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UA95949C2 - Бензоимидазол-2-илпиримидины и пиразины как модуляторы рецептора гистамина h4 - Google Patents

Бензоимидазол-2-илпиримидины и пиразины как модуляторы рецептора гистамина h4

Info

Publication number
UA95949C2
UA95949C2 UAA200812740A UAA200812740A UA95949C2 UA 95949 C2 UA95949 C2 UA 95949C2 UA A200812740 A UAA200812740 A UA A200812740A UA A200812740 A UAA200812740 A UA A200812740A UA 95949 C2 UA95949 C2 UA 95949C2
Authority
UA
Ukraine
Prior art keywords
benzoimidazol
pyrazines
pyrimidines
histamine
modulators
Prior art date
Application number
UAA200812740A
Other languages
English (en)
Ukrainian (uk)
Inventor
Джеймс П. Эдвардс
Девид Э. Киндрачук
Дженнифер Д. Венейбл
Кристофер М. Мейпс
Дениэл Дж. Пиппел
Original Assignee
Янссен Фармацевтика, Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38581554&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA95949(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика, Н.В. filed Critical Янссен Фармацевтика, Н.В.
Publication of UA95949C2 publication Critical patent/UA95949C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P37/08—Antiallergic agents
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)

Abstract

Данное изобретение относится к бензоимидазол-2-илпиримидинам и пиразинам, фармацевтическим композициям и способам лечения заболеваний, нарушений и состояний, опосредованных активностью рецептора гистамина Н, которые включают аллергию, астму, аутоиммунные заболевания и зуд.
UAA200812740A 2006-03-31 2007-03-30 Бензоимидазол-2-илпиримидины и пиразины как модуляторы рецептора гистамина h4 UA95949C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78819006P 2006-03-31 2006-03-31

Publications (1)

Publication Number Publication Date
UA95949C2 true UA95949C2 (ru) 2011-09-26

Family

ID=38581554

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200812740A UA95949C2 (ru) 2006-03-31 2007-03-30 Бензоимидазол-2-илпиримидины и пиразины как модуляторы рецептора гистамина h4

Country Status (34)

Country Link
US (6) US7507737B2 (ru)
EP (1) EP2007752B1 (ru)
JP (1) JP5066175B2 (ru)
KR (1) KR101054325B1 (ru)
CN (1) CN101460483B (ru)
AR (1) AR059380A1 (ru)
AT (1) ATE478067T1 (ru)
AU (1) AU2007235576B2 (ru)
BR (1) BRPI0710083A2 (ru)
CA (1) CA2648036C (ru)
CO (1) CO6160328A2 (ru)
CR (1) CR10413A (ru)
CY (1) CY1111169T1 (ru)
DE (1) DE602007008545D1 (ru)
DK (1) DK2007752T3 (ru)
EA (1) EA016264B1 (ru)
EC (1) ECSP088815A (ru)
ES (1) ES2348829T3 (ru)
IL (2) IL194453A0 (ru)
ME (1) ME01143B (ru)
MX (1) MX2008012655A (ru)
NI (1) NI200800260A (ru)
NO (1) NO341523B1 (ru)
NZ (1) NZ571691A (ru)
PE (1) PE20080130A1 (ru)
PL (1) PL2007752T3 (ru)
PT (1) PT2007752E (ru)
RS (1) RS51423B (ru)
SI (1) SI2007752T1 (ru)
TW (1) TWI400234B (ru)
UA (1) UA95949C2 (ru)
UY (1) UY30253A1 (ru)
WO (1) WO2007117399A2 (ru)
ZA (1) ZA200809328B (ru)

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UA95949C2 (ru) 2006-03-31 2011-09-26 Янссен Фармацевтика, Н.В. Бензоимидазол-2-илпиримидины и пиразины как модуляторы рецептора гистамина h4
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SI2858647T1 (sl) 2012-06-08 2018-11-30 Sensorion Inhibitorji receptorja H4 za zdravljenje tinitusa
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