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NO322567B1 - Anvendelse av melatonin ved fremstilling av medikament for behandling av resistens mot anti-hypertensiva og relaterte tilstander - Google Patents

Anvendelse av melatonin ved fremstilling av medikament for behandling av resistens mot anti-hypertensiva og relaterte tilstander Download PDF

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Publication number
NO322567B1
NO322567B1 NO20023102A NO20023102A NO322567B1 NO 322567 B1 NO322567 B1 NO 322567B1 NO 20023102 A NO20023102 A NO 20023102A NO 20023102 A NO20023102 A NO 20023102A NO 322567 B1 NO322567 B1 NO 322567B1
Authority
NO
Norway
Prior art keywords
melatonin
profile
cortisol
use according
formulation
Prior art date
Application number
NO20023102A
Other languages
English (en)
Norwegian (no)
Other versions
NO20023102D0 (no
NO20023102L (no
Inventor
Moshe Laudon
Nava Zisapel
Original Assignee
Neurim Pharma 1991
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurim Pharma 1991 filed Critical Neurim Pharma 1991
Publication of NO20023102D0 publication Critical patent/NO20023102D0/no
Publication of NO20023102L publication Critical patent/NO20023102L/no
Publication of NO322567B1 publication Critical patent/NO322567B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
NO20023102A 2000-01-05 2002-06-27 Anvendelse av melatonin ved fremstilling av medikament for behandling av resistens mot anti-hypertensiva og relaterte tilstander NO322567B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IL2000/000009 WO2001049286A1 (en) 2000-01-05 2000-01-05 Method and formulation for treating resistance to antihypertensives and related conditions

Publications (3)

Publication Number Publication Date
NO20023102D0 NO20023102D0 (no) 2002-06-27
NO20023102L NO20023102L (no) 2002-08-30
NO322567B1 true NO322567B1 (no) 2006-10-30

Family

ID=11042938

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023102A NO322567B1 (no) 2000-01-05 2002-06-27 Anvendelse av melatonin ved fremstilling av medikament for behandling av resistens mot anti-hypertensiva og relaterte tilstander

Country Status (31)

Country Link
US (3) US7332177B1 (xx)
EP (1) EP1272177B1 (xx)
JP (1) JP4996803B2 (xx)
CN (1) CN1414851A (xx)
AT (1) ATE359072T1 (xx)
AU (1) AU782266B2 (xx)
BG (1) BG65637B1 (xx)
BR (1) BR0016918A (xx)
CA (1) CA2396129C (xx)
CY (2) CY1108018T1 (xx)
CZ (1) CZ299931B6 (xx)
DE (1) DE60034373T2 (xx)
DK (1) DK1272177T3 (xx)
EA (1) EA004679B1 (xx)
EE (1) EE200200379A (xx)
ES (1) ES2284471T3 (xx)
HK (1) HK1052655A1 (xx)
HU (1) HU227002B1 (xx)
IL (1) IL150190A0 (xx)
IS (1) IS6439A (xx)
MX (1) MXPA02005783A (xx)
NO (1) NO322567B1 (xx)
NZ (1) NZ520078A (xx)
PL (1) PL201219B1 (xx)
PT (1) PT1272177E (xx)
SI (1) SI1272177T1 (xx)
SK (1) SK287508B6 (xx)
TR (1) TR200201724T2 (xx)
TW (1) TWI260983B (xx)
UA (1) UA77394C2 (xx)
WO (1) WO2001049286A1 (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144900A (en) * 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
IL155666A (en) 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
US20050020666A1 (en) * 2003-07-25 2005-01-27 Dabur Research Foundation Cardioprotective agents
WO2005063240A1 (en) * 2003-12-22 2005-07-14 The Brigham And Women's Hospital, Inc. Methods and compositions for treatment of hypertension
JP3964417B2 (ja) * 2004-09-27 2007-08-22 国立大学法人金沢大学 インドール誘導体を有効成分とするα2受容体遮断剤及び血管拡張剤
KR101053780B1 (ko) * 2008-02-29 2011-08-02 동아제약주식회사 도세탁셀을 함유하는 단일액상의 안정한 약제학적 조성물
US20130325151A1 (en) * 2010-10-25 2013-12-05 Uico, Llc Control system with solid state touch sensor for complex surface geometry
US8691275B2 (en) 2011-01-28 2014-04-08 Zx Pharma, Llc Controlled-release melatonin compositions and related methods
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
WO2018033546A1 (en) * 2016-08-18 2018-02-22 Koninklijke Philips N.V. Blood-pressure management
US10849856B2 (en) 2016-10-31 2020-12-01 Neurim Pharmaceuticals Ltd. Melatonin mini-tablets and method of manufacturing the same
CN109922795B (zh) 2016-10-31 2021-10-08 纽里姆药物有限公司 褪黑素小片剂及其制备方法
WO2019038586A1 (en) 2017-08-19 2019-02-28 Ftf Pharma Private Limited PHARMACEUTICAL COMPOSITION OF MELATONIN
ES2724933A1 (es) * 2018-03-13 2019-09-17 Ocupharm Diagnostics Sl Terapia combinada con melatonina para la reducción de la presión intraocular
GB2617102A (en) * 2022-03-29 2023-10-04 John Hemming Trading Ltd Sleep therapy

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69229490T2 (de) * 1991-05-09 2000-02-17 Neurim Pharmaceuticals (1991) Ltd., Tel Aviv Melatonin enthaltende Arzneimittel
ZA928011B (en) * 1991-10-18 1993-06-23 Alza Corp Transdermal administration of melatonin.
US5646049A (en) 1992-03-27 1997-07-08 Abbott Laboratories Scheduling operation of an automated analytical system
IL105240A (en) 1992-04-07 1999-04-11 Neurim Pharma 1991 The use of melatonin in the preparation of a drug for the treatment of benign prostatic hyperplasia
WO1995002068A1 (en) 1993-07-09 1995-01-19 Wakunaga Seiyaku Kabushiki Kaisha Method of discriminating nucleic acid and testing set for discriminating nucleic acid
CN1083263C (zh) 1995-02-01 2002-04-24 纽里姆药品(1991)有限公司 褪黑激素在治疗药物成瘾之患者中的应用
US5648727A (en) 1995-10-24 1997-07-15 Dpc Cirrus Inc. Capacitive level sensing pipette probe
US5700828A (en) * 1995-12-07 1997-12-23 Life Resuscitation Technologies, Inc. Treatment or prevention of anoxic or ischemic brain injury with melatonin-containing compositions
US5849338A (en) * 1996-04-10 1998-12-15 Chronorx Llc Unit dosage forms for treatment of vasoconstriction and related conditions
RU2134108C1 (ru) 1998-10-06 1999-08-10 Заславская Рина Михайловна Средство для лечения артериальной гипертонии, способ лечения артериальной гипертонии

Also Published As

Publication number Publication date
PL356325A1 (en) 2004-06-28
UA77394C2 (uk) 2006-12-15
US7332177B1 (en) 2008-02-19
EA200200738A1 (ru) 2002-12-26
NO20023102D0 (no) 2002-06-27
CA2396129A1 (en) 2001-07-12
HU227002B1 (en) 2010-04-28
EP1272177A1 (en) 2003-01-08
HUP0204089A2 (hu) 2003-04-28
HK1052655A1 (zh) 2003-09-26
TR200201724T2 (tr) 2003-03-21
PT1272177E (pt) 2007-07-11
TWI260983B (en) 2006-09-01
BR0016918A (pt) 2004-03-23
CY1108018T1 (el) 2011-04-06
NZ520078A (en) 2004-02-27
SK9732002A3 (en) 2002-11-06
JP4996803B2 (ja) 2012-08-08
US8728511B2 (en) 2014-05-20
NO20023102L (no) 2002-08-30
IS6439A (is) 2002-06-24
BG106978A (en) 2003-03-31
SK287508B6 (sk) 2010-12-07
EP1272177A4 (en) 2004-04-28
SI1272177T1 (sl) 2007-10-31
EA004679B1 (ru) 2004-06-24
HUP0204089A3 (en) 2005-12-28
PL201219B1 (pl) 2009-03-31
MXPA02005783A (es) 2003-10-14
JP2003519181A (ja) 2003-06-17
AU782266B2 (en) 2005-07-14
DK1272177T3 (da) 2007-08-06
AU1888200A (en) 2001-07-16
CY2007033I2 (el) 2009-11-04
IL150190A0 (en) 2002-12-01
EE200200379A (et) 2003-10-15
CA2396129C (en) 2010-11-30
CZ299931B6 (cs) 2008-12-29
US8075914B2 (en) 2011-12-13
US20120070501A1 (en) 2012-03-22
ES2284471T3 (es) 2007-11-16
ATE359072T1 (de) 2007-05-15
DE60034373T2 (de) 2007-12-20
CY2007033I1 (el) 2009-11-04
DE60034373D1 (de) 2007-05-24
US20080085317A1 (en) 2008-04-10
BG65637B1 (bg) 2009-04-30
EP1272177B1 (en) 2007-04-11
CZ20022346A3 (cs) 2002-11-13
WO2001049286A1 (en) 2001-07-12
CN1414851A (zh) 2003-04-30

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