NO911861L - Stabilisert fgf-sammensetning. - Google Patents

Stabilisert fgf-sammensetning.

Info

Publication number: NO911861L
Authority: NO; Norway
Prior art keywords: fgf; sos; methods; treatment; compositions
Prior art date: 1990-05-15

Application number

NO91911861A

Other languages

English (en)

Norwegian (no)

Other versions

NO911861D0 (no

Inventor

Sandor Szabo

Moses Judah Folkman

Yuen Shing

Original Assignee

Childrens Medical Center

Brigham & Womens Hospital

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-15

Filing date

1991-05-14

Publication date

1991-11-18

1991-05-14 Application filed by Childrens Medical Center, Brigham & Womens Hospital filed Critical Childrens Medical Center

1991-05-14 Publication of NO911861D0 publication Critical patent/NO911861D0/no

1991-11-18 Publication of NO911861L publication Critical patent/NO911861L/no

Links

239000000203 mixture Substances 0.000 title abstract 3
102000018233 Fibroblast Growth Factor Human genes 0.000 abstract 6
108050007372 Fibroblast Growth Factor Proteins 0.000 abstract 6
229940126864 fibroblast growth factor Drugs 0.000 abstract 6
WEPNHBQBLCNOBB-FZJVNAOYSA-N sucrose octasulfate Chemical compound OS(=O)(=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@H](COS(=O)(=O)O)O[C@]1(COS(O)(=O)=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](COS(O)(=O)=O)O1 WEPNHBQBLCNOBB-FZJVNAOYSA-N 0.000 abstract 6
238000000034 method Methods 0.000 abstract 3
238000009007 Diagnostic Kit Methods 0.000 abstract 1
208000025865 Ulcer Diseases 0.000 abstract 1
206010052428 Wound Diseases 0.000 abstract 1
208000027418 Wounds and injury Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
229910052782 aluminium Inorganic materials 0.000 abstract 1
230000000536 complexating effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
159000000001 potassium salts Chemical class 0.000 abstract 1
230000002797 proteolythic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1
MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 abstract 1
229960004291 sucralfate Drugs 0.000 abstract 1
231100000397 ulcer Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Investigating Or Analysing Biological Materials (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO91911861A 1990-05-15 1991-05-14 Stabilisert fgf-sammensetning. NO911861L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/524,144 US5202311A (en)	1988-08-19	1990-05-15	Stabilized fgf composition

Publications (2)

Publication Number	Publication Date
NO911861D0 NO911861D0 (no)	1991-05-14
NO911861L true NO911861L (no)	1991-11-18

Family

ID=24087954

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO91911861A NO911861L (no)	1990-05-15	1991-05-14	Stabilisert fgf-sammensetning.

Country Status (13)

Country	Link
US (1)	US5202311A (zh)
EP (1)	EP0457223A1 (zh)
JP (1)	JPH04330017A (zh)
KR (1)	KR910019637A (zh)
CN (1)	CN1058149A (zh)
AU (1)	AU637904B2 (zh)
CA (1)	CA2042569A1 (zh)
FI (1)	FI912348L (zh)
HU (1)	HU208635B (zh)
IE (1)	IE911655A1 (zh)
IL (1)	IL98040A0 (zh)
NO (1)	NO911861L (zh)
RU (1)	RU2070722C1 (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5260071A (en) *	1989-12-18	1993-11-09	Lemelson Jerome H	Drug units and methods for using same
US6077823A (en) *	1991-03-11	2000-06-20	Creative Biomolecules, Inc.	Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US5482929A (en) *	1991-12-26	1996-01-09	Kaken Pharmaceutical Co., Ltd.	Composition of stabilized fibroblast growth factor
WO1994028020A1 (en) *	1993-05-18	1994-12-08	Bukh Meditec A/S	A method for the preparation of interferons
ATE203913T1 (de)	1993-05-31	2001-08-15	Kaken Pharma Co Ltd	Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält
US5783568A (en) *	1994-06-10	1998-07-21	Sugen, Inc.	Methods for treating cancer and other cell proliferative diseases
JP3263598B2 (ja) *	1995-11-01	2002-03-04	有限会社ドット	経鼻吸収用生理活性ペプチド組成物
US20110207666A1 (en) *	1996-03-05	2011-08-25	Depuy Spine, Inc.	Method of promoting bone growth with hyaluronic acid and growth factors
US5942499A (en) *	1996-03-05	1999-08-24	Orquest, Inc.	Method of promoting bone growth with hyaluronic acid and growth factors
US6221854B1 (en)	1996-03-05	2001-04-24	Orquest, Inc.	Method of promoting bone growth with hyaluronic acid and growth factors
US6645945B1 (en)	1996-03-05	2003-11-11	Depuy Acromed, Inc.	Method of treating diseased, injured or abnormal cartilage with hyaluronic acid and growth factors
GB9721497D0 (en) *	1997-10-09	1997-12-10	Ciba Geigy Ag	Organic compounds
RU2196571C2 (ru) *	1998-12-07	2003-01-20	Санкт-Петербургская Государственная Химико-Фармацевтическая Академия	Средство для лечения заболеваний, вызываемых бактериями и простейшими
US8227411B2 (en) *	2002-08-20	2012-07-24	BioSurface Engineering Technologies, Incle	FGF growth factor analogs
US7598224B2 (en)	2002-08-20	2009-10-06	Biosurface Engineering Technologies, Inc.	Dual chain synthetic heparin-binding growth factor analogs
US20080227696A1 (en) *	2005-02-22	2008-09-18	Biosurface Engineering Technologies, Inc.	Single branch heparin-binding growth factor analogs
WO2005082005A2 (en)	2004-02-20	2005-09-09	Biosurface Engineering Technologies, Inc., Et Al.	Positive modulator of bone morphogenic protein-2
JP2009541358A (ja)	2006-06-22	2009-11-26	バイオサーフェスエンジニアリングテクノロジーズ，インク．	骨形成を強化するためにｂｍｐ−２増幅因子／共活性化因子を送達するための組成物および方法
GB0622688D0 (en)	2006-11-14	2006-12-27	Diosamine Dev Corp	Novel compounds
AU2007234612B2 (en) *	2006-12-14	2013-06-27	Johnson & Johnson Regenerative Therapeutics, Llc	Protein stabilization formulations
US7678764B2 (en)	2007-06-29	2010-03-16	Johnson & Johnson Regenerative Therapeutics, Llc	Protein formulations for use at elevated temperatures
JP5323832B2 (ja)	2007-08-07	2013-10-23	アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー	酸性水溶液中にｇｄｆ−５を含むタンパク質製剤
JP5599778B2 (ja) *	2008-04-14	2014-10-01	デピュイ・シンセス・プロダクツ・エルエルシー	液体緩衝ｇｄｆ−５製剤
US9347037B2 (en) *	2013-02-11	2016-05-24	Evan Masataka Masutani	Methods and apparatus for building complex 3D scaffolds and biomimetic scaffolds built therefrom
WO2017089016A1 (en)	2015-11-27	2017-06-01	Masarykova Univerzita	Thermostable fgf2 polypeptide, use thereof
WO2020188019A1 (en) *	2019-03-20	2020-09-24	Reponex Pharmaceuticals A/S	Targeting biological agents to mucosal defects of the gastrointestinal tract
EP4183796A1 (en)	2021-11-19	2023-05-24	Enantis s.r.o.	Thermostable fgf10 polypeptide or fragment thereof use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4912093A (en) *	1986-10-01	1990-03-27	Marion Laboratories, Inc.	Use of synthetic sulfated saccharides to enhance wound healing
AU607690B2 (en) *	1985-12-24	1991-03-14	Marion Laboratories, Inc.	Use of synthetic sulfated saccharides to enhance wound healing
DE3628829C1 (de) *	1986-08-25	1988-02-11	Pantelis Bozoglou	Naehmaschine zum Annaehen eines Gummibandes
DK505488D0 (da) *	1987-12-21	1988-09-09	Bar Shalom Daniel	Middel og anvendelse af samme
AU614137B2 (en) *	1988-06-06	1991-08-22	Takeda Chemical Industries Ltd.	Stabilized fgf composition and production thereof
US5100668A (en) *	1988-06-14	1992-03-31	Massachusetts Institute Of Technology	Controlled release systems containing heparin and growth factors
US5175147A (en) *	1988-08-19	1992-12-29	Takeda Chemical Industries, Ltd	Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
DE3900198A1 (de) *	1989-01-05	1990-07-12	Merck Patent Gmbh	Topisch anwendbare pharmazeutische zubereitung
FR2644066B1 (fr) *	1989-03-09	1994-05-13	Therapeutiques Substitutives	Compositions stabilisees comprenant des fgfs, leur procede d'obtention et leurs applications therapeutiques, chirurgicales et cosmetologiques
CA2020654A1 (en) *	1989-07-07	1991-01-08	Yohko Akiyama	Stabilized fgf composition and production thereof

1990
- 1990-05-15 US US07/524,144 patent/US5202311A/en not_active Expired - Fee Related
1991
- 1991-05-02 IL IL98040A patent/IL98040A0/xx unknown
- 1991-05-11 EP EP91107682A patent/EP0457223A1/en not_active Withdrawn
- 1991-05-14 IE IE165591A patent/IE911655A1/en unknown
- 1991-05-14 HU HU911613A patent/HU208635B/hu not_active IP Right Cessation
- 1991-05-14 RU SU914895442A patent/RU2070722C1/ru active
- 1991-05-14 CN CN91103961A patent/CN1058149A/zh active Pending
- 1991-05-14 NO NO91911861A patent/NO911861L/no unknown
- 1991-05-14 FI FI912348A patent/FI912348L/fi not_active Application Discontinuation
- 1991-05-14 CA CA002042569A patent/CA2042569A1/en not_active Abandoned
- 1991-05-14 AU AU77030/91A patent/AU637904B2/en not_active Ceased
- 1991-05-15 JP JP3110430A patent/JPH04330017A/ja not_active Withdrawn
- 1991-05-15 KR KR1019910007897A patent/KR910019637A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
FI912348A7 (fi)	1991-11-16
IL98040A0 (en)	1992-06-21
CN1058149A (zh)	1992-01-29
HU208635B (en)	1993-12-28
NO911861D0 (no)	1991-05-14
RU2070722C1 (ru)	1996-12-20
CA2042569A1 (en)	1991-11-16
JPH04330017A (ja)	1992-11-18
AU7703091A (en)	1991-11-21
FI912348L (fi)	1991-11-16
FI912348A0 (fi)	1991-05-14
HUT57061A (en)	1991-11-28
IE911655A1 (en)	1991-11-20
AU637904B2 (en)	1993-06-10
KR910019637A (ko)	1991-12-19
US5202311A (en)	1993-04-13
EP0457223A1 (en)	1991-11-21

Publication	Publication Date	Title
NO911861L (no)	1991-11-18	Stabilisert fgf-sammensetning.
JPS6429362A (en)	1989-01-31	3-demethylmevalonic acid derivative
NO871361D0 (no)	1987-04-01	Fremgangsmaate for redusering av fluidtap i sementsammensetninger som kan inneholde vesentlige saltkonsentrasjoner.
DK103384A (da)	1984-08-26	Quinoloncarboxylsyrer eller salte eller hydrater deraf, deres fremstilling og anvendelse som antibakterielle midler
ES8603191A1 (es)	1985-12-01	Un procedimiento para preparar un derivado de mono-sialo-gangliosido
DE69005950D1 (de)	1994-02-24	Zweiwertige Metallsalze von 2-N,N-di(carboxymethyl)amino,3-cyano,4-carboxymethyl,5-carboxy-thiophensäure, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
RU95112575A (ru)	1997-06-20	Соль арилпропионовой кислоты, способ ее получения и фармацевтическая композиция
DK127986A (da)	1986-09-27	Citronsyreestere eller salt deraf, fremgangsmaade til fremstilling deraf og anvendelse af saadanne forbindelser som overfladeaktive midler
FI871143A0 (fi)	1987-03-16	Nya derivater av karboxylsyra, foerfarande foer framstaellning av dessa, deras anvaendning samt laekemedel som innehaoller dessa foereningar.
AU555971B2 (en)	1986-10-16	Stable oral compositions containing zinc and fluoride compounds
AU578783B2 (en)	1988-11-03	Pyridopyrimidines, several processes for their preparation and their use as medicaments
DK72289A (da)	1989-08-18	Cephemcarboxylsyreestere, deres fremstilling og anvendelse
EP0194901A3 (en)	1987-12-16	Isoprenoidamine derivatives, compositions containing them, their preparation, and their use
AU1706083A (en)	1984-01-26	Novel derivatives of guanine i
EP0331092A3 (en)	1990-11-07	Alpha-amino-carboxylic-acid derivatives, their preparation and use
DK0402806T3 (da)	1994-01-17	Krystallinske cephem-syreadditionssalte og fremgangsmåde til fremstilling heraf
GR3002624T3 (en)	1993-01-25	Primycine-containing colloidal basic gel, process for its preparation and pharmaceutical or pharmaco-cosmetic compositions containing the basic gel
DK300583D0 (da)	1983-06-29	Racemiske eller optisk aktive eburnanoximderivater eller syreadditionssalte deraf, deres fremstilling og anvendelse
DE3361628D1 (en)	1986-02-06	Substituted 5-phenylthio-6-amino-pyrimidinones, process for their preparation and their use, and preparations containing these compounds
DK251284A (da)	1984-11-24	Substituerede 1,2,3-triazino(4',5'.4,5)thieno(2,3-b)-quinolin-4(3h)-oner eller syreadditionssalte deraf og deres fremstilling
DK284588D0 (da)	1988-05-25	Beta-lactam-forbindelser, deres fremstilling og anvendelse som laegemidler.
AU2508584A (en)	1984-09-06	N-arylpiperazine derivatives
JPS57130545A (en)	1982-08-13	Urea adsorbing agent
DK180086D0 (da)	1986-04-18	12b-substituerede 1-hydroxymethyl-octahydroindolo(2,3-a)-quinolizinderivater eller isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika
AU3471589A (en)	1989-12-21	Novel 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, processes for the preparation of these compounds their use as pharmaceuticals