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NO20083070L - Nye N-(fluor-pyrazinyl)-fenylsulfonamidler som modulatorer av kemokin-reseptor CCR4 - Google Patents

Nye N-(fluor-pyrazinyl)-fenylsulfonamidler som modulatorer av kemokin-reseptor CCR4

Info

Publication number
NO20083070L
NO20083070L NO20083070A NO20083070A NO20083070L NO 20083070 L NO20083070 L NO 20083070L NO 20083070 A NO20083070 A NO 20083070A NO 20083070 A NO20083070 A NO 20083070A NO 20083070 L NO20083070 L NO 20083070L
Authority
NO
Norway
Prior art keywords
pyrazinyl
fluoro
phenylsulfone
modulators
agents
Prior art date
Application number
NO20083070A
Other languages
English (en)
Inventor
David Ranulft Cheshire
Nicholas Kindon
Bryan Roberts
Antonio Mete
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20083070L publication Critical patent/NO20083070L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C07D241/22—Benzenesulfonamido pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Oppfinnelsen tilveiebringer N-(fluor-pyrazinyl)-fenylsulfonamider med formel (I) hvor R1-R5 er som definert i spesifikasjonen; prosesser og intermediater anvendt i deres tillaging, farmasøytiske sammensetninger som inneholder dem og deres anvendelse i terapi.
NO20083070A 2005-12-12 2008-07-08 Nye N-(fluor-pyrazinyl)-fenylsulfonamidler som modulatorer av kemokin-reseptor CCR4 NO20083070L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0502733 2005-12-12
PCT/SE2006/001409 WO2007069978A1 (en) 2005-12-12 2006-12-11 Novel n-(fluoro-pyrazinyl)-phenylsulfonamid.es as moodulators of chemokine receptor ccr4.

Publications (1)

Publication Number Publication Date
NO20083070L true NO20083070L (no) 2008-08-28

Family

ID=38163190

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083070A NO20083070L (no) 2005-12-12 2008-07-08 Nye N-(fluor-pyrazinyl)-fenylsulfonamidler som modulatorer av kemokin-reseptor CCR4

Country Status (20)

Country Link
US (2) US20080293742A1 (no)
EP (1) EP1968951B1 (no)
JP (1) JP2009519332A (no)
KR (1) KR20080091139A (no)
CN (1) CN101370793B (no)
AR (1) AR058319A1 (no)
AT (1) ATE513819T1 (no)
AU (1) AU2006325573A1 (no)
BR (1) BRPI0619602A2 (no)
CA (1) CA2631342A1 (no)
CL (1) CL2006003449A1 (no)
EC (1) ECSP088603A (no)
ES (1) ES2366807T3 (no)
IL (1) IL191761A0 (no)
NO (1) NO20083070L (no)
RU (1) RU2008122401A (no)
TW (1) TW200730512A (no)
UY (1) UY29999A1 (no)
WO (1) WO2007069978A1 (no)
ZA (1) ZA200804921B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI328007B (en) 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
EP2749554B1 (en) * 2009-04-22 2017-12-20 SMA Therapeutics, Inc. 2,5-disubstituted arylsulfonamide CCR3 antagonists
WO2015027296A1 (en) * 2013-09-02 2015-03-05 The University Of Melbourne A method of treatment
CN104447756A (zh) * 2014-11-10 2015-03-25 常州大学 一种五氟磺草胺中间体的制备方法
CN104402890A (zh) * 2014-11-10 2015-03-11 常州大学 一种制备五氟磺草胺的方法
AU2018360766B2 (en) 2017-11-06 2024-09-19 Rapt Therapeutics, Inc. Anticancer agents
CN110028501B (zh) 2018-01-12 2022-02-22 迈德欣国际有限公司 化合物及其制备方法和用途
CN108929279A (zh) * 2018-07-27 2018-12-04 同济大学 一种含氟氨基吡嗪类化合物及其制备方法与应用
CN113893220A (zh) * 2020-07-07 2022-01-07 迈德欣国际有限公司 鼻粘膜给药剂型和其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928151A (en) * 1959-07-14 1963-06-06 Farmaceutici Italia Pyrazine derivatives
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
AU719327B2 (en) 1996-03-05 2000-05-04 Astrazeneca Ab 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
US6638937B2 (en) * 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
WO2002004434A1 (en) 2000-07-07 2002-01-17 Angiogene Pharmaceuticals Limited Colchinol derivatives as vascular damaging agents
KR20030022264A (ko) 2000-07-07 2003-03-15 앤지오젠 파마슈티칼스 리미티드 신생 혈관 형성 억제제인 콜치놀 유도체
SE0102439D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
ATE312096T1 (de) 2001-12-18 2005-12-15 Neue verbindungen
TWI328007B (en) * 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
SE0301650D0 (sv) * 2003-06-04 2003-06-04 Astrazeneca Ab Novel compounds
SE0301653D0 (sv) * 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
SE0301654D0 (sv) * 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
SE0302304D0 (sv) * 2003-08-27 2003-08-27 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
US20080293742A1 (en) 2008-11-27
ATE513819T1 (de) 2011-07-15
AR058319A1 (es) 2008-01-30
CN101370793B (zh) 2012-01-04
BRPI0619602A2 (pt) 2011-10-11
UY29999A1 (es) 2007-07-31
KR20080091139A (ko) 2008-10-09
CA2631342A1 (en) 2007-06-21
ECSP088603A (es) 2008-08-29
WO2007069978A1 (en) 2007-06-21
HK1121760A1 (en) 2009-04-30
AU2006325573A1 (en) 2007-06-21
IL191761A0 (en) 2008-12-29
EP1968951B1 (en) 2011-06-22
JP2009519332A (ja) 2009-05-14
EP1968951A1 (en) 2008-09-17
ZA200804921B (en) 2009-09-30
CN101370793A (zh) 2009-02-18
TW200730512A (en) 2007-08-16
US20100144759A1 (en) 2010-06-10
RU2008122401A (ru) 2010-01-20
CL2006003449A1 (es) 2008-02-08
ES2366807T3 (es) 2011-10-25

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