IS7347A - Valkvæð ensímesterun og leysisrof á epímerískri Dvítamínhliðstæðu og aðskiljun epímeranna - Google Patents
Valkvæð ensímesterun og leysisrof á epímerískri Dvítamínhliðstæðu og aðskiljun epímerannaInfo
- Publication number
- IS7347A IS7347A IS7347A IS7347A IS7347A IS 7347 A IS7347 A IS 7347A IS 7347 A IS7347 A IS 7347A IS 7347 A IS7347 A IS 7347A IS 7347 A IS7347 A IS 7347A
- Authority
- IS
- Iceland
- Prior art keywords
- epimers
- solubilization
- analogues
- separation
- vitamin
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 230000032050 esterification Effects 0.000 title 1
- 238000005886 esterification reaction Methods 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 230000007928 solubilization Effects 0.000 title 1
- 238000005063 solubilization Methods 0.000 title 1
- 150000003712 vitamin E derivatives Chemical class 0.000 title 1
- 229930003316 Vitamin D Natural products 0.000 abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
- 235000019166 vitamin D Nutrition 0.000 abstract 2
- 239000011710 vitamin D Substances 0.000 abstract 2
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 2
- 229940046008 vitamin d Drugs 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34808202P | 2002-01-10 | 2002-01-10 | |
| US34997702P | 2002-01-18 | 2002-01-18 | |
| PCT/US2003/000623 WO2003060094A2 (en) | 2002-01-10 | 2003-01-09 | Selective enzymatic esterification and solvolysis of epimeric vitamin d analog and separation of the epimers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS7347A true IS7347A (is) | 2004-07-07 |
Family
ID=26995556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS7347A IS7347A (is) | 2002-01-10 | 2004-07-07 | Valkvæð ensímesterun og leysisrof á epímerískri Dvítamínhliðstæðu og aðskiljun epímeranna |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8129173B2 (is) |
| EP (1) | EP1470220B1 (is) |
| JP (1) | JP2005514929A (is) |
| KR (1) | KR100630859B1 (is) |
| CN (1) | CN1639329A (is) |
| AT (1) | ATE527372T1 (is) |
| AU (1) | AU2003210473A1 (is) |
| CA (1) | CA2472178A1 (is) |
| HR (1) | HRP20040674A2 (is) |
| IL (1) | IL162920A0 (is) |
| IS (1) | IS7347A (is) |
| MX (1) | MXPA04006741A (is) |
| NO (1) | NO20043323L (is) |
| PL (1) | PL373677A1 (is) |
| WO (1) | WO2003060094A2 (is) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263580B2 (en) * | 1998-09-11 | 2012-09-11 | Stiefel Research Australia Pty Ltd | Vitamin formulation |
| CA2489593C (en) | 2002-06-13 | 2009-09-29 | Teva Pharmaceutical Industries Ltd | Epimerization of analogs of vitamin d |
| WO2004046097A1 (en) * | 2002-11-18 | 2004-06-03 | Teva Pharmaceutical Industries Ltd. | A crystallization method for purification of calcipotriene |
| MY139521A (en) | 2004-03-18 | 2009-10-30 | Leo Pharma As | Stereoselective synthesis of vitamin d analogues |
| PL207034B1 (pl) | 2004-12-30 | 2010-10-29 | Inst Farmaceutyczny | Sposób wytwarzania bezwodnego kalcypotriolu |
| TW200643172A (en) * | 2005-06-01 | 2006-12-16 | Formosa Lab Inc | Selective enzymatic esterfication and solvolysis of epimeric vitamin D analog and separation and epimerization of the epimers |
| ES2447301T3 (es) | 2005-06-01 | 2014-03-11 | Glaxosmithkline Intellectual Property Development Limited | Formulación vitamínica |
| CN100404686C (zh) * | 2005-06-10 | 2008-07-23 | 台耀化学股份有限公司 | 维生素d衍生物异构物的分离及异构化的方法 |
| CN101906443B (zh) * | 2010-06-25 | 2012-07-25 | 绍兴文理学院 | (2S)-[2-(t-叔丁基)二甲基硅氧基]-2-环丙基-1-乙基-三苯基膦的合成方法 |
| US9119528B2 (en) | 2012-10-30 | 2015-09-01 | Dexcom, Inc. | Systems and methods for providing sensitive and specific alarms |
| CN103694156B (zh) * | 2014-01-07 | 2015-09-02 | 成都医路康医学技术服务有限公司 | 一种银屑病治疗药物钙泊三醇的制备方法 |
| CN104830943B (zh) * | 2015-03-18 | 2019-03-01 | 上海皓元生物医药科技有限公司 | 一种艾尔骨化醇中间体的制备方法 |
| CN106188122B (zh) * | 2015-05-05 | 2019-05-14 | 上海医药工业研究院 | 一种手性烯丙醇类化合物的差向异构化方法 |
| ES2984076T3 (es) * | 2019-03-19 | 2024-10-28 | Siemens Healthcare Diagnostics Inc | Composiciones, dispositivos y métodos para mitigar la interferencia de lipoproteínas en ensayos de diagnóstico in vitro para analitos hidrofóbicos |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594340A (en) * | 1984-11-29 | 1986-06-10 | Hoffmann-La Roche Inc. | 25,26-dehydro-1α,24R-dihydroxycholecalciferol and 25,26-dehydro-1α,24S-dihydroxycholecalciferol and the epimeric mixture |
| EP0227826B1 (en) | 1985-08-02 | 1989-10-25 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Novel vitamin d analogues |
| DE3743824C2 (de) * | 1987-12-23 | 1997-03-06 | Hoechst Ag | Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung |
| US4996158A (en) * | 1987-12-26 | 1991-02-26 | Junichi Oda | Optical resolution of racemic alcohols |
| US5401731A (en) * | 1989-06-29 | 1995-03-28 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) | Vitamin D analogues |
| DE3933034A1 (de) * | 1989-10-02 | 1991-04-11 | Schering Ag | 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung |
| ATE145942T1 (de) * | 1990-08-13 | 1996-12-15 | Suntory Ltd | Verfahren zur herstellung optisch aktiver alpha- hydroxyalkenderivate |
| ES2200238T3 (es) | 1991-01-08 | 2004-03-01 | Bone Care International, Inc. | Procedimiento para la preparacion de la 1-alpha-24-dihidroxi vitamina d2. |
| US5786348A (en) * | 1991-01-08 | 1998-07-28 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2 |
| US5413935A (en) * | 1991-04-24 | 1995-05-09 | E. R. Squibb & Sons, Inc. | Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase |
| US6262283B1 (en) * | 1996-12-06 | 2001-07-17 | Magainin Pharmaceuticals Inc. | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
| JPH11130711A (ja) | 1997-10-24 | 1999-05-18 | Teijin Ltd | １α，２４，２５−トリヒドロキシビタミンＤ３類の合成中間体およびその製造法 |
| AU2413499A (en) * | 1997-12-17 | 1999-07-05 | Schering Aktiengesellschaft | Vitamin d derivatives with phosphorous atoms in the side chains |
| GB9908327D0 (en) | 1999-04-12 | 1999-06-09 | Chirotech Technology Ltd | Process for the preparation of prostaglandin precursors |
| US6362350B1 (en) | 1999-07-01 | 2002-03-26 | Wisconsin Alumni Research Foundation | Crystalline 1α, 24(S)-dihydroxyvitamin D2 and method of purification thereof |
| JP2001204484A (ja) | 2000-01-20 | 2001-07-31 | Eisai Co Ltd | 酵素を用いる光学活性体の製造法 |
| NL1015313C2 (nl) | 2000-05-26 | 2001-11-27 | Dsm Nv | Werkwijze voor de bereiding van enantiomeer verrijkte esters en alcoholen. |
| CA2489593C (en) | 2002-06-13 | 2009-09-29 | Teva Pharmaceutical Industries Ltd | Epimerization of analogs of vitamin d |
-
2003
- 2003-01-09 CA CA002472178A patent/CA2472178A1/en not_active Abandoned
- 2003-01-09 AU AU2003210473A patent/AU2003210473A1/en not_active Abandoned
- 2003-01-09 CN CNA038056267A patent/CN1639329A/zh active Pending
- 2003-01-09 MX MXPA04006741A patent/MXPA04006741A/es not_active Application Discontinuation
- 2003-01-09 WO PCT/US2003/000623 patent/WO2003060094A2/en not_active Ceased
- 2003-01-09 HR HR20040674A patent/HRP20040674A2/xx not_active Application Discontinuation
- 2003-01-09 EP EP03729607A patent/EP1470220B1/en not_active Expired - Lifetime
- 2003-01-09 JP JP2003560181A patent/JP2005514929A/ja active Pending
- 2003-01-09 AT AT03729607T patent/ATE527372T1/de not_active IP Right Cessation
- 2003-01-09 US US10/339,226 patent/US8129173B2/en not_active Expired - Fee Related
- 2003-01-09 KR KR1020047010769A patent/KR100630859B1/ko not_active Expired - Fee Related
- 2003-01-09 PL PL03373677A patent/PL373677A1/xx not_active Application Discontinuation
- 2003-01-09 IL IL16292003A patent/IL162920A0/xx not_active IP Right Cessation
-
2004
- 2004-07-07 IS IS7347A patent/IS7347A/is unknown
- 2004-08-10 NO NO20043323A patent/NO20043323L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL373677A1 (en) | 2005-09-05 |
| KR100630859B1 (ko) | 2006-10-04 |
| IL162920A0 (en) | 2005-11-20 |
| CN1639329A (zh) | 2005-07-13 |
| EP1470220B1 (en) | 2011-10-05 |
| HRP20040674A2 (en) | 2005-06-30 |
| US20030166226A1 (en) | 2003-09-04 |
| WO2003060094A3 (en) | 2003-12-24 |
| EP1470220A4 (en) | 2007-12-05 |
| ATE527372T1 (de) | 2011-10-15 |
| WO2003060094A2 (en) | 2003-07-24 |
| KR20040081122A (ko) | 2004-09-20 |
| NO20043323L (no) | 2004-08-10 |
| CA2472178A1 (en) | 2003-07-24 |
| JP2005514929A (ja) | 2005-05-26 |
| US8129173B2 (en) | 2012-03-06 |
| AU2003210473A1 (en) | 2003-07-30 |
| EP1470220A2 (en) | 2004-10-27 |
| MXPA04006741A (es) | 2006-05-31 |
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