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NO20081466L - Kondensert imidazoloderivater for inhibering av aldosteronsyntese og aromatase - Google Patents

Kondensert imidazoloderivater for inhibering av aldosteronsyntese og aromatase

Info

Publication number
NO20081466L
NO20081466L NO20081466A NO20081466A NO20081466L NO 20081466 L NO20081466 L NO 20081466L NO 20081466 A NO20081466 A NO 20081466A NO 20081466 A NO20081466 A NO 20081466A NO 20081466 L NO20081466 L NO 20081466L
Authority
NO
Norway
Prior art keywords
aromatase
compound
disease
hypertension
formula
Prior art date
Application number
NO20081466A
Other languages
English (en)
Other versions
NO340854B1 (no
Inventor
Gary Michael Ksander
Fariborz Firooznia
Erik Meredith
Lauren G Monovich
Julien Papillon
Qi-Ying Hu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37610275&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20081466(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20081466L publication Critical patent/NO20081466L/no
Publication of NO340854B1 publication Critical patent/NO340854B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Den foreliggende oppfinnelsen tilveiebringer en forbindelse med formel (I): Nevnte forbindelse er hemmer av aldosteronsyntase og aromatase, og kan dermed benyttes for behandlingen av en lidelse eller sykdom styrt av aldosteronsyntase eller aromatase. Følgelig kan forbindelsen med formel I anvendes i behandling av hypokalemi, hypertensjon, kongistiv hjertefeil, artriell fibrilering, nyrefeil spesielt kronisk nyrefeil, restinose, atherosklerose, syndrom X, fedme, post-hjerteinfarkt, koronare hjertesykdommer, inflammasjon, øket dannelse av kollagen, fibrose slik som hjerte- eller hjertemuskelfibrose og remodelering etter hypertensjon og endotelial dysfunksjon, gynekomasti, osteoporose, prostatacancer, endometriose, livmorfibroider, dysfunksjonell livmorblødning, endometriell hyperplaci, polycystisk ovariesykdom, infertilitet, fibrocystisk hjertesykdom, hjertecancer og fibrocystisk mastopati. Til slutt tilveiebringer den foreliggende oppfinnelsen en farmaøsytisk sammensetning.
NO20081466A 2005-08-25 2008-03-25 Kondenserte imidazolderivater, farmasøytiske sammensetninger omfattende slike og anvendelse for behandling av sykdommer forbundet med hemmingen av aldosteronsyntase og aromatase NO340854B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71144205P 2005-08-25 2005-08-25
PCT/US2006/032912 WO2007024945A1 (en) 2005-08-25 2006-08-23 Condensed imidazolo derivatives for the inhibition of aldosterone synthase and aromatase

Publications (2)

Publication Number Publication Date
NO20081466L true NO20081466L (no) 2008-05-23
NO340854B1 NO340854B1 (no) 2017-07-03

Family

ID=37610275

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081466A NO340854B1 (no) 2005-08-25 2008-03-25 Kondenserte imidazolderivater, farmasøytiske sammensetninger omfattende slike og anvendelse for behandling av sykdommer forbundet med hemmingen av aldosteronsyntase og aromatase

Country Status (33)

Country Link
US (4) US8314097B2 (no)
EP (3) EP2270011A1 (no)
JP (2) JP5225086B2 (no)
KR (3) KR101324872B1 (no)
CN (2) CN102408429B (no)
AR (1) AR057772A1 (no)
AU (1) AU2006283105C1 (no)
BR (1) BRPI0615095B8 (no)
CA (1) CA2619660C (no)
DK (1) DK1919916T3 (no)
EA (1) EA014940B1 (no)
EC (1) ECSP088201A (no)
ES (2) ES2417498T3 (no)
GT (1) GT200600381A (no)
HR (1) HRP20130797T1 (no)
IL (2) IL189024A (no)
JO (1) JO2882B1 (no)
MA (1) MA29771B1 (no)
MX (1) MX2008002545A (no)
MY (1) MY151601A (no)
NO (1) NO340854B1 (no)
NZ (1) NZ565476A (no)
PE (2) PE20070517A1 (no)
PH (1) PH12013502342A1 (no)
PL (1) PL1919916T3 (no)
PT (1) PT1919916E (no)
SG (1) SG165319A1 (no)
SI (1) SI1919916T1 (no)
TN (1) TNSN08082A1 (no)
TW (2) TWI382986B (no)
UA (1) UA96737C2 (no)
WO (1) WO2007024945A1 (no)
ZA (1) ZA200800589B (no)

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ZA200800589B (en) 2009-04-29
SI1919916T1 (sl) 2013-09-30
IL189024A (en) 2013-11-28
UA96737C2 (ru) 2011-12-12
PL1919916T3 (pl) 2013-08-30
AR057772A1 (es) 2007-12-19
US9278969B2 (en) 2016-03-08
NZ565476A (en) 2011-06-30
TNSN08082A1 (en) 2009-07-14
MX2008002545A (es) 2008-03-14
CA2619660C (en) 2015-01-06
EP1919916A1 (en) 2008-05-14
BRPI0615095B1 (pt) 2020-10-20
ES2417498T3 (es) 2013-08-08
AU2006283105C1 (en) 2011-03-10
US8314097B2 (en) 2012-11-20
KR101549759B1 (ko) 2015-09-04
TWI487708B (zh) 2015-06-11
US8835646B2 (en) 2014-09-16
ES2527209T3 (es) 2015-01-21
BRPI0615095A2 (pt) 2011-05-03
KR20130083470A (ko) 2013-07-22
TW200740822A (en) 2007-11-01
US20130287789A1 (en) 2013-10-31
CN102408429B (zh) 2014-07-30
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JP2009506048A (ja) 2009-02-12
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GT200600381A (es) 2007-03-28
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WO2007024945A1 (en) 2007-03-01
AU2006283105B2 (en) 2010-08-12
EA014940B1 (ru) 2011-04-29
JP2013006852A (ja) 2013-01-10
DK1919916T3 (da) 2013-07-01
CN102408429A (zh) 2012-04-11
HRP20130797T1 (en) 2013-09-30
IL189024A0 (en) 2008-08-07
EA200800488A1 (ru) 2008-08-29
SG165319A1 (en) 2010-10-28
US20070049616A1 (en) 2007-03-01
IL221869A (en) 2016-06-30
JP5225086B2 (ja) 2013-07-03
PT1919916E (pt) 2013-07-10
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HK1117518A1 (en) 2009-01-16
KR20080046637A (ko) 2008-05-27

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