NO20043902L - Kontrollert syntese av ziprasidon og sammensetninger derav - Google Patents

Kontrollert syntese av ziprasidon og sammensetninger derav

Info

Publication number: NO20043902L
Authority: NO; Norway
Prior art keywords: ziprasidone; compositions; controlled synthesis; synthesis; controlled
Prior art date: 2002-02-20

Application number

NO20043902A

Other languages

English (en)

Inventor

Frank Robert Busch

Jr Harry Ralph Howard

Adam Worth Grobin

Kyle Robert Leeman

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-20

Filing date

2004-09-17

Publication date

2004-09-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27761437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20043902(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-09-17 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2004-09-17 Publication of NO20043902L publication Critical patent/NO20043902L/no

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Liquid Crystal Substances (AREA)
Indole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)

NO20043902A 2002-02-20 2004-09-17 Kontrollert syntese av ziprasidon og sammensetninger derav NO20043902L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US35880602P	2002-02-20	2002-02-20
US35903802P	2002-02-21	2002-02-21
US36045902P	2002-02-27	2002-02-27
PCT/IB2003/000642 WO2003070246A1 (en)	2002-02-20	2003-02-17	Controlled synthesis of ziprasidone and compositions thereof

Publications (1)

Publication Number	Publication Date
NO20043902L true NO20043902L (no)	2004-09-17

Family

ID=27761437

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20043902A NO20043902L (no)	2002-02-20	2004-09-17	Kontrollert syntese av ziprasidon og sammensetninger derav
NO20100584A NO20100584L (no)	2002-02-20	2010-04-22	Fremgangsmate ved bruk av HPLC for a male mengden 5-(2-kloretyl)-1,3-dihydro-2H-indol-on i et preparat omfattende 6-klor-5-(2-kloretyl)-1,3 dihydro-2H-indol-2-on

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20100584A NO20100584L (no)	2002-02-20	2010-04-22	Fremgangsmate ved bruk av HPLC for a male mengden 5-(2-kloretyl)-1,3-dihydro-2H-indol-on i et preparat omfattende 6-klor-5-(2-kloretyl)-1,3 dihydro-2H-indol-2-on

Country Status (41)

Country	Link
EP (1)	EP1476162B1 (no)
JP (1)	JP4554938B2 (no)
KR (1)	KR100773622B1 (no)
CN (2)	CN1635892A (no)
AP (1)	AP2004003103A0 (no)
AR (1)	AR038563A1 (no)
AT (1)	ATE359787T1 (no)
AU (2)	AU2003206035A1 (no)
BR (1)	BR0307833A (no)
CA (1)	CA2475302C (no)
CO (1)	CO5611138A2 (no)
CY (1)	CY1106467T1 (no)
DE (1)	DE60313289T2 (no)
DK (1)	DK1476162T3 (no)
EA (1)	EA007866B1 (no)
EC (1)	ECSP045239A (no)
ES (1)	ES2283745T3 (no)
GE (1)	GEP20074030B (no)
GT (1)	GT200300040A (no)
HR (1)	HRP20040711A2 (no)
IL (1)	IL163277A (no)
IS (1)	IS7344A (no)
MA (1)	MA27177A1 (no)
MX (1)	MXPA04006993A (no)
MY (1)	MY139523A (no)
NO (2)	NO20043902L (no)
NZ (1)	NZ534443A (no)
OA (1)	OA12774A (no)
PA (1)	PA8567001A1 (no)
PE (1)	PE20030942A1 (no)
PL (1)	PL372238A1 (no)
PT (1)	PT1476162E (no)
RS (1)	RS60404A (no)
SI (1)	SI1476162T1 (no)
SV (1)	SV2004001485A (no)
TN (1)	TNSN04159A1 (no)
TW (1)	TW200307546A (no)
UA (1)	UA77057C2 (no)
UY (1)	UY27668A1 (no)
WO (1)	WO2003070246A1 (no)
ZA (1)	ZA200406276B (no)

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NZ520240A (en)	2000-03-06	2005-04-29	Acadia Pharm Inc	Azacyclic compounds for use in the treatment of serotonin related diseases
ATE466014T1 (de)	2001-12-28	2010-05-15	Acadia Pharm Inc	Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
US7538222B2 (en)	2002-06-24	2009-05-26	Acadia Pharmaceuticals, Inc.	N-substituted piperidine derivatives as serotonin receptor agents
BR0312217A (pt)	2002-06-24	2005-05-10	Acadia Pharm Inc	Compostos, métodos de inibição da atividade/ativação de um receptor monoaminérgico e método de tratamento de condição doentia associada a um receptor de monoaminergético
US7253186B2 (en)	2002-06-24	2007-08-07	Carl-Magnus Andersson	N-substituted piperidine derivatives as serotonin receptor agents
WO2004050655A1 (en) *	2002-12-04	2004-06-17	Dr. Reddy's Laboratories Limited	Polymorphic forms of ziprasidone and its hydrochloride
AU2003300814A1 (en)	2002-12-04	2004-06-23	Dr. Reddy's Laboratories Inc.	Polymorphic forms of ziprasidone and its hydrochloride
WO2004064738A2 (en)	2003-01-16	2004-08-05	Acadia Pharmaceuticals Inc.	Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases
US7199144B2 (en)	2003-04-21	2007-04-03	Teva Pharmaceuticals Industries, Ltd.	Process for the preparation of valsartan and intermediates thereof
DE602004013405T2 (de)	2003-03-17	2009-05-07	Teva Pharmaceutical Industries Ltd.	Polymorphe formen von valsartan
WO2004094392A1 (en) *	2003-04-21	2004-11-04	Teva Pharmaceutical Industries Ltd.	Process for the preparation of valsartan
WO2005016325A2 (en)	2003-06-03	2005-02-24	Teva Pharmaceutical Industries Ltd.	CRISTALLINE ZIPRASIDONE HCl AND PROCESSES FOR PREPARATION THEREOF
WO2005040160A2 (en)	2003-10-24	2005-05-06	Teva Pharmaceutical Industries Ltd.	Processes for preparation of ziprasidone
WO2005061493A2 (en) *	2003-12-18	2005-07-07	Teva Pharmaceutical Industries Ltd.	Polymorphic form b2 of ziprasidone base
ATE451367T1 (de)	2004-02-27	2009-12-15	Ranbaxy Lab Ltd	Verfahren zur herstellung von ziprasidon
CA2467538C (en)	2004-05-14	2010-08-24	Apotex Pharmachem Inc.	New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
US7820695B2 (en)	2004-05-21	2010-10-26	Acadia Pharmaceuticals, Inc.	Selective serotonin receptor inverse agonists as therapeutics for disease
CA2471219A1 (en)	2004-06-14	2005-12-14	Apotex Pharmachem Inc.	Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
US7790899B2 (en)	2004-09-27	2010-09-07	Acadia Pharmaceuticals, Inc.	Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
PL2289879T3 (pl)	2004-09-27	2015-05-29	Acadia Pharm Inc	Synteza formy krystalicznej soli winianowej n-(4-fluorobenzylo)-n-(1-metylopiperydyn-4-ylo)-n'-(4-(2-metylopropyloksy)fenylometylo)karbamidu
ES2250001B1 (es) *	2004-09-29	2007-06-01	Medichem, S.A.	Proceso para la purificacion de ziprasidona.
ES2250000B1 (es) *	2004-09-29	2007-06-01	Medichem, S.A.	Procedimiento para la preparacion de ziprasidona.
EP1841764A1 (en) *	2005-01-27	2007-10-10	Hetero Drugs Limited	Process for ziprasidone using novel intermediates
ITMI20052216A1 (it) *	2005-11-18	2007-05-19	Dipharma Spa	Procedimento per la preparazione di ziprasidone
CN100491375C (zh) *	2006-07-01	2009-05-27	浙江美诺华药物化学有限公司	一种齐拉西酮的制备方法
ES2423485T3 (es)	2007-03-19	2013-09-20	Acadia Pharmaceuticals Inc.	Asociaciones de agonistas y antagonistas inversos 5-HT2A con antipsicóticos
CN102234272A (zh) *	2010-04-21	2011-11-09	上海医药工业研究院	盐酸齐拉西酮半水合物的制备方法
CN102234273B (zh) *	2010-04-21	2015-08-05	上海医药工业研究院	甲磺酸齐拉西酮半水合物及其制备方法
SI3325444T1 (sl)	2015-07-20	2021-11-30	Acadia Pharmaceuticals Inc.	Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C
WO2017165635A1 (en)	2016-03-25	2017-09-28	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en)	2016-03-25	2021-03-23	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome P450 modulators
EP3558311A1 (en)	2016-12-20	2019-10-30	Acadia Pharmaceuticals Inc.	Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
CN108239085A (zh) *	2016-12-26	2018-07-03	四川科瑞德凯华制药有限公司	一种甲磺酸齐拉西酮的纯化及制备方法
US11135211B2 (en)	2017-04-28	2021-10-05	Acadia Pharmaceuticals Inc.	Pimavanserin for treating impulse control disorder
EP3675827A1 (en)	2017-08-30	2020-07-08	Acadia Pharmaceuticals Inc.	Formulations of pimavanserin
CN112724066B (zh) *	2021-02-04	2022-10-21	海南鑫开源医药科技有限公司	一种盐酸齐拉西酮中间体中的二卤杂质及其制备方法
CN116046966A (zh) *	2023-01-17	2023-05-02	北京协和建昊医药技术开发有限责任公司	一种流动相配置装置及其配置方法

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JP3102896B2 (ja) *	1996-05-07	2000-10-23	ファイザーインク．	５―（２―（４―（１，２―ベンズイソチアゾール―３―イル）―１―ピペラジニル）エチル）―６―クロロ―１，３―ジヒドロ―２（１ｈ）―インドール―２―オン（＝ジプラシドン）のメシレート三水和物、その調製法およびドーパミンｄ２アンタゴニストとしてのその使用
TW491847B (en) *	1996-05-07	2002-06-21	Pfizer	Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
IL127497A (en) *	1997-12-18	2002-07-25	Pfizer Prod Inc	Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
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2003
- 2003-02-14 UY UY27668A patent/UY27668A1/es not_active Application Discontinuation
- 2003-02-17 SI SI200330811T patent/SI1476162T1/sl unknown
- 2003-02-17 GE GE5684A patent/GEP20074030B/en unknown
- 2003-02-17 PT PT03702918T patent/PT1476162E/pt unknown
- 2003-02-17 AT AT03702918T patent/ATE359787T1/de active
- 2003-02-17 JP JP2003569202A patent/JP4554938B2/ja not_active Expired - Fee Related
- 2003-02-17 UA UA20040806969A patent/UA77057C2/uk unknown
- 2003-02-17 CA CA002475302A patent/CA2475302C/en not_active Expired - Fee Related
- 2003-02-17 KR KR1020047012980A patent/KR100773622B1/ko not_active Expired - Fee Related
- 2003-02-17 BR BR0307833-7A patent/BR0307833A/pt not_active IP Right Cessation
- 2003-02-17 CN CNA038042460A patent/CN1635892A/zh active Pending
- 2003-02-17 RS YU60404A patent/RS60404A/sr unknown
- 2003-02-17 PE PE2003000168A patent/PE20030942A1/es not_active Application Discontinuation
- 2003-02-17 NZ NZ534443A patent/NZ534443A/en not_active IP Right Cessation
- 2003-02-17 OA OA1200400216A patent/OA12774A/en unknown
- 2003-02-17 EP EP03702918A patent/EP1476162B1/en not_active Revoked
- 2003-02-17 DE DE60313289T patent/DE60313289T2/de not_active Revoked
- 2003-02-17 MX MXPA04006993A patent/MXPA04006993A/es not_active Application Discontinuation
- 2003-02-17 PL PL03372238A patent/PL372238A1/xx not_active Application Discontinuation
- 2003-02-17 ES ES03702918T patent/ES2283745T3/es not_active Expired - Lifetime
- 2003-02-17 WO PCT/IB2003/000642 patent/WO2003070246A1/en not_active Ceased
- 2003-02-17 HR HRP20040711 patent/HRP20040711A2/xx not_active Application Discontinuation
- 2003-02-17 CN CN200910261963A patent/CN101735212A/zh active Pending
- 2003-02-17 AU AU2003206035A patent/AU2003206035A1/en not_active Abandoned
- 2003-02-17 AP APAP/P/2004/003103A patent/AP2004003103A0/en unknown
- 2003-02-17 DK DK03702918T patent/DK1476162T3/da active
- 2003-02-17 EA EA200400815A patent/EA007866B1/ru not_active IP Right Cessation
- 2003-02-18 TW TW092103292A patent/TW200307546A/zh unknown
- 2003-02-18 AR ARP030100527A patent/AR038563A1/es unknown
- 2003-02-18 GT GT200300040A patent/GT200300040A/es unknown
- 2003-02-18 MY MYPI20030564A patent/MY139523A/en unknown
- 2003-02-19 SV SV2003001485A patent/SV2004001485A/es not_active Application Discontinuation
- 2003-02-20 PA PA20038567001A patent/PA8567001A1/es unknown
2004
- 2004-07-05 IS IS7344A patent/IS7344A/is unknown
- 2004-07-29 IL IL163277A patent/IL163277A/en unknown
- 2004-08-05 ZA ZA200406276A patent/ZA200406276B/en unknown
- 2004-08-13 CO CO04079019A patent/CO5611138A2/es unknown
- 2004-08-17 MA MA27827A patent/MA27177A1/fr unknown
- 2004-08-19 EC EC2004005239A patent/ECSP045239A/es unknown
- 2004-08-19 TN TNP2004000159A patent/TNSN04159A1/fr unknown
- 2004-09-17 NO NO20043902A patent/NO20043902L/no not_active Application Discontinuation
2007
- 2007-05-10 CY CY20071100629T patent/CY1106467T1/el unknown
2009
- 2009-05-21 AU AU2009202008A patent/AU2009202008A1/en not_active Ceased
2010
- 2010-04-22 NO NO20100584A patent/NO20100584L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20100584L (no)	2004-09-17
EA200400815A1 (ru)	2004-12-30
ATE359787T1 (de)	2007-05-15
DE60313289T2 (de)	2007-12-27
DK1476162T3 (da)	2007-07-02
CN1635892A (zh)	2005-07-06
MXPA04006993A (es)	2004-11-10
UY27668A1 (es)	2003-10-31
WO2003070246A1 (en)	2003-08-28
AU2003206035A1 (en)	2003-09-09
GEP20074030B (en)	2007-02-12
RS60404A (sr)	2006-10-27
AU2009202008A1 (en)	2009-06-11
PL372238A1 (en)	2005-07-11
EP1476162B1 (en)	2007-04-18
PA8567001A1 (es)	2003-12-10
ECSP045239A (es)	2004-09-28
SV2004001485A (es)	2004-05-07
ZA200406276B (en)	2005-09-20
AR038563A1 (es)	2005-01-19
IS7344A (is)	2004-07-05
PT1476162E (pt)	2007-06-25
UA77057C2 (en)	2006-10-16
CY1106467T1 (el)	2012-01-25
HRP20040711A2 (en)	2004-12-31
GT200300040A (es)	2007-01-12
EA007866B1 (ru)	2007-02-27
KR20040086417A (ko)	2004-10-08
TW200307546A (en)	2003-12-16
PE20030942A1 (es)	2003-11-08
DE60313289D1 (de)	2007-05-31
JP2005525347A (ja)	2005-08-25
CA2475302A1 (en)	2003-08-28
MA27177A1 (fr)	2005-01-03
CA2475302C (en)	2009-05-12
ES2283745T3 (es)	2007-11-01
CO5611138A2 (es)	2006-02-28
BR0307833A (pt)	2004-12-07
TNSN04159A1 (fr)	2007-03-12
OA12774A (en)	2006-07-04
KR100773622B1 (ko)	2007-11-05
AP2004003103A0 (en)	2004-09-30
CN101735212A (zh)	2010-06-16
MY139523A (en)	2009-10-30
JP4554938B2 (ja)	2010-09-29
NZ534443A (en)	2007-07-27
SI1476162T1 (sl)	2007-08-31
EP1476162A1 (en)	2004-11-17
IL163277A (en)	2010-05-31

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