DE60307044D1 - Agonisten des corticotropin-freisetzenden faktor rezeptors 2 - Google Patents

Agonisten des corticotropin-freisetzenden faktor rezeptors 2

Info

Publication number: DE60307044D1
Authority: DE; Germany
Prior art keywords: agonists; factor receptor; releasing factor; corticotropin releasing; corticotropin
Prior art date: 2002-01-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60307044T

Other languages

English (en)

Other versions

DE60307044T2 (de

Inventor

Joseph Isfort

Adam Mazur

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Chilcott Co LLC

Original Assignee

Procter and Gamble Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-16

Filing date

2003-01-16

Publication date

2006-09-07

2003-01-16 Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co

2006-09-07 Publication of DE60307044D1 publication Critical patent/DE60307044D1/de

2007-02-15 Application granted granted Critical

2007-02-15 Publication of DE60307044T2 publication Critical patent/DE60307044T2/de

2023-01-17 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Molecular Biology (AREA)
Physical Education & Sports Medicine (AREA)
Toxicology (AREA)
Zoology (AREA)
Neurology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DE60307044T 2002-01-16 2003-01-16 Agonisten des corticotropin-freisetzenden faktor rezeptors 2 Expired - Lifetime DE60307044T2 (de)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
US34911702P	2002-01-16	2002-01-16
US349117P		2002-01-16
US37633702P	2002-04-29	2002-04-29
US376337P		2002-04-29
US38889502P	2002-06-14	2002-06-14
US388895P		2002-06-14
US41198802P	2002-09-19	2002-09-19
US411988P		2002-09-19
PCT/US2003/001461 WO2003062269A2 (en)	2002-01-16	2003-01-16	Corticotropin releasing factor receptor 2 agonists

Publications (2)

Publication Number	Publication Date
DE60307044D1 true DE60307044D1 (de)	2006-09-07
DE60307044T2 DE60307044T2 (de)	2007-02-15

Family

ID=27617822

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DE60318547T Expired - Lifetime DE60318547T2 (de)	2002-01-16	2003-01-16	Agonisten des corticotropin-freisetzenden faktor rezeptors 2
DE60307044T Expired - Lifetime DE60307044T2 (de)	2002-01-16	2003-01-16	Agonisten des corticotropin-freisetzenden faktor rezeptors 2
DE60313845T Expired - Lifetime DE60313845T2 (de)	2002-01-16	2003-01-16	Agonisten des corticotropin-freisetzenden faktor rezeptors 2
DE60321730T Expired - Lifetime DE60321730D1 (de)	2002-01-16	2003-01-16	Agonisten des corticotropin-freisetzenden Faktor Rezeptors 2

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE60318547T Expired - Lifetime DE60318547T2 (de)	2002-01-16	2003-01-16	Agonisten des corticotropin-freisetzenden faktor rezeptors 2

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DE60313845T Expired - Lifetime DE60313845T2 (de)	2002-01-16	2003-01-16	Agonisten des corticotropin-freisetzenden faktor rezeptors 2
DE60321730T Expired - Lifetime DE60321730D1 (de)	2002-01-16	2003-01-16	Agonisten des corticotropin-freisetzenden Faktor Rezeptors 2

Country Status (29)

Country	Link
US (7)	US6936585B2 (de)
EP (4)	EP1724283B1 (de)
JP (3)	JP4508648B2 (de)
KR (3)	KR100758858B1 (de)
CN (3)	CN100475844C (de)
AR (3)	AR038143A1 (de)
AT (4)	ATE362488T1 (de)
AU (2)	AU2003205197B2 (de)
BR (3)	BR0306878A (de)
CA (3)	CA2470743C (de)
CY (1)	CY1106133T1 (de)
DE (4)	DE60318547T2 (de)
DK (2)	DK1465923T3 (de)
ES (4)	ES2299701T3 (de)
IL (5)	IL162529A0 (de)
MA (3)	MA27592A1 (de)
MX (3)	MXPA04006883A (de)
MY (1)	MY140306A (de)
NO (3)	NO20043366L (de)
NZ (3)	NZ533600A (de)
PE (3)	PE20030849A1 (de)
PL (3)	PL373139A1 (de)
PT (2)	PT1465923E (de)
RU (1)	RU2294333C2 (de)
SA (3)	SA03230564A (de)
SI (1)	SI1465921T1 (de)
TW (3)	TW200302276A (de)
WO (3)	WO2003062268A2 (de)
ZA (1)	ZA200404995B (de)

Families Citing this family (19)

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Publication number	Priority date	Publication date	Assignee	Title
WO2002024732A2 (en) *	2000-09-22	2002-03-28	Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften	Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US6936585B2 (en) *	2002-01-16	2005-08-30	The Procter & Gamble Company	Corticotropin releasing factor 2 receptor agonists
WO2005103690A2 (en) *	2004-04-24	2005-11-03	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with corticotropin releasing hormone receptor 2 (crhr2)
AU2006235045A1 (en) *	2005-03-30	2006-10-19	J. Craig Venter Institute, Inc.	Haemophilus influenzae type b
WO2007090087A2 (en) *	2006-01-27	2007-08-09	Research Development Foundation	Use of corticotropin releasing factor receptor-2 inhibitors for treating insulin-related diseases
WO2009033773A2 (en) *	2007-09-11	2009-03-19	Mondobiotech Laboratories Ag	Use endothelin 2, alone or combined with a nonapeptide, a peptide as a therapeutic agent
AU2008297874A1 (en) *	2007-09-11	2009-03-19	Mondobiotech Laboratories Ag	Use of secretin and optionally urodilatin as therapeutic agents
WO2009046874A1 (en) *	2007-09-11	2009-04-16	Mondobiotech Laboratories Ag	Therapeutic combination of trh-potentiating peptide and stresscopin
ES2723098T3 (es) *	2008-11-04	2019-08-21	Janssen Pharmaceutica Nv	Agonistas del péptido CRHR2 y usos de los mismos
EP2206726A1 (de) *	2009-01-08	2010-07-14	Universite Joseph Fourier	Nichtinvasive Instrumente zum Nachweisen anfälliger atherosklerotischer Plaques
CN102711801A (zh) *	2009-11-04	2012-10-03	詹森药业有限公司	用顶压素样肽治疗心力衰竭的方法
US9314506B2 (en)	2011-10-24	2016-04-19	Research Development Foundation	Methods for increasing insulin secretion by co-stimulation of corticotropin-releasing factor receptors
CN104220098B (zh) *	2012-02-14	2018-04-10	加利福尼亚大学董事会	用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达
JOP20170153A1 (ar) *	2016-07-15	2019-01-30	Lilly Co Eli	نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة
EP3528622A4 (de) *	2016-10-20	2020-08-05	Cortene Inc.	Verfahren zur behandlung von krankheiten infolge einer maladaptierten stressreaktion
CN110755434B (zh) *	2018-07-27	2022-03-15	中国医学科学院药物研究所	化合物palosuran防治骨骼肌萎缩等疾病的用途
WO2025184558A1 (en) *	2024-02-28	2025-09-04	Caradon Therapeutics, Inc.	Modified urocortin 3
WO2025222010A1 (en) *	2024-04-19	2025-10-23	Neurocrine Biosciences, Inc.	Corticotropin releasing factor receptor 2 (crfr2) agonists
WO2025230248A1 (ko) *	2024-04-30	2025-11-06	한미약품 주식회사	Crf2 수용체 작용제와 그 아실화 결합체의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5235036A (en) *	1991-05-31	1993-08-10	The Salk Institute For Biological Studies	Crf analogs
EP0860501A3 (de)	1994-06-14	1999-05-19	Neurocrine Biosciences, Inc.	Corticotropin freisetzende Rezeptoren des Faktor 2
US5786203A (en) *	1994-06-14	1998-07-28	Neurocrine Biosciences, Inc.	Isolated nucleic acid encoding corticotropin-releasing factor2 receptors
US5824771A (en) *	1994-12-12	1998-10-20	The Salk Institute For Biological Studies	Cyclic CRF agonists
US5663292A (en) *	1994-12-12	1997-09-02	The Salk Institute For Biological Studies	Cyclic CRF analogs
US5660824A (en)	1995-05-24	1997-08-26	Grabstein; Kenneth H.	Muscle trophic factor
AU6277796A (en)	1995-06-13	1997-01-15	Salk Institute For Biological Studies, The	Urocortin peptides
US5869450A (en)	1996-03-06	1999-02-09	The Regents Of The University Of California	Anti-inflammatory compositions and method with corticotropin-releasing factor analogs
US6838274B2 (en)	2000-08-04	2005-01-04	Research Development Foundation	Urocortin proteins and uses thereof
WO2002024732A2 (en) *	2000-09-22	2002-03-28	Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften	Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US20020082409A1 (en)	2000-10-26	2002-06-27	Hsu Sheau Yu	Stresscopins and their uses
US6670140B2 (en) *	2001-03-06	2003-12-30	The Procter & Gamble Company	Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US6936585B2 (en) *	2002-01-16	2005-08-30	The Procter & Gamble Company	Corticotropin releasing factor 2 receptor agonists

2002
- 2002-12-11 US US10/317,252 patent/US6936585B2/en not_active Expired - Lifetime
- 2002-12-11 US US10/315,964 patent/US7192923B2/en not_active Expired - Fee Related
- 2002-12-11 US US10/317,251 patent/US7192924B2/en not_active Expired - Fee Related
2003
- 2003-01-10 TW TW092100532A patent/TW200302276A/zh unknown
- 2003-01-10 TW TW092100533A patent/TWI300442B/zh not_active IP Right Cessation
- 2003-01-10 TW TW092100535A patent/TW200302278A/zh unknown
- 2003-01-14 PE PE2003000041A patent/PE20030849A1/es not_active Application Discontinuation
- 2003-01-14 PE PE2003000040A patent/PE20030974A1/es not_active Application Discontinuation
- 2003-01-14 PE PE2003000039A patent/PE20030747A1/es not_active Application Discontinuation
- 2003-01-15 MY MYPI20030136A patent/MY140306A/en unknown
- 2003-01-15 AR ARP030100100A patent/AR038143A1/es unknown
- 2003-01-15 AR ARP030100101A patent/AR038144A1/es unknown
- 2003-01-15 AR ARP030100099A patent/AR038142A1/es unknown
- 2003-01-16 PT PT03731965T patent/PT1465923E/pt unknown
- 2003-01-16 BR BR0306878-1A patent/BR0306878A/pt not_active IP Right Cessation
- 2003-01-16 JP JP2003562145A patent/JP4508648B2/ja not_active Expired - Fee Related
- 2003-01-16 PL PL03373139A patent/PL373139A1/xx not_active Application Discontinuation
- 2003-01-16 PT PT03703867T patent/PT1465921E/pt unknown
- 2003-01-16 WO PCT/US2003/001451 patent/WO2003062268A2/en not_active Ceased
- 2003-01-16 KR KR1020047011057A patent/KR100758858B1/ko not_active Expired - Fee Related
- 2003-01-16 ES ES03731963T patent/ES2299701T3/es not_active Expired - Lifetime
- 2003-01-16 MX MXPA04006883A patent/MXPA04006883A/es active IP Right Grant
- 2003-01-16 AT AT03731965T patent/ATE362488T1/de not_active IP Right Cessation
- 2003-01-16 JP JP2003562154A patent/JP4489434B2/ja not_active Expired - Fee Related
- 2003-01-16 EP EP06117810A patent/EP1724283B1/de not_active Expired - Lifetime
- 2003-01-16 EP EP03731965A patent/EP1465923B1/de not_active Expired - Lifetime
- 2003-01-16 IL IL15252903A patent/IL162529A0/xx unknown
- 2003-01-16 MX MXPA04006884A patent/MXPA04006884A/es active IP Right Grant
- 2003-01-16 NZ NZ533600A patent/NZ533600A/en unknown
- 2003-01-16 MX MXPA04006885A patent/MXPA04006885A/es active IP Right Grant
- 2003-01-16 ES ES03731965T patent/ES2287484T3/es not_active Expired - Lifetime
- 2003-01-16 CA CA2470743A patent/CA2470743C/en not_active Expired - Fee Related
- 2003-01-16 AT AT03703867T patent/ATE334147T1/de not_active IP Right Cessation
- 2003-01-16 KR KR1020047011052A patent/KR100758857B1/ko not_active Expired - Fee Related
- 2003-01-16 ES ES03703867T patent/ES2269976T3/es not_active Expired - Lifetime
- 2003-01-16 AU AU2003205197A patent/AU2003205197B2/en not_active Ceased
- 2003-01-16 RU RU2004124847/13A patent/RU2294333C2/ru active
- 2003-01-16 KR KR1020047011051A patent/KR100735586B1/ko not_active Expired - Fee Related
- 2003-01-16 JP JP2003562146A patent/JP4508649B2/ja not_active Expired - Fee Related
- 2003-01-16 AT AT06117810T patent/ATE398632T1/de not_active IP Right Cessation
- 2003-01-16 EP EP03731963A patent/EP1465922B1/de not_active Expired - Lifetime
- 2003-01-16 DE DE60318547T patent/DE60318547T2/de not_active Expired - Lifetime
- 2003-01-16 NZ NZ533599A patent/NZ533599A/en unknown
- 2003-01-16 BR BR0306826-9A patent/BR0306826A/pt not_active IP Right Cessation
- 2003-01-16 DE DE60307044T patent/DE60307044T2/de not_active Expired - Lifetime
- 2003-01-16 IL IL16253003A patent/IL162530A0/xx unknown
- 2003-01-16 NZ NZ533598A patent/NZ533598A/en unknown
- 2003-01-16 IL IL16243103A patent/IL162431A0/xx unknown
- 2003-01-16 CN CNB038023520A patent/CN100475844C/zh not_active Expired - Fee Related
- 2003-01-16 CN CNA038023709A patent/CN1617887A/zh active Pending
- 2003-01-16 EP EP03703867A patent/EP1465921B1/de not_active Expired - Lifetime
- 2003-01-16 DE DE60313845T patent/DE60313845T2/de not_active Expired - Lifetime
- 2003-01-16 BR BR0306838-2A patent/BR0306838A/pt not_active Application Discontinuation
- 2003-01-16 CA CA2470731A patent/CA2470731C/en not_active Expired - Fee Related
- 2003-01-16 DK DK03731965T patent/DK1465923T3/da active
- 2003-01-16 WO PCT/US2003/001461 patent/WO2003062269A2/en not_active Ceased
- 2003-01-16 PL PL03371364A patent/PL371364A1/xx unknown
- 2003-01-16 SI SI200330360T patent/SI1465921T1/sl unknown
- 2003-01-16 ES ES06117810T patent/ES2309909T3/es not_active Expired - Lifetime
- 2003-01-16 AT AT03731963T patent/ATE383372T1/de not_active IP Right Cessation
- 2003-01-16 WO PCT/US2003/001454 patent/WO2003062277A1/en not_active Ceased
- 2003-01-16 PL PL03373529A patent/PL373529A1/xx not_active Application Discontinuation
- 2003-01-16 DE DE60321730T patent/DE60321730D1/de not_active Expired - Lifetime
- 2003-01-16 AU AU2003237419A patent/AU2003237419B2/en not_active Ceased
- 2003-01-16 CN CNB038023644A patent/CN100391972C/zh not_active Expired - Fee Related
- 2003-01-16 CA CA2470656A patent/CA2470656C/en not_active Expired - Fee Related
- 2003-01-16 DK DK03703867T patent/DK1465921T3/da active
- 2003-03-01 SA SA03230564D patent/SA03230564A/ar unknown
- 2003-03-01 SA SA3230565A patent/SA03230565B1/ar unknown
- 2003-03-01 SA SA3230564A patent/SA03230564B1/ar unknown
2004
- 2004-06-24 ZA ZA2004/04995A patent/ZA200404995B/en unknown
- 2004-07-13 MA MA27780A patent/MA27592A1/fr unknown
- 2004-07-13 MA MA27778A patent/MA27590A1/fr unknown
- 2004-07-13 MA MA27779A patent/MA27591A1/fr unknown
- 2004-08-13 NO NO20043366A patent/NO20043366L/no not_active Application Discontinuation
- 2004-08-13 NO NO20043371A patent/NO20043371L/no not_active Application Discontinuation
- 2004-08-16 NO NO20043396A patent/NO20043396L/no not_active Application Discontinuation
2005
- 2005-05-04 US US11/121,612 patent/US7462597B2/en not_active Expired - Fee Related
2006
- 2006-07-28 CY CY20061101051T patent/CY1106133T1/el unknown
2007
- 2007-02-02 US US11/701,576 patent/US7608701B2/en not_active Expired - Fee Related
- 2007-02-02 US US11/701,912 patent/US7632933B2/en not_active Expired - Fee Related
2009
- 2009-01-07 IL IL196384A patent/IL196384A0/en unknown
- 2009-03-24 IL IL197774A patent/IL197774A0/en unknown
- 2009-10-26 US US12/605,718 patent/US7897731B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7462597B2 (en)	2008-12-09
IL162529A0 (en)	2005-11-20
PT1465923E (pt)	2007-08-06
JP2005525101A (ja)	2005-08-25
TWI300442B (en)	2008-09-01
CA2470731A1 (en)	2003-07-31
IL197774A0 (en)	2009-12-24
ATE362488T1 (de)	2007-06-15
NZ533598A (en)	2007-03-30
EP1465921B1 (de)	2006-07-26
CA2470743C (en)	2011-12-13
MA27590A1 (fr)	2005-11-01
US6936585B2 (en)	2005-08-30
NO20043396L (no)	2004-10-06
AR038144A1 (es)	2004-12-29
US20060025339A1 (en)	2006-02-02
CN1617887A (zh)	2005-05-18
ES2269976T3 (es)	2007-04-01
KR100758858B1 (ko)	2007-09-14
IL162530A0 (en)	2005-11-20
HK1078095A1 (zh)	2006-03-03
RU2004124847A (ru)	2005-04-20
WO2003062269A3 (en)	2003-11-06
DK1465921T3 (da)	2006-11-27
DE60307044T2 (de)	2007-02-15
NO20043371L (no)	2004-10-06
EP1724283A2 (de)	2006-11-22
WO2003062269A2 (en)	2003-07-31
CN1617886A (zh)	2005-05-18
JP4508649B2 (ja)	2010-07-21
EP1465921A2 (de)	2004-10-13
DK1465923T3 (da)	2007-07-02
AR038143A1 (es)	2004-12-29
CN100475844C (zh)	2009-04-08
DE60313845T2 (de)	2008-01-31
US7192923B2 (en)	2007-03-20
PL373139A1 (en)	2005-08-22
BR0306826A (pt)	2005-09-06
JP4508648B2 (ja)	2010-07-21
PL371364A1 (en)	2005-06-13
US7632933B2 (en)	2009-12-15
SA03230564A (ar)	2005-12-03
EP1465923A1 (de)	2004-10-13
KR100758857B1 (ko)	2007-09-14
CN100391972C (zh)	2008-06-04
ES2299701T3 (es)	2008-06-01
PE20030974A1 (es)	2003-12-26
ES2287484T3 (es)	2007-12-16
KR100735586B1 (ko)	2007-07-04
JP2005522191A (ja)	2005-07-28
MA27591A1 (fr)	2005-11-01
WO2003062277A1 (en)	2003-07-31
EP1724283A3 (de)	2007-04-11
EP1724283B1 (de)	2008-06-18
MXPA04006884A (es)	2004-12-06
PL373529A1 (en)	2005-09-05
JP4489434B2 (ja)	2010-06-23
MXPA04006885A (es)	2004-12-06
BR0306838A (pt)	2005-04-05
US20030148956A1 (en)	2003-08-07
US7897731B2 (en)	2011-03-01
DE60318547D1 (de)	2008-02-21
MY140306A (en)	2009-12-31
ES2309909T3 (es)	2008-12-16
CA2470743A1 (en)	2003-07-31
ZA200404995B (en)	2005-06-29
RU2294333C2 (ru)	2007-02-27
SA03230564B1 (ar)	2006-10-31
DE60313845D1 (de)	2007-06-28
US20100197579A1 (en)	2010-08-05
WO2003062268A3 (en)	2003-11-27
WO2003062268A2 (en)	2003-07-31
CY1106133T1 (el)	2011-06-08
NZ533599A (en)	2007-03-30
ATE334147T1 (de)	2006-08-15
NZ533600A (en)	2007-02-23
ATE383372T1 (de)	2008-01-15
CA2470656C (en)	2011-06-28
DE60318547T2 (de)	2008-12-24
US20080004435A1 (en)	2008-01-03
EP1465922B1 (de)	2008-01-09
PT1465921E (pt)	2006-12-29
PE20030849A1 (es)	2003-12-01
MA27592A1 (fr)	2005-11-01
AR038142A1 (es)	2004-12-29
BR0306878A (pt)	2004-10-26
IL196384A0 (en)	2011-07-31
KR20040082392A (ko)	2004-09-24
KR20040082390A (ko)	2004-09-24
EP1465922A2 (de)	2004-10-13
IL162431A0 (en)	2005-11-20
US7192924B2 (en)	2007-03-20
US20030148958A1 (en)	2003-08-07
NO20043366L (no)	2004-10-06
US7608701B2 (en)	2009-10-27
PE20030747A1 (es)	2003-10-23
SA03230565A (ar)	2005-12-03
AU2003205197B2 (en)	2006-03-02
US20090124793A1 (en)	2009-05-14
MXPA04006883A (es)	2004-12-06
CA2470731C (en)	2011-06-21
DE60321730D1 (de)	2008-07-31
US20030148957A1 (en)	2003-08-07
CN1617885A (zh)	2005-05-18
SA03230565B1 (ar)	2006-10-31
CA2470656A1 (en)	2003-07-31
TW200302277A (en)	2003-08-01
TW200302278A (en)	2003-08-01
KR20040082389A (ko)	2004-09-24
AU2003237419B2 (en)	2006-04-13
SI1465921T1 (sl)	2006-10-31
TW200302276A (en)	2003-08-01
ATE398632T1 (de)	2008-07-15
EP1465923B1 (de)	2007-05-16
JP2005521387A (ja)	2005-07-21

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