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NO20082594L - Pyrimidinylbenzotiofenforbindelser - Google Patents

Pyrimidinylbenzotiofenforbindelser

Info

Publication number
NO20082594L
NO20082594L NO20082594A NO20082594A NO20082594L NO 20082594 L NO20082594 L NO 20082594L NO 20082594 A NO20082594 A NO 20082594A NO 20082594 A NO20082594 A NO 20082594A NO 20082594 L NO20082594 L NO 20082594L
Authority
NO
Norway
Prior art keywords
pyrimidinylbenzotiofenforbindelser
cancer
useful
formula
treatment
Prior art date
Application number
NO20082594A
Other languages
English (en)
Inventor
Chuan Shih
Ho-Shen Lin
Michael Enrico Richett
Karl Robert Dahnke
Q May Wang
Bo Zhang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20082594L publication Critical patent/NO20082594L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser med Formel I: som er anvendelige i behandlingen av cancer og inflammatoriske sykdommer.
NO20082594A 2005-11-18 2008-06-10 Pyrimidinylbenzotiofenforbindelser NO20082594L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73809705P 2005-11-18 2005-11-18
PCT/US2006/060911 WO2007092095A2 (en) 2005-11-18 2006-11-15 [4-(benzo [b] thi0phen-2-yl) pyrimidin-2yl] -amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases.

Publications (1)

Publication Number Publication Date
NO20082594L true NO20082594L (no) 2008-06-10

Family

ID=38345605

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082594A NO20082594L (no) 2005-11-18 2008-06-10 Pyrimidinylbenzotiofenforbindelser

Country Status (27)

Country Link
US (1) US7547691B2 (no)
EP (1) EP1989200B1 (no)
JP (1) JP2009516697A (no)
KR (1) KR100990771B1 (no)
CN (1) CN101309918B (no)
AR (1) AR057911A1 (no)
AT (1) ATE437873T1 (no)
AU (1) AU2006337626B2 (no)
BR (1) BRPI0618245A2 (no)
CA (1) CA2629336A1 (no)
CR (1) CR9947A (no)
DE (1) DE602006008187D1 (no)
DK (1) DK1989200T3 (no)
EA (1) EA014426B1 (no)
EC (1) ECSP088456A (no)
ES (1) ES2329085T3 (no)
IL (1) IL190489A0 (no)
MA (1) MA30053B1 (no)
NO (1) NO20082594L (no)
PE (1) PE20070833A1 (no)
PL (1) PL1989200T3 (no)
PT (1) PT1989200E (no)
SI (1) SI1989200T1 (no)
TN (1) TNSN08227A1 (no)
TW (1) TW200800201A (no)
WO (1) WO2007092095A2 (no)
ZA (1) ZA200803940B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA95949C2 (ru) 2006-03-31 2011-09-26 Янссен Фармацевтика, Н.В. Бензоимидазол-2-илпиримидины и пиразины как модуляторы рецептора гистамина h4
US20080021217A1 (en) * 2006-07-20 2008-01-24 Allen Borchardt Heterocyclic inhibitors of rho kinase
US8063212B2 (en) 2006-12-21 2011-11-22 Eli Lilly And Company Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer
JP5166441B2 (ja) * 2006-12-21 2013-03-21 イーライ リリー アンド カンパニー 癌治療用イミダゾリジノニルアミノピリミジン化合物
PE20090216A1 (es) 2007-05-16 2009-02-28 Lilly Co Eli Compuestos triazolil aminopirimidina
KR101131254B1 (ko) 2007-05-16 2012-04-24 일라이 릴리 앤드 캄파니 트리아졸릴 아미노피리미딘 화합물
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
US8309720B2 (en) 2008-06-30 2012-11-13 Janssen Pharmaceutica Nv Process for the preparation of substituted pyrimidine derivatives
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
EP2467137A1 (en) 2009-08-19 2012-06-27 Ambit Biosciences Corporation Biaryl compounds and methods of use thereof
RU2552999C2 (ru) 2010-04-27 2015-06-10 Хатчисон Медифарма Лимитед Соединения пиримидинилиндола
JP2014512364A (ja) 2011-04-07 2014-05-22 コーネル ユニバーシティー 水溶液中で二量体化できる単量体、およびその使用法
US9245773B2 (en) 2011-09-02 2016-01-26 Taiwan Semiconductor Manufacturing Company, Ltd. Semiconductor device packaging methods and structures thereof
CN103159742B (zh) * 2011-12-16 2015-08-12 北京韩美药品有限公司 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
EP2812324B1 (en) 2012-02-08 2021-09-01 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
CN105085434B (zh) * 2014-05-09 2018-02-09 上海特化医药科技有限公司 硫乙拉嗪或其中间体的制备方法
WO2017076888A1 (en) * 2015-11-03 2017-05-11 Janssen Pharmaceutica Nv 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same
CN116283877A (zh) 2016-07-29 2023-06-23 赛诺维信制药公司 化合物、组合物及其用途
AU2017301767A1 (en) 2016-07-29 2019-02-14 Pgi Drug Discovery Llc Compounds and compositions and uses thereof
WO2018140512A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
EP3573970A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
EP3573964A1 (en) * 2017-01-26 2019-12-04 Araxes Pharma LLC Benzothiophene and benzothiazole compounds and methods of use thereof
EP3630745A2 (en) 2017-05-25 2020-04-08 Araxes Pharma LLC Covalent inhibitors of kras
WO2018218069A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant kras, hras or nras
KR20200036008A (ko) 2017-08-02 2020-04-06 선오비온 파마슈티컬스 인코포레이티드 이소크로만 화합물 및 이의 용도
AU2019312670B2 (en) 2018-08-01 2025-01-02 Araxes Pharma Llc Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3752589A (en) * 1988-05-16 1989-12-12 Georgia State University Research Foundation, Inc. Nucleic acid interacting unfused heteropolycyclic compounds
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
EP1831207B1 (en) * 2004-12-17 2012-11-14 Amgen Inc. Aminopyrimidine compounds as plk inhibitors

Also Published As

Publication number Publication date
PL1989200T3 (pl) 2009-12-31
BRPI0618245A2 (pt) 2011-08-23
EP1989200B1 (en) 2009-07-29
US20080306082A1 (en) 2008-12-11
MA30053B1 (fr) 2008-12-01
AU2006337626A1 (en) 2007-08-16
CA2629336A1 (en) 2007-08-16
KR100990771B1 (ko) 2010-10-29
DK1989200T3 (da) 2009-11-09
ZA200803940B (en) 2009-09-30
ATE437873T1 (de) 2009-08-15
KR20080059451A (ko) 2008-06-27
EA014426B1 (ru) 2010-12-30
ES2329085T3 (es) 2009-11-20
US7547691B2 (en) 2009-06-16
IL190489A0 (en) 2008-11-03
CR9947A (es) 2008-11-28
PE20070833A1 (es) 2007-08-27
PT1989200E (pt) 2009-10-12
TNSN08227A1 (en) 2009-10-30
SI1989200T1 (sl) 2009-12-31
EP1989200A2 (en) 2008-11-12
AU2006337626A8 (en) 2008-06-19
JP2009516697A (ja) 2009-04-23
ECSP088456A (es) 2008-06-30
CN101309918B (zh) 2010-12-29
DE602006008187D1 (de) 2009-09-10
AU2006337626B2 (en) 2012-03-22
AR057911A1 (es) 2007-12-26
TW200800201A (en) 2008-01-01
EA200801362A1 (ru) 2009-02-27
CN101309918A (zh) 2008-11-19
WO2007092095A2 (en) 2007-08-16
WO2007092095A3 (en) 2007-11-08

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Legal Events

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