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UA85702C2 - 3-[ 4-гетероциклил-1,2,3-триазол-1-ил]-n-арилбензамиды как ингибиторы продуцирования цитокинов, предназначены для лечения хронических воспалительных заболеваний - Google Patents

3-[ 4-гетероциклил-1,2,3-триазол-1-ил]-n-арилбензамиды как ингибиторы продуцирования цитокинов, предназначены для лечения хронических воспалительных заболеваний

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Publication number
UA85702C2
UA85702C2 UAA200610490A UAA200610490A UA85702C2 UA 85702 C2 UA85702 C2 UA 85702C2 UA A200610490 A UAA200610490 A UA A200610490A UA A200610490 A UAA200610490 A UA A200610490A UA 85702 C2 UA85702 C2 UA 85702C2
Authority
UA
Ukraine
Prior art keywords
chronic inflammatory
benzamides
triazol
heterocyclyl
inhibitors
Prior art date
Application number
UAA200610490A
Other languages
English (en)
Ukrainian (uk)
Inventor
Дерек Коган
Минг-Хонг Хао
Виктор Марк Ками
Крейг Эндрю Миллер
Метью Расселл Недертон
Алан Девид Свинаймер
Original Assignee
Бёрингер Ингельхайм Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Фармасьютикалз, Инк. filed Critical Бёрингер Ингельхайм Фармасьютикалз, Инк.
Publication of UA85702C2 publication Critical patent/UA85702C2/ru

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Abstract

В заявке описаны соединения формулы, (I)которые ингибируют продуцирование цитокинов, которые принимают участие в воспалительных процессах, и поэтому применимы для лечения заболеваний и патологических состояний, которые включают воспаления, таких как хроническое воспалительное заболевание.Также описаны способы получения этих соединений и фармацевтические композиции, которые включают эти соединения.
UAA200610490A 2004-03-09 2005-04-03 3-[ 4-гетероциклил-1,2,3-триазол-1-ил]-n-арилбензамиды как ингибиторы продуцирования цитокинов, предназначены для лечения хронических воспалительных заболеваний UA85702C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55144504P 2004-03-09 2004-03-09

Publications (1)

Publication Number Publication Date
UA85702C2 true UA85702C2 (ru) 2009-02-25

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UAA200610490A UA85702C2 (ru) 2004-03-09 2005-04-03 3-[ 4-гетероциклил-1,2,3-триазол-1-ил]-n-арилбензамиды как ингибиторы продуцирования цитокинов, предназначены для лечения хронических воспалительных заболеваний

Country Status (30)

Country Link
US (2) US7214802B2 (ru)
EP (2) EP1887003A1 (ru)
JP (1) JP4850824B2 (ru)
KR (1) KR20060129077A (ru)
CN (1) CN1930144A (ru)
AR (1) AR048315A1 (ru)
AT (1) ATE432273T1 (ru)
AU (1) AU2005223738B2 (ru)
BR (1) BRPI0508561A (ru)
CA (1) CA2557856C (ru)
CY (1) CY1109333T1 (ru)
DE (1) DE602005014621D1 (ru)
DK (1) DK1725544T3 (ru)
EA (1) EA011634B1 (ru)
EC (1) ECSP066833A (ru)
ES (1) ES2327940T3 (ru)
HR (1) HRP20090334T1 (ru)
IL (1) IL177937A0 (ru)
MY (1) MY143000A (ru)
NO (1) NO20064120L (ru)
NZ (1) NZ550148A (ru)
PE (1) PE20051146A1 (ru)
PL (1) PL1725544T3 (ru)
PT (1) PT1725544E (ru)
RS (1) RS50796B (ru)
SI (1) SI1725544T1 (ru)
TW (1) TW200602313A (ru)
UA (1) UA85702C2 (ru)
WO (1) WO2005090333A1 (ru)
ZA (1) ZA200606177B (ru)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009536618A (ja) * 2006-04-18 2009-10-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ４−及び５−イミダゾリル環を含むサイトカイン阻害化合物の製造方法及びその中間体
MX2008015457A (es) * 2006-07-07 2009-01-16 Boehringer Ingelheim Int Derivados de heteroaril substituido en fenil y el uso de los mismos como agentes anti-tumorales.
TWI386405B (zh) 2006-09-05 2013-02-21 咪唑衍生物
CL2008001943A1 (es) * 2007-07-02 2009-09-11 Boehringer Ingelheim Int Compuestos derivados de fenil-triazol, inhibidores de enzimas de señales especificas que participan del control de la proliferacion celular; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, infecciones, enfermedades inflamatorias y autoinmunes.
EP2176249A2 (en) * 2007-07-02 2010-04-21 Boehringer Ingelheim International GmbH New chemical compounds
US8278340B2 (en) 2007-11-27 2012-10-02 North Carolina State University Inhibition of biofilms in plants with imidazole derivatives
WO2009123753A1 (en) * 2008-04-04 2009-10-08 North Carolina State University Inhibition of bacterial biofilms with imidazole-phenyl derivatives
WO2009131654A2 (en) 2008-04-21 2009-10-29 North Carolina State University Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives
MX2011001844A (es) * 2008-09-02 2011-04-05 Neurosearch As Derivados de triazol y su uso como moduladores del receptor de acetilcolina nicotinico.
AR073501A1 (es) 2008-09-08 2010-11-10 Boehringer Ingelheim Int Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa
UY32146A (es) 2008-09-29 2010-04-30 Boehringer Ingelheim Int Derivados de las 5-[4-(1,5-dimetil-1h-pirazol-4-il)-1,2,3-triazol-1-il]-6-metil-nicotinamidas n-(sustituidas) y de las n-{5-[4-(1,5-dimetil-1h-pirazol-4-il)-1,2,3-triazol-1-il]-6-metil-piridin-3-il}-benzamidas sustituidas y composiciones conteniéndolos
US9625475B2 (en) 2008-09-29 2017-04-18 Abbvie Inc. Indole and indoline derivatives and methods of use thereof
CN102227431A (zh) 2008-09-29 2011-10-26 雅培制药有限公司 吲哚和二氢吲哚衍生物及其应用方法
US20110294668A1 (en) * 2008-12-08 2011-12-01 North Carolina State University Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives
WO2010094695A1 (en) 2009-02-17 2010-08-26 Boehringer Ingelheim International Gmbh Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases
US9221765B2 (en) 2009-06-10 2015-12-29 North Carolina State University Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives
WO2011008312A2 (en) 2009-07-14 2011-01-20 Abbott Laboratories Indole and indoline derivatives and methods of use thereof
US8778959B2 (en) 2009-12-17 2014-07-15 Abbvie Inc. AZA-bridged ring-fused indoles and indolines
WO2011084434A2 (en) 2009-12-17 2011-07-14 Abbott Laboratories Aza-ring fused indole and indoline derivatives
ES2512241T3 (es) 2009-12-17 2014-10-23 Abbvie Inc. Indoles e indolinas de anillos condensados con amina cabeza de puente útiles para tratar trastornos neurodegenerativos y neuropsiquiátricos
WO2011085128A1 (en) 2010-01-07 2011-07-14 Selexagen Therapeutics, Inc. Hedgehog inhibitors
WO2011085261A1 (en) * 2010-01-08 2011-07-14 Selexagen Therapeutics, Inc. Hedgehog inhibitors
US9290507B2 (en) 2010-03-26 2016-03-22 Boehringer Ingelheim International Gmbh B-RAF kinase inhibitors
EP2552907B1 (en) 2010-03-26 2014-10-22 Boehringer Ingelheim International GmbH Pyridyltriazoles
US8609669B2 (en) 2010-11-16 2013-12-17 Abbvie Inc. Potassium channel modulators
US8466181B2 (en) * 2010-12-10 2013-06-18 Hoffmann-La Roche Inc. 1,2,3-triazole-imidazole compounds
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
PL2668183T3 (pl) * 2011-01-28 2018-10-31 Immunic Ag Inhibitowanie IL17 i IFN-gamma do leczenia zapalenia autoimmunologicznego
KR101875248B1 (ko) * 2011-01-28 2018-08-02 4에스체 디스코베리 게엠베하 자가면역 염증의 치료를 위한 il17 및 ifn-감마 억제
US8889684B2 (en) 2011-02-02 2014-11-18 Boehringer Ingelheim International Gmbh Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
WO2012158399A1 (en) 2011-05-13 2012-11-22 Abbott Laboratories Condensed 2 - carbamoylpyridazinones as potassium channel modulators
US9156837B2 (en) 2011-07-29 2015-10-13 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9447099B2 (en) * 2011-10-04 2016-09-20 Hoffmann-La Roche Inc. Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
AR098311A1 (es) * 2013-11-05 2016-05-26 Bayer Cropscience Ag Compuestos para el control de artrópodos
WO2017108737A1 (en) 2015-12-23 2017-06-29 Chiesi Farmaceutici S.P.A. 1-(3-tert-butyl-phenyl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro- naphthalen-1-yl)-urea derivatives and their use as p38 mapk inhibitors
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
NZ796735A (en) 2017-02-06 2025-12-19 Univ Case Western Reserve Compositions and methods of modulating short-chain dehydrogenase activity
CA3091142C (en) 2018-02-26 2023-04-11 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
EP3759095A1 (en) 2018-03-01 2021-01-06 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity
EP3817811B1 (en) * 2018-07-04 2024-04-03 Boehringer Ingelheim International GmbH Triazole benzamide derivatives as gpr142 agonists
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
CN120463720A (zh) 2018-11-21 2025-08-12 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
BR112022002698A2 (pt) 2019-08-14 2022-07-19 Incyte Corp Compostos de imidazolil pirimidinilamina como inibidores de cdk2
BR112022006977A2 (pt) 2019-10-11 2022-09-20 Incyte Corp Aminas bicíclicas como inibidores de cdk2
JP2024500558A (ja) * 2020-12-04 2024-01-09 エウブルス バイオセラピューティクス インク． ヘテロアリール－アセチレン、その医薬組成物、及びその治療的応用
WO2022188792A1 (zh) * 2021-03-12 2022-09-15 四川科伦博泰生物医药股份有限公司 具有蛋白激酶抑制活性的杂环化合物、包含其的药物组合物及其制备方法和用途
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
EP4434971A4 (en) 2021-11-19 2025-11-19 Nippon Soda Co PROCESS FOR THE PRODUCTION OF A 2-ALKYLTHIO-1-IMIDAZOYLETHANONE COMPOUND
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4302051A1 (de) 1993-01-26 1994-07-28 Thomae Gmbh Dr K 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2732967B1 (fr) 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
AU708883B2 (en) * 1996-06-10 1999-08-12 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
JP4385414B2 (ja) * 1997-10-13 2009-12-16 アステラス製薬株式会社 アミド若しくはアミン誘導体
WO1999051580A1 (en) * 1998-04-08 1999-10-14 Abbott Laboratories Pyrazole inhibitors of cytokine production
CA2332957A1 (en) * 1998-06-05 1999-12-09 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
EP1121048A4 (en) 1998-10-13 2003-06-25 Somanetics Corp MULTICHANNEL NON-VULNERANT TISSUE OXIMETER
EP1123287B1 (en) 1998-10-23 2003-07-30 Dow AgroSciences LLC Insecticidal 3- (substituted pyridyl) -1, 2, 4-triazoles
US6451820B1 (en) * 2000-03-23 2002-09-17 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents
US6498423B1 (en) 2001-06-27 2002-12-24 Welch Allyn, Inc. Lamp thermal control by directed air flow
US7297708B2 (en) 2001-09-06 2007-11-20 Bristol-Myers Squibb Company Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
US7132438B2 (en) 2001-10-09 2006-11-07 Amgen Inc. Benzimidazole derivatives
AU2003209388A1 (en) 2002-01-29 2003-09-02 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
CA2524321A1 (en) * 2003-05-01 2004-11-18 Bristol-Myers Squibb Company Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors

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