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NO20043323L - Selektiv enzymatisk forestring og solvolyse av epimerisk vitamin D-analog og separasjon av epimerene - Google Patents

Selektiv enzymatisk forestring og solvolyse av epimerisk vitamin D-analog og separasjon av epimerene

Info

Publication number
NO20043323L
NO20043323L NO20043323A NO20043323A NO20043323L NO 20043323 L NO20043323 L NO 20043323L NO 20043323 A NO20043323 A NO 20043323A NO 20043323 A NO20043323 A NO 20043323A NO 20043323 L NO20043323 L NO 20043323L
Authority
NO
Norway
Prior art keywords
epimers
analog
solvolysis
separation
enzymatic esterification
Prior art date
Application number
NO20043323A
Other languages
English (en)
Norwegian (no)
Inventor
Evgeny Shapiro
Anchel Schwartz
Ayelet Fishman
Reinhard Effenberger
Asher Maymon
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of NO20043323L publication Critical patent/NO20043323L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO20043323A 2002-01-10 2004-08-10 Selektiv enzymatisk forestring og solvolyse av epimerisk vitamin D-analog og separasjon av epimerene NO20043323L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34808202P 2002-01-10 2002-01-10
US34997702P 2002-01-18 2002-01-18
PCT/US2003/000623 WO2003060094A2 (fr) 2002-01-10 2003-01-09 Esterification et solvolyse enzymatiques selectives d'un analogue epimerique de la vitamine d et separation des epimeres

Publications (1)

Publication Number Publication Date
NO20043323L true NO20043323L (no) 2004-08-10

Family

ID=26995556

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20043323A NO20043323L (no) 2002-01-10 2004-08-10 Selektiv enzymatisk forestring og solvolyse av epimerisk vitamin D-analog og separasjon av epimerene

Country Status (15)

Country Link
US (1) US8129173B2 (fr)
EP (1) EP1470220B1 (fr)
JP (1) JP2005514929A (fr)
KR (1) KR100630859B1 (fr)
CN (1) CN1639329A (fr)
AT (1) ATE527372T1 (fr)
AU (1) AU2003210473A1 (fr)
CA (1) CA2472178A1 (fr)
HR (1) HRP20040674A2 (fr)
IL (1) IL162920A0 (fr)
IS (1) IS7347A (fr)
MX (1) MXPA04006741A (fr)
NO (1) NO20043323L (fr)
PL (1) PL373677A1 (fr)
WO (1) WO2003060094A2 (fr)

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US8263580B2 (en) * 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
AU2003275987A1 (en) 2002-06-13 2003-12-31 Teva Pharmaceutical Industries Ltd. Epimerization of analogs of vitamin d
EP1458678A1 (fr) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited Procede de cristallisation de purification du calcipotriene
US8362287B2 (en) 2004-03-18 2013-01-29 Leo Pharma A/S Stereoselective synthesis of vitamin D analogues
PL207034B1 (pl) 2004-12-30 2010-10-29 Inst Farmaceutyczny Sposób wytwarzania bezwodnego kalcypotriolu
TW200643172A (en) * 2005-06-01 2006-12-16 Formosa Lab Inc Selective enzymatic esterfication and solvolysis of epimeric vitamin D analog and separation and epimerization of the epimers
JP5612263B2 (ja) * 2005-06-01 2014-10-22 スティーフェル リサーチ オーストラリア ピーティーワイ リミテッド ビタミン製剤
CN100404686C (zh) * 2005-06-10 2008-07-23 台耀化学股份有限公司 维生素d衍生物异构物的分离及异构化的方法
CN101906443B (zh) * 2010-06-25 2012-07-25 绍兴文理学院 (2S)-[2-(t-叔丁基)二甲基硅氧基]-2-环丙基-1-乙基-三苯基膦的合成方法
US9119528B2 (en) 2012-10-30 2015-09-01 Dexcom, Inc. Systems and methods for providing sensitive and specific alarms
CN103694156B (zh) * 2014-01-07 2015-09-02 成都医路康医学技术服务有限公司 一种银屑病治疗药物钙泊三醇的制备方法
CN104830943B (zh) * 2015-03-18 2019-03-01 上海皓元生物医药科技有限公司 一种艾尔骨化醇中间体的制备方法
CN106188122B (zh) * 2015-05-05 2019-05-14 上海医药工业研究院 一种手性烯丙醇类化合物的差向异构化方法
US11358143B2 (en) * 2019-03-19 2022-06-14 Siemens Healthcare Diagnostics Inc. Compositions, devices, and methods of mitigating lipoprotein interference in in vitro diagnostic assays for hydrophobic analytes

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594340A (en) * 1984-11-29 1986-06-10 Hoffmann-La Roche Inc. 25,26-dehydro-1α,24R-dihydroxycholecalciferol and 25,26-dehydro-1α,24S-dihydroxycholecalciferol and the epimeric mixture
AU603340B2 (en) * 1985-08-02 1990-11-15 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
DE3743824C2 (de) * 1987-12-23 1997-03-06 Hoechst Ag Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung
US4996158A (en) * 1987-12-26 1991-02-26 Junichi Oda Optical resolution of racemic alcohols
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
DE69123402T2 (de) * 1990-08-13 1997-04-03 Suntory Ltd Verfahren zur Herstellung optisch aktiver Alpha-Hydroxyalkenderivate
US5789397A (en) * 1991-01-08 1998-08-04 Bone Care International, Inc. Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
ES2200238T3 (es) 1991-01-08 2004-03-01 Bone Care International, Inc. Procedimiento para la preparacion de la 1-alpha-24-dihidroxi vitamina d2.
US5413935A (en) * 1991-04-24 1995-05-09 E. R. Squibb & Sons, Inc. Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase
US6262283B1 (en) * 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
JPH11130711A (ja) 1997-10-24 1999-05-18 Teijin Ltd １α，２４，２５−トリヒドロキシビタミンＤ３類の合成中間体およびその製造法
AU2413499A (en) * 1997-12-17 1999-07-05 Schering Aktiengesellschaft Vitamin d derivatives with phosphorous atoms in the side chains
GB9908327D0 (en) * 1999-04-12 1999-06-09 Chirotech Technology Ltd Process for the preparation of prostaglandin precursors
US6362350B1 (en) 1999-07-01 2002-03-26 Wisconsin Alumni Research Foundation Crystalline 1α, 24(S)-dihydroxyvitamin D2 and method of purification thereof
JP2001204484A (ja) 2000-01-20 2001-07-31 Eisai Co Ltd 酵素を用いる光学活性体の製造法
NL1015313C2 (nl) * 2000-05-26 2001-11-27 Dsm Nv Werkwijze voor de bereiding van enantiomeer verrijkte esters en alcoholen.
AU2003275987A1 (en) * 2002-06-13 2003-12-31 Teva Pharmaceutical Industries Ltd. Epimerization of analogs of vitamin d

Also Published As

Publication number Publication date
US8129173B2 (en) 2012-03-06
EP1470220A4 (fr) 2007-12-05
WO2003060094A3 (fr) 2003-12-24
US20030166226A1 (en) 2003-09-04
EP1470220A2 (fr) 2004-10-27
MXPA04006741A (es) 2006-05-31
CA2472178A1 (fr) 2003-07-24
KR100630859B1 (ko) 2006-10-04
HRP20040674A2 (en) 2005-06-30
JP2005514929A (ja) 2005-05-26
EP1470220B1 (fr) 2011-10-05
IL162920A0 (en) 2005-11-20
KR20040081122A (ko) 2004-09-20
ATE527372T1 (de) 2011-10-15
WO2003060094A2 (fr) 2003-07-24
AU2003210473A1 (en) 2003-07-30
IS7347A (is) 2004-07-07
CN1639329A (zh) 2005-07-13
PL373677A1 (en) 2005-09-05

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