[go: up one dir, main page]

NO991700L - Benzimidazol-2-karbamater for behandling av virusinfeksjoner og cancer - Google Patents

Benzimidazol-2-karbamater for behandling av virusinfeksjoner og cancer

Info

Publication number
NO991700L
NO991700L NO991700A NO991700A NO991700L NO 991700 L NO991700 L NO 991700L NO 991700 A NO991700 A NO 991700A NO 991700 A NO991700 A NO 991700A NO 991700 L NO991700 L NO 991700L
Authority
NO
Norway
Prior art keywords
viral infections
benzimidazole
carbamates
cancer
treatment
Prior art date
Application number
NO991700A
Other languages
English (en)
Other versions
NO991700D0 (no
Inventor
James Berger Camden
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO991700D0 publication Critical patent/NO991700D0/no
Publication of NO991700L publication Critical patent/NO991700L/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Farmasøytisk preparat som inhiberer veksten av tumorer og cancere i pattedyr og som kan anvendes for å behandle virus- infeksjoner som omfatter et fungicid. Det spesielle fungicid som anvendes er et benzimidazolderivat med formel (I), hvor R er valgt fra gruppen bestående av H, karboksyl, (-CO2H), hydroksyl, amino eller estere (-CO2R'), hvor R1 er valgt fra gruppen bestående av alkoksy, haloalkyl, alkenyl og cykloalkyl, hvor alkylgruppene har fra l til 8 karbonatomer eller CH3CH2(OCH2CH2) n_ eller CH3CH2CH2-(OCH2CH2CH2) n_ eller (CH3)2CH-(OCH(CH3)CH2)n_hvor n er fra l til 3, de farmasøy- tisk akseptable salter derav, eller blandinger derav.
NO991700A 1997-05-16 1999-04-09 Benzimidazol-2-karbamater for behandling av virusinfeksjoner og cancer NO991700L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/857,811 US6506783B1 (en) 1997-05-16 1997-05-16 Cancer treatments and pharmaceutical compositions therefor
PCT/US1997/021565 WO1998051304A1 (en) 1997-05-16 1997-11-26 Benzimidazole-2-carbamates for the treatment of viral infections and cancer

Publications (2)

Publication Number Publication Date
NO991700D0 NO991700D0 (no) 1999-04-09
NO991700L true NO991700L (no) 2000-01-13

Family

ID=25326784

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991700A NO991700L (no) 1997-05-16 1999-04-09 Benzimidazol-2-karbamater for behandling av virusinfeksjoner og cancer

Country Status (22)

Country Link
US (13) US6506783B1 (no)
EP (1) EP0956017B1 (no)
JP (1) JP2001527523A (no)
KR (1) KR20000049065A (no)
CN (1) CN1254282A (no)
AR (1) AR010008A1 (no)
AT (1) ATE363904T1 (no)
AU (1) AU728690B2 (no)
BR (1) BR9714634A (no)
CA (1) CA2268840C (no)
CZ (1) CZ125299A3 (no)
DE (1) DE69737793D1 (no)
HU (1) HUP0001170A3 (no)
IL (1) IL129352A0 (no)
NO (1) NO991700L (no)
NZ (1) NZ335159A (no)
PE (1) PE11099A1 (no)
PL (1) PL335541A1 (no)
SK (1) SK47099A3 (no)
TR (1) TR199901528T2 (no)
WO (1) WO1998051304A1 (no)
ZA (1) ZA979096B (no)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177460B1 (en) 1995-04-12 2001-01-23 The Procter & Gamble Company Method of treatment for cancer or viral infections
US6262093B1 (en) 1995-04-12 2001-07-17 The Proctor & Gamble Company Methods of treating cancer with benzimidazoles
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US5770616A (en) 1995-06-07 1998-06-23 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of cancers
US6265427B1 (en) 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
US6686391B2 (en) 1995-08-04 2004-02-03 University Of Arizona Foundation N-chlorophenylcarbamate and N-chlorophenylthiocarbamate compositions
US5900429A (en) 1997-01-28 1999-05-04 The Procter & Gamble Company Method for inhibiting the growth of cancers
US6506783B1 (en) * 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
US6245789B1 (en) 1998-05-19 2001-06-12 The Procter & Gamble Company HIV and viral treatment
US6423734B1 (en) 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
US6384049B1 (en) * 2000-05-25 2002-05-07 The Procter & Gamble Company Cancer treatment
US6380232B1 (en) 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6608096B1 (en) * 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6462062B1 (en) 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6407105B1 (en) * 2000-09-26 2002-06-18 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
WO2002041891A2 (en) * 2000-11-01 2002-05-30 The Procter & Gamble Company Hiv treatment with benzimidazoles
DE60117858T2 (de) * 2000-12-07 2006-11-30 Universiteit Utrecht Holding B.V. Zusammensetzung zur behandlung von entzündlichen erkrankungen
WO2002067932A1 (en) * 2001-01-11 2002-09-06 Board Of Regents, The University Of Texas System Antihelminthic drugs as a treatment for hyperproliferative diseases
US6515074B2 (en) * 2001-01-22 2003-02-04 Delphi Technologies, Inc. Thermoplastic polymer alloy compositions and process for manufacture thereof
US6693125B2 (en) * 2001-01-24 2004-02-17 Combinatorx Incorporated Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders
AUPR626001A0 (en) * 2001-07-10 2001-08-02 Mcgregor, Neil A method of treatment and/or prophylaxis
CA2461227C (en) * 2001-09-24 2012-05-15 Jessie L.-S Au Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy
EP1487439A1 (en) * 2002-03-26 2004-12-22 The Arizona Board Of Regents, On Behalf Of The University Of Arizona Solubilization of weak bases
US20050152962A1 (en) * 2002-06-12 2005-07-14 Metselaar Josbert M. Composition for treatment of inflammatory disorders
US8492443B2 (en) * 2002-07-08 2013-07-23 Joe S. Wilkins, Jr. Treatment for herpes simplex virus and other infectious diseases
EP1393720A1 (en) * 2002-08-27 2004-03-03 Universiteit Utrecht Vesicle-encapsulated corticosteroids for treatment of cancer
AU2003900064A0 (en) * 2003-01-09 2003-01-23 Penam Investments Pty. Ltd. A method of treatment or prophylaxis of viral infection.
US7169801B2 (en) * 2003-03-17 2007-01-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP1598353A1 (en) * 2004-05-17 2005-11-23 Boehringer Ingelheim International GmbH Pyrrolobenzimidazolones and their use as antiproliferative agents
WO2006040329A1 (en) * 2004-10-12 2006-04-20 Novo Nordisk A/S 1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds
US7193254B2 (en) * 2004-11-30 2007-03-20 International Business Machines Corporation Structure and method of applying stresses to PFET and NFET transistor channels for improved performance
US20090286838A1 (en) * 2004-12-06 2009-11-19 Newsouth Innovations Pty Limited Treatment for cancer
CA2593714C (en) 2005-02-04 2013-09-10 Survac Aps Survivin peptide vaccine
US7265248B1 (en) 2005-04-29 2007-09-04 Technology Innovations, Llc Compositions and methods for the treatment of malaria
CA2627306A1 (en) * 2005-11-01 2007-05-10 Transtech Pharma, Inc. Pharmaceutical use of substituted amides
JP2009513611A (ja) * 2005-11-01 2009-04-02 ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー 置換アミドの医薬用途
WO2007055598A1 (en) * 2005-11-09 2007-05-18 Protemix Corporation Limited Treatment of mitochondria-related diseases and improvement of age-related metabolic deficits
EP1991226B1 (en) * 2006-02-28 2013-03-20 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase
CA2646588A1 (en) * 2006-03-21 2007-09-27 High Point Pharmaceuticals, Llc Adamantane derivatives for the treatment of the metabolic syndrome
CN101448782A (zh) 2006-04-07 2009-06-03 高点制药有限责任公司 对1型11β-羟基甾体脱氢酶具有活性的化合物
EP2029726A4 (en) * 2006-06-09 2010-07-28 Univ Miami ASSESSMENT OF CELL COMPOSITION AND FRACTIVITY AND USES THEREOF
EP2038255A2 (en) * 2006-06-16 2009-03-25 High Point Pharmaceuticals, LLC Pharmaceutical use of substituted piperidine carboxamides
EP1878721A1 (en) * 2006-07-13 2008-01-16 Novo Nordisk A/S 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
CA2657078A1 (en) * 2006-07-13 2008-01-17 High Point Pharmaceuticals, Llc 11beta-hydroxysteroid dehydrogenase type 1 active compounds
EP2146952A1 (en) * 2007-02-23 2010-01-27 High Point Pharmaceuticals, LLC N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
WO2008101886A1 (en) * 2007-02-23 2008-08-28 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
US8334305B2 (en) * 2007-02-23 2012-12-18 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
EA016951B1 (ru) * 2007-02-23 2012-08-30 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи N-АДАМАНТИЛБЕНЗАМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ 11-β-ГИДРОКСИСТЕРОИДДЕГИДРОГЕНАЗЫ
JP2010520864A (ja) * 2007-03-09 2010-06-17 ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー ヒドロキシステロイドデヒドロゲナーゼインヒビターとしてのインドール−及びベンズイミダゾールアミド類
JP2010522766A (ja) * 2007-03-28 2010-07-08 ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー 11ベータ−hsd1活性化合物
EP2152081B1 (en) * 2007-04-11 2012-10-24 High Point Pharmaceuticals, LLC Novel compounds
ES2393230T3 (es) * 2007-04-24 2012-12-19 High Point Pharmaceuticals, Llc Uso farmacéutico de amidas sustituidas
US8389553B2 (en) * 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
CN101808518A (zh) * 2007-06-27 2010-08-18 默沙东公司 作为组蛋白脱乙酰酶抑制剂的吡啶基和嘧啶基衍生物
US8835506B2 (en) 2008-06-05 2014-09-16 Stc.Unm Methods and related compositions for the treatment of cancer
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
US8513430B2 (en) 2010-07-27 2013-08-20 High Point Pharmaceuticals, Llc Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators
WO2012149334A2 (en) 2011-04-27 2012-11-01 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
TWI664982B (zh) 2012-05-09 2019-07-11 西方健康科學大學 前體脂質體睪固酮調配物
US9649313B2 (en) * 2012-11-26 2017-05-16 The University Of North Carolina At Chapel Hill Use of ITK inhibitors for the treatment of cancer
WO2016077648A1 (en) * 2014-11-11 2016-05-19 Neymeyer Calvin E Method of treating pre-cancerous lesion with glyphosate, and compositions thereof
WO2016187767A1 (en) * 2015-05-25 2016-12-01 Hutchison Medipharma Limited Pharmaceutical compositions and use thereof
WO2018081361A1 (en) * 2016-10-28 2018-05-03 Children's Hospital Medical Center Methods and compositions for treatment of myelodyspastic syndromes and/or acute myleoid leukemias
CN109633026A (zh) * 2019-01-03 2019-04-16 上海市农业科学院 一种液相色谱-串联质谱检测多菌灵及其代谢物的方法
EP3907230B1 (en) 2020-03-30 2024-08-28 Biometrix Technology Inc. Novel benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent comprising the same
KR102583547B1 (ko) 2020-03-30 2023-10-06 (주)바이오메트릭스 테크놀로지 신규한 벤지미다졸 유도체, 이의 제조방법 및 이의 항암제 용도
KR102449266B1 (ko) 2020-06-23 2022-09-30 (주)바이오메트릭스 테크놀로지 항암 활성 그리고 항바이러스 활성을 갖는 신규한 벤지미다졸-탄수화물 결합체 화합물(Benzimidazole carbohydrate conjugate compound) 및 이의 제조 방법
US12043644B2 (en) 2020-06-23 2024-07-23 Biometrix Technology Inc Benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent or anti-virus agent comprising the same
KR102342313B1 (ko) 2021-08-27 2021-12-24 (주)바이오메트릭스 테크놀로지 벤지미다졸-탄수화물 결합체 화합물을 포함하는 미셀, 이의 제조방법, 이의 항암제 또는 항바이러스제로서의 용도

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE158398C (no)
DE136499C (no)
US2933502A (en) 1958-02-12 1960-04-19 Du Pont Benzimidazolone derivatives
US3010968A (en) 1959-11-25 1961-11-28 Du Pont Process for manufacture of certain alkyl esters of benzimidazole carbamic acids
NL134354C (no) 1963-05-23
US3499761A (en) 1964-07-20 1970-03-10 Gaf Corp Silver halide emulsions containing alkyl esters of benzimidazole carbamic acid antifogging agents
BE666795A (no) 1964-08-04 1966-01-13
USRE28403E (en) 1964-08-04 1975-04-29 Butyl and n-propoxy-z-carbo- methoxyaminobenzimidazoles
US3541213A (en) 1966-05-06 1970-11-17 Du Pont Fungicidal and mite ovicidal substituted 2-aminobenzimidazoles
US3399212A (en) 1966-05-16 1968-08-27 Smith Kline French Lab Benzimidazole ureas
US3480642A (en) 1967-03-22 1969-11-25 Smithkline Corp Process for producing 2-carbalkoxyaminobenzimidazoles
US3881014A (en) 1968-11-05 1975-04-29 Bayer Ag N-tritylimidazoles for treating fungal infections
BE744970A (fr) 1969-01-28 1970-07-27 Lilly Co Eli Agents antiviraux et immuno-depresseurs
BE759337A (fr) 1969-11-24 1971-05-24 Lilly Co Eli Benzimidazol (2,1-b)-quinazolin (6h) ones qui sont des immuno-depresseurs, et nouvelles benzimidazo (2,1-b) quinazolin-12-(6h) ones
FR2046114A5 (en) 1970-01-30 1971-03-05 Dynachim Sarl Benzimidazole derivs anthelmintic, antifung - al bactericidal, aericidal, insecticidal, nema
US3956262A (en) 1970-12-09 1976-05-11 Beecham Group Limited Triazenoimidazoles
US3738995A (en) 1971-05-14 1973-06-12 Du Pont Solvent process for the preparation of 1 - carbamoyl-substituted 2 - benzimidazolecarbamates
DE2144505A1 (de) 1971-09-06 1973-03-15 Boehringer Sohn Ingelheim S-triazino- eckige klammer auf 1,2-a eckige klammer zu-benzimidazole
FR2155888A1 (en) 1971-10-13 1973-05-25 Agot Aime Solid anthelmintic composn - for more economical treatment of ruminants
DE2227919C2 (de) 1972-06-08 1982-12-23 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Benzimidazol-2-yl-carbaminsäure-methylester
DE2253324A1 (de) 1972-10-31 1974-05-09 Bayer Ag 1-alkoxycarbonyl-2- eckige klammer auf bis-(alkoxycarbonyl)-amino eckige klammer zu -benzimidazole, verfahren zu ihrer herstellung, sowie ihre verwendung als fungizide
US4046906A (en) 1973-04-21 1977-09-06 Hoechst Aktiengesellschaft Salts of alkyl 2-benzimidazole-carbamate
JPS5142565A (en) 1974-10-09 1976-04-10 Copal Co Ltd onnoff taimaa
US4001423A (en) 1975-06-20 1977-01-04 Dodds Dale I 2-(2-ethoxy)ethoxyethyl benzimidazolecarbamate
DE2527677A1 (de) 1975-06-21 1977-01-20 Bayer Ag Verfahren zur herstellung von 2,4- dioxo-1,2,3,4-tetrahydro-s-triazino- eckige klammer auf 1,2-a eckige klammer zu -benzimidazolen
US4086235A (en) 1976-04-12 1978-04-25 Syntex (U.S.A.) Inc. 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
IN159210B (no) 1982-01-11 1987-04-11 Council Scient Ind Res
IN158878B (no) 1982-07-15 1987-02-07 Council Scient Ind Res
HU193951B (en) 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them
US4731366A (en) 1986-08-05 1988-03-15 Harbor Branch Oceanographic Institution, Inc. Discorhabdin compositions and their methods of use
GB2210875B (en) 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
US5329012A (en) 1987-10-29 1994-07-12 The Research Foundation Of State University Of New York Bis(acyloxmethyl)imidazole compounds
US5114951A (en) 1989-04-11 1992-05-19 Burroughs Wellcome Company Agents for combating multiple drug resistance
US5149527A (en) 1990-09-18 1992-09-22 Oncotech, Inc. Immunopotentiating protocol for chemotherapy-responsive tumors
US5284662A (en) 1990-10-01 1994-02-08 Ciba-Geigy Corp. Oral osmotic system for slightly soluble active agents
JPH04223274A (ja) 1990-12-26 1992-08-13 Kansei Corp 加速度センサ
GB9106278D0 (en) 1991-03-25 1991-05-08 Smithkline Beecham Plc Method of treatment
US5310748A (en) 1992-05-11 1994-05-10 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
US5364875A (en) 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5290801A (en) 1992-05-29 1994-03-01 The Du Pont Merck Pharmaceutical Company Benzimidazoles for the treatment of atherosclerosis
JPH08500112A (ja) 1992-08-12 1996-01-09 ジ・アップジョン・カンパニー タキソールと組み合わせるプロテインキナーゼ阻害剤および関連化合物
FR2703057B1 (fr) 1993-03-24 1995-06-16 Elysees Balzac Financiere Matériau alvéolaire cellulosique renfermant un agent biocide et procédé pour sa préparation.
RO118000B1 (ro) 1993-03-31 2002-12-30 Merck & Co Inc Metoda pentru tratamentul sida, prevenirea si tratamentul infectiei cu hiv sau inhibarea proteazei hiv si compozitie farmaceutica pentru aplicarea metodei
US5434163A (en) 1993-05-14 1995-07-18 The Medical College Of Pennsylvania Treatment of Cryptococcus neoformans infection
US5554373A (en) 1993-11-05 1996-09-10 Seabrook; Samuel G. Compositions containing anti-microbial agents and methods for making and using same
JP3213471B2 (ja) 1994-04-13 2001-10-02 ポーラ化成工業株式会社 薬効成分含有リポソーム製剤の製造方法
DE69637178D1 (de) 1995-04-12 2007-09-06 Uaf Technologies And Res Llc N-chlorphenylcarbamate enthaltendes arzneimittel sowie n-chlorphenylthiocarbamate zur hemmung des wachstums von viren
US6177460B1 (en) * 1995-04-12 2001-01-23 The Procter & Gamble Company Method of treatment for cancer or viral infections
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6262093B1 (en) * 1995-04-12 2001-07-17 The Proctor & Gamble Company Methods of treating cancer with benzimidazoles
NZ305784A (en) 1995-04-12 2001-03-30 Procter & Gamble Benzimidazole containing medicaments for treating cancers, tumors and viral infections
US5665713A (en) 1995-04-12 1997-09-09 Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
ZA962879B (en) * 1995-04-12 1997-03-17 Procter & Gamble A pharmaceutical composition for inhibiting the growth of viruses and cancers
ZA962880B (en) 1995-04-12 1997-03-17 Procter & Gamble A pharmaceutical composition for inhibiting the growth of viruses and cancers
US5656615A (en) 1995-04-12 1997-08-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of cancers and viruses in mammals
US5629341A (en) 1995-04-12 1997-05-13 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6200992B1 (en) 1995-06-07 2001-03-13 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of cancers
MX9707809A (es) * 1995-06-07 1998-01-31 Procter & Gamble Una composicion farmaceutica que contiene bencimidazol para inhibir el crecimiento de canceres.
US5770616A (en) 1995-06-07 1998-06-23 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of cancers
US20010039291A1 (en) 1995-06-07 2001-11-08 The Procter & Gamble Company Compositions and methods of treatment for cancer or viral infections
HUP9802634A3 (en) 1995-06-07 1999-05-28 Procter & Gamble Use of benzimidazoles for the manufacture of pharmaceutical compositions for the treatment of leukemia
US6265427B1 (en) 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
US5665751A (en) 1995-06-07 1997-09-09 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of cancers
PL324905A1 (en) 1995-08-03 1998-06-22 Procter & Gamble Application of griseofulvin in carcinoma development inhibition
MX9707808A (es) 1995-08-04 1998-01-31 Procter & Gamble Una composicion farmaceutica que contiene n-clorofenilcarbamatos y n-clorofiniltiocarbamatos para inhibir el crecimiento de virus y canceres.
US5908855A (en) 1996-07-16 1999-06-01 The Procter & Gamble Company Compositions for treating viral infections
US6686391B2 (en) 1995-08-04 2004-02-03 University Of Arizona Foundation N-chlorophenylcarbamate and N-chlorophenylthiocarbamate compositions
AU711966B2 (en) 1995-08-04 1999-10-28 Procter & Gamble Company, The Use of fluconazole for inhibiting the growth of cancers
WO1997012613A1 (en) 1995-10-05 1997-04-10 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
US5627094A (en) * 1995-12-04 1997-05-06 Chartered Semiconductor Manufacturing Pte, Ltd. Stacked container capacitor using chemical mechanical polishing
US6541213B1 (en) * 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
DE19623226A1 (de) * 1996-06-11 1997-12-18 Basf Ag Katalysatorsysteme vom Typ der Ziegler-Natta-Katalysatoren
US6056973A (en) * 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
US5825811A (en) 1997-01-16 1998-10-20 Motorola, Inc. Method and apparatus for facilitating inbound channel access
US5900429A (en) 1997-01-28 1999-05-04 The Procter & Gamble Company Method for inhibiting the growth of cancers
PE11499A1 (es) 1997-05-16 1999-03-01 Procter & Gamble Tratamiento del hiv y cancer
US6506783B1 (en) * 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
US5908885A (en) * 1997-07-01 1999-06-01 University Of South Alabama Polysuccinimide and polyaspartate as additives to cementitious materials
US6245789B1 (en) 1998-05-19 2001-06-12 The Procter & Gamble Company HIV and viral treatment
DE19842116C2 (de) 1998-09-07 2001-02-08 Schuelke & Mayr Gmbh Verwendung von Derivaten von Methylenbisoxazolidin und dadurch erhaltene Zusammensetzungen
US6248843B1 (en) * 1998-09-18 2001-06-19 Mcwhorter Technologies, Inc. Powder coatings based on branched oligoesters and triazole blocked polyisocyanates
EP1119345B1 (en) 1998-10-09 2009-04-29 General Mills, Inc. Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles
US6211177B1 (en) 1998-11-24 2001-04-03 Cell Pathways, Inc. Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives
US20010053773A1 (en) 1998-12-22 2001-12-20 The Procter & Gamble Company Method for inhibiting the growth of cancers
CN1161112C (zh) * 1999-02-23 2004-08-11 株式会社柳韩洋行 含氯雷他定和伪麻黄碱的药物胶囊组合物
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6136835A (en) * 1999-05-17 2000-10-24 The Procter & Gamble Company Methods of treatment for viral infections
US6423734B1 (en) * 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
US6135835A (en) * 1999-08-16 2000-10-24 Future Beach Corporation Aquatic vehicle
US20010047021A1 (en) 2000-04-28 2001-11-29 The Procter & Gamble Company Cancer treatment
US6384049B1 (en) 2000-05-25 2002-05-07 The Procter & Gamble Company Cancer treatment
US6290929B1 (en) 2000-07-28 2001-09-18 The Procter & Gamble Company Cancer treatment
US6518269B1 (en) 2000-07-28 2003-02-11 University Of Arizona Foundation Cancer treatment
US6608096B1 (en) * 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6380232B1 (en) * 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6407105B1 (en) 2000-09-26 2002-06-18 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6462062B1 (en) 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
MXPA03002601A (es) 2000-09-26 2005-02-25 Univ Arizona Foundation Compuestos y metodos de uso de los mismos en el tratamiento del cancer o de infecciones virales.
WO2002041891A2 (en) 2000-11-01 2002-05-30 The Procter & Gamble Company Hiv treatment with benzimidazoles

Also Published As

Publication number Publication date
NO991700D0 (no) 1999-04-09
IL129352A0 (en) 2000-02-17
US6864275B1 (en) 2005-03-08
US6506783B1 (en) 2003-01-14
BR9714634A (pt) 2000-05-23
CA2268840A1 (en) 1998-11-19
NZ335159A (en) 2001-09-28
US6423735B1 (en) 2002-07-23
WO1998051304A1 (en) 1998-11-19
US6710065B1 (en) 2004-03-23
US20050192328A1 (en) 2005-09-01
US6900235B1 (en) 2005-05-31
EP0956017A1 (en) 1999-11-17
DE69737793D1 (de) 2007-07-19
HUP0001170A3 (en) 2001-07-30
CN1254282A (zh) 2000-05-24
US6420411B1 (en) 2002-07-16
US6077862A (en) 2000-06-20
AU728690B2 (en) 2001-01-18
PL335541A1 (en) 2000-04-25
US6984654B2 (en) 2006-01-10
EP0956017B1 (en) 2007-06-06
AU7402798A (en) 1998-12-08
US20050288349A1 (en) 2005-12-29
KR20000049065A (ko) 2000-07-25
CZ125299A3 (cs) 1999-09-15
AR010008A1 (es) 2000-05-17
US20050119236A1 (en) 2005-06-02
PE11099A1 (es) 1999-03-01
TR199901528T2 (xx) 1999-09-21
US6423736B1 (en) 2002-07-23
ATE363904T1 (de) 2007-06-15
SK47099A3 (en) 2000-05-16
CA2268840C (en) 2006-10-03
JP2001527523A (ja) 2001-12-25
US6482843B1 (en) 2002-11-19
HUP0001170A2 (hu) 2001-05-28
US6407131B1 (en) 2002-06-18
ZA979096B (en) 1998-08-28

Similar Documents

Publication Publication Date Title
NO991700L (no) Benzimidazol-2-karbamater for behandling av virusinfeksjoner og cancer
AP1895A (en) Novel benzoimidazole derivatives useful as antiproliferative agents.
BG93979A (bg) Производни на n-(4-пиперидинил)(дихидробензофуран или дихидро-2н-бензопиран)карбоксамид, фармацевтичен състав, който ги съдържа, метод за получаване на производните и приложението им
BR9916790A (pt) Uso de um composto, composto, processo para amanufatura do mesmo, composição farmacêtica, e,método para produzir um efeito de dano vascularem um animal de sangue quente
LU91761I2 (fr) Vernakalant et ses dérivés pharmaceutiquement acceptables et en particulier son sel d'hydrochlorure (BRINAVESS®)
ATE139783T1 (de) Azasteroide zur behandlung prostatischer hypertrophie, ihre herstellung und verwendung
NZ330216A (en) Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and use in treatment of atherosclerosis
EP0941998A3 (en) 3,6-ketal and enol ether macrolide antibiotics
EA200100983A1 (ru) Производные 13-метилэритромицина
FR2741619B1 (fr) Nouveaux derives de 2,3,5-trimethyl-4-hydroxy-anilides, leur preparation et leur application en therapeutique
DK0992509T3 (da) Nye makrolid-derivater
DK0984019T3 (da) C11-carbamater fra antibakterielle macrolider
KR910016915A (ko) 과콜레스테롤혈증 치료제
IS5588A (is) Æxliseyðandi miðlar
RU94037246A (ru) Применение 2-фенил-3-ароилбензотиофенов для ингибирования разрушения хряща
DE69012560D1 (de) Makrolide zur behandlung reversibler obstruktiver atemwegserkrankungen.
MXPA05008706A (es) 4-[(2, 4- dicloro-5 -metoxifenil) amino]-6 -alcoxi -3- quinolincarbonitrilos para tratamiento de lesiones isquemicas.
NO178025C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive (benzhydryloksyetylpiperidyl)alifatiske syrederivater
NO20020804D0 (no) Nye A-500359-derivater
BR0107282A (pt) Composto, composição farmacêutica e métodos para prevenir ou tratar uma condição em um mamìfero e para inibir a coagulação de amostras biológicas
ATE100439T1 (de) 2-(2-hydroxy-3-phenoxypropylamino)-ethoxybenzol derivate.
DE69824855D1 (de) Macrozyklische laktone, zusammensetzungen und verfahren zur verwendung
EA200200292A1 (ru) Производные гигромицина
AP9901559A0 (en) Tricyclic 3-keto derivatives of 6-0-methylerythromycin.
NO20005551L (no) 2"-deoksyhygromycinderivater

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application