233A1 (en) *	2010-03-19	2011-10-20	Sanford-Burnham Medical Research Institute	Benzoisothiazolones as inhibitors of phosphomannose isomerase
CN102933576A (zh)	2010-04-08	2013-02-13	百时美施贵宝公司	作为gpr119调节剂的嘧啶基哌啶基氧基吡啶酮类似物
JP2013523894A (ja)	2010-04-14	2013-06-17	ブリストル−マイヤーズスクイブカンパニー	新規グルコキナーゼアクチベーターおよびその使用方法
BR112012028445A2 (pt)	2010-05-06	2016-07-19	Bristol Myers Squibb Co	compostos de heteroarila bicíclica como moduladores de gpr119
US8729084B2 (en)	2010-05-06	2014-05-20	Bristol-Myers Squibb Company	Benzofuranyl analogues as GPR119 modulators
WO2011153712A1 (en)	2010-06-12	2011-12-15	Theracos, Inc.	Crystalline form of benzylbenzene sglt2 inhibitor
WO2012018950A1 (en)	2010-08-03	2012-02-09	Beth Israel Deaconess Medical Center	Methods and compositions for treatment of metabolic disorders
TWI445696B (zh) *	2010-11-29	2014-07-21	Univ Nat Yang Ming	標靶人類胸線核苷酸激酶誘導惡性腫瘤中的ｄｎａ修復毒性
US9662328B2 (en)	2010-11-29	2017-05-30	National Yang-Ming University	Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells
TWI631963B (zh)	2011-01-05	2018-08-11	雷西肯製藥股份有限公司	包含鈉－葡萄糖共同輸送體１與２之抑制劑的組合物與應用方法
EP2850073B1 (en)	2012-05-16	2017-07-19	Bristol-Myers Squibb Company	Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators
AU2013348233C1 (en)	2012-11-20	2018-09-06	Lexicon Pharmaceuticals, Inc.	Inhibitors of sodium glucose cotransporter 1
CN103232842B (zh) *	2013-04-15	2015-11-18	山东大学	一种基于聚集诱导荧光增强材料的亚硫酸氢根离子的荧光探针及快速检验试纸
US9593113B2 (en)	2013-08-22	2017-03-14	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor
US9580422B2 (en)	2013-10-22	2017-02-28	Bristol-Myers Squibb Company	Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
US20160046651A1 (en) *	2014-07-22	2016-02-18	Washington University	Treatment of malaria using inhibitors of the ispd enzyme in the non-mevalonate pathway
CN104230839A (zh) *	2014-09-25	2014-12-24	上海化学试剂研究所有限公司	一种n-取代苯并异噻唑啉酮衍生物的合成方法
US9925190B2 (en) *	2015-02-16	2018-03-27	University of Pittsburgh—of the Commonwealth System of Higher Education	Small molecules targeting HIV-1 Nef
KR20170138570A (ko)	2015-04-30	2017-12-15	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	대사 장애를 치료하기 위한 항-aP2 항체 및 항원 결합 물질
EP3487862A1 (en)	2016-07-22	2019-05-29	Bristol-Myers Squibb Company	Glucokinase activators and methods of using same
US11752173B2 (en)	2017-12-19	2023-09-12	Beijing Jiyuan Biological Technology Co., Ltd.	FGF21 and GLP1 double gene-modified mesenchymal stem cell and use in treating a metabolic disease
US20200385406A1 (en) *	2017-12-22	2020-12-10	Southern Research Institute	Substituted heterocyclic-pyridinones as hiv-1 nef-hck inhibitors
EP3842410A4 (en)	2018-08-23	2022-07-06	Qingdao Wholesometech Co., Ltd.	Fibric acid compound and medical use thereof
MX2021003545A (es)	2018-09-26	2021-05-27	Lexicon Pharmaceuticals Inc	Formas solidas cristalinas de n-(1-((2-(dimetilamino)etil)amino)-2 -metil-1-oxopropan-2-il)-4-(4-(2-metil-5-((2s,3r,4r,5s,6r)-3,4,5- trihidroxi-6-(metiltio)tetrahidro-2h-piran-2-il)bencil)fenil)buta namida y metodos para su sintesis.
CN111253335B (zh) *	2020-03-12	2023-06-06	浙江扬帆新材料股份有限公司	一种n-取代苯并异噻唑啉-3-酮衍生物的新合成方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE724034C (de) *	1938-11-04	1942-08-17	Algemeene Kunstvezel Mij N V	Verfahren zum Erzeugen farbiger Glasfasern
US3012039A (en) *	1958-03-14	1961-12-05	Ici Ltd	2-p-chlorobenzyl-1, 2-benzisothiazolone
US3517022A (en) *	1967-10-03	1970-06-23	Rohm & Haas	Certain 2-carbamoyl-1,2-benzisothiazolones
US3661974A (en) *	1970-04-27	1972-05-09	Sherwin Williams Co	2-carbalkoxy-phenyl sulfenamides
GB1306493A (en) *	1970-04-27	1973-02-14	Sherwin Williams Co	Aromatic sulphenamides the preparation thereof and cyclization thereof
US3761489A (en) *	1971-12-20	1973-09-25	Sherwin Williams Co	Substituted n-alkyl benzisothiazolinones
US4049817A (en) *	1972-08-14	1977-09-20	Sandoz Ltd.	Synergistic compositions
US3965107A (en) *	1974-07-08	1976-06-22	Rohm And Haas Company	Isothiazolopyridinones
IT1039699B (it) *	1975-07-03	1979-12-10	Prephar	Composizione spermicida a base di derivati benzisotiazolici
DE2602643C2 (de) *	1976-01-24	1984-12-20	Bayer Ag, 5090 Leverkusen	1,2-Benzisothiazolinone-3, Verfahren zu ihrer Herstellung sowie Arzneimittel
GB1560726A (en) *	1976-04-28	1980-02-06	Beecham Group Ltd	Isothiazolo-pyridines
FR2492376A1 (fr) *	1980-10-17	1982-04-23	Cird	Polymethylene-4,5 isothiazoline-4 ones-3, leur procede de preparation et leurs utilisation comme agents bactericides et fongicides
DE3041036A1 (de) *	1980-10-31	1982-06-09	A. Nattermann & Cie GmbH, 5000 Köln	Verwendung von benzisothiazolen
US4458942A (en) *	1981-12-07	1984-07-10	American Seating Company	Three-quarter fold retracting chair
LU84091A1 (fr) *	1982-04-16	1984-03-02	Oreal	Derives n-carbamoyl d'isothiazolo-(5,4b)pyridine one-3,leur procede de preparation et leurs utilisations comme agents bactericides et fongicides
FR2555450B1 (fr) *	1983-11-24	1988-04-01	Oreal	Composition anti-acneique contenant en tant que compose actif un derive d'isothiazolo-(5,4b) pyridine one-3
FR2631028B1 (fr) *	1988-05-09	1990-07-13	Cird	Adamantyl-2 isothiazoline-4 ones-3, leur procede de preparation et leur utilisation comme agents bactericides et fongicides
US5405851A (en) *	1990-06-19	1995-04-11	Burroughs Wellcome Co.	Pharmaceutical compounds
JPH0477476A (ja) *	1990-07-19	1992-03-11	Sankyo Co Ltd	抗潰瘍剤
US5219875A (en) *	1990-11-27	1993-06-15	Rohm And Haas Company	Antimicrobial compositions comprising iodopropargyl butylcarbamate and 1,2-benzisothiazolin-3-one and methods of controlling microbes
NO304832B1 (no) *	1992-05-27	1999-02-22	Ube Industries	Aminokinolonderivater samt middel mot HIV
FR2695378B1 (fr) *	1992-09-10	1994-12-02	Aerospatiale	Dispositif à sangle pour le maintien temporaire d'objets ensemble.
RU2118322C1 (ru) *	1993-07-05	1998-08-27	Дюфар Интернэшнл Рисерч Б.В.	2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли

1995
- 1995-05-31 US US08/456,149 patent/US5620997A/en not_active Expired - Fee Related
- 1995-12-15 CO CO95059308A patent/CO4700292A1/es unknown
- 1995-12-15 TW TW084113376A patent/TW418206B/zh not_active IP Right Cessation
1996
- 1996-04-09 IL IL11785996A patent/IL117859A/xx not_active IP Right Cessation
- 1996-04-19 SV SV1996000026A patent/SV1996000026A/es unknown
- 1996-04-26 ES ES96913177T patent/ES2192224T3/es not_active Expired - Lifetime
- 1996-04-26 SK SK1622-97A patent/SK162297A3/sk unknown
- 1996-04-26 KR KR1019970708611A patent/KR19990022132A/ko not_active Abandoned
- 1996-04-26 DK DK96913177T patent/DK0828488T3/da active
- 1996-04-26 CA CA002218253A patent/CA2218253A1/en not_active Abandoned
- 1996-04-26 JP JP53647396A patent/JP2002502353A/ja not_active Abandoned
- 1996-04-26 EA EA199700444A patent/EA000898B1/ru not_active IP Right Cessation
- 1996-04-26 NZ NZ307023A patent/NZ307023A/en unknown
- 1996-04-26 MX MX9707948A patent/MX9707948A/es not_active IP Right Cessation
- 1996-04-26 PL PL96323683A patent/PL323683A1/xx unknown
- 1996-04-26 AT AT96913177T patent/ATE232385T1/de not_active IP Right Cessation
- 1996-04-26 CN CN96194276A patent/CN1114402C/zh not_active Expired - Fee Related
- 1996-04-26 KR KR10-2003-7011364A patent/KR20040004547A/ko not_active Ceased
- 1996-04-26 WO PCT/US1996/005821 patent/WO1996038144A1/en not_active Ceased
- 1996-04-26 EE EE9700287A patent/EE9700287A/xx unknown
- 1996-04-26 AU AU55771/96A patent/AU723233B2/en not_active Ceased
- 1996-04-26 PT PT96913177T patent/PT828488E/pt unknown
- 1996-04-26 CZ CZ973739A patent/CZ373997A3/cs unknown
- 1996-04-26 DE DE69626203T patent/DE69626203T2/de not_active Expired - Fee Related
- 1996-04-26 EP EP96913177A patent/EP0828488B1/en not_active Expired - Lifetime
- 1996-04-26 HU HU9900917A patent/HUP9900917A3/hu unknown
- 1996-04-26 GE GEAP19964062A patent/GEP20012375B/en unknown
- 1996-05-07 US US08/646,188 patent/US5668162A/en not_active Expired - Fee Related
- 1996-05-08 HR HR960216A patent/HRP960216B1/xx not_active IP Right Cessation
- 1996-05-15 HN HN1996000017A patent/HN1996000017A/es unknown
- 1996-05-15 AR ARP960102576A patent/AR002740A1/es not_active Application Discontinuation
- 1996-05-24 GT GT199600026A patent/GT199600026A/es unknown
- 1996-05-24 SV SV1996000033A patent/SV1996000033A/es not_active Application Discontinuation
- 1996-05-29 MY MYPI96002063A patent/MY118452A/en unknown
- 1996-05-30 ZA ZA964441A patent/ZA964441B/xx unknown
- 1996-05-30 UY UY24244A patent/UY24244A1/es unknown
- 1996-05-30 PE PE1996000385A patent/PE55097A1/es not_active Application Discontinuation
- 1996-11-26 US US08/757,716 patent/US5733921A/en not_active Expired - Fee Related
1997
- 1997-06-26 US US08/882,846 patent/US6133270A/en not_active Expired - Fee Related
- 1997-11-12 OA OA70126A patent/OA10745A/en unknown
- 1997-11-27 BG BG102077A patent/BG62792B1/bg unknown
- 1997-11-28 NO NO975496A patent/NO975496L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU5577196A (en)	1996-12-18
US6133270A (en)	2000-10-17
IL117859A0 (en)	1996-08-04
CA2218253A1 (en)	1996-12-05
US5668162A (en)	1997-09-16
ES2192224T3 (es)	2003-10-01
GEP20012375B (en)	2001-03-25
EP0828488A1 (en)	1998-03-18
BG102077A (en)	1998-11-30
EE9700287A (et)	1998-06-15
BG62792B1 (bg)	2000-08-31
ATE232385T1 (de)	2003-02-15
AR002740A1 (es)	1998-04-29
PE55097A1 (es)	1998-01-16
NZ307023A (en)	2001-03-30
AU723233B2 (en)	2000-08-24
CZ373997A3 (cs)	1998-11-11
TW418206B (en)	2001-01-11
SV1996000026A (es)	1997-03-05
SK162297A3 (en)	2000-04-10
IL117859A (en)	2000-07-16
WO1996038144A1 (en)	1996-12-05
CN1114402C (zh)	2003-07-16
PL323683A1 (en)	1998-04-14
KR20040004547A (ko)	2004-01-13
US5733921A (en)	1998-03-31
HUP9900917A3 (en)	2003-04-28
NO975496L (no)	1998-01-22
CN1185737A (zh)	1998-06-24
DE69626203D1 (en)	2003-03-20
OA10745A (en)	2002-12-10
PT828488E (pt)	2003-06-30
HN1996000017A (es)	2000-03-24
ZA964441B (en)	1996-12-10
MX9707948A (es)	1997-12-31
US5620997A (en)	1997-04-15
EP0828488B1 (en)	2003-02-12
EA199700444A1 (ru)	1998-06-25
HUP9900917A2 (hu)	1999-09-28
SV1996000033A (es)	1998-01-29
CO4700292A1 (es)	1998-12-29
EA000898B1 (ru)	2000-06-26
UY24244A1 (es)	2001-10-25
DE69626203T2 (de)	2003-11-20
DK0828488T3 (da)	2003-05-19
MY118452A (en)	2004-11-30
HRP960216B1 (en)	2001-12-31
JP2002502353A (ja)	2002-01-22
KR19990022132A (ko)	1999-03-25
HRP960216A2 (en)	1997-08-31
GT199600026A (es)	1997-11-15

Publication	Publication Date	Title
DK0828488T3 (da)	2003-05-19	Isothiazoloner
DE69627553D1 (de)	2003-05-22	Lüftströmungssteuervorrichtung
DE69608259D1 (de)	2000-06-15	Verbunddamenbinde
FI956003A0 (fi)	1995-12-14	Exponeringsautomatik foer roentgenavbildningsanordning
ATA135896A (de)	2001-02-15	Skibob
FI101610B1 (fi)	1998-07-31	Näytetunnistin
DE69624316D1 (de)	2002-11-21	Titenstrahldruckgerät
DE59610613D1 (de)	2003-08-28	Leibungsbefestigungswinkel
ATE198470T1 (de)	2001-01-15	Alkenyl-benzoylguanidine
DK0725062T3 (da)	2001-09-24	4-Mercapto-benzoylguanidin-derivater
ATE240972T1 (de)	2003-06-15	Cyclopeptolide
ITPI950018A0 (it)	1995-03-16	Vibrapack
ATA119896A (de)	2002-04-15	Scheibenmähwerk
BR9609803A (pt)	1999-07-06	Polihidroxialquilamidobetaínas
BR9609863A (pt)	1999-03-16	Fecho
DE69529336D1 (de)	2003-02-13	Schrämlagemaschine
FIU950291U0 (fi)	1995-06-05	Laegereldstomme
SE9501817D0 (sv)	1995-05-17	När/långsyntssimdykningsglasögon
KR960030307U (ko)	1996-10-22	다시
FI1898U1 (fi)	1995-05-09	Bildbrev
FI1881U1 (fi)	1995-04-27	Avfallsuppsamlingsbehaollares pressanordning
FI1999U1 (fi)	1995-07-07	Flasktvaettanordning
FI2072U1 (fi)	1995-08-29	Draganordning foer skidloepare
FI1939U1 (fi)	1995-06-09	Haengbro
FI2032U1 (fi)	1995-07-20	Tillaeggsanordning foer rullskridsko

Legal Events

Date	Code	Title	Description
2005-10-17	FC2A	Withdrawal, rejection or dismissal of laid open patent application