NO20081582L - Benzamidforbindelser anvendbare som histon-deacetylaseinhibitorer - Google Patents
Benzamidforbindelser anvendbare som histon-deacetylaseinhibitorerInfo
- Publication number
- NO20081582L NO20081582L NO20081582A NO20081582A NO20081582L NO 20081582 L NO20081582 L NO 20081582L NO 20081582 A NO20081582 A NO 20081582A NO 20081582 A NO20081582 A NO 20081582A NO 20081582 L NO20081582 L NO 20081582L
- Authority
- NO
- Norway
- Prior art keywords
- histone deacetylase
- benzamide compounds
- compounds useful
- deacetylase inhibitors
- relates
- Prior art date
Links
- 150000003936 benzamides Chemical class 0.000 title abstract 2
- 229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 2
- 108090000353 Histone deacetylase Proteins 0.000 abstract 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Oppfinnelsen angår benzamidforbindelser med formel (I): (I) hvor R1 er en C-bundet pyrazolring som eventuelt er substituert med én eller flere grupper valgt fra C1-4-alkyl, C3-4-cykloalkyl, C1-4-alkoksy og C3-4-cykloalkoksy, eller et farmasøytisk akseptabelt salt eller promedikamentform derav. Oppfinnelsen angår også fremgangsmåter for fremstilling av slike forbindelser, farmasøytiske preparater inneholdende dem, og anvendelse av dem ved fremstilling av et medikament for anvendelse som antiproliferativt middel ved forebygging eller behandling av tumorer eller andre proliferative lidelser som er sensitive overfor hemning av histon-deacetylase (HDAC). 61
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0521244.4A GB0521244D0 (en) | 2005-10-19 | 2005-10-19 | Benzamide compounds |
| PCT/GB2006/003838 WO2007045844A1 (en) | 2005-10-19 | 2006-10-17 | Benzamide compounds useful as histone deacetylase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20081582L true NO20081582L (no) | 2008-05-06 |
| NO340878B1 NO340878B1 (no) | 2017-07-03 |
Family
ID=35458263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081582A NO340878B1 (no) | 2005-10-19 | 2008-04-01 | Benzamidforbindelser som er anvendbare som histon-deacetylasehemmere |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8207202B2 (no) |
| EP (1) | EP1954690B1 (no) |
| JP (1) | JP5340736B2 (no) |
| KR (1) | KR101464004B1 (no) |
| CN (1) | CN101331123B (no) |
| AR (1) | AR057162A1 (no) |
| AU (1) | AU2006303111B2 (no) |
| BR (1) | BRPI0617654B8 (no) |
| CA (1) | CA2625970C (no) |
| CY (1) | CY1114521T1 (no) |
| DK (1) | DK1954690T3 (no) |
| EC (1) | ECSP088457A (no) |
| ES (1) | ES2422859T3 (no) |
| GB (1) | GB0521244D0 (no) |
| HR (1) | HRP20130683T1 (no) |
| IL (1) | IL190429A (no) |
| ME (1) | ME01595B (no) |
| MY (1) | MY145569A (no) |
| NO (1) | NO340878B1 (no) |
| NZ (1) | NZ566944A (no) |
| PL (1) | PL1954690T3 (no) |
| PT (1) | PT1954690E (no) |
| RS (1) | RS52881B (no) |
| RU (1) | RU2448965C2 (no) |
| SA (1) | SA06270384B1 (no) |
| SI (1) | SI1954690T1 (no) |
| TW (1) | TWI385162B (no) |
| UA (1) | UA98757C2 (no) |
| UY (1) | UY29869A1 (no) |
| WO (1) | WO2007045844A1 (no) |
| ZA (1) | ZA200803096B (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007028198A1 (de) | 2007-06-16 | 2008-12-24 | Schebo (R) . Biotech Ag | Neue Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Therapie |
| JP5564033B2 (ja) | 2008-03-27 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規インヒビターとしてのアザ−ビシクロヘキシル置換インドリルアルキルアミノ誘導体 |
| US9265734B2 (en) | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| WO2010144371A1 (en) * | 2009-06-08 | 2010-12-16 | Gilead Colorado, Inc. | Alkanoylamino benzamide aniline hdac inihibitor compounds |
| EP2680694B1 (en) | 2011-02-28 | 2019-01-02 | BioMarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US9617259B2 (en) | 2013-03-14 | 2017-04-11 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| EP2968233A4 (en) | 2013-03-14 | 2016-08-03 | Chdi Foundation Inc | HISTON DEACETYLASE HEMMER AND COMPOSITIONS AND METHOD FOR USE THEREOF |
| US20160031863A1 (en) * | 2013-03-14 | 2016-02-04 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| JP6503338B2 (ja) | 2013-03-15 | 2019-04-17 | バイオマリン ファーマシューティカル インコーポレイテッド | Ｈｄａｃ阻害剤 |
| BR112015027114B1 (pt) * | 2013-04-29 | 2021-12-21 | Chong Kun Dang Pharmaceutical Corp | Compostos inibidores seletivos de histona desacetilase e seu uso |
| SG11201610093QA (en) | 2014-06-02 | 2016-12-29 | Chdi Foundation Inc | Histone deacetylase inhibitors and compositions and methods of use thereof |
| KR102236356B1 (ko) | 2017-11-24 | 2021-04-05 | 주식회사 종근당 | 루푸스의 예방 또는 치료를 위한 조성물 |
| GB201913988D0 (en) | 2019-09-27 | 2019-11-13 | Celleron Therapeutics Ltd | Novel treatment |
| GB201914006D0 (en) * | 2019-09-27 | 2019-11-13 | Celleron Therapeutics Ltd | Combination Therapy |
| CN118772107A (zh) * | 2023-04-06 | 2024-10-15 | 微境生物医药科技(上海)有限公司 | Hdac抑制剂及其用途 |
| GB202315149D0 (en) | 2023-10-03 | 2023-11-15 | Celleron Therapeutics Ltd | Combination therapy |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH117273A4 (no) | 1973-01-26 | 1976-07-15 | ||
| CH187973A4 (de) | 1973-02-09 | 1977-03-31 | Hoechst Ag | Verfahren zum optischen Aufhellen von Textilmaterialien |
| DE2918965A1 (de) | 1979-05-11 | 1980-11-20 | Bayer Ag | Benzofuranverbindungen sowie deren verwendung als optische aufheller |
| IT1232252B (it) | 1989-02-22 | 1992-01-28 | Rotta Research Lab | Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione |
| JPH05239069A (ja) | 1992-02-28 | 1993-09-17 | Canon Inc | 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置 |
| JP4405602B2 (ja) | 1998-04-16 | 2010-01-27 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | ヒストン脱アセチル化酵素阻害剤 |
| GB9826412D0 (en) | 1998-12-03 | 1999-01-27 | Glaxo Group Ltd | Chemical compounds |
| JP4390024B2 (ja) | 1999-04-23 | 2009-12-24 | アステラス製薬株式会社 | 新規なジアゼパン誘導体又はその塩 |
| US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| BR0014078A (pt) | 1999-09-17 | 2002-12-31 | Millennium Pharm Inc | Inibidores de fator xa |
| KR20100035666A (ko) | 1999-11-23 | 2010-04-05 | 메틸진 인크. | 히스톤 디아세틸라제의 억제제 |
| AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| EP1217000A1 (en) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
| KR20040048411A (ko) | 2001-09-14 | 2004-06-09 | 메틸진, 인크. | 히스톤 데아세틸라아제의 억제제 |
| DE10204115A1 (de) | 2002-02-01 | 2003-08-07 | Bayer Cropscience Ag | DELTA·1·-Pyrroline |
| TWI319387B (en) * | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| US20040072770A1 (en) | 2002-07-03 | 2004-04-15 | Besterman Jeffrey M. | Methods for specifically inhibiting histone deacetylase-7 and 8 |
| AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
| WO2005030704A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| EP1735319B1 (en) | 2004-03-26 | 2017-05-03 | MethylGene Inc. | Inhibitors of histone deacetylase |
| AR050926A1 (es) | 2004-09-03 | 2006-12-06 | Astrazeneca Ab | Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac) |
| GB0427758D0 (en) | 2004-12-18 | 2005-01-19 | Astrazeneca Ab | Novel benzamide compounds |
| GB0500828D0 (en) | 2005-01-15 | 2005-02-23 | Astrazeneca Ab | Benzamide derivatives |
| GB0501146D0 (en) | 2005-01-20 | 2005-02-23 | Astrazeneca Ab | Novel benzamide derivatives |
| GB0526351D0 (en) | 2005-12-23 | 2006-02-01 | Astrazeneca Ab | Novel benzamide derivatives |
| GB0526352D0 (en) | 2005-12-23 | 2006-02-01 | Astrazeneca Ab | Benzamide derivatives |
-
2005
- 2005-10-19 GB GBGB0521244.4A patent/GB0521244D0/en not_active Ceased
-
2006
- 2006-10-17 PT PT67947838T patent/PT1954690E/pt unknown
- 2006-10-17 RU RU2008119411/04A patent/RU2448965C2/ru active
- 2006-10-17 ES ES06794783T patent/ES2422859T3/es active Active
- 2006-10-17 KR KR1020087011411A patent/KR101464004B1/ko active Active
- 2006-10-17 CN CN200680047678.9A patent/CN101331123B/zh active Active
- 2006-10-17 PL PL06794783T patent/PL1954690T3/pl unknown
- 2006-10-17 RS RS20130325A patent/RS52881B/sr unknown
- 2006-10-17 CA CA2625970A patent/CA2625970C/en active Active
- 2006-10-17 UA UAA200805465A patent/UA98757C2/ru unknown
- 2006-10-17 AU AU2006303111A patent/AU2006303111B2/en active Active
- 2006-10-17 US US12/090,611 patent/US8207202B2/en active Active
- 2006-10-17 NZ NZ566944A patent/NZ566944A/en unknown
- 2006-10-17 ME MEP-2013-85A patent/ME01595B/me unknown
- 2006-10-17 EP EP06794783.8A patent/EP1954690B1/en active Active
- 2006-10-17 SI SI200631627T patent/SI1954690T1/sl unknown
- 2006-10-17 JP JP2008536114A patent/JP5340736B2/ja active Active
- 2006-10-17 WO PCT/GB2006/003838 patent/WO2007045844A1/en not_active Ceased
- 2006-10-17 DK DK06794783.8T patent/DK1954690T3/da active
- 2006-10-17 HR HRP20130683TT patent/HRP20130683T1/hr unknown
- 2006-10-17 BR BRPI0617654A patent/BRPI0617654B8/pt active IP Right Grant
- 2006-10-18 UY UY29869A patent/UY29869A1/es not_active Application Discontinuation
- 2006-10-19 AR ARP060104581A patent/AR057162A1/es active IP Right Grant
- 2006-10-19 TW TW095138558A patent/TWI385162B/zh not_active IP Right Cessation
- 2006-10-28 SA SA6270384A patent/SA06270384B1/ar unknown
-
2008
- 2008-03-25 IL IL190429A patent/IL190429A/en active IP Right Grant
- 2008-04-01 NO NO20081582A patent/NO340878B1/no unknown
- 2008-04-08 ZA ZA200803096A patent/ZA200803096B/xx unknown
- 2008-04-16 MY MYPI20081121A patent/MY145569A/en unknown
- 2008-05-17 EC EC2008008457A patent/ECSP088457A/es unknown
-
2012
- 2012-05-15 US US13/472,095 patent/US8735429B2/en active Active
-
2013
- 2013-07-31 CY CY20131100650T patent/CY1114521T1/el unknown
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