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NO20060596L - Indazolforbindelser og farmasoytiske forbindelser for inhibering av proteingkinaser, og fremgangsmater til anvendelse derav - Google Patents

Indazolforbindelser og farmasoytiske forbindelser for inhibering av proteingkinaser, og fremgangsmater til anvendelse derav

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Publication number
NO20060596L
NO20060596L NO20060596A NO20060596A NO20060596L NO 20060596 L NO20060596 L NO 20060596L NO 20060596 A NO20060596 A NO 20060596A NO 20060596 A NO20060596 A NO 20060596A NO 20060596 L NO20060596 L NO 20060596L
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Norway
Prior art keywords
alkyl
aryl
compounds
heteroaryl
protein kinases
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Application number
NO20060596A
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English (en)
Inventor
Michael David Johnson
Jr Theodore Otto Johnson
Hiep The Luu
Siegfried Heinz Reich
Anna Maria Tempczyk-Russell
Christine Thomas
Michael Brennan Wallace
Michael Raymond Collins
Michael D Varney
Robert Steven Kania
Allen John Borchardt
John F Braganza
Stephen James Cripps
Steven Lee Bender
Ye Hua
Cynthia Louise Palmer
Min Teng
Original Assignee
Agouron Pharma
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22498654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20060596(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of NO20060596L publication Critical patent/NO20060596L/no
Application filed by Agouron Pharma filed Critical Agouron Pharma

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Abstract

Det beskrives indazol-forbindelser som modulerer og/eller inhiberer aktiviteten av visse proteinkinaser, som har formel III: hvor: r' er C6-Ci4 aryl eller C2-C9 heteroaryl, eller en gmppe med formel CH=CH-R^ eUer CH=N-R^, hvor R^ er C1-C12 alkyl, C3-C12 cykloalkyl, C2-C9 heterocykloalkyl, Ce-C^ aryl eller C2-C9 heteroaryl; Y er 0, S, C=CH2, C=0, S=0, S, SO2, CHCH3, NH eller iV^-(Ci-C8 alkyl); R* er C1-C12 alkyl, C2-C12 aleknyl, C3-C12 cykloalkyl, C2-C9 heterocykloalkyl, Ce-C^ aryl, C2-C9 heteroaryl, C1-C12 alkoksyl eller Ce-Cu aryloksyl; R^° er uavhengig valgt fra hydrogen, halogen og Ci-Cg alkyl; hvor hver av de nevnte Ri, R3 og Rg gmppene kan valgfiitt være substituert med halogen, Ci-Cg alkyl, -OH, -NO2, -CN, -CO2H, -0-(Ci-C8 aUcyl), - C6-C14 aryl, - Ce-Cn aryl-Ci-Cg alkyl, -CO2CH3, -CONH2, -OCH2CONH2, -NH2, -SO2NH2, haloalkyl eller -0-haloalkyl; eUer et farmasøytisk akseptable salt derav. Disse forbindelsene, og farmasøytiske materialer som innholder disse, er i stand til å mediere tyrosinkinase signaltiansduksjon, og dermed modulere og/eller inhibere uønsket celleproliferasjon. Oppfinnelsen vedrører også terapeutisk og profylaktisk anvendelse av farmasøytiske materialer som inneholder slike forbindelser, for å behandle kreft og likeledes andre sykdomsformer assosiert med uønsket angiogenese og/eUer cellulær prohferasjon, så som diabetes retinopaty, neovaskulær glaukom, rheumtoid artritt og psoriasis.
NO20060596A 1999-07-02 2006-02-06 Indazolforbindelser og farmasoytiske forbindelser for inhibering av proteingkinaser, og fremgangsmater til anvendelse derav NO20060596L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14213099P 1999-07-02 1999-07-02
PCT/US2000/018263 WO2001002369A2 (en) 1999-07-02 2000-06-30 Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use

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NO20060596L true NO20060596L (no) 2002-03-01

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NO20015797A NO322507B1 (no) 1999-07-02 2001-11-28 Indazolforbindelser og farmasøytisk materiale derav for inhibering av proteinkinaser, og bruk derav som et medikament.
NO20060596A NO20060596L (no) 1999-07-02 2006-02-06 Indazolforbindelser og farmasoytiske forbindelser for inhibering av proteingkinaser, og fremgangsmater til anvendelse derav
NO2013004C NO2013004I2 (no) 1999-07-02 2013-02-26 Axitinib, valgfritt i form av et farmasøytisk aksentabelt salt

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NO20015797A NO322507B1 (no) 1999-07-02 2001-11-28 Indazolforbindelser og farmasøytisk materiale derav for inhibering av proteinkinaser, og bruk derav som et medikament.

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NO2013004C NO2013004I2 (no) 1999-07-02 2013-02-26 Axitinib, valgfritt i form av et farmasøytisk aksentabelt salt

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TR200500745T2 (tr) 1999-02-10 2005-05-23 Astrazeneca Ab Damar gelişimi inhibitörleri olarak kuinazolin türevleri.
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
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