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NO20064120L - 3-'4-heterocyklyl-1,2,3,-triazol-l-yll-N-aryl-benzamid er som inhibitorer av cytokinproduksjon for behandling av kroniske inflammatoriske sykdommer - Google Patents

3-'4-heterocyklyl-1,2,3,-triazol-l-yll-N-aryl-benzamid er som inhibitorer av cytokinproduksjon for behandling av kroniske inflammatoriske sykdommer

Info

Publication number
NO20064120L
NO20064120L NO20064120A NO20064120A NO20064120L NO 20064120 L NO20064120 L NO 20064120L NO 20064120 A NO20064120 A NO 20064120A NO 20064120 A NO20064120 A NO 20064120A NO 20064120 L NO20064120 L NO 20064120L
Authority
NO
Norway
Prior art keywords
treatment
chronic inflammatory
triazol
benzamide
heterocyclyl
Prior art date
Application number
NO20064120A
Other languages
English (en)
Inventor
Ming-Hong Hao
Victor Marc Kamhi
Craig Andrew Miller
Mattew Russel Netherton
Derek Cogan
Alan David Swinamer
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20064120L publication Critical patent/NO20064120L/no

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Abstract

Beskrevet forbindelser med formel (I) · som hemmer produksjon av cytokiner involvert i inflammatoriske prosesser og er således anvendelige for behandling av sykdommer og patologiske tilstander som involverer inflammasjon så som kronisk inflammatorisk sykdom. Også beskrevet er prosesser for fremstilling av disse forbindelser og farmasøytiske preparater omfattende disse forbindelser.
NO20064120A 2004-03-09 2006-09-13 3-'4-heterocyklyl-1,2,3,-triazol-l-yll-N-aryl-benzamid er som inhibitorer av cytokinproduksjon for behandling av kroniske inflammatoriske sykdommer NO20064120L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55144504P 2004-03-09 2004-03-09
PCT/US2005/006997 WO2005090333A1 (en) 2004-03-09 2005-03-04 3-‘4-heterocyclyl -1,2,3,-triazol-1-yl!-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases

Publications (1)

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NO20064120L true NO20064120L (no) 2006-09-26

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NO20064120A NO20064120L (no) 2004-03-09 2006-09-13 3-'4-heterocyklyl-1,2,3,-triazol-l-yll-N-aryl-benzamid er som inhibitorer av cytokinproduksjon for behandling av kroniske inflammatoriske sykdommer

Country Status (30)

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US (2) US7214802B2 (no)
EP (2) EP1725544B1 (no)
JP (1) JP4850824B2 (no)
KR (1) KR20060129077A (no)
CN (1) CN1930144A (no)
AR (1) AR048315A1 (no)
AT (1) ATE432273T1 (no)
AU (1) AU2005223738B2 (no)
BR (1) BRPI0508561A (no)
CA (1) CA2557856C (no)
CY (1) CY1109333T1 (no)
DE (1) DE602005014621D1 (no)
DK (1) DK1725544T3 (no)
EA (1) EA011634B1 (no)
EC (1) ECSP066833A (no)
ES (1) ES2327940T3 (no)
HR (1) HRP20090334T1 (no)
IL (1) IL177937A0 (no)
MY (1) MY143000A (no)
NO (1) NO20064120L (no)
NZ (1) NZ550148A (no)
PE (1) PE20051146A1 (no)
PL (1) PL1725544T3 (no)
PT (1) PT1725544E (no)
RS (1) RS50796B (no)
SI (1) SI1725544T1 (no)
TW (1) TW200602313A (no)
UA (1) UA85702C2 (no)
WO (1) WO2005090333A1 (no)
ZA (1) ZA200606177B (no)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2647266A1 (en) 2006-04-18 2007-10-25 Boehringer Ingelheim International Gmbh Process for making cytokine inhibiting compounds containing 4- and 5- imidazolyl rings and the intermediates thereof
JP5153773B2 (ja) * 2006-07-07 2013-02-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング フェニル置換ヘテロアリール誘導体及び抗癌剤としてのその使用
JP4388997B2 (ja) 2006-09-05 2009-12-24 協和発酵キリン株式会社 イミダゾール誘導体
CL2008001943A1 (es) * 2007-07-02 2009-09-11 Boehringer Ingelheim Int Compuestos derivados de fenil-triazol, inhibidores de enzimas de señales especificas que participan del control de la proliferacion celular; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, infecciones, enfermedades inflamatorias y autoinmunes.
JP2010531850A (ja) * 2007-07-02 2010-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規化合物
EP2224809A4 (en) * 2007-11-27 2014-06-11 Univ North Carolina State INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES
US9005643B2 (en) * 2008-04-04 2015-04-14 North Carolina State University Inhibition of bacterial biofilms with imidazole-phenyl derivatives
WO2009131654A2 (en) 2008-04-21 2009-10-29 North Carolina State University Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives
CN102131797A (zh) * 2008-09-02 2011-07-20 神经研究公司 三唑衍生物和它们用作烟碱乙酰胆碱受体调节剂的用途
AR073501A1 (es) 2008-09-08 2010-11-10 Boehringer Ingelheim Int Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa
WO2010036998A2 (en) 2008-09-29 2010-04-01 Abbott Laboratories Indole and indoline derivatives and methods of use thereof
US9625475B2 (en) 2008-09-29 2017-04-18 Abbvie Inc. Indole and indoline derivatives and methods of use thereof
MX2011003292A (es) * 2008-09-29 2011-04-21 Boehringer Ingelheim Int Compuestos antiproliferativos.
WO2010077603A1 (en) * 2008-12-08 2010-07-08 North Carolina State University Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives
JP5603883B2 (ja) 2009-02-17 2014-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング B−Rafキナーゼを阻害するためのピリミドピリミジン誘導体
WO2010144686A1 (en) 2009-06-10 2010-12-16 North Carolina State University Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives
WO2011008312A2 (en) 2009-07-14 2011-01-20 Abbott Laboratories Indole and indoline derivatives and methods of use thereof
US8809532B2 (en) 2009-12-17 2014-08-19 Abbvie Inc. Aza-ring fused indole and indoline derivatives
US8524703B2 (en) 2009-12-17 2013-09-03 Abbvie Inc. Bridgehead amine ring-fused indoles and indolines
US8778959B2 (en) 2009-12-17 2014-07-15 Abbvie Inc. AZA-bridged ring-fused indoles and indolines
PH12012501389A1 (en) 2010-01-07 2012-10-29 Selexagen Therapeutics Inc Hedgehog inhibitors
WO2011085261A1 (en) * 2010-01-08 2011-07-14 Selexagen Therapeutics, Inc. Hedgehog inhibitors
EP2552907B1 (en) 2010-03-26 2014-10-22 Boehringer Ingelheim International GmbH Pyridyltriazoles
US9290507B2 (en) 2010-03-26 2016-03-22 Boehringer Ingelheim International Gmbh B-RAF kinase inhibitors
US8609669B2 (en) 2010-11-16 2013-12-17 Abbvie Inc. Potassium channel modulators
US8466181B2 (en) * 2010-12-10 2013-06-18 Hoffmann-La Roche Inc. 1,2,3-triazole-imidazole compounds
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
JP5883034B2 (ja) * 2011-01-28 2016-03-09 4エスツェー ディスカバリー ゲゼルシャフト ミット ベシュレンクテル ハフツング 自己免疫性炎症の治療のためのIL17及びIFN−γ阻害
CN103476771B (zh) * 2011-01-28 2015-12-23 4Sc探索有限责任公司 用于治疗自身免疫炎症的IL17和IFN-γ抑制
US8889684B2 (en) 2011-02-02 2014-11-18 Boehringer Ingelheim International Gmbh Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
WO2012158399A1 (en) 2011-05-13 2012-11-22 Abbott Laboratories Condensed 2 - carbamoylpyridazinones as potassium channel modulators
EP2738170B1 (en) 2011-07-29 2017-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9447099B2 (en) * 2011-10-04 2016-09-20 Hoffmann-La Roche Inc. Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
AR098311A1 (es) 2013-11-05 2016-05-26 Bayer Cropscience Ag Compuestos para el control de artrópodos
EP3394059B1 (en) 2015-12-23 2020-11-25 Chiesi Farmaceutici S.p.A. 1-(3-tert-butyl-phenyl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro- naphthalen-1-yl)-urea derivatives and their use as p38 mapk inhibitors
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
WO2018102552A1 (en) 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
KR102526964B1 (ko) 2018-02-26 2023-04-28 길리애드 사이언시즈, 인코포레이티드 Hbv 복제 억제제로서의 치환된 피롤리진 화합물
US11724997B2 (en) 2018-03-01 2023-08-15 Annapurna Bio, Inc. Compounds and compositions for treating conditions associated with APJ receptor activity
CN112368049B (zh) * 2018-07-04 2024-03-29 勃林格殷格翰国际有限公司 作为gpr142激动剂的三唑苯甲酰胺衍生物
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
KR102921276B1 (ko) 2018-11-21 2026-02-03 케이스 웨스턴 리저브 유니버시티 단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
US11472791B2 (en) 2019-03-05 2022-10-18 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
MX2022001940A (es) 2019-08-14 2022-05-10 Incyte Corp Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2.
CN119930610A (zh) 2019-10-11 2025-05-06 因赛特公司 作为cdk2抑制剂的双环胺
IL303382A (en) * 2020-12-04 2023-08-01 Eubulus Biotherapeutics Inc Heteroaryl-acetylenes, pharmaceutical compositions thereof, and their therapeutic applications
CN116761801A (zh) * 2021-03-12 2023-09-15 四川科伦博泰生物医药股份有限公司 具有蛋白激酶抑制活性的杂环化合物、包含其的药物组合物及其制备方法和用途
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
EP4434971A4 (en) 2021-11-19 2025-11-19 Nippon Soda Co PROCESS FOR THE PRODUCTION OF A 2-ALKYLTHIO-1-IMIDAZOYLETHANONE COMPOUND
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4302051A1 (de) 1993-01-26 1994-07-28 Thomae Gmbh Dr K 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2732967B1 (fr) 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
EP0906307B1 (en) * 1996-06-10 2005-04-27 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
JP4385414B2 (ja) * 1997-10-13 2009-12-16 アステラス製薬株式会社 アミド若しくはアミン誘導体
CA2327185A1 (en) * 1998-04-08 1999-10-14 Abbott Laboratories Pyrazole inhibitors of cytokine production
CA2332957A1 (en) * 1998-06-05 1999-12-09 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
USRE45616E1 (en) 1998-10-13 2015-07-21 Covidien Lp Multi-channel non-invasive tissue oximeter
AU1130700A (en) 1998-10-23 2000-05-15 Dow Agrosciences Llc Insecticidal 1-(substituted pyridyl)-1,2,4-triazoles
US6451820B1 (en) * 2000-03-23 2002-09-17 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents
US6498423B1 (en) 2001-06-27 2002-12-24 Welch Allyn, Inc. Lamp thermal control by directed air flow
US7297708B2 (en) 2001-09-06 2007-11-20 Bristol-Myers Squibb Company Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
ES2367422T3 (es) 2001-10-09 2011-11-03 Amgen Inc. Derivados de imidazol como agentes antiinflamatorios.
WO2003063781A2 (en) 2002-01-29 2003-08-07 Merck & Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
AU2004236240C1 (en) * 2003-05-01 2010-11-04 Bristol-Myers Squibb Company Aryl-substituted pyrazole compounds useful as kinase inhibitors

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