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NO20070249L - Pyrrazolo-pyrimidin derivater - Google Patents

Pyrrazolo-pyrimidin derivater

Info

Publication number
NO20070249L
NO20070249L NO20070249A NO20070249A NO20070249L NO 20070249 L NO20070249 L NO 20070249L NO 20070249 A NO20070249 A NO 20070249A NO 20070249 A NO20070249 A NO 20070249A NO 20070249 L NO20070249 L NO 20070249L
Authority
NO
Norway
Prior art keywords
pyrrazolo
pyrimidine derivatives
compounds
well
regulation
Prior art date
Application number
NO20070249A
Other languages
English (en)
Inventor
Erwin Goetschi
Juergen Wichmann
Thomas Johannes Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20070249L publication Critical patent/NO20070249L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen angår forbindelser med formel (I) hvor R1, R2 , R3 , R4 , R5 og p er som definert i beskrivelsen og kravene, så vel som farmasøytisk akseptable salter derav, som farmasøytisk aktive substanser, fremstilling av disse, medikamenter basert på en forbindelse i henhold til oppfinnelsen samt deres produksjon, så vel som anvendelse av forbindelsene i henhold til oppfinnelsen for regulering eller forebygging av sykdommer mediert av metabotropiske glutamatreseptorer og for fremstilling av tilsvarende medikamenter.
NO20070249A 2004-06-21 2007-01-15 Pyrrazolo-pyrimidin derivater NO20070249L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04102837 2004-06-21
PCT/EP2005/006302 WO2005123738A1 (en) 2004-06-21 2005-06-13 Pyrrazolo-pyrimidine derivatives

Publications (1)

Publication Number Publication Date
NO20070249L true NO20070249L (no) 2007-02-15

Family

ID=34971089

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070249A NO20070249L (no) 2004-06-21 2007-01-15 Pyrrazolo-pyrimidin derivater

Country Status (25)

Country Link
US (1) US7378417B2 (no)
EP (1) EP1761541B1 (no)
JP (1) JP4608542B2 (no)
CN (1) CN100528876C (no)
AR (1) AR049521A1 (no)
AT (1) ATE383361T1 (no)
AU (1) AU2005254657B2 (no)
BR (1) BRPI0512330A (no)
CA (1) CA2571487C (no)
DE (1) DE602005004287T2 (no)
DK (1) DK1761541T3 (no)
ES (1) ES2299044T3 (no)
HR (1) HRP20080070T3 (no)
IL (1) IL179736A (no)
MX (1) MXPA06014809A (no)
MY (1) MY143368A (no)
NO (1) NO20070249L (no)
NZ (1) NZ551660A (no)
PL (1) PL1761541T3 (no)
PT (1) PT1761541E (no)
RU (1) RU2378277C2 (no)
SI (1) SI1761541T1 (no)
TW (1) TWI301835B (no)
WO (1) WO2005123738A1 (no)
ZA (1) ZA200610102B (no)

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WO2006084634A1 (en) * 2005-02-11 2006-08-17 F.Hoffmann-La Roche Ag Pyrazolo-pyrimidine derivatives as mglur2 antagonists
DE602006012815D1 (de) 2005-03-23 2010-04-22 Hoffmann La Roche Acetylenylpyrazolopyrimidinderivate als mglur2-antagonsten
JP5048675B2 (ja) 2005-09-27 2012-10-17 エフ．ホフマン−ラ ロシュ アーゲー ｍＧｌｕＲ２アンタゴニストとしてのオキサジアゾリルピラゾロ−ピリミジン類
US8372851B2 (en) * 2005-10-21 2013-02-12 Exelixis, Inc. Pyrazolo pyrimidines as casein kinase II (CK2) modulators
AU2008279759A1 (en) * 2007-07-20 2009-01-29 Merck & Co., Inc. Pyrazolo[1,5-a]pyrimidine derivatives
PE20110828A1 (es) * 2008-10-31 2011-11-22 Genentech Inc Compuestos de pirazolopirimidina como inhibidores de jak
AR078171A1 (es) 2009-09-15 2011-10-19 Sanofi Aventis Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas
WO2012075393A2 (en) * 2010-12-02 2012-06-07 President And Fellows Of Harvard College Activators of proteasomal degradation and uses thereof
MX385600B (es) 2010-12-08 2025-03-18 Us Health Pirazolopirimidinas sustituidas como activadores de la glucocerebrosidasa.
US10953012B2 (en) 2011-04-26 2021-03-23 Bioenergenix Llc Heterocyclic compounds for the inhibition of pask
US9464035B2 (en) 2012-03-28 2016-10-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Salicylic acid derivatives useful as glucocerebrosidase activators
EP2925292A1 (en) 2012-10-23 2015-10-07 F. Hoffmann-La Roche AG Mglu2/3 antagonists for the treatment of autistic disorders
WO2014066743A1 (en) 2012-10-25 2014-05-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
US10392389B2 (en) 2012-10-25 2019-08-27 Bioenergenix Llc Heterocyclic compounds for the inhibition of PASK
RU2016144702A (ru) 2014-04-23 2018-05-24 Ф. Хоффманн-Ля Рош Аг Антагонисты mglu2/3 для лечения интеллектуальной недостаточности
JOP20150179B1 (ar) * 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
WO2016073891A1 (en) 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
WO2016073889A1 (en) 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
SI3215511T1 (sl) 2014-11-06 2024-07-31 Bial-R&D Investments, S. A. Substituirani pirazolo(1,5-a)pirimidini in njihova uporaba pri zdravljenju zdravstvenih motenj
AU2015357169B2 (en) 2014-12-03 2021-03-04 Janssen Pharmaceutica Nv Radiolabelled mGluR2 PET ligands
US10738016B2 (en) 2015-10-13 2020-08-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. BRD4-kinase inhibitors as cancer therapeutics
JP6927974B2 (ja) 2015-12-18 2021-09-01 ヤンセン ファーマシューティカ エヌ．ベー． 放射性標識ｍＧｌｕＲ２／３ＰＥＴリガンド
US11045562B2 (en) 2015-12-18 2021-06-29 Janssen Pharmaceutica Nv Radiolabelled mGluR2/3 PET ligands
WO2017176961A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
BR112018070586A8 (pt) * 2016-04-06 2023-03-14 Lysosomal Therapeutics Inc Compostos de pirazol[1,5-a]pirimidinil carboxamida e seu uso no tratamento de distúrbios médicos
EP3440081A4 (en) 2016-04-06 2019-09-18 Lysosomal Therapeutics Inc. PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER
US11345698B2 (en) 2016-05-05 2022-05-31 Bial—R&D Investments, S.A. Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders
BR112018072552A8 (pt) 2016-05-05 2023-03-14 Lysosomal Therapeutics Inc Compostos de imidazo [1,2-b]piridazinas e imidazo [1,5-b] piridazinas substituídas, composição farmacêutica que os compreende e seu uso no tratamento de distúrbios médicos
AU2019360941B2 (en) * 2018-10-15 2025-02-27 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017212A (en) * 1986-03-20 1991-05-21 Takeda Chemical Industries, Ltd. Sulfonylurea compounds and herbicidal use
EP0729758A3 (en) * 1995-03-02 1997-10-29 Pfizer Pyrazolopyrimidines and pyrrolopyrimidines for the treatment of neuronal and other diseases
GB9712718D0 (en) * 1997-06-18 1997-08-20 Heights Design Production Ltd Binding apparatus
DK0891978T3 (da) * 1997-07-18 2002-07-01 Hoffmann La Roche 5H-Thiazol(3,2-a)pyrimidinderivativer
EP1218379A2 (en) * 1999-09-30 2002-07-03 Neurogen Corporation CERTAIN ALKYLENE DIAMINE-SUBSTITUTED PYRAZOLO 1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO 1,5-a]-1,3,5-TRIAZINES
HUP0400851A3 (en) * 2001-04-12 2010-03-29 Hoffmann La Roche Dihydro-benzo[b][1,4]diazepin-2-one derivatives as mglur2 antagonists ii, process for their preparation and pharmaceutical compositions containing them
US7534800B2 (en) * 2002-03-28 2009-05-19 Eisai R & D Development Co., Ltd. 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders
US7329662B2 (en) * 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine

Also Published As

Publication number Publication date
HK1105971A1 (zh) 2008-02-29
BRPI0512330A (pt) 2008-02-26
WO2005123738A1 (en) 2005-12-29
IL179736A (en) 2010-12-30
TW200626598A (en) 2006-08-01
EP1761541A1 (en) 2007-03-14
ZA200610102B (en) 2008-08-27
JP4608542B2 (ja) 2011-01-12
DE602005004287T2 (de) 2008-12-24
AU2005254657B2 (en) 2011-03-17
PL1761541T3 (pl) 2008-06-30
US7378417B2 (en) 2008-05-27
EP1761541B1 (en) 2008-01-09
US20050282827A1 (en) 2005-12-22
RU2006143571A (ru) 2008-07-27
MY143368A (en) 2011-04-29
IL179736A0 (en) 2007-05-15
HRP20080070T3 (en) 2008-05-31
AR049521A1 (es) 2006-08-09
PT1761541E (pt) 2008-03-13
ES2299044T3 (es) 2008-05-16
CN1964973A (zh) 2007-05-16
RU2378277C2 (ru) 2010-01-10
SI1761541T1 (sl) 2008-06-30
MXPA06014809A (es) 2007-02-12
DE602005004287D1 (de) 2008-02-21
TWI301835B (en) 2008-10-11
DK1761541T3 (da) 2008-04-28
ATE383361T1 (de) 2008-01-15
JP2008503510A (ja) 2008-02-07
CN100528876C (zh) 2009-08-19
CA2571487A1 (en) 2005-12-29
CA2571487C (en) 2013-04-30
NZ551660A (en) 2009-08-28
AU2005254657A1 (en) 2005-12-29

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Legal Events

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