NO20064120L - 3-'4-heterocyklyl-1,2,3,-triazol-l-yll-N-aryl-benzamid er som inhibitorer av cytokinproduksjon for behandling av kroniske inflammatoriske sykdommer - Google Patents
3-'4-heterocyklyl-1,2,3,-triazol-l-yll-N-aryl-benzamid er som inhibitorer av cytokinproduksjon for behandling av kroniske inflammatoriske sykdommerInfo
- Publication number
- NO20064120L NO20064120L NO20064120A NO20064120A NO20064120L NO 20064120 L NO20064120 L NO 20064120L NO 20064120 A NO20064120 A NO 20064120A NO 20064120 A NO20064120 A NO 20064120A NO 20064120 L NO20064120 L NO 20064120L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- chronic inflammatory
- triazol
- benzamide
- heterocyclyl
- Prior art date
Links
- 208000037976 chronic inflammation Diseases 0.000 title abstract 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 title abstract 2
- 230000016396 cytokine production Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Organic Chemistry (AREA)
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Abstract
Beskrevet forbindelser med formel (I) · som hemmer produksjon av cytokiner involvert i inflammatoriske prosesser og er således anvendelige for behandling av sykdommer og patologiske tilstander som involverer inflammasjon så som kronisk inflammatorisk sykdom. Også beskrevet er prosesser for fremstilling av disse forbindelser og farmasøytiske preparater omfattende disse forbindelser.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55144504P | 2004-03-09 | 2004-03-09 | |
| PCT/US2005/006997 WO2005090333A1 (en) | 2004-03-09 | 2005-03-04 | 3-‘4-heterocyclyl -1,2,3,-triazol-1-yl!-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20064120L true NO20064120L (no) | 2006-09-26 |
Family
ID=34962594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20064120A NO20064120L (no) | 2004-03-09 | 2006-09-13 | 3-'4-heterocyklyl-1,2,3,-triazol-l-yll-N-aryl-benzamid er som inhibitorer av cytokinproduksjon for behandling av kroniske inflammatoriske sykdommer |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7214802B2 (no) |
| EP (2) | EP1725544B1 (no) |
| JP (1) | JP4850824B2 (no) |
| KR (1) | KR20060129077A (no) |
| CN (1) | CN1930144A (no) |
| AR (1) | AR048315A1 (no) |
| AT (1) | ATE432273T1 (no) |
| AU (1) | AU2005223738B2 (no) |
| BR (1) | BRPI0508561A (no) |
| CA (1) | CA2557856C (no) |
| CY (1) | CY1109333T1 (no) |
| DE (1) | DE602005014621D1 (no) |
| DK (1) | DK1725544T3 (no) |
| EA (1) | EA011634B1 (no) |
| EC (1) | ECSP066833A (no) |
| ES (1) | ES2327940T3 (no) |
| HR (1) | HRP20090334T1 (no) |
| IL (1) | IL177937A0 (no) |
| MY (1) | MY143000A (no) |
| NO (1) | NO20064120L (no) |
| NZ (1) | NZ550148A (no) |
| PE (1) | PE20051146A1 (no) |
| PL (1) | PL1725544T3 (no) |
| PT (1) | PT1725544E (no) |
| RS (1) | RS50796B (no) |
| SI (1) | SI1725544T1 (no) |
| TW (1) | TW200602313A (no) |
| UA (1) | UA85702C2 (no) |
| WO (1) | WO2005090333A1 (no) |
| ZA (1) | ZA200606177B (no) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2647266A1 (en) | 2006-04-18 | 2007-10-25 | Boehringer Ingelheim International Gmbh | Process for making cytokine inhibiting compounds containing 4- and 5- imidazolyl rings and the intermediates thereof |
| JP5153773B2 (ja) * | 2006-07-07 | 2013-02-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | フェニル置換ヘテロアリール誘導体及び抗癌剤としてのその使用 |
| JP4388997B2 (ja) | 2006-09-05 | 2009-12-24 | 協和発酵キリン株式会社 | イミダゾール誘導体 |
| CL2008001943A1 (es) * | 2007-07-02 | 2009-09-11 | Boehringer Ingelheim Int | Compuestos derivados de fenil-triazol, inhibidores de enzimas de señales especificas que participan del control de la proliferacion celular; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, infecciones, enfermedades inflamatorias y autoinmunes. |
| JP2010531850A (ja) * | 2007-07-02 | 2010-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物 |
| EP2224809A4 (en) * | 2007-11-27 | 2014-06-11 | Univ North Carolina State | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES |
| US9005643B2 (en) * | 2008-04-04 | 2015-04-14 | North Carolina State University | Inhibition of bacterial biofilms with imidazole-phenyl derivatives |
| WO2009131654A2 (en) | 2008-04-21 | 2009-10-29 | North Carolina State University | Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives |
| CN102131797A (zh) * | 2008-09-02 | 2011-07-20 | 神经研究公司 | 三唑衍生物和它们用作烟碱乙酰胆碱受体调节剂的用途 |
| AR073501A1 (es) | 2008-09-08 | 2010-11-10 | Boehringer Ingelheim Int | Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa |
| WO2010036998A2 (en) | 2008-09-29 | 2010-04-01 | Abbott Laboratories | Indole and indoline derivatives and methods of use thereof |
| US9625475B2 (en) | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
| MX2011003292A (es) * | 2008-09-29 | 2011-04-21 | Boehringer Ingelheim Int | Compuestos antiproliferativos. |
| WO2010077603A1 (en) * | 2008-12-08 | 2010-07-08 | North Carolina State University | Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives |
| JP5603883B2 (ja) | 2009-02-17 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | B−Rafキナーゼを阻害するためのピリミドピリミジン誘導体 |
| WO2010144686A1 (en) | 2009-06-10 | 2010-12-16 | North Carolina State University | Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives |
| WO2011008312A2 (en) | 2009-07-14 | 2011-01-20 | Abbott Laboratories | Indole and indoline derivatives and methods of use thereof |
| US8809532B2 (en) | 2009-12-17 | 2014-08-19 | Abbvie Inc. | Aza-ring fused indole and indoline derivatives |
| US8524703B2 (en) | 2009-12-17 | 2013-09-03 | Abbvie Inc. | Bridgehead amine ring-fused indoles and indolines |
| US8778959B2 (en) | 2009-12-17 | 2014-07-15 | Abbvie Inc. | AZA-bridged ring-fused indoles and indolines |
| PH12012501389A1 (en) | 2010-01-07 | 2012-10-29 | Selexagen Therapeutics Inc | Hedgehog inhibitors |
| WO2011085261A1 (en) * | 2010-01-08 | 2011-07-14 | Selexagen Therapeutics, Inc. | Hedgehog inhibitors |
| EP2552907B1 (en) | 2010-03-26 | 2014-10-22 | Boehringer Ingelheim International GmbH | Pyridyltriazoles |
| US9290507B2 (en) | 2010-03-26 | 2016-03-22 | Boehringer Ingelheim International Gmbh | B-RAF kinase inhibitors |
| US8609669B2 (en) | 2010-11-16 | 2013-12-17 | Abbvie Inc. | Potassium channel modulators |
| US8466181B2 (en) * | 2010-12-10 | 2013-06-18 | Hoffmann-La Roche Inc. | 1,2,3-triazole-imidazole compounds |
| US8710055B2 (en) | 2010-12-21 | 2014-04-29 | Boehringer Ingelheim International Gmbh | Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors |
| JP5883034B2 (ja) * | 2011-01-28 | 2016-03-09 | 4エスツェー ディスカバリー ゲゼルシャフト ミット ベシュレンクテル ハフツング | 自己免疫性炎症の治療のためのIL17及びIFN−γ阻害 |
| CN103476771B (zh) * | 2011-01-28 | 2015-12-23 | 4Sc探索有限责任公司 | 用于治疗自身免疫炎症的IL17和IFN-γ抑制 |
| US8889684B2 (en) | 2011-02-02 | 2014-11-18 | Boehringer Ingelheim International Gmbh | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors |
| WO2012158399A1 (en) | 2011-05-13 | 2012-11-22 | Abbott Laboratories | Condensed 2 - carbamoylpyridazinones as potassium channel modulators |
| EP2738170B1 (en) | 2011-07-29 | 2017-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9447099B2 (en) * | 2011-10-04 | 2016-09-20 | Hoffmann-La Roche Inc. | Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
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