NO324211B1 - Nye benzazepinderivater, farmasoytisk middel inneholdende forbindelsene samt deres anvendelse ved fremstilling av medikamenter - Google Patents
Nye benzazepinderivater, farmasoytisk middel inneholdende forbindelsene samt deres anvendelse ved fremstilling av medikamenter Download PDFInfo
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- NO324211B1 NO324211B1 NO19984852A NO984852A NO324211B1 NO 324211 B1 NO324211 B1 NO 324211B1 NO 19984852 A NO19984852 A NO 19984852A NO 984852 A NO984852 A NO 984852A NO 324211 B1 NO324211 B1 NO 324211B1
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- 201000010374 Down Syndrome Diseases 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 208000024827 Alzheimer disease Diseases 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 7
- 206010044688 Trisomy 21 Diseases 0.000 claims description 6
- 206010012289 Dementia Diseases 0.000 claims description 5
- 239000008177 pharmaceutical agent Substances 0.000 claims description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 208000037280 Trisomy Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0071696A AT403803B (de) | 1996-04-19 | 1996-04-19 | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| PCT/AT1997/000074 WO1997040049A1 (de) | 1996-04-19 | 1997-04-21 | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO984852D0 NO984852D0 (no) | 1998-10-16 |
| NO984852L NO984852L (no) | 1998-11-16 |
| NO324211B1 true NO324211B1 (no) | 2007-09-10 |
Family
ID=3497932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19984852A NO324211B1 (no) | 1996-04-19 | 1998-10-16 | Nye benzazepinderivater, farmasoytisk middel inneholdende forbindelsene samt deres anvendelse ved fremstilling av medikamenter |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6638925B2 (is) |
| EP (2) | EP1757608A1 (is) |
| AT (1) | AT403803B (is) |
| AU (1) | AU2498597A (is) |
| BG (1) | BG64560B1 (is) |
| CZ (1) | CZ300211B6 (is) |
| IS (1) | IS4839A (is) |
| NO (1) | NO324211B1 (is) |
| PL (2) | PL189834B1 (is) |
| RO (1) | RO120136B1 (is) |
| TW (1) | TWI224595B (is) |
| WO (1) | WO1997040049A1 (is) |
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| AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| US7214686B2 (en) * | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
| WO2000032199A1 (de) * | 1998-12-01 | 2000-06-08 | Sanochemia Pharmazeutika Aktiengesellschaft | Verwendung von galanthamin und galanthaminderivaten bei akuten funktionellen hirnschäden |
| EP1177196B1 (en) * | 1999-05-04 | 2004-03-10 | Neurosearch A/S | Heteroaryl diazabicycloalkanes, their preparation and use |
| KR100768245B1 (ko) * | 2000-03-31 | 2007-10-17 | 자노케미아 파마조이티카 악티엔게젤샤프트 | 신규한 갈란타민 유도체 및 유사체 |
| ATE263171T1 (de) * | 2000-03-31 | 2004-04-15 | Sanochemia Pharmazeutika Ag | Neue derivate und analoga von galanthamin |
| EP1289996B1 (en) * | 2000-05-25 | 2005-04-06 | Targacept, Inc. | Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands |
| US6440970B1 (en) * | 2000-05-25 | 2002-08-27 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| CA2410945A1 (en) * | 2000-07-04 | 2002-01-10 | Neurosearch A/S | Aryl and heteroaryl diazabicycloalkanes, their preparation and use |
| EA200300392A1 (ru) * | 2000-10-19 | 2003-10-30 | Пфайзер Продактс Инк. | Производные пиперазина с мостиковой связью |
| US20040029894A1 (en) * | 2000-12-07 | 2004-02-12 | Nobuya Matsuoka | Nootropic effect enhancer |
| EP1389189A2 (en) * | 2001-05-22 | 2004-02-18 | Neurogen Corporation | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues |
| DE10129265A1 (de) * | 2001-06-18 | 2003-01-02 | Hf Arzneimittelforsch Gmbh | Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie |
| JP4721386B2 (ja) * | 2001-07-10 | 2011-07-13 | 第一三共株式会社 | 新規ガランタミン類縁体 |
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| EP1519939B9 (en) * | 2002-07-05 | 2011-04-06 | Targacept, Inc. | N-aryl diazaspirocyclic compounds and methods of preparation and use thereof |
| AU2003254016A1 (en) | 2002-07-19 | 2004-02-09 | Catholic Healthcare West | Methods and compositions relating to chimeric nicotinic receptor subunits |
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| AT414125B (de) * | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
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| AT500143A1 (de) * | 2004-04-22 | 2005-11-15 | Sanochemia Pharmazeutika Ag | Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung |
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| UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
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| US20100168081A1 (en) * | 2005-08-11 | 2010-07-01 | Adriana Di Polo | Galantamine as a neuroprotective drug for retinal ganglion cells |
| CN101248073A (zh) * | 2005-08-22 | 2008-08-20 | 塔加西普特公司 | 杂芳基-取代的二氮杂三环烷类、其制备方法及其应用 |
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| JP2009536665A (ja) * | 2006-05-09 | 2009-10-15 | アストラゼネカ・アクチエボラーグ | （２ｓ）−（４ｅ）−ｎ−メチル−５−［３−（５−イソプロポキシピリジン）イル］−４−ペンテン−２−アミンの新規な塩形態 |
| SI2041088T1 (sl) * | 2006-06-28 | 2014-05-30 | Amgen Inc. | Inhibitorji transporter-1 glicina |
| US20080085888A1 (en) * | 2006-09-15 | 2008-04-10 | Breining Scott R | Therapeutic Combinations |
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| ES2362326T3 (es) * | 2007-10-01 | 2011-07-01 | Comentis, Inc. | Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor nicotínico alfa 7 de la acetilcolina para el tratamiento de enfermedad de alzheimer. |
| JP5504253B2 (ja) | 2008-04-14 | 2014-05-28 | ニューロダイン ライフ サイエンス インコーポレイテッド | ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体 |
| PE20121556A1 (es) | 2009-12-07 | 2012-12-05 | Targacept Inc | 3,6-diazabiciclo[3.1.1]heptanos como ligandos de receptores nicotinicos neuronales de acetilcolina |
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| WO2013160728A1 (en) | 2012-04-26 | 2013-10-31 | Alma Mater Studiorum - Universita' Di Bologna | Dual targeting compounds for the treatment of alzheimer's disease |
| CN104447767B (zh) * | 2013-09-24 | 2018-08-03 | 连云港金康医药科技有限公司 | 氮杂双环[3,2,1]辛烷衍生物及其应用 |
| US20170166561A1 (en) | 2014-07-11 | 2017-06-15 | Alpharmagen, Llc | Quinuclidine compounds for modulating alpha7-nicotinic acetylcholine receptor activity |
| WO2017189834A1 (en) * | 2016-04-29 | 2017-11-02 | New Mexico Tech Research Foundation | Methods for treatment of resistant cancer |
| CN118908968B (zh) * | 2024-10-09 | 2025-03-04 | 威胜生物医药(苏州)股份有限公司 | 一种加兰他敏中间体衍生物及其催化氧化制备方法 |
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| US4663318A (en) | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
| AU632458B2 (en) | 1987-05-04 | 1993-01-07 | Bonnie Davis | Compounds for the treatment of alzheimer's disease |
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| AT401058B (de) | 1994-10-21 | 1996-06-25 | Waldheim Pharmazeutika Gmbh | Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins |
| US6407229B1 (en) | 1994-10-21 | 2002-06-18 | Sanochemia Pharmazeutika Ag | Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine |
| KR100352212B1 (ko) * | 1994-10-21 | 2003-04-18 | 자노케미아 파마조이티카 악티엔게젤샤프트 | 4a,5,9,10,11,12-헥사히드로-6H-벤조푸로[3a,3,2-ef][2]벤즈아제핀유도체의제조방법 |
| GB9519268D0 (en) | 1995-09-21 | 1995-11-22 | Chiroscience Ltd | Preparation of alkaloids |
| AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| WO2000032199A1 (de) | 1998-12-01 | 2000-06-08 | Sanochemia Pharmazeutika Aktiengesellschaft | Verwendung von galanthamin und galanthaminderivaten bei akuten funktionellen hirnschäden |
| AT414125B (de) | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
-
1996
- 1996-04-19 AT AT0071696A patent/AT403803B/de not_active IP Right Cessation
-
1997
- 1997-04-21 EP EP06025028A patent/EP1757608A1/de not_active Withdrawn
- 1997-04-21 CZ CZ0332498A patent/CZ300211B6/cs not_active IP Right Cessation
- 1997-04-21 US US09/242,339 patent/US6638925B2/en not_active Expired - Fee Related
- 1997-04-21 WO PCT/AT1997/000074 patent/WO1997040049A1/de not_active Ceased
- 1997-04-21 AU AU24985/97A patent/AU2498597A/en not_active Abandoned
- 1997-04-21 RO RO98-01487A patent/RO120136B1/ro unknown
- 1997-04-21 PL PL97329411A patent/PL189834B1/pl not_active IP Right Cessation
- 1997-04-21 PL PL97361697A patent/PL190032B1/pl not_active IP Right Cessation
- 1997-04-21 EP EP97916263A patent/EP0897387A1/de not_active Ceased
- 1997-05-09 TW TW086106195A patent/TWI224595B/zh not_active IP Right Cessation
-
1998
- 1998-08-28 IS IS4839A patent/IS4839A/is unknown
- 1998-10-12 BG BG102836A patent/BG64560B1/bg unknown
- 1998-10-16 NO NO19984852A patent/NO324211B1/no not_active IP Right Cessation
-
2003
- 2003-08-26 US US10/647,283 patent/US7101890B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0897387A1 (de) | 1999-02-24 |
| US6638925B2 (en) | 2003-10-28 |
| US7101890B2 (en) | 2006-09-05 |
| BG102836A (en) | 1999-09-30 |
| TWI224595B (en) | 2004-12-01 |
| BG64560B1 (bg) | 2005-07-29 |
| AT403803B (de) | 1998-05-25 |
| US20030092700A1 (en) | 2003-05-15 |
| CZ300211B6 (cs) | 2009-03-18 |
| PL189834B1 (pl) | 2005-09-30 |
| IS4839A (is) | 1998-08-28 |
| PL190032B1 (pl) | 2005-10-31 |
| ATA71696A (de) | 1997-10-15 |
| US20040067974A1 (en) | 2004-04-08 |
| EP1757608A1 (de) | 2007-02-28 |
| WO1997040049A1 (de) | 1997-10-30 |
| CZ332498A3 (cs) | 1999-05-12 |
| PL329411A1 (en) | 1999-03-29 |
| RO120136B1 (ro) | 2005-09-30 |
| NO984852L (no) | 1998-11-16 |
| NO984852D0 (no) | 1998-10-16 |
| AU2498597A (en) | 1997-11-12 |
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