NO952365L - Nye selektive aromatase-inhiberende forbindelser - Google Patents

Nye selektive aromatase-inhiberende forbindelser

Info

Publication number: NO952365L
Authority: NO; Norway
Prior art keywords: pct; choh; date; compounds; sec
Prior art date: 1992-12-16

Application number

NO952365A

Other languages

English (en)

Other versions

NO952365D0 (no

NO310237B1 (no

Inventor

Arto Johannes Karjalainen

Marja-Liisa Sodervall

Arja Marketta Kalapudas

Reino Olavi Pelkonen

Aire Marja Laine

Risto Arvo Sakari Lammintausta

Jarmo Sakari Salonen

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-16

Filing date

1995-06-15

Publication date

1995-06-15

1995-06-15 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1995-06-15 Publication of NO952365L publication Critical patent/NO952365L/no

1995-06-15 Publication of NO952365D0 publication Critical patent/NO952365D0/no

2001-06-11 Publication of NO310237B1 publication Critical patent/NO310237B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pyridine Compounds (AREA)

NO19952365A 1992-12-16 1995-06-15 Nye selektive aromatase-inhiberende forbindelser, farmasöytisk preparat og anvendelse av forbindelsene NO310237B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9226209A GB2273704B (en)	1992-12-16	1992-12-16	Triazolyl diaryl selective aromatase inhibiting compounds
PCT/FI1993/000539 WO1994013645A1 (en)	1992-12-16	1993-12-14	Novel selective aromatase inhibiting compounds

Publications (3)

Publication Number	Publication Date
NO952365L true NO952365L (no)	1995-06-15
NO952365D0 NO952365D0 (no)	1995-06-15
NO310237B1 NO310237B1 (no)	2001-06-11

Family

ID=10726697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19952365A NO310237B1 (no)	1992-12-16	1995-06-15	Nye selektive aromatase-inhiberende forbindelser, farmasöytisk preparat og anvendelse av forbindelsene

Country Status (31)

Country	Link
US (2)	US5703109A (no)
EP (1)	EP0674626B1 (no)
JP (1)	JP3186771B2 (no)
KR (1)	KR100347639B1 (no)
CN (1)	CN1056835C (no)
AT (1)	ATE194833T1 (no)
AU (1)	AU682332B2 (no)
BG (1)	BG62930B1 (no)
CA (1)	CA2150904A1 (no)
CZ (1)	CZ283043B6 (no)
DE (1)	DE69329072T2 (no)
DK (1)	DK0674626T3 (no)
EE (1)	EE03155B1 (no)
ES (1)	ES2148312T3 (no)
FI (1)	FI952867A0 (no)
GB (1)	GB2273704B (no)
GR (1)	GR3034618T3 (no)
HR (1)	HRP931494B1 (no)
IL (1)	IL107714A (no)
LT (1)	LT3151B (no)
NO (1)	NO310237B1 (no)
NZ (1)	NZ258588A (no)
PL (1)	PL176413B1 (no)
PT (1)	PT674626E (no)
RO (1)	RO113986B1 (no)
RU (1)	RU2131418C1 (no)
SI (1)	SI9300663B (no)
SK (1)	SK281667B6 (no)
TW (1)	TW327169B (no)
WO (1)	WO1994013645A1 (no)
ZA (1)	ZA938717B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6063930A (en) *	1996-04-03	2000-05-16	Merck & Co., Inc.	Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
AU715658B2 (en) *	1996-04-03	2000-02-10	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US6080870A (en) *	1996-04-03	2000-06-27	Merck & Co., Inc.	Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5972921A (en) *	1997-12-12	1999-10-26	Hormos Medical Oy Ltd.	Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
DE60118363T2 (de) *	2000-07-10	2006-12-07	Hormos Medical Ltd.	Methoden zur behandlung des kryptorchysmus
EP2269603B1 (en) *	2001-02-19	2015-05-20	Novartis AG	Treatment of breast tumors with a rapamycin derivative in combination with exemestane
FI20010905A0 (fi) *	2001-05-02	2001-05-02	Vetcare Oy	Uusi eläinlääke
CN1325482C (zh) *	2001-12-11	2007-07-11	埃默里大学	双(氰基苯基)甲基－三唑在预防乳腺癌中的用途
RU2222326C1 (ru) *	2002-10-09	2004-01-27	Российский онкологический научный центр им. Н.Н.Блохина РАМН	Способ лечения саркомы юинга
JP2004196795A (ja) *	2002-12-16	2004-07-15	Wyeth	外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
EP1431292A1 (en) *	2002-12-16	2004-06-23	Laboratoire Theramex	1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors
US7345073B2 (en)	2003-02-07	2008-03-18	Hormos Medical Ltd.	Method for treating cryptorchidism
US20040248989A1 (en)	2003-06-05	2004-12-09	Risto Santti	Method for the treatment or prevention of lower urinary tract symptoms
BRPI0417407A (pt) *	2003-12-15	2007-04-03	Theramex	derivados de 1-n-fenil-amino-1h-imidazol e composições farmacêuticas contendo estes
JP5123935B2 (ja)	2006-05-22	2013-01-23	ホルモスメディカルリミテッド	選択的エストロゲン受容体モジュレーターまたはアロマターゼ阻害剤を用いた慢性非細菌性前立腺炎の治療方法
GB0914767D0 (en) *	2009-08-24	2009-09-30	Sterix Ltd	Compound
WO2011127232A2 (en)	2010-04-08	2011-10-13	Emory University	Substituted androst-4-ene diones
AR083626A1 (es) *	2010-05-27	2013-03-13	Bayer Cropscience Ag	Derivados de alcanoles heterociclicos
KR101583521B1 (ko)	2015-07-31	2016-01-08	(주) 엘림비엠에스	내오염, 내마모 성능과 시공 작업성 및 광도 성능이 개선된 피브이씨 타일 바닥의 코팅방법
US10905252B2 (en)	2018-04-19	2021-02-02	Wonderland Switzerland Ag	Child carrier

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1580535A (en) *	1976-08-27	1980-12-03	Ici Ltd	Substituted ketones and their use as herbicides
US4937250A (en)	1988-03-07	1990-06-26	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US5112845A (en) *	1986-03-07	1992-05-12	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US5071861A (en)	1986-03-07	1991-12-10	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US4749713A (en) *	1986-03-07	1988-06-07	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US4978672A (en)	1986-03-07	1990-12-18	Ciba-Geigy Corporation	Alpha-heterocyclc substituted tolunitriles
AU627559B2 (en)	1989-03-30	1992-08-27	Farmos-Yhtyma Oy	Novel aromatase inhibiting 4(5)-imidazoles
EP0408509B1 (de) *	1989-07-14	1996-03-06	Ciba-Geigy Ag	Substituierte Benzonitrile
US5077374A (en) *	1990-04-20	1991-12-31	Phillips Petroleum Company	Aromatic sulfide polymers and method of preparation
DE4039559A1 (de) *	1990-12-07	1992-06-11	Schering Ag	Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
GB9125924D0 (en) *	1991-06-18	1992-02-05	Orion Yhtymae Oy	Stereoisomers of an imidazole derivative

1992
- 1992-12-16 GB GB9226209A patent/GB2273704B/en not_active Expired - Fee Related
1993
- 1993-11-22 ZA ZA938717A patent/ZA938717B/xx unknown
- 1993-11-23 IL IL10771493A patent/IL107714A/xx not_active IP Right Cessation
- 1993-12-03 LT LTIP1524A patent/LT3151B/lt not_active IP Right Cessation
- 1993-12-14 WO PCT/FI1993/000539 patent/WO1994013645A1/en not_active Ceased
- 1993-12-14 NZ NZ258588A patent/NZ258588A/en unknown
- 1993-12-14 CZ CZ951532A patent/CZ283043B6/cs not_active IP Right Cessation
- 1993-12-14 JP JP51384094A patent/JP3186771B2/ja not_active Expired - Fee Related
- 1993-12-14 RO RO95-01149A patent/RO113986B1/ro unknown
- 1993-12-14 RU RU95114360/04A patent/RU2131418C1/ru not_active IP Right Cessation
- 1993-12-14 CA CA002150904A patent/CA2150904A1/en not_active Abandoned
- 1993-12-14 PT PT94901975T patent/PT674626E/pt unknown
- 1993-12-14 AT AT94901975T patent/ATE194833T1/de not_active IP Right Cessation
- 1993-12-14 PL PL93309350A patent/PL176413B1/pl unknown
- 1993-12-14 KR KR1019950702444A patent/KR100347639B1/ko not_active Expired - Fee Related
- 1993-12-14 DE DE69329072T patent/DE69329072T2/de not_active Expired - Fee Related
- 1993-12-14 SK SK778-95A patent/SK281667B6/sk unknown
- 1993-12-14 EP EP94901975A patent/EP0674626B1/en not_active Expired - Lifetime
- 1993-12-14 AU AU56523/94A patent/AU682332B2/en not_active Ceased
- 1993-12-14 FI FI952867A patent/FI952867A0/fi unknown
- 1993-12-14 US US08/436,389 patent/US5703109A/en not_active Expired - Fee Related
- 1993-12-14 ES ES94901975T patent/ES2148312T3/es not_active Expired - Lifetime
- 1993-12-14 DK DK94901975T patent/DK0674626T3/da active
- 1993-12-14 TW TW082110583A patent/TW327169B/zh active
- 1993-12-15 CN CN93120844A patent/CN1056835C/zh not_active Expired - Fee Related
- 1993-12-15 HR HR931494A patent/HRP931494B1/xx not_active IP Right Cessation
- 1993-12-16 SI SI9300663A patent/SI9300663B/sl unknown
1994
- 1994-11-22 EE EE9400434A patent/EE03155B1/xx not_active IP Right Cessation
1995
- 1995-06-05 BG BG99699A patent/BG62930B1/bg unknown
- 1995-06-15 NO NO19952365A patent/NO310237B1/no unknown
1997
- 1997-09-15 US US08/929,424 patent/US5962495A/en not_active Expired - Fee Related
2000
- 2000-10-13 GR GR20000402303T patent/GR3034618T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL107714A0 (en)	1994-02-27
KR950704263A (ko)	1995-11-17
LT3151B (en)	1995-01-31
BG62930B1 (bg)	2000-11-30
EP0674626A1 (en)	1995-10-04
CA2150904A1 (en)	1994-06-23
WO1994013645A1 (en)	1994-06-23
GR3034618T3 (en)	2001-01-31
DK0674626T3 (da)	2000-11-13
EE03155B1 (et)	1999-02-15
PT674626E (pt)	2000-11-30
DE69329072D1 (de)	2000-08-24
GB2273704A (en)	1994-06-29
US5962495A (en)	1999-10-05
FI952867A7 (fi)	1995-06-09
CZ283043B6 (cs)	1997-12-17
PL176413B1 (pl)	1999-05-31
DE69329072T2 (de)	2000-12-21
AU682332B2 (en)	1997-10-02
CN1056835C (zh)	2000-09-27
TW327169B (en)	1998-02-21
SK281667B6 (sk)	2001-06-11
IL107714A (en)	2003-07-31
ZA938717B (en)	1994-06-30
HRP931494A2 (en)	1996-08-31
ATE194833T1 (de)	2000-08-15
FI952867A0 (fi)	1995-06-09
RO113986B1 (ro)	1998-12-30
NO952365D0 (no)	1995-06-15
SI9300663B (sl)	2002-02-28
BG99699A (bg)	1996-04-30
RU95114360A (ru)	1997-06-10
CZ153295A3 (en)	1995-11-15
NZ258588A (en)	1996-11-26
NO310237B1 (no)	2001-06-11
SI9300663A (en)	1994-09-30
GB2273704B (en)	1997-01-22
HRP931494B1 (en)	2001-06-30
SK77895A3 (en)	1995-12-06
JPH08504424A (ja)	1996-05-14
RU2131418C1 (ru)	1999-06-10
ES2148312T3 (es)	2000-10-16
EP0674626B1 (en)	2000-07-19
GB9226209D0 (en)	1993-02-10
CN1093357A (zh)	1994-10-12
AU5652394A (en)	1994-07-04
JP3186771B2 (ja)	2001-07-11
LTIP1524A (en)	1994-07-15
PL309350A1 (en)	1995-10-02
US5703109A (en)	1997-12-30
KR100347639B1 (ko)	2002-11-29

Publication	Publication Date	Title
NO952365L (no)	1995-06-15	Nye selektive aromatase-inhiberende forbindelser
MY125675A (en)	2006-08-30	4-aminoquinazoline derivatives, their use as inhibitors of the effects of vegf and processes for the preparation of such compounds
JPS6044294B2 (ja)	1985-10-02	アニリド誘導体
NO991700L (no)	2000-01-13	Benzimidazol-2-karbamater for behandling av virusinfeksjoner og cancer
DE60025848D1 (en)	2006-04-13	Pyrimidin-derivate als selective inhibitoren von cox-2
TW498066B (en)	2002-08-11	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
MXPA03002495A (es)	2004-05-05	Proceso para preparacion de compuestos de n-(fenil sustituido)-3-alquil, aril- y heteroarilsulfonil-2-hidroxi-2-alquil- y haloalquilpropanamida.
LTIP175A (lt)	1994-08-25	Nauji selektyviai aromatazę inhibuojantys 4(5)-imidazolai
DK0880540T3 (da)	2002-10-07	17-Beta-cyclopropyl(amino/oxy)-4-azasteroider som aktive inhibitorer af testosteron 5-alfa-reduktase og C17-20-lyase
JP2001511798A (ja)	2001-08-14	オキシド−スクアレンシクラーゼ抑制剤として有用な複素環化合物
RU94044457A (ru)	1996-10-10	Применение бензтиофенов для ингибирования гирсутизма и алопеции у женщин
GR3025050T3 (en)	1998-01-30	Etoposide derivatives, process for their preparation, their use as a drug and in the preparation of a drug for treating cancer.
NO913712L (no)	1992-03-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater.
Chaaban et al.	2016	Synthesis and Anti‐Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene‐1, 4‐diones