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NO20091972L - Nye fluorenderivater, sammensetninger inneholdende dem og anvendelse derav som inhibitorer av protein chaperone HSP 90 - Google Patents

Nye fluorenderivater, sammensetninger inneholdende dem og anvendelse derav som inhibitorer av protein chaperone HSP 90

Info

Publication number
NO20091972L
NO20091972L NO20091972A NO20091972A NO20091972L NO 20091972 L NO20091972 L NO 20091972L NO 20091972 A NO20091972 A NO 20091972A NO 20091972 A NO20091972 A NO 20091972A NO 20091972 L NO20091972 L NO 20091972L
Authority
NO
Norway
Prior art keywords
alkyl
inhibitors
conh2
compositions containing
fluorene derivatives
Prior art date
Application number
NO20091972A
Other languages
English (en)
Inventor
Fabienne Thompson
Patrick Mailliet
Jean-Marie Ruxer
Helene Goulaouic
Francois Vallee
Herve Minoux
Fabienne Pilorge
Luc Bertin
Stephane Hourcade
Maria Mendez-Perez
Peter Hamley
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38069221&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20091972(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20091972L publication Critical patent/NO20091972L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/02—Ophthalmic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
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  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Foreliggende oppfinnelsen angår nye produkter med formel (I): hvori Het representerer et eventuelt substituert mono eller bicyklisk heterocykel som inneholder 1 til 4 heteroatomer valgt fra N, O eller S; Rl representerer X-(A-B)n-CONH2, X-(A-B)n-O-CONH2, X-(A-B)n-NH-CONH2, X(CH2)m-heterocykloalkyl, X-(CH2)m-aryI og X-(CH2)m-heteroaryI hvor X representerer -O-C(O), -NH-C(O), NH-CS, -NH-CO-CH2-O-; -NH-CO-CH2-S-CH2-CO-NH-; -NH-CO-(CH2)2-SO2-; -NH-CO-CH2-N(CH3)-CO-; A og B representerer en enkelt binding, CH2, CH-alkyl, CH-aralkyl, n = 1, 2 og m = 0, 1; R2 og R'2 representerer H, halogen, CF3, nitro, cyano, alkyl, hydroksy, merkapto, amino, alkylamino, dialkylamino, alkoksy, alkyltio, karboksy fri eller forestret med et alkyl, karboksamid, CO-NH(alkyl) og NH-CO-alkylradikal; p = 1 til 4 og p'= 1 til 3; L representerer en enkelt binding, CH2, C(O), O, S eller NH, alle nevnte radikalene er eventuelt substituerte. Oppfinnelsen angår også alle de isomere formene av produktene og saltene derav anvendt som legemidler.
NO20091972A 2006-10-24 2009-05-20 Nye fluorenderivater, sammensetninger inneholdende dem og anvendelse derav som inhibitorer av protein chaperone HSP 90 NO20091972L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0609331A FR2907453B1 (fr) 2006-10-24 2006-10-24 Nouveaux derives du fluorene,compositions les contenant et utilisation
PCT/FR2007/001703 WO2008049994A1 (fr) 2006-10-24 2007-10-17 Nouveaux derives du fluorene, compositions les contenant et utilisation comme inhibiteurs de la proteine chpaerone hsp90

Publications (1)

Publication Number Publication Date
NO20091972L true NO20091972L (no) 2009-05-20

Family

ID=38069221

Family Applications (1)

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NO20091972A NO20091972L (no) 2006-10-24 2009-05-20 Nye fluorenderivater, sammensetninger inneholdende dem og anvendelse derav som inhibitorer av protein chaperone HSP 90

Country Status (23)

Country Link
US (1) US8163750B2 (no)
EP (1) EP2078009B1 (no)
JP (1) JP5431944B2 (no)
KR (1) KR20090080948A (no)
CN (1) CN101528735A (no)
AR (1) AR063507A1 (no)
AU (1) AU2007310767A1 (no)
BR (1) BRPI0718202A2 (no)
CA (1) CA2664115A1 (no)
CL (1) CL2007003046A1 (no)
CO (1) CO6160311A2 (no)
CR (1) CR10690A (no)
EA (1) EA200970400A1 (no)
FR (1) FR2907453B1 (no)
IL (1) IL197887A0 (no)
MA (1) MA30904B1 (no)
MX (1) MX2009004049A (no)
NO (1) NO20091972L (no)
PE (1) PE20081261A1 (no)
TN (1) TN2009000086A1 (no)
TW (1) TW200825083A (no)
UY (1) UY30667A1 (no)
WO (1) WO2008049994A1 (no)

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UY30667A1 (es) 2008-05-31
MA30904B1 (fr) 2009-11-02
CR10690A (es) 2009-07-23
CL2007003046A1 (es) 2008-05-30
WO2008049994A1 (fr) 2008-05-02
JP2010507634A (ja) 2010-03-11
EA200970400A1 (ru) 2009-10-30
MX2009004049A (es) 2009-04-28
TW200825083A (en) 2008-06-16
PE20081261A1 (es) 2008-10-15
EP2078009A1 (fr) 2009-07-15
EP2078009B1 (fr) 2015-03-18
AR063507A1 (es) 2009-01-28
FR2907453B1 (fr) 2008-12-26
CN101528735A (zh) 2009-09-09
TN2009000086A1 (en) 2010-08-19
CO6160311A2 (es) 2010-05-20
AU2007310767A1 (en) 2008-05-02
FR2907453A1 (fr) 2008-04-25
CA2664115A1 (fr) 2008-05-02
IL197887A0 (en) 2009-12-24
US20100130503A1 (en) 2010-05-27
BRPI0718202A2 (pt) 2013-11-12
US8163750B2 (en) 2012-04-24
KR20090080948A (ko) 2009-07-27
JP5431944B2 (ja) 2014-03-05

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