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UA98757C2 - Бензамидные соединения, полезные как ингибиторы деацетилазы гистонов - Google Patents

Бензамидные соединения, полезные как ингибиторы деацетилазы гистонов

Info

Publication number
UA98757C2
UA98757C2 UAA200805465A UAA200805465A UA98757C2 UA 98757 C2 UA98757 C2 UA 98757C2 UA A200805465 A UAA200805465 A UA A200805465A UA A200805465 A UAA200805465 A UA A200805465A UA 98757 C2 UA98757 C2 UA 98757C2
Authority
UA
Ukraine
Prior art keywords
histone deacetylase
benzamide compounds
compounds useful
deacetylase inhibitors
compounds
Prior art date
Application number
UAA200805465A
Other languages
English (en)
Ukrainian (uk)
Inventor
Девид Майкл Эндрюс
Элайн Софи Элизабет Стоукс
Эндрю ТЕРНЕР
Майкл Джеймс Веринг
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA98757C2 publication Critical patent/UA98757C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Изобретение касается бензамидных соединений формулы (I):(I),где Rпредставляет собой С-связанное пиразольное кольцо, которое необязательно замещено одной или несколькими группами, выбранными из Салкила, Сциклоалкила, Салкокси и Сциклоалкокси;или их фармацевтически приемлемой соли или пролекарств.Изобретение также касается способов получения таких соединений, фармацевтических композиций, которые их содержат, и их применения для приготовления лекарственного средства для применения как антипролиферативного средства для предотвращения или лечения опухолей или других пролиферативных состояний, которые чувствительны к ингибированию деацетилазы гистонов (HDAC).
UAA200805465A 2005-10-19 2006-10-17 Бензамидные соединения, полезные как ингибиторы деацетилазы гистонов UA98757C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0521244.4A GB0521244D0 (en) 2005-10-19 2005-10-19 Benzamide compounds

Publications (1)

Publication Number Publication Date
UA98757C2 true UA98757C2 (ru) 2012-06-25

Family

ID=35458263

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200805465A UA98757C2 (ru) 2005-10-19 2006-10-17 Бензамидные соединения, полезные как ингибиторы деацетилазы гистонов

Country Status (31)

Country Link
US (2) US8207202B2 (ru)
EP (1) EP1954690B1 (ru)
JP (1) JP5340736B2 (ru)
KR (1) KR101464004B1 (ru)
CN (1) CN101331123B (ru)
AR (1) AR057162A1 (ru)
AU (1) AU2006303111B2 (ru)
BR (1) BRPI0617654B8 (ru)
CA (1) CA2625970C (ru)
CY (1) CY1114521T1 (ru)
DK (1) DK1954690T3 (ru)
EC (1) ECSP088457A (ru)
ES (1) ES2422859T3 (ru)
GB (1) GB0521244D0 (ru)
HR (1) HRP20130683T1 (ru)
IL (1) IL190429A (ru)
ME (1) ME01595B (ru)
MY (1) MY145569A (ru)
NO (1) NO340878B1 (ru)
NZ (1) NZ566944A (ru)
PL (1) PL1954690T3 (ru)
PT (1) PT1954690E (ru)
RS (1) RS52881B (ru)
RU (1) RU2448965C2 (ru)
SA (1) SA06270384B1 (ru)
SI (1) SI1954690T1 (ru)
TW (1) TWI385162B (ru)
UA (1) UA98757C2 (ru)
UY (1) UY29869A1 (ru)
WO (1) WO2007045844A1 (ru)
ZA (1) ZA200803096B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007028198A1 (de) 2007-06-16 2008-12-24 Schebo (R) . Biotech Ag Neue Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Therapie
US8476289B2 (en) 2008-03-27 2013-07-02 Janssen Pharmaceutica Nv Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace
WO2010028192A1 (en) 2008-09-03 2010-03-11 Repligen Corporation Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
WO2010144371A1 (en) * 2009-06-08 2010-12-16 Gilead Colorado, Inc. Alkanoylamino benzamide aniline hdac inihibitor compounds
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US9540395B2 (en) 2011-02-28 2017-01-10 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
EP2968233A4 (en) 2013-03-14 2016-08-03 Chdi Foundation Inc HISTON DEACETYLASE HEMMER AND COMPOSITIONS AND METHOD FOR USE THEREOF
WO2014159214A1 (en) * 2013-03-14 2014-10-02 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
EP2968207A4 (en) 2013-03-14 2016-09-28 Chdi Foundation Inc HISTON DEACETYLASE INHIBITORS AND COMPOSITIONS
ES2680224T3 (es) 2013-03-15 2018-09-05 Biomarin Pharmaceutical Inc. Inhibidores de HDAC
US9878986B2 (en) * 2013-04-29 2018-01-30 Chong Kun Dang Pharmaceutical Corp. Compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same
CA2951026A1 (en) 2014-06-02 2015-12-10 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
KR102236356B1 (ko) 2017-11-24 2021-04-05 주식회사 종근당 루푸스의 예방 또는 치료를 위한 조성물
GB201914006D0 (en) * 2019-09-27 2019-11-13 Celleron Therapeutics Ltd Combination Therapy
GB201913988D0 (en) * 2019-09-27 2019-11-13 Celleron Therapeutics Ltd Novel treatment
CN118772107A (zh) * 2023-04-06 2024-10-15 微境生物医药科技(上海)有限公司 Hdac抑制剂及其用途
GB202315149D0 (en) 2023-10-03 2023-11-15 Celleron Therapeutics Ltd Combination therapy

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH117273A4 (ru) 1973-01-26 1976-07-15
CH187973A4 (de) 1973-02-09 1977-03-31 Hoechst Ag Verfahren zum optischen Aufhellen von Textilmaterialien
DE2918965A1 (de) 1979-05-11 1980-11-20 Bayer Ag Benzofuranverbindungen sowie deren verwendung als optische aufheller
IT1232252B (it) 1989-02-22 1992-01-28 Rotta Research Lab Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione
JPH05239069A (ja) 1992-02-28 1993-09-17 Canon Inc 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置
JP4405602B2 (ja) 1998-04-16 2010-01-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト ヒストン脱アセチル化酵素阻害剤
GB9826412D0 (en) 1998-12-03 1999-01-27 Glaxo Group Ltd Chemical compounds
JP4390024B2 (ja) 1999-04-23 2009-12-24 アステラス製薬株式会社 新規なジアゼパン誘導体又はその塩
BR0014078A (pt) 1999-09-17 2002-12-31 Millennium Pharm Inc Inibidores de fator xa
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
KR20070053362A (ko) 1999-11-23 2007-05-23 메틸진, 인크. 히스톤 디아세틸라제의 억제제
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
AU2002327627B2 (en) 2001-09-14 2006-09-14 Methylgene Inc. Inhibitors of histone deacetylase
DE10204115A1 (de) 2002-02-01 2003-08-07 Bayer Cropscience Ag DELTA·1·-Pyrroline
TWI319387B (en) * 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
GB0209715D0 (en) * 2002-04-27 2002-06-05 Astrazeneca Ab Chemical compounds
US20040072770A1 (en) 2002-07-03 2004-04-15 Besterman Jeffrey M. Methods for specifically inhibiting histone deacetylase-7 and 8
AR043633A1 (es) 2003-03-20 2005-08-03 Schering Corp Ligandos de receptores de canabinoides
US7868205B2 (en) 2003-09-24 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
WO2005092899A1 (en) 2004-03-26 2005-10-06 Methylgene Inc. Inhibitors of histone deacetylase
AR050926A1 (es) 2004-09-03 2006-12-06 Astrazeneca Ab Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac)
GB0427758D0 (en) 2004-12-18 2005-01-19 Astrazeneca Ab Novel benzamide compounds
GB0500828D0 (en) 2005-01-15 2005-02-23 Astrazeneca Ab Benzamide derivatives
GB0501146D0 (en) 2005-01-20 2005-02-23 Astrazeneca Ab Novel benzamide derivatives
GB0526352D0 (en) 2005-12-23 2006-02-01 Astrazeneca Ab Benzamide derivatives
GB0526351D0 (en) 2005-12-23 2006-02-01 Astrazeneca Ab Novel benzamide derivatives

Also Published As

Publication number Publication date
GB0521244D0 (en) 2005-11-30
CN101331123A (zh) 2008-12-24
AU2006303111A1 (en) 2007-04-26
DK1954690T3 (da) 2013-07-29
NZ566944A (en) 2011-05-27
BRPI0617654A2 (pt) 2011-08-02
HRP20130683T1 (en) 2013-10-11
TWI385162B (zh) 2013-02-11
ZA200803096B (en) 2009-02-25
ES2422859T3 (es) 2013-09-16
KR101464004B1 (ko) 2014-11-20
MY145569A (en) 2012-02-29
RU2448965C2 (ru) 2012-04-27
BRPI0617654B1 (pt) 2020-09-15
PT1954690E (pt) 2013-07-31
IL190429A0 (en) 2008-11-03
SI1954690T1 (sl) 2013-08-30
SA06270384B1 (ar) 2010-08-02
CA2625970A1 (en) 2007-04-26
EP1954690B1 (en) 2013-05-15
HK1121749A1 (en) 2009-04-30
US20120225907A1 (en) 2012-09-06
NO340878B1 (no) 2017-07-03
BRPI0617654B8 (pt) 2021-05-25
RS52881B (sr) 2014-02-28
AU2006303111B2 (en) 2010-11-25
KR20080067656A (ko) 2008-07-21
IL190429A (en) 2012-08-30
WO2007045844A1 (en) 2007-04-26
PL1954690T3 (pl) 2013-09-30
CN101331123B (zh) 2015-11-25
ME01595B (me) 2014-09-20
JP2009512668A (ja) 2009-03-26
JP5340736B2 (ja) 2013-11-13
TW200800944A (en) 2008-01-01
ECSP088457A (es) 2008-06-30
NO20081582L (no) 2008-05-06
EP1954690A1 (en) 2008-08-13
US8735429B2 (en) 2014-05-27
US8207202B2 (en) 2012-06-26
UY29869A1 (es) 2007-05-31
US20080269294A1 (en) 2008-10-30
CY1114521T1 (el) 2016-10-05
CA2625970C (en) 2015-12-01
RU2008119411A (ru) 2009-11-27
AR057162A1 (es) 2007-11-21

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