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MA27177A1 - Synthese controlee de ziprasidone et compositions en contenant. - Google Patents

Synthese controlee de ziprasidone et compositions en contenant.

Info

Publication number
MA27177A1
MA27177A1 MA27827A MA27827A MA27177A1 MA 27177 A1 MA27177 A1 MA 27177A1 MA 27827 A MA27827 A MA 27827A MA 27827 A MA27827 A MA 27827A MA 27177 A1 MA27177 A1 MA 27177A1
Authority
MA
Morocco
Prior art keywords
ziprasidone
compositions
container
chloroziprasidone
february
Prior art date
Application number
MA27827A
Other languages
English (en)
Inventor
Frank Robert Busch
Harry Ralph Howard Jr
Adam Worth Grobin
Kyle Robert Leeman
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27761437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA27177(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA27177A1 publication Critical patent/MA27177A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

DEPOSANT Société dite : PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 20 Février 2002 60/358,806 US 21 Février 2002 60/359,038 US 27 février 2002 60/360,459 Voir en annexe le titre de l'invention et le texte de l'abrégé Synthèse contrôlée de ziprasidone et compositions en contenant La présente invention propose une composition de ziprasidone qui comprend une quantité non supérieure à 1000 ppm de des-chloroziprasidone, avantageusement non supérieure à environ 500 ppm de des-chloroziprasidone, et plus avantageusement non supérieure à environ 100 ppm de des-chloroziprasidone. Des procédés pour la synthèse et l'utilisation de ces compositions de ziprasidone sont également proposés.
MA27827A 2002-02-20 2004-08-17 Synthese controlee de ziprasidone et compositions en contenant. MA27177A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35880602P 2002-02-20 2002-02-20
US35903802P 2002-02-21 2002-02-21
US36045902P 2002-02-27 2002-02-27

Publications (1)

Publication Number Publication Date
MA27177A1 true MA27177A1 (fr) 2005-01-03

Family

ID=27761437

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27827A MA27177A1 (fr) 2002-02-20 2004-08-17 Synthese controlee de ziprasidone et compositions en contenant.

Country Status (41)

Country Link
EP (1) EP1476162B1 (fr)
JP (1) JP4554938B2 (fr)
KR (1) KR100773622B1 (fr)
CN (2) CN1635892A (fr)
AP (1) AP2004003103A0 (fr)
AR (1) AR038563A1 (fr)
AT (1) ATE359787T1 (fr)
AU (2) AU2003206035A1 (fr)
BR (1) BR0307833A (fr)
CA (1) CA2475302C (fr)
CO (1) CO5611138A2 (fr)
CY (1) CY1106467T1 (fr)
DE (1) DE60313289T2 (fr)
DK (1) DK1476162T3 (fr)
EA (1) EA007866B1 (fr)
EC (1) ECSP045239A (fr)
ES (1) ES2283745T3 (fr)
GE (1) GEP20074030B (fr)
GT (1) GT200300040A (fr)
HR (1) HRP20040711A2 (fr)
IL (1) IL163277A (fr)
IS (1) IS7344A (fr)
MA (1) MA27177A1 (fr)
MX (1) MXPA04006993A (fr)
MY (1) MY139523A (fr)
NO (2) NO20043902L (fr)
NZ (1) NZ534443A (fr)
OA (1) OA12774A (fr)
PA (1) PA8567001A1 (fr)
PE (1) PE20030942A1 (fr)
PL (1) PL372238A1 (fr)
PT (1) PT1476162E (fr)
RS (1) RS60404A (fr)
SI (1) SI1476162T1 (fr)
SV (1) SV2004001485A (fr)
TN (1) TNSN04159A1 (fr)
TW (1) TW200307546A (fr)
UA (1) UA77057C2 (fr)
UY (1) UY27668A1 (fr)
WO (1) WO2003070246A1 (fr)
ZA (1) ZA200406276B (fr)

Families Citing this family (37)

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CA2397981C (fr) 2000-03-06 2010-12-21 Acadia Pharmaceuticals, Inc. Composes azacycliques utilises dans le traitement de maladies liees a la serotonine
EP1461339B1 (fr) 2001-12-28 2010-04-28 Acadia Pharmaceuticals Inc. Composes spiroazacycliques utilises comme modulateurs du recepteur de monoamine
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
IL165907A0 (en) 2002-06-24 2006-01-15 Acadia Pharm Inc N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
WO2004050655A1 (fr) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Formes polymorphes de ziprasidone et son chlorhydrate
US7488729B2 (en) 2002-12-04 2009-02-10 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
CN1816524B (zh) 2003-01-16 2012-06-27 阿卡蒂亚药品公司 用于神经退行性疾病的治疗的选择性五羟色胺2a/2c受体反向激动剂
DE602004013405T2 (de) 2003-03-17 2009-05-07 Teva Pharmaceutical Industries Ltd. Polymorphe formen von valsartan
US7199144B2 (en) 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
WO2004094392A1 (fr) * 2003-04-21 2004-11-04 Teva Pharmaceutical Industries Ltd. Processus de preparation de valsartan
KR20060015750A (ko) 2003-06-03 2006-02-20 테바 파마슈티컬 인더스트리즈 리미티드 지프라시돈 HCl의 다형 형태 및 그 제조 방법
WO2005040160A2 (fr) 2003-10-24 2005-05-06 Teva Pharmaceutical Industries Ltd. Procedes de preparation de ziprasidone
CN1934108A (zh) * 2003-12-18 2007-03-21 特瓦制药工业有限公司 齐拉西酮碱的多晶型b2
US20080312254A1 (en) 2004-02-27 2008-12-18 Ranbaxy Laboratories Limited Process for the Preparation of Ziprasidone
CA2467538C (fr) 2004-05-14 2010-08-24 Apotex Pharmachem Inc. Nouveau chlorhydrate de ziprasidone amorphe (chlorhydrate de 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydr o-2h-indol-2-one) et procedes pour sa production
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
CA2471219A1 (fr) 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Preparation amelioree d'une forme anhydre du chlorhydrate de 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one (chlorhydrate de ziprasidone)
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
CN102153505B (zh) 2004-09-27 2014-10-22 阿卡蒂亚药品公司 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
ES2250000B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Procedimiento para la preparacion de ziprasidona.
WO2006080025A1 (fr) * 2005-01-27 2006-08-03 Hetero Drugs Limited Procédé de synthèse de la ziprasidone impliquant de nouveaux intermédiaires
ITMI20052216A1 (it) * 2005-11-18 2007-05-19 Dipharma Spa Procedimento per la preparazione di ziprasidone
CN100491375C (zh) * 2006-07-01 2009-05-27 浙江美诺华药物化学有限公司 一种齐拉西酮的制备方法
US20090053329A1 (en) 2007-03-19 2009-02-26 Acadia Pharmaceuticals, Inc. Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
CN102234272A (zh) * 2010-04-21 2011-11-09 上海医药工业研究院 盐酸齐拉西酮半水合物的制备方法
CN102234273B (zh) * 2010-04-21 2015-08-05 上海医药工业研究院 甲磺酸齐拉西酮半水合物及其制备方法
SI3325444T1 (sl) 2015-07-20 2021-11-30 Acadia Pharmaceuticals Inc. Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C
WO2017165635A1 (fr) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Association de pimavansérine et de modulateurs du cytochrome p450
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2018118626A1 (fr) 2016-12-20 2018-06-28 Acadia Pharmaceuticals Inc. Pimavansérine seule ou en association pour une utilisation dans le traitement de la psychose liée à la maladie d'alzheimer
CN108239085A (zh) * 2016-12-26 2018-07-03 四川科瑞德凯华制药有限公司 一种甲磺酸齐拉西酮的纯化及制备方法
US11135211B2 (en) 2017-04-28 2021-10-05 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
EP3675827A1 (fr) 2017-08-30 2020-07-08 Acadia Pharmaceuticals Inc. Formulations de pimavansérine
CN112724066B (zh) * 2021-02-04 2022-10-21 海南鑫开源医药科技有限公司 一种盐酸齐拉西酮中间体中的二卤杂质及其制备方法
CN116046966A (zh) * 2023-01-17 2023-05-02 北京协和建昊医药技术开发有限责任公司 一种流动相配置装置及其配置方法

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US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5312925A (en) * 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5338846A (en) * 1992-08-26 1994-08-16 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt
US5359068A (en) * 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one
WO1997017336A1 (fr) 1995-11-07 1997-05-15 Pfizer Inc. Procedes et intermediaires de preparation de 3-(1-piperazinyl)-1,2-benzisothiazole
NZ508303A (en) * 1996-05-07 2001-07-27 Pfizer Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2(1H)-indol-2-one (ziprasidone) useful as a dopamine D2 antagonist
TW491847B (en) 1996-05-07 2002-06-21 Pfizer Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
US6150366A (en) * 1998-06-15 2000-11-21 Pfizer Inc. Ziprasidone formulations

Also Published As

Publication number Publication date
KR20040086417A (ko) 2004-10-08
ECSP045239A (es) 2004-09-28
GT200300040A (es) 2007-01-12
SV2004001485A (es) 2004-05-07
CN1635892A (zh) 2005-07-06
PA8567001A1 (es) 2003-12-10
ES2283745T3 (es) 2007-11-01
DK1476162T3 (da) 2007-07-02
CN101735212A (zh) 2010-06-16
KR100773622B1 (ko) 2007-11-05
UA77057C2 (en) 2006-10-16
CO5611138A2 (es) 2006-02-28
GEP20074030B (en) 2007-02-12
EA200400815A1 (ru) 2004-12-30
MXPA04006993A (es) 2004-11-10
AP2004003103A0 (en) 2004-09-30
WO2003070246A1 (fr) 2003-08-28
CA2475302C (fr) 2009-05-12
NO20100584L (no) 2004-09-17
BR0307833A (pt) 2004-12-07
EP1476162B1 (fr) 2007-04-18
EP1476162A1 (fr) 2004-11-17
TNSN04159A1 (fr) 2007-03-12
CA2475302A1 (fr) 2003-08-28
CY1106467T1 (el) 2012-01-25
EA007866B1 (ru) 2007-02-27
IL163277A (en) 2010-05-31
AU2003206035A1 (en) 2003-09-09
PL372238A1 (en) 2005-07-11
NZ534443A (en) 2007-07-27
PE20030942A1 (es) 2003-11-08
RS60404A (sr) 2006-10-27
NO20043902L (no) 2004-09-17
SI1476162T1 (sl) 2007-08-31
JP2005525347A (ja) 2005-08-25
ZA200406276B (en) 2005-09-20
HRP20040711A2 (en) 2004-12-31
DE60313289D1 (de) 2007-05-31
MY139523A (en) 2009-10-30
OA12774A (en) 2006-07-04
TW200307546A (en) 2003-12-16
AU2009202008A1 (en) 2009-06-11
DE60313289T2 (de) 2007-12-27
JP4554938B2 (ja) 2010-09-29
UY27668A1 (es) 2003-10-31
AR038563A1 (es) 2005-01-19
IS7344A (is) 2004-07-05
PT1476162E (pt) 2007-06-25
ATE359787T1 (de) 2007-05-15

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