NO20062335L - Nye diazaspiroalkaner og deres anvendelse i behandlingen av CCR8 medierte sykdommer - Google Patents
Nye diazaspiroalkaner og deres anvendelse i behandlingen av CCR8 medierte sykdommerInfo
- Publication number
- NO20062335L NO20062335L NO20062335A NO20062335A NO20062335L NO 20062335 L NO20062335 L NO 20062335L NO 20062335 A NO20062335 A NO 20062335A NO 20062335 A NO20062335 A NO 20062335A NO 20062335 L NO20062335 L NO 20062335L
- Authority
- NO
- Norway
- Prior art keywords
- diazaspiroalkanes
- treatment
- new
- mediated diseases
- ccr8 mediated
- Prior art date
Links
- 102100036305 C-C chemokine receptor type 8 Human genes 0.000 title 1
- 101000716063 Homo sapiens C-C chemokine receptor type 8 Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
Abstract
Det beskrives forbindelser med den generelle formel (I) der A, B, W, X, Y, Z, D, E, R1 og n er som angitt i beskrivelsen. Det beskrives videre fremgangsmåter for deres fremstilling, farmasøytiske preparater inneholdende forbindelsene samt deres anvendelse i terapi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302811A SE0302811D0 (sv) | 2003-10-23 | 2003-10-23 | Novel compounds |
| PCT/SE2004/001522 WO2005040167A1 (en) | 2003-10-23 | 2004-10-21 | Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062335L true NO20062335L (no) | 2006-07-19 |
Family
ID=29546627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062335A NO20062335L (no) | 2003-10-23 | 2006-05-23 | Nye diazaspiroalkaner og deres anvendelse i behandlingen av CCR8 medierte sykdommer |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20070249648A1 (no) |
| EP (1) | EP1678178A1 (no) |
| JP (1) | JP2007509141A (no) |
| KR (1) | KR20060088557A (no) |
| CN (1) | CN1898239A (no) |
| AR (1) | AR046600A1 (no) |
| AU (1) | AU2004284028B2 (no) |
| BR (1) | BRPI0415613A (no) |
| CA (1) | CA2542226A1 (no) |
| IL (1) | IL174698A0 (no) |
| MX (1) | MXPA06004300A (no) |
| NO (1) | NO20062335L (no) |
| SE (1) | SE0302811D0 (no) |
| TW (1) | TW200528451A (no) |
| UY (1) | UY28572A1 (no) |
| WO (1) | WO2005040167A1 (no) |
| ZA (1) | ZA200603174B (no) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| SE0303090D0 (sv) | 2003-11-20 | 2003-11-20 | Astrazeneca Ab | Novel compounds |
| SE0303541D0 (sv) | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
| EP1720545B1 (en) * | 2004-03-03 | 2014-10-29 | ChemoCentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| JP2008534679A (ja) * | 2005-04-04 | 2008-08-28 | アストラゼネカ・アクチエボラーグ | 新規ジアザスピロアルカン類およびccr8介在疾患の処置のためのそれらの使用 |
| EP1869044A1 (en) * | 2005-04-04 | 2007-12-26 | AstraZeneca AB | Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases |
| US20090215807A1 (en) * | 2005-04-04 | 2009-08-27 | Stephen Connolly | Novel Diazaspiroalkanes and Their Use for Treatment of CCR8 Mediated Diseases |
| GB0514018D0 (en) * | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| TW200800999A (en) * | 2005-09-06 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| WO2007056155A1 (en) * | 2005-11-03 | 2007-05-18 | Chembridge Research Laboratories, Inc. | Heterocyclic compounds as tyrosine kinase modulators |
| US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
| MX2008015696A (es) * | 2006-06-09 | 2009-02-10 | Icos Corp | Acidos fenil aceticos sustituidos como antagonistas de dp-2. |
| JP2009543860A (ja) * | 2006-07-19 | 2009-12-10 | アストラゼネカ・アクチエボラーグ | 新規三環系スピロピペリジン化合物、それらの合成およびケモカイン受容体活性モジュレーターとしてのそれらの使用 |
| AR062841A1 (es) * | 2006-09-15 | 2008-12-10 | Schering Corp | Tratamiento del dolor, diabetes, y trastornos del metabolismo de los lipidos |
| JP2010503675A (ja) | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | 疼痛、糖尿病および脂質代謝の障害の治療に有用なスピロ縮合アゼチジン誘導体 |
| KR20090071589A (ko) | 2006-09-15 | 2009-07-01 | 쉐링 코포레이션 | 통증 및 지질 대사 장애의 치료에 유용한 아제티딘 및 아제티돈 유도체 |
| WO2008099165A1 (en) * | 2007-02-15 | 2008-08-21 | Astrazeneca Ab | Piperidine derivatives and their use for treatment of ccr8 mediated diseases |
| US8278313B2 (en) | 2008-03-11 | 2012-10-02 | Abbott Laboratories | Macrocyclic spiro pyrimidine derivatives |
| US8436005B2 (en) | 2008-04-03 | 2013-05-07 | Abbott Laboratories | Macrocyclic pyrimidine derivatives |
| WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
| WO2010141817A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| US8268853B2 (en) | 2009-06-25 | 2012-09-18 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
| CA2792234C (en) * | 2010-03-19 | 2014-05-27 | Pfizer Inc. | 2,3 dihydro-1h-inden-1-yl-2,7-diazaspiro [3.5] nonane derivatives and their use as antagonists or inverse agonists of the ghrelin receptor |
| US9493474B2 (en) | 2011-10-31 | 2016-11-15 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| GB201122113D0 (en) * | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| AU2013272288B2 (en) * | 2012-06-08 | 2018-01-18 | The United States Government As Represented By The Department Of Veterans Affairs | FBXO3 inhibitors |
| ES2618703T3 (es) | 2012-06-13 | 2017-06-22 | F. Hoffmann-La Roche Ag | Nuevos compuestos diazaspirocicloalcano y azaspirocicloalcano |
| CN104684915B (zh) | 2012-09-25 | 2017-10-31 | 霍夫曼-拉罗奇有限公司 | 新型双环衍生物 |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| WO2015048567A1 (en) * | 2013-09-26 | 2015-04-02 | Sanford-Burnham Medical Research Institute | Spirocyclic ebi2 modulators |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| KR20160087900A (ko) | 2013-11-26 | 2016-07-22 | 에프. 호프만-라 로슈 아게 | 신규한 옥타하이드로-사이클로부타[1,2-c;3,4-c'']다이피롤-2-일 |
| WO2015140130A1 (en) * | 2014-03-17 | 2015-09-24 | Remynd Nv | Oxadiazole compounds |
| CN106029667B (zh) | 2014-03-26 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物 |
| AU2015238537B2 (en) | 2014-03-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| KR20180005178A (ko) | 2015-04-10 | 2018-01-15 | 아락세스 파마 엘엘씨 | 치환된 퀴나졸린 화합물 및 이의 사용방법 |
| TN2017000544A1 (en) | 2015-07-31 | 2019-04-12 | Pfizer | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors |
| EP3344619B1 (en) | 2015-09-04 | 2020-10-28 | H. Hoffnabb-La Roche Ag | Phenoxymethyl derivatives |
| CN115124538A (zh) | 2015-09-24 | 2022-09-30 | 豪夫迈·罗氏有限公司 | 作为atx抑制剂的二环化合物 |
| RU2725138C2 (ru) | 2015-09-24 | 2020-06-30 | Ф. Хоффманн-Ля Рош Аг | Новые бициклические соединения в качестве двойных ингибиторов аутотаксина (atx)/карбоангидразы (ca) |
| KR20180054635A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서 이환형 화합물 |
| KR20180054634A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물 |
| EP3356353A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
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| AU2016355433C1 (en) | 2015-11-16 | 2021-12-16 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
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| JP2020506903A (ja) | 2017-01-23 | 2020-03-05 | ファイザー・インク | Magl阻害薬としての複素環式スピロ化合物 |
| EP3573970A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
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| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | Atxインヒビターとしての新規二環式化合物 |
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| AR116020A1 (es) | 2018-09-03 | 2021-03-25 | Bayer Ag | COMPUESTOS DE 3,9-DIAZAESPIRO[5.5]UNDECANO COMO INHIBIDORES DE GGTasa I Y SU USO PARA EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
| CN113207291A (zh) * | 2018-10-24 | 2021-08-03 | 亚瑞克西斯制药公司 | 2-(2-丙烯酰基-2,6-二氮杂螺[3.4]辛-6-基)-6-(1h-吲唑-4-基)苄腈衍生物及相关化合物作为用于抑制肿瘤转移的g12c突变kras蛋白的抑制剂 |
| US20230038589A1 (en) * | 2020-07-03 | 2023-02-09 | Nanjing Immunophage Biotech Co., Ltd. | Methods and compositions for targeting Tregs using CCR8 inhibitors |
| PE20240050A1 (es) | 2021-01-29 | 2024-01-09 | Cedilla Therapeutics Inc | Inhibidores de cdk2 y metodos de uso de los mismos |
| EP4358954A4 (en) | 2021-06-26 | 2025-09-03 | Cedilla Therapeutics Inc | CDK2 INHIBITORS AND METHODS OF USE THEREOF |
| EP4415706A4 (en) * | 2021-10-13 | 2025-08-27 | Vanqua Bio Inc | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND THEIR USES |
| TW202430180A (zh) | 2022-11-30 | 2024-08-01 | 瑞士商愛杜西亞製藥有限公司 | 作為ccr8調節劑之芳基-及雜芳基-磺醯胺衍生物 |
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|---|---|---|---|---|
| US4010201A (en) * | 1974-04-12 | 1977-03-01 | The Upjohn Company | Organic compounds |
| US4263317A (en) * | 1979-09-06 | 1981-04-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s |
| WO1999040070A1 (en) * | 1998-02-04 | 1999-08-12 | Banyu Pharmaceutical Co., Ltd. | N-acyl cyclic amine derivatives |
| AU2002363236A1 (en) * | 2001-10-30 | 2003-05-12 | Millennium Pharmaceuticals, Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
| SE0202133D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| EP1534695B1 (en) * | 2002-08-09 | 2010-09-29 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| US20070021498A1 (en) * | 2004-10-14 | 2007-01-25 | Nafizal Hossain | Novel tricyclic spiroderivatives as modulators of chemokine receptor activity |
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2003
- 2003-10-23 SE SE0302811A patent/SE0302811D0/xx unknown
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2004
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- 2004-10-21 CA CA002542226A patent/CA2542226A1/en not_active Abandoned
- 2004-10-21 MX MXPA06004300A patent/MXPA06004300A/es unknown
- 2004-10-21 US US10/575,525 patent/US20070249648A1/en not_active Abandoned
- 2004-10-21 JP JP2006536485A patent/JP2007509141A/ja active Pending
- 2004-10-21 KR KR1020067007682A patent/KR20060088557A/ko not_active Withdrawn
- 2004-10-21 CN CNA200480038668XA patent/CN1898239A/zh active Pending
- 2004-10-21 UY UY28572A patent/UY28572A1/es unknown
- 2004-10-21 AU AU2004284028A patent/AU2004284028B2/en not_active Ceased
- 2004-10-21 WO PCT/SE2004/001522 patent/WO2005040167A1/en not_active Ceased
- 2004-10-21 EP EP04793824A patent/EP1678178A1/en not_active Withdrawn
- 2004-10-22 TW TW093132291A patent/TW200528451A/zh unknown
- 2004-10-22 AR ARP040103863A patent/AR046600A1/es not_active Application Discontinuation
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| UY28572A1 (es) | 2005-05-31 |
| WO2005040167A1 (en) | 2005-05-06 |
| IL174698A0 (en) | 2006-08-20 |
| EP1678178A1 (en) | 2006-07-12 |
| AU2004284028A1 (en) | 2005-05-06 |
| BRPI0415613A (pt) | 2006-12-05 |
| KR20060088557A (ko) | 2006-08-04 |
| AR046600A1 (es) | 2005-12-14 |
| ZA200603174B (en) | 2007-03-28 |
| JP2007509141A (ja) | 2007-04-12 |
| MXPA06004300A (es) | 2006-06-05 |
| TW200528451A (en) | 2005-09-01 |
| SE0302811D0 (sv) | 2003-10-23 |
| CN1898239A (zh) | 2007-01-17 |
| AU2004284028B2 (en) | 2008-03-06 |
| CA2542226A1 (en) | 2005-05-06 |
| US20070249648A1 (en) | 2007-10-25 |
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