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NO20070258L - Benzyltriazolonforbindelser som ikke-nukleoside revers transkriptase inhibitorer - Google Patents

Benzyltriazolonforbindelser som ikke-nukleoside revers transkriptase inhibitorer

Info

Publication number
NO20070258L
NO20070258L NO20070258A NO20070258A NO20070258L NO 20070258 L NO20070258 L NO 20070258L NO 20070258 A NO20070258 A NO 20070258A NO 20070258 A NO20070258 A NO 20070258A NO 20070258 L NO20070258 L NO 20070258L
Authority
NO
Norway
Prior art keywords
compounds
benzyltriazolone
reverse transcriptase
transcriptase inhibitors
nucleoside reverse
Prior art date
Application number
NO20070258A
Other languages
English (en)
Other versions
NO338376B1 (no
Inventor
James Patrick Dunn
Richard Todd Elworthy
Dimitrios Stefanidis
Kevin Zachary Sweeney
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20070258L publication Critical patent/NO20070258L/no
Publication of NO338376B1 publication Critical patent/NO338376B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser med formel (I), metoder for behandling av sykdommer mediert av humant immunsviktvirus ved administrering av en forbindelse med formel (I) og farmasøytiske preparater for behandling av sykdommer mediert av human immunsviktvirus inneholdende en forbindelse med formel hvor R1, R2, R3, R4 og R5, er som definert her.
NO20070258A 2004-07-27 2007-01-15 Benzyltriazolonforbindelser, fremgangsmåte for fremstilling av slike, farmasøytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdom NO338376B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59131104P 2004-07-27 2004-07-27
PCT/EP2005/007893 WO2006010545A1 (en) 2004-07-27 2005-07-20 Benzyltriazolone compounds as non-nucleoside reverse transcriptase inhibitors

Publications (2)

Publication Number Publication Date
NO20070258L true NO20070258L (no) 2007-01-15
NO338376B1 NO338376B1 (no) 2016-08-15

Family

ID=35056908

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070258A NO338376B1 (no) 2004-07-27 2007-01-15 Benzyltriazolonforbindelser, fremgangsmåte for fremstilling av slike, farmasøytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdom

Country Status (16)

Country Link
US (1) US7666891B2 (no)
EP (1) EP1773790B1 (no)
JP (1) JP4675959B2 (no)
CN (1) CN1993332B (no)
AR (1) AR050266A1 (no)
AU (1) AU2005266530B2 (no)
BR (1) BRPI0513858B8 (no)
CA (1) CA2574308C (no)
ES (1) ES2391461T3 (no)
IL (1) IL180495A (no)
MX (1) MX2007000788A (no)
NO (1) NO338376B1 (no)
RU (1) RU2394028C2 (no)
SG (1) SG148179A1 (no)
TW (1) TWI299334B (no)
WO (1) WO2006010545A1 (no)

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AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
AU2006303368B2 (en) 2005-10-19 2011-05-26 F. Hoffmann-La Roche Ag Non-Nucleoside Reverse Transcriptase Inhibitors
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u
EP2057125B1 (en) * 2006-08-16 2011-03-30 F. Hoffmann-La Roche AG Non-nucleoside reverse transcriptase inhibitors
TW200831085A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
JP2010522706A (ja) 2007-03-29 2010-07-08 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素阻害剤
CN101679414A (zh) * 2007-04-09 2010-03-24 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
AU2008257772B2 (en) * 2007-05-30 2013-06-20 F. Hoffmann-La Roche Ag Process for preparing triazolones
CA2687747C (en) 2007-05-30 2015-11-17 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
KR20100039348A (ko) * 2007-06-22 2010-04-15 에프. 호프만-라 로슈 아게 비-뉴클레오사이드 역 전사효소 억제제로서 우레아 및 카바메이트 유도체
KR101610415B1 (ko) * 2007-12-21 2016-04-07 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
US20090181068A1 (en) 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
CN101723909B (zh) * 2008-10-29 2011-12-28 天津药物研究院 三唑酮类化合物、其制备方法和用途
CN101735023B (zh) * 2008-11-24 2014-07-09 联化科技股份有限公司 一种3-溴-5-氯苯酚的制备方法
US8927684B2 (en) 2009-11-18 2015-01-06 National Research Council Of Canada Fluorinated monomers, oligomers and polymers for use in organic electronic devices
CN102146022B (zh) * 2010-02-05 2013-07-03 中国中化股份有限公司 3-氯-5-溴苯酚的制备方法
CN103025696B (zh) 2010-07-15 2015-08-12 阿尔比马尔公司 用于制备4-溴代-2-甲氧基苯甲醛的方法
CN109384765A (zh) * 2012-09-26 2019-02-26 默沙东公司 逆转录酶抑制剂的晶型
US9676754B2 (en) 2012-12-20 2017-06-13 Inception 2, Inc. Triazolone compounds and uses thereof
CN105579440A (zh) 2013-09-06 2016-05-11 因森普深2公司 三唑酮化合物及其应用
GB2598624A (en) * 2020-09-07 2022-03-09 Lorico Aurelio Use of triazole analogues for inhibition of a tripartite VOR protein complex in multicellular organisms

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Also Published As

Publication number Publication date
CN1993332B (zh) 2011-04-06
US20060025462A1 (en) 2006-02-02
WO2006010545A1 (en) 2006-02-02
MX2007000788A (es) 2007-03-23
US7666891B2 (en) 2010-02-23
EP1773790A1 (en) 2007-04-18
RU2394028C2 (ru) 2010-07-10
BRPI0513858B1 (pt) 2020-11-10
NO338376B1 (no) 2016-08-15
CN1993332A (zh) 2007-07-04
EP1773790B1 (en) 2012-08-15
TW200616979A (en) 2006-06-01
SG148179A1 (en) 2008-12-31
JP4675959B2 (ja) 2011-04-27
BRPI0513858A (pt) 2008-05-20
IL180495A0 (en) 2007-06-03
BRPI0513858B8 (pt) 2021-05-25
CA2574308C (en) 2014-03-25
RU2007106928A (ru) 2008-09-10
JP2008508211A (ja) 2008-03-21
ES2391461T3 (es) 2012-11-27
AU2005266530B2 (en) 2012-04-12
AU2005266530A1 (en) 2006-02-02
TWI299334B (en) 2008-08-01
CA2574308A1 (en) 2006-02-02
IL180495A (en) 2013-12-31
AR050266A1 (es) 2006-10-11

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