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NO20091509L - Substituerte tetrahydropyrrolopyrazinforbindelser med affinitet KCNQ2/3 K+ kanal og anvendelse derav i medikamenter - Google Patents

Substituerte tetrahydropyrrolopyrazinforbindelser med affinitet KCNQ2/3 K+ kanal og anvendelse derav i medikamenter

Info

Publication number
NO20091509L
NO20091509L NO20091509A NO20091509A NO20091509L NO 20091509 L NO20091509 L NO 20091509L NO 20091509 A NO20091509 A NO 20091509A NO 20091509 A NO20091509 A NO 20091509A NO 20091509 L NO20091509 L NO 20091509L
Authority
NO
Norway
Prior art keywords
kcnq2
affinity
drugs
channel
compounds
Prior art date
Application number
NO20091509A
Other languages
English (en)
Inventor
Thomas Christoph
Beatrix Merla
Stefan Oberborsch
Wolfgang Schroder
Klaus Schiene
Robert Frank
Gregor Bahrenberg
Sven Kuehnert
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of NO20091509L publication Critical patent/NO20091509L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse angår substituerte tetrahydropyrrolopyrazinforbindelser, fremgangsmåter for deres fremstilling, legemiddel inneholdende disse forbindelsene så vel som anvendelse av disse forbindelsene for fremstilling av legemiddel.
NO20091509A 2006-10-17 2009-04-17 Substituerte tetrahydropyrrolopyrazinforbindelser med affinitet KCNQ2/3 K+ kanal og anvendelse derav i medikamenter NO20091509L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006049452A DE102006049452A1 (de) 2006-10-17 2006-10-17 Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln
PCT/EP2007/008957 WO2008046582A1 (de) 2006-10-17 2007-10-16 Substituierte tetrahydropyrrolopyrazin-verbindungen mit affinität zum kcnq2/3 k+ kanal und deren verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
NO20091509L true NO20091509L (no) 2009-05-28

Family

ID=39125609

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091509A NO20091509L (no) 2006-10-17 2009-04-17 Substituerte tetrahydropyrrolopyrazinforbindelser med affinitet KCNQ2/3 K+ kanal og anvendelse derav i medikamenter

Country Status (17)

Country Link
US (3) US7625900B2 (no)
EP (2) EP2112993A1 (no)
JP (1) JP5256203B2 (no)
KR (1) KR20090084873A (no)
CN (1) CN101547925A (no)
AU (1) AU2007312557B2 (no)
BR (1) BRPI0715298A2 (no)
CA (1) CA2666647A1 (no)
CO (1) CO6160331A2 (no)
DE (1) DE102006049452A1 (no)
EC (1) ECSP099320A (no)
IL (1) IL198073A (no)
MX (1) MX2009004108A (no)
NO (1) NO20091509L (no)
NZ (1) NZ576021A (no)
RU (1) RU2469037C2 (no)
WO (2) WO2008046582A1 (no)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011003849A (es) * 2008-10-24 2011-05-23 Gruenenthal Gmbh 4,5,6,7-tetrahidrotienopiridinas sustituidas como moduladores de kcnq2/3.
US8367700B2 (en) 2008-12-17 2013-02-05 Gruenenthal Gmbh Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators
CA2750635A1 (en) * 2009-02-23 2010-08-26 Merck Canada Inc. Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
TWI504395B (zh) 2009-03-10 2015-10-21 Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier
TWI461197B (zh) 2009-03-12 2014-11-21 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier
TW201038565A (en) 2009-03-12 2010-11-01 Gruenenthal Gmbh Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators
AU2011295406B2 (en) 2010-08-27 2015-08-06 Grunenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
KR101983979B1 (ko) 2010-08-27 2019-05-30 그뤼넨탈 게엠베하 Ｋｃｎｑ２／３ 조절제로서의 치환된 ２-옥소- 및 ２-티옥소-디하이드로퀴놀린-３-카복스아미드
TWI522349B (zh) 2010-08-27 2016-02-21 歌林達股份有限公司 作為ｋｃｎｑ２／３調節劑之被取代之２－氧基－喹啉－３－甲醯胺
CA2804824A1 (en) 2010-08-27 2012-03-01 Gruenenthal Gmbh Substituted quinoline-3-carboxamides as kcnq2/3 modulators
AU2011297937B2 (en) 2010-09-01 2015-10-01 Grunenthal Gmbh Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators
EA022582B1 (ru) 2010-10-20 2016-01-29 Грюненталь Гмбх Замещенные 6-аминоникотинамиды в качестве модуляторов kcnq2/3
US9168259B2 (en) 2010-10-20 2015-10-27 Grünenthal GmbH Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
CN103201279A (zh) 2010-11-05 2013-07-10 赛诺米克斯公司 作为trpm8的调节剂有用的化合物
CN102229610B (zh) * 2011-04-22 2014-10-29 中山大学 一种光学纯手性1,2,3,4-四氢吡咯并[1,2-a]吡嗪化合物的合成方法
HUE030859T2 (en) 2012-04-18 2017-06-28 Gruenenthal Gmbh Substituted 6-amino-nicotinamides bearing an OH-containing group as modulators of KCNQ2 / 3
AU2013248638A1 (en) 2012-04-18 2014-12-04 Grünenthal GmbH Substituted 4-aminobenzamides as KCNQ2/3 modulators
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
WO2014082737A1 (en) 2012-11-28 2014-06-05 Grunenthal Gmbh Specific carboxamides as kcnq2/3 modulators
WO2014082738A1 (en) 2012-11-28 2014-06-05 Grünenthal GmbH Heteroquinoline-3-carboxamides as kcnq2/3 modulators
US9688684B2 (en) * 2013-12-19 2017-06-27 Merck Patent Gmbh Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors
RU2745616C1 (ru) 2015-10-01 2021-03-29 Сеномикс, Инк. Соединения, используемые в качестве модуляторов trpm8
WO2018189214A1 (en) * 2017-04-12 2018-10-18 F. Hoffmann-La Roche Ag A method for labeling of aldehyde containing target molecules

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Publication number Priority date Publication date Assignee Title
US4188389A (en) * 1978-11-03 1980-02-12 Ayerst Mckenna & Harrison, Inc. 1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines
TW224974B (no) * 1991-07-02 1994-06-11 Hoffmann La Roche
EP0572863A1 (de) * 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag ZNS Pyrazinoindole
US5378846A (en) * 1993-06-11 1995-01-03 Russian-American Institute For New Drug Development 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives
IL157313A0 (en) 2001-02-20 2004-02-19 Bristol Myers Squibb Co Modulators of kcnq potassium channels and uses thereof
EA007983B1 (ru) * 2001-09-19 2007-02-27 Авентис Фарма С.А. Индолизины в качестве ингибиторов киназных белков
UA77515C2 (en) * 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
SE524324C2 (sv) * 2002-04-20 2004-07-27 Sqs Ab Förfarande och anordning vid ett värdeutrymme
AU2003278927A1 (en) * 2002-09-27 2004-04-19 Janssen Pharmaceutica N.V. 3,4-disubstituted pyrroles and their for use in treating inflammatory diseases
US7247628B2 (en) * 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
EP1663962A4 (en) * 2003-08-22 2007-08-22 Dendreon Corp COMPOSITIONS AND METHODS FOR TREATING A DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION
CA2585735A1 (en) * 2004-11-02 2006-05-11 Pfizer Inc. Novel compounds of substituted and unsubstituted adamantyl amides

Also Published As

Publication number Publication date
RU2469037C2 (ru) 2012-12-10
RU2009118491A (ru) 2010-11-27
IL198073A (en) 2013-03-24
MX2009004108A (es) 2009-04-28
WO2008046581A3 (de) 2008-06-12
US20100004252A1 (en) 2010-01-07
US20090258880A1 (en) 2009-10-15
WO2008046582A1 (de) 2008-04-24
CN101547925A (zh) 2009-09-30
DE102006049452A1 (de) 2008-05-08
IL198073A0 (en) 2009-12-24
CO6160331A2 (es) 2010-05-20
AU2007312557A1 (en) 2008-04-24
WO2008046581A2 (de) 2008-04-24
EP2144913A2 (de) 2010-01-20
JP2010506869A (ja) 2010-03-04
US8017772B2 (en) 2011-09-13
AU2007312557B2 (en) 2013-06-13
ECSP099320A (es) 2009-06-30
CA2666647A1 (en) 2008-04-24
JP5256203B2 (ja) 2013-08-07
BRPI0715298A2 (pt) 2014-10-29
US7625900B2 (en) 2009-12-01
EP2112993A1 (de) 2009-11-04
AU2007312557A8 (en) 2009-06-25
KR20090084873A (ko) 2009-08-05
US20080167315A1 (en) 2008-07-10
US7879858B2 (en) 2011-02-01
NZ576021A (en) 2011-03-31

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RE Reestablishment of rights (par. 72 patents act)
FC2A Withdrawal, rejection or dismissal of laid open patent application