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NO20083501L - Azaindoler som er anvendelige som inhibitorer for Janus-kinaser - Google Patents

Azaindoler som er anvendelige som inhibitorer for Janus-kinaser

Info

Publication number
NO20083501L
NO20083501L NO20083501A NO20083501A NO20083501L NO 20083501 L NO20083501 L NO 20083501L NO 20083501 A NO20083501 A NO 20083501A NO 20083501 A NO20083501 A NO 20083501A NO 20083501 L NO20083501 L NO 20083501L
Authority
NO
Norway
Prior art keywords
inhibitors
janus kinases
useful
azaindoles useful
azaindoles
Prior art date
Application number
NO20083501A
Other languages
English (en)
Inventor
Tiansheng Wang
Jian Wang
Gabriel Martinez-Botella
Francesco Salituro
Luc Farmer
Albert Pierce
Marion Wannamker
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38197739&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083501(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20083501L publication Critical patent/NO20083501L/no

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase

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Abstract

Den foreliggende oppfinnelsen angår forbindelser anvendelige som inhibitorer av proteinkinaser, særlig av JAK-familiekinaser. Oppfinnelsen tilveiebringer også farmasøytisk akseptable sammensetninger omfattende nevnte forbindelser og fremgangsmåter for anvendelse av sammensetningene i behandlingen av ulike sykdommer, tilstander eller forstyrrelser.
NO20083501A 2006-01-17 2008-08-13 Azaindoler som er anvendelige som inhibitorer for Janus-kinaser NO20083501L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75936706P 2006-01-17 2006-01-17
US84247106P 2006-09-06 2006-09-06
PCT/US2007/001225 WO2007084557A2 (en) 2006-01-17 2007-01-17 Azaindoles useful as inhibitors of janus kinases

Publications (1)

Publication Number Publication Date
NO20083501L true NO20083501L (no) 2008-10-14

Family

ID=38197739

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083501A NO20083501L (no) 2006-01-17 2008-08-13 Azaindoler som er anvendelige som inhibitorer for Janus-kinaser

Country Status (19)

Country Link
US (6) US7767816B2 (no)
EP (3) EP1973911B1 (no)
JP (4) JP5591471B2 (no)
KR (3) KR101235103B1 (no)
CN (3) CN104650077A (no)
AR (1) AR060316A1 (no)
AU (1) AU2007207533B8 (no)
BR (2) BRPI0706537A2 (no)
CA (1) CA2636189A1 (no)
CL (1) CL2008002140A1 (no)
HK (1) HK1210780A1 (no)
IL (1) IL191902A0 (no)
NO (1) NO20083501L (no)
NZ (3) NZ601687A (no)
RU (2) RU2453548C2 (no)
TW (4) TWI423976B (no)
UA (1) UA95940C2 (no)
WO (1) WO2007084557A2 (no)
ZA (2) ZA200805053B (no)

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EP2516434B1 (en) 2009-12-23 2015-05-27 Takeda Pharmaceutical Company Limited Fused heteroaromatic pyrrolidinones as syk inhibitors
LT3354652T (lt) 2010-03-10 2020-09-25 Incyte Holdings Corporation Piperidin-4-il azetidino dariniai kaip jak1 inhibitoriai
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