NO20043366L - Kortikotropinfrigjorende faktor-2 reseptoragonister - Google Patents

Kortikotropinfrigjorende faktor-2 reseptoragonister

Info

Publication number: NO20043366L
Authority: NO; Norway
Prior art keywords: corticotropin; receptor agonists; releasing factor; releasing; factor
Prior art date: 2002-01-16

Application number

NO20043366A

Other languages

English (en)

Norwegian (no)

Inventor

Adam Wieslaw Mazur

Robert Joseph Isfort

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-16

Filing date

2004-08-13

Publication date

2004-10-06

2004-08-13 Application filed by Procter & Gamble filed Critical Procter & Gamble

2004-10-06 Publication of NO20043366L publication Critical patent/NO20043366L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Molecular Biology (AREA)
Physical Education & Sports Medicine (AREA)
Toxicology (AREA)
Zoology (AREA)
Neurology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

NO20043366A 2002-01-16 2004-08-13 Kortikotropinfrigjorende faktor-2 reseptoragonister NO20043366L (no)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US34911702P	2002-01-16	2002-01-16
US37633702P	2002-04-29	2002-04-29
US38889502P	2002-06-14	2002-06-14
US41198802P	2002-09-19	2002-09-19
PCT/US2003/001461 WO2003062269A2 (en)	2002-01-16	2003-01-16	Corticotropin releasing factor receptor 2 agonists

Publications (1)

Publication Number	Publication Date
NO20043366L true NO20043366L (no)	2004-10-06

Family

ID=27617822

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO20043366A NO20043366L (no)	2002-01-16	2004-08-13	Kortikotropinfrigjorende faktor-2 reseptoragonister
NO20043371A NO20043371L (no)	2002-01-16	2004-08-13	Kortikotropinfrigjorendefaktorreseptor-2 agonister
NO20043396A NO20043396L (no)	2002-01-16	2004-08-16	Kortikotropinfrigjorende faktorreseptor 2-agonister

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NO20043371A NO20043371L (no)	2002-01-16	2004-08-13	Kortikotropinfrigjorendefaktorreseptor-2 agonister
NO20043396A NO20043396L (no)	2002-01-16	2004-08-16	Kortikotropinfrigjorende faktorreseptor 2-agonister

Country Status (29)

Country	Link
US (7)	US6936585B2 (es)
EP (4)	EP1724283B1 (es)
JP (3)	JP4508648B2 (es)
KR (3)	KR100758858B1 (es)
CN (3)	CN100475844C (es)
AR (3)	AR038143A1 (es)
AT (4)	ATE362488T1 (es)
AU (2)	AU2003205197B2 (es)
BR (3)	BR0306878A (es)
CA (3)	CA2470743C (es)
CY (1)	CY1106133T1 (es)
DE (4)	DE60318547T2 (es)
DK (2)	DK1465923T3 (es)
ES (4)	ES2299701T3 (es)
IL (5)	IL162529A0 (es)
MA (3)	MA27592A1 (es)
MX (3)	MXPA04006883A (es)
MY (1)	MY140306A (es)
NO (3)	NO20043366L (es)
NZ (3)	NZ533600A (es)
PE (3)	PE20030849A1 (es)
PL (3)	PL373139A1 (es)
PT (2)	PT1465923E (es)
RU (1)	RU2294333C2 (es)
SA (3)	SA03230564A (es)
SI (1)	SI1465921T1 (es)
TW (3)	TW200302276A (es)
WO (3)	WO2003062268A2 (es)
ZA (1)	ZA200404995B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002024732A2 (en) *	2000-09-22	2002-03-28	Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften	Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US6936585B2 (en) *	2002-01-16	2005-08-30	The Procter & Gamble Company	Corticotropin releasing factor 2 receptor agonists
WO2005103690A2 (en) *	2004-04-24	2005-11-03	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with corticotropin releasing hormone receptor 2 (crhr2)
AU2006235045A1 (en) *	2005-03-30	2006-10-19	J. Craig Venter Institute, Inc.	Haemophilus influenzae type b
WO2007090087A2 (en) *	2006-01-27	2007-08-09	Research Development Foundation	Use of corticotropin releasing factor receptor-2 inhibitors for treating insulin-related diseases
WO2009033773A2 (en) *	2007-09-11	2009-03-19	Mondobiotech Laboratories Ag	Use endothelin 2, alone or combined with a nonapeptide, a peptide as a therapeutic agent
AU2008297874A1 (en) *	2007-09-11	2009-03-19	Mondobiotech Laboratories Ag	Use of secretin and optionally urodilatin as therapeutic agents
WO2009046874A1 (en) *	2007-09-11	2009-04-16	Mondobiotech Laboratories Ag	Therapeutic combination of trh-potentiating peptide and stresscopin
ES2723098T3 (es) *	2008-11-04	2019-08-21	Janssen Pharmaceutica Nv	Agonistas del péptido CRHR2 y usos de los mismos
EP2206726A1 (en) *	2009-01-08	2010-07-14	Universite Joseph Fourier	Non-invasive tools for detecting vulnerable atherosclerotic plaques
CN102711801A (zh) *	2009-11-04	2012-10-03	詹森药业有限公司	用顶压素样肽治疗心力衰竭的方法
US9314506B2 (en)	2011-10-24	2016-04-19	Research Development Foundation	Methods for increasing insulin secretion by co-stimulation of corticotropin-releasing factor receptors
CN104220098B (zh) *	2012-02-14	2018-04-10	加利福尼亚大学董事会	用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达
JOP20170153A1 (ar) *	2016-07-15	2019-01-30	Lilly Co Eli	نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة
EP3528622A4 (en) *	2016-10-20	2020-08-05	Cortene Inc.	METHODS OF TREATING ILLNESSES DUE TO IMPROPER STRESS RESPONSE
CN110755434B (zh) *	2018-07-27	2022-03-15	中国医学科学院药物研究所	化合物palosuran防治骨骼肌萎缩等疾病的用途
WO2025184558A1 (en) *	2024-02-28	2025-09-04	Caradon Therapeutics, Inc.	Modified urocortin 3
WO2025222010A1 (en) *	2024-04-19	2025-10-23	Neurocrine Biosciences, Inc.	Corticotropin releasing factor receptor 2 (crfr2) agonists
WO2025230248A1 (ko) *	2024-04-30	2025-11-06	한미약품 주식회사	Crf2 수용체 작용제와 그 아실화 결합체의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5235036A (en) *	1991-05-31	1993-08-10	The Salk Institute For Biological Studies	Crf analogs
EP0860501A3 (en)	1994-06-14	1999-05-19	Neurocrine Biosciences, Inc.	Corticotropin-releasing factor2 receptors
US5786203A (en) *	1994-06-14	1998-07-28	Neurocrine Biosciences, Inc.	Isolated nucleic acid encoding corticotropin-releasing factor2 receptors
US5824771A (en) *	1994-12-12	1998-10-20	The Salk Institute For Biological Studies	Cyclic CRF agonists
US5663292A (en) *	1994-12-12	1997-09-02	The Salk Institute For Biological Studies	Cyclic CRF analogs
US5660824A (en)	1995-05-24	1997-08-26	Grabstein; Kenneth H.	Muscle trophic factor
AU6277796A (en)	1995-06-13	1997-01-15	Salk Institute For Biological Studies, The	Urocortin peptides
US5869450A (en)	1996-03-06	1999-02-09	The Regents Of The University Of California	Anti-inflammatory compositions and method with corticotropin-releasing factor analogs
US6838274B2 (en)	2000-08-04	2005-01-04	Research Development Foundation	Urocortin proteins and uses thereof
WO2002024732A2 (en) *	2000-09-22	2002-03-28	Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften	Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US20020082409A1 (en)	2000-10-26	2002-06-27	Hsu Sheau Yu	Stresscopins and their uses
US6670140B2 (en) *	2001-03-06	2003-12-30	The Procter & Gamble Company	Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US6936585B2 (en) *	2002-01-16	2005-08-30	The Procter & Gamble Company	Corticotropin releasing factor 2 receptor agonists

2002
- 2002-12-11 US US10/317,252 patent/US6936585B2/en not_active Expired - Lifetime
- 2002-12-11 US US10/315,964 patent/US7192923B2/en not_active Expired - Fee Related
- 2002-12-11 US US10/317,251 patent/US7192924B2/en not_active Expired - Fee Related
2003
- 2003-01-10 TW TW092100532A patent/TW200302276A/zh unknown
- 2003-01-10 TW TW092100533A patent/TWI300442B/zh not_active IP Right Cessation
- 2003-01-10 TW TW092100535A patent/TW200302278A/zh unknown
- 2003-01-14 PE PE2003000041A patent/PE20030849A1/es not_active Application Discontinuation
- 2003-01-14 PE PE2003000040A patent/PE20030974A1/es not_active Application Discontinuation
- 2003-01-14 PE PE2003000039A patent/PE20030747A1/es not_active Application Discontinuation
- 2003-01-15 MY MYPI20030136A patent/MY140306A/en unknown
- 2003-01-15 AR ARP030100100A patent/AR038143A1/es unknown
- 2003-01-15 AR ARP030100101A patent/AR038144A1/es unknown
- 2003-01-15 AR ARP030100099A patent/AR038142A1/es unknown
- 2003-01-16 PT PT03731965T patent/PT1465923E/pt unknown
- 2003-01-16 BR BR0306878-1A patent/BR0306878A/pt not_active IP Right Cessation
- 2003-01-16 JP JP2003562145A patent/JP4508648B2/ja not_active Expired - Fee Related
- 2003-01-16 PL PL03373139A patent/PL373139A1/xx not_active Application Discontinuation
- 2003-01-16 PT PT03703867T patent/PT1465921E/pt unknown
- 2003-01-16 WO PCT/US2003/001451 patent/WO2003062268A2/en not_active Ceased
- 2003-01-16 KR KR1020047011057A patent/KR100758858B1/ko not_active Expired - Fee Related
- 2003-01-16 ES ES03731963T patent/ES2299701T3/es not_active Expired - Lifetime
- 2003-01-16 MX MXPA04006883A patent/MXPA04006883A/es active IP Right Grant
- 2003-01-16 AT AT03731965T patent/ATE362488T1/de not_active IP Right Cessation
- 2003-01-16 JP JP2003562154A patent/JP4489434B2/ja not_active Expired - Fee Related
- 2003-01-16 EP EP06117810A patent/EP1724283B1/en not_active Expired - Lifetime
- 2003-01-16 EP EP03731965A patent/EP1465923B1/en not_active Expired - Lifetime
- 2003-01-16 IL IL15252903A patent/IL162529A0/xx unknown
- 2003-01-16 MX MXPA04006884A patent/MXPA04006884A/es active IP Right Grant
- 2003-01-16 NZ NZ533600A patent/NZ533600A/en unknown
- 2003-01-16 MX MXPA04006885A patent/MXPA04006885A/es active IP Right Grant
- 2003-01-16 ES ES03731965T patent/ES2287484T3/es not_active Expired - Lifetime
- 2003-01-16 CA CA2470743A patent/CA2470743C/en not_active Expired - Fee Related
- 2003-01-16 AT AT03703867T patent/ATE334147T1/de not_active IP Right Cessation
- 2003-01-16 KR KR1020047011052A patent/KR100758857B1/ko not_active Expired - Fee Related
- 2003-01-16 ES ES03703867T patent/ES2269976T3/es not_active Expired - Lifetime
- 2003-01-16 AU AU2003205197A patent/AU2003205197B2/en not_active Ceased
- 2003-01-16 RU RU2004124847/13A patent/RU2294333C2/ru active
- 2003-01-16 KR KR1020047011051A patent/KR100735586B1/ko not_active Expired - Fee Related
- 2003-01-16 JP JP2003562146A patent/JP4508649B2/ja not_active Expired - Fee Related
- 2003-01-16 AT AT06117810T patent/ATE398632T1/de not_active IP Right Cessation
- 2003-01-16 EP EP03731963A patent/EP1465922B1/en not_active Expired - Lifetime
- 2003-01-16 DE DE60318547T patent/DE60318547T2/de not_active Expired - Lifetime
- 2003-01-16 NZ NZ533599A patent/NZ533599A/en unknown
- 2003-01-16 BR BR0306826-9A patent/BR0306826A/pt not_active IP Right Cessation
- 2003-01-16 DE DE60307044T patent/DE60307044T2/de not_active Expired - Lifetime
- 2003-01-16 IL IL16253003A patent/IL162530A0/xx unknown
- 2003-01-16 NZ NZ533598A patent/NZ533598A/en unknown
- 2003-01-16 IL IL16243103A patent/IL162431A0/xx unknown
- 2003-01-16 CN CNB038023520A patent/CN100475844C/zh not_active Expired - Fee Related
- 2003-01-16 CN CNA038023709A patent/CN1617887A/zh active Pending
- 2003-01-16 EP EP03703867A patent/EP1465921B1/en not_active Expired - Lifetime
- 2003-01-16 DE DE60313845T patent/DE60313845T2/de not_active Expired - Lifetime
- 2003-01-16 BR BR0306838-2A patent/BR0306838A/pt not_active Application Discontinuation
- 2003-01-16 CA CA2470731A patent/CA2470731C/en not_active Expired - Fee Related
- 2003-01-16 DK DK03731965T patent/DK1465923T3/da active
- 2003-01-16 WO PCT/US2003/001461 patent/WO2003062269A2/en not_active Ceased
- 2003-01-16 PL PL03371364A patent/PL371364A1/xx unknown
- 2003-01-16 SI SI200330360T patent/SI1465921T1/sl unknown
- 2003-01-16 ES ES06117810T patent/ES2309909T3/es not_active Expired - Lifetime
- 2003-01-16 AT AT03731963T patent/ATE383372T1/de not_active IP Right Cessation
- 2003-01-16 WO PCT/US2003/001454 patent/WO2003062277A1/en not_active Ceased
- 2003-01-16 PL PL03373529A patent/PL373529A1/xx not_active Application Discontinuation
- 2003-01-16 DE DE60321730T patent/DE60321730D1/de not_active Expired - Lifetime
- 2003-01-16 AU AU2003237419A patent/AU2003237419B2/en not_active Ceased
- 2003-01-16 CN CNB038023644A patent/CN100391972C/zh not_active Expired - Fee Related
- 2003-01-16 CA CA2470656A patent/CA2470656C/en not_active Expired - Fee Related
- 2003-01-16 DK DK03703867T patent/DK1465921T3/da active
- 2003-03-01 SA SA03230564D patent/SA03230564A/ar unknown
- 2003-03-01 SA SA3230565A patent/SA03230565B1/ar unknown
- 2003-03-01 SA SA3230564A patent/SA03230564B1/ar unknown
2004
- 2004-06-24 ZA ZA2004/04995A patent/ZA200404995B/en unknown
- 2004-07-13 MA MA27780A patent/MA27592A1/fr unknown
- 2004-07-13 MA MA27778A patent/MA27590A1/fr unknown
- 2004-07-13 MA MA27779A patent/MA27591A1/fr unknown
- 2004-08-13 NO NO20043366A patent/NO20043366L/no not_active Application Discontinuation
- 2004-08-13 NO NO20043371A patent/NO20043371L/no not_active Application Discontinuation
- 2004-08-16 NO NO20043396A patent/NO20043396L/no not_active Application Discontinuation
2005
- 2005-05-04 US US11/121,612 patent/US7462597B2/en not_active Expired - Fee Related
2006
- 2006-07-28 CY CY20061101051T patent/CY1106133T1/el unknown
2007
- 2007-02-02 US US11/701,576 patent/US7608701B2/en not_active Expired - Fee Related
- 2007-02-02 US US11/701,912 patent/US7632933B2/en not_active Expired - Fee Related
2009
- 2009-01-07 IL IL196384A patent/IL196384A0/en unknown
- 2009-03-24 IL IL197774A patent/IL197774A0/en unknown
- 2009-10-26 US US12/605,718 patent/US7897731B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7462597B2 (en)	2008-12-09
IL162529A0 (en)	2005-11-20
PT1465923E (pt)	2007-08-06
JP2005525101A (ja)	2005-08-25
TWI300442B (en)	2008-09-01
CA2470731A1 (en)	2003-07-31
IL197774A0 (en)	2009-12-24
ATE362488T1 (de)	2007-06-15
NZ533598A (en)	2007-03-30
EP1465921B1 (en)	2006-07-26
CA2470743C (en)	2011-12-13
MA27590A1 (fr)	2005-11-01
US6936585B2 (en)	2005-08-30
NO20043396L (no)	2004-10-06
AR038144A1 (es)	2004-12-29
US20060025339A1 (en)	2006-02-02
CN1617887A (zh)	2005-05-18
ES2269976T3 (es)	2007-04-01
KR100758858B1 (ko)	2007-09-14
IL162530A0 (en)	2005-11-20
HK1078095A1 (zh)	2006-03-03
DE60307044D1 (de)	2006-09-07
RU2004124847A (ru)	2005-04-20
WO2003062269A3 (en)	2003-11-06
DK1465921T3 (da)	2006-11-27
DE60307044T2 (de)	2007-02-15
NO20043371L (no)	2004-10-06
EP1724283A2 (en)	2006-11-22
WO2003062269A2 (en)	2003-07-31
CN1617886A (zh)	2005-05-18
JP4508649B2 (ja)	2010-07-21
EP1465921A2 (en)	2004-10-13
DK1465923T3 (da)	2007-07-02
AR038143A1 (es)	2004-12-29
CN100475844C (zh)	2009-04-08
DE60313845T2 (de)	2008-01-31
US7192923B2 (en)	2007-03-20
PL373139A1 (en)	2005-08-22
BR0306826A (pt)	2005-09-06
JP4508648B2 (ja)	2010-07-21
PL371364A1 (en)	2005-06-13
US7632933B2 (en)	2009-12-15
SA03230564A (ar)	2005-12-03
EP1465923A1 (en)	2004-10-13
KR100758857B1 (ko)	2007-09-14
CN100391972C (zh)	2008-06-04
ES2299701T3 (es)	2008-06-01
PE20030974A1 (es)	2003-12-26
ES2287484T3 (es)	2007-12-16
KR100735586B1 (ko)	2007-07-04
JP2005522191A (ja)	2005-07-28
MA27591A1 (fr)	2005-11-01
WO2003062277A1 (en)	2003-07-31
EP1724283A3 (en)	2007-04-11
EP1724283B1 (en)	2008-06-18
MXPA04006884A (es)	2004-12-06
PL373529A1 (en)	2005-09-05
JP4489434B2 (ja)	2010-06-23
MXPA04006885A (es)	2004-12-06
BR0306838A (pt)	2005-04-05
US20030148956A1 (en)	2003-08-07
US7897731B2 (en)	2011-03-01
DE60318547D1 (de)	2008-02-21
MY140306A (en)	2009-12-31
ES2309909T3 (es)	2008-12-16
CA2470743A1 (en)	2003-07-31
ZA200404995B (en)	2005-06-29
RU2294333C2 (ru)	2007-02-27
SA03230564B1 (ar)	2006-10-31
DE60313845D1 (de)	2007-06-28
US20100197579A1 (en)	2010-08-05
WO2003062268A3 (en)	2003-11-27
WO2003062268A2 (en)	2003-07-31
CY1106133T1 (el)	2011-06-08
NZ533599A (en)	2007-03-30
ATE334147T1 (de)	2006-08-15
NZ533600A (en)	2007-02-23
ATE383372T1 (de)	2008-01-15
CA2470656C (en)	2011-06-28
DE60318547T2 (de)	2008-12-24
US20080004435A1 (en)	2008-01-03
EP1465922B1 (en)	2008-01-09
PT1465921E (pt)	2006-12-29
PE20030849A1 (es)	2003-12-01
MA27592A1 (fr)	2005-11-01
AR038142A1 (es)	2004-12-29
BR0306878A (pt)	2004-10-26
IL196384A0 (en)	2011-07-31
KR20040082392A (ko)	2004-09-24
KR20040082390A (ko)	2004-09-24
EP1465922A2 (en)	2004-10-13
IL162431A0 (en)	2005-11-20
US7192924B2 (en)	2007-03-20
US20030148958A1 (en)	2003-08-07
US7608701B2 (en)	2009-10-27
PE20030747A1 (es)	2003-10-23
SA03230565A (ar)	2005-12-03
AU2003205197B2 (en)	2006-03-02
US20090124793A1 (en)	2009-05-14
MXPA04006883A (es)	2004-12-06
CA2470731C (en)	2011-06-21
DE60321730D1 (de)	2008-07-31
US20030148957A1 (en)	2003-08-07
CN1617885A (zh)	2005-05-18
SA03230565B1 (ar)	2006-10-31
CA2470656A1 (en)	2003-07-31
TW200302277A (en)	2003-08-01
TW200302278A (en)	2003-08-01
KR20040082389A (ko)	2004-09-24
AU2003237419B2 (en)	2006-04-13
SI1465921T1 (sl)	2006-10-31
TW200302276A (en)	2003-08-01
ATE398632T1 (de)	2008-07-15
EP1465923B1 (en)	2007-05-16
JP2005521387A (ja)	2005-07-21

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