NO20031853D0 - Spiro-pyrimidin-2,4,6-trion metalloproteinase inhibitorer - Google Patents

Spiro-pyrimidin-2,4,6-trion metalloproteinase inhibitorer

Info

Publication number: NO20031853D0
Authority: NO; Norway
Prior art keywords: spiro; pyrimidine; metalloproteinase inhibitors; trione metalloproteinase; trione
Prior art date: 2000-10-26

Application number

NO20031853A

Other languages

English (en)

Other versions

NO20031853L (no

Inventor

Brian Scott Bronk

Marc Carl Noe

Martin James Wythes

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-26

Filing date

2003-04-24

Publication date

2003-04-24

2003-04-24 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2003-04-24 Publication of NO20031853D0 publication Critical patent/NO20031853D0/no

2003-06-23 Publication of NO20031853L publication Critical patent/NO20031853L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Gynecology & Obstetrics (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Pregnancy & Childbirth (AREA)
Hematology (AREA)
Cardiology (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)

NO20031853A 2000-10-26 2003-04-24 Spiro-pyrimidin-2,4,6-trion metalloproteinaseinhibitorer NO20031853L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24338900P	2000-10-26	2000-10-26
PCT/IB2001/001986 WO2002034753A2 (en)	2000-10-26	2001-10-23	Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors

Publications (2)

Publication Number	Publication Date
NO20031853D0 true NO20031853D0 (no)	2003-04-24
NO20031853L NO20031853L (no)	2003-06-23

Family

ID=22918584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20031853A NO20031853L (no)	2000-10-26	2003-04-24	Spiro-pyrimidin-2,4,6-trion metalloproteinaseinhibitorer

Country Status (32)

Country	Link
EP (1)	EP1332146A2 (no)
JP (1)	JP2004518635A (no)
KR (1)	KR20040004412A (no)
CN (1)	CN1501937A (no)
AP (1)	AP2001002318A0 (no)
AR (1)	AR035069A1 (no)
AU (1)	AU2002210813A1 (no)
BG (1)	BG107653A (no)
BR (1)	BR0114913A (no)
CA (1)	CA2425283A1 (no)
CZ (1)	CZ20031083A3 (no)
EA (1)	EA005762B1 (no)
EC (1)	ECSP034567A (no)
EE (1)	EE200300196A (no)
GT (1)	GT200100213A (no)
HN (1)	HN2001000244A (no)
HR (1)	HRP20030332A2 (no)
HU (1)	HUP0301577A3 (no)
IL (1)	IL154948A0 (no)
IS (1)	IS6762A (no)
MA (1)	MA26957A1 (no)
MX (1)	MXPA03003735A (no)
NO (1)	NO20031853L (no)
OA (1)	OA12529A (no)
PA (1)	PA8531401A1 (no)
PE (1)	PE20020589A1 (no)
PL (1)	PL366201A1 (no)
SK (1)	SK4972003A3 (no)
SV (1)	SV2003000705A (no)
TN (1)	TNSN01149A1 (no)
WO (1)	WO2002034753A2 (no)
ZA (1)	ZA200302190B (no)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002064578A1 (en)	2001-02-14	2002-08-22	Warner-Lambert Company Llc	Benzo thiadiazine matrix metalloproteinase inhibitors
PA8539501A1 (es)	2001-02-14	2002-09-30	Warner Lambert Co	Compuestos triazolo como inhibidores de mmp
DOP2002000332A (es)	2001-02-14	2002-08-30	Warner Lambert Co	Inhibidores de piridina de metaloproteinasas de la matriz
DOP2002000333A (es)	2001-02-14	2002-09-30	Warner Lambert Co	Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
BR0207209A (pt)	2001-02-14	2004-01-27	Warner Lambert Co	Inibidores de metaloproteinase de matriz de pirimidina
US6924276B2 (en)	2001-09-10	2005-08-02	Warner-Lambert Company	Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
US6962922B2 (en)	2001-10-12	2005-11-08	Warner-Lambert Company Llc	Alkynylated quinazoline compounds
MXPA04002537A (es)	2001-10-12	2004-05-31	Warner Lambert Co	Alquinos como inhibidores de metaloproteinasa de matriz.
US6894057B2 (en)	2002-03-08	2005-05-17	Warner-Lambert Company	Oxo-azabicyclic compounds
AU2003228701A1 (en) *	2002-04-25	2003-11-10	Bristol-Myers Squibb Company	Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases
WO2003091258A1 (en) *	2002-04-26	2003-11-06	Pfizer Products Inc.	N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
ATE304015T1 (de) *	2002-04-26	2005-09-15	Pfizer Prod Inc	Triaryl-oxy-aryl-spiro-pyrimidin-2, 4, 6-trion metalloproteinase inhibitoren
MXPA05001603A (es) *	2002-08-13	2005-04-25	Warner Lambert Co	Derivados monociclicos como inhibidores de metaloproteinasa de matriz.
AU2003253186A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
PA8578101A1 (es)	2002-08-13	2004-05-07	Warner Lambert Co	Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
WO2004014378A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
AU2003253150A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Chromone derivatives as matrix metalloproteinase inhibitors
WO2004014375A2 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Fused bicyclic metalloproteinase inhibitors
WO2004014908A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Heterobicylcic metalloproteinase inhibitors
AU2003250470A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidinone fused bicyclic metalloproteinase inhibitors
CA2497656A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
WO2004014866A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Azaisoquinoline derivatives as matrix metalloproteinase inhibitors
US7208490B2 (en)	2002-10-07	2007-04-24	Pharmacia & Upjohn Company Llc	Tricyclic tetrahydroquinoline antibacterial agents
GB0223249D0 (en) *	2002-10-08	2002-11-13	Amersham Plc	Improved imaging agents
WO2004084903A1 (en) *	2003-03-27	2004-10-07	F. Hoffmann-La Roche Ag	Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis
WO2004084902A1 (en) *	2003-03-28	2004-10-07	F. Hoffmann-La Roche Ag	Use of a trioxopyrimidine for the treatment of chronic wounds
FR2858232B1 (fr) *	2003-07-29	2006-03-03	Pierre Potier	Utilisation d'un derive de biguanide pour proteger la peau des radiations uvb
BRPI0509562A (pt) *	2004-04-01	2007-09-25	Hoffmann La Roche	uso de uma trioxopirimidina para o tratamento e a prevenção de doenças inflamatórias brÈnquicas
DOP2006000268A (es)	2005-12-22	2007-07-31	Pfizer Prod Inc	Agentes antibacterianos
US8153166B2 (en) *	2006-06-08	2012-04-10	Chih-Hsiung Lin	Composition for prophylaxis or treatment of urinary system infection and method thereof
CN102285934B (zh) *	2009-01-08	2013-08-14	四川大学	螺环二烯酮衍生物及其制备方法和用途
HRP20180647T1 (hr) *	2012-12-10	2018-06-01	Chugai Seiyaku Kabushiki Kaisha	Derivat hidantoina
KR101594506B1 (ko) *	2014-03-20	2016-02-17	한국화학연구원	골 관련 질환 치료용 조성물
CN106572994B (zh)	2014-06-09	2020-09-18	中外制药株式会社	含有乙内酰脲衍生物的药物组合物
EP3886853A4 (en)	2018-11-30	2022-07-06	Nuvation Bio Inc.	DIARYLHYDANTOI COMPOUNDS AND METHODS OF USE THEREOF
CN110092790B (zh) *	2019-06-11	2020-07-24	东北农业大学	一种生物碱类化合物及其制备方法和应用
WO2025226892A1 (en) *	2024-04-24	2025-10-30	Septerna, Inc.	Spirocycle-containing diaminomethylene pyrimidine-2,4,6-trione agonists of parathyroid hormone 1 and incretin receptors
WO2025226895A1 (en) *	2024-04-24	2025-10-30	Septerna, Inc.	Agonists of parathyroid hormone 1 and incretin receptors comprising substituted or modified diaminomethylene pyrimidine-2,4,6-triones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3714093A (en) *	1970-05-19	1973-01-30	American Home Prod	Spiro [heterocycloalkyl-2'(1'h)-quinazoline]-4'(3'h)-ones
CA2294259A1 (en) *	1997-06-21	1998-12-30	Roche Diagnostics Gmbh	Barbituric acid derivatives with antimetastatic and antitumor activity
US6265578B1 (en) *	1999-02-12	2001-07-24	Hoffmann-La Roche Inc.	Pyrimidine-2,4,6-triones
HN2000000137A (es) *	1999-08-12	2001-02-02	Pfizer Prod Inc	Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas

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Also Published As

Publication number	Publication date
NO20031853L (no)	2003-06-23
PL366201A1 (en)	2005-01-24
ZA200302190B (en)	2004-04-28
HRP20030332A2 (en)	2003-06-30
EE200300196A (et)	2003-10-15
CN1501937A (zh)	2004-06-02
HUP0301577A3 (en)	2006-02-28
BR0114913A (pt)	2003-07-01
WO2002034753A3 (en)	2002-08-15
PE20020589A1 (es)	2002-07-06
IL154948A0 (en)	2003-10-31
AR035069A1 (es)	2004-04-14
CA2425283A1 (en)	2002-05-02
TNSN01149A1 (fr)	2005-11-10
MXPA03003735A (es)	2003-07-28
HN2001000244A (es)	2003-11-07
JP2004518635A (ja)	2004-06-24
EP1332146A2 (en)	2003-08-06
EA005762B1 (ru)	2005-06-30
WO2002034753A2 (en)	2002-05-02
EA200300306A1 (ru)	2003-08-28
ECSP034567A (es)	2003-06-25
BG107653A (bg)	2003-12-31
CZ20031083A3 (cs)	2004-03-17
HUP0301577A2 (hu)	2003-11-28
OA12529A (en)	2006-06-02
IS6762A (is)	2003-03-27
SV2003000705A (es)	2003-01-13
AU2002210813A1 (en)	2002-05-06
KR20040004412A (ko)	2004-01-13
GT200100213A (es)	2002-07-03
MA26957A1 (fr)	2004-12-20
AP2001002318A0 (en)	2001-12-31
SK4972003A3 (en)	2004-05-04
PA8531401A1 (es)	2003-06-30

Publication	Publication Date	Title
EE200300196A (et)	2003-10-15	Spiropürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid
EE200300195A (et)	2003-10-15	Pürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid
ATE308544T1 (de)	2005-11-15	N-substituiete heteroaryloxy-aryl-spiro- pyrimidine-2,4,6-trion metalloproteinase inhibitoren
EE200200069A (et)	2003-04-15	Metalloproteinaaside inhibiitoriteks olevad pürimidiin-3,4,6-trioonid
ATE237329T1 (de)	2003-05-15	Metalloprotease inhibitoren
ATE484496T1 (de)	2010-10-15	Metalloproteinaseinhibitoren
ATE304015T1 (de)	2005-09-15	Triaryl-oxy-aryl-spiro-pyrimidin-2, 4, 6-trion metalloproteinase inhibitoren
EE200300439A (et)	2003-12-15	Metalloproteinaasi inhibiitorid
CY2012007I1 (el)	2014-07-02	Πεπτιδομιμητικοι αναστολεις πρωτεασης
EE200300452A (et)	2004-02-16	Metalloproteinaasi inhibiitorid
DK1272488T3 (da)	2006-07-17	Tri-aryl-substitueret ethan-PDE4-inhibitorer
NO20014243L (no)	2001-10-17	Dihetero-substituerte metalloproteaseinhibitorer
IT1318444B1 (it)	2003-08-25	Dispositivo di autotrasfusione intraoperatoria.
ID29320A (id)	2001-08-23	Fluida-fluida kental bebas padatan
MA25758A1 (fr)	2003-04-01	Inhibiteurs de protease.
NO20025005L (no)	2002-12-06	Proteaseinhibitorer
DE50110971D1 (de)	2006-10-26	Werkzeughalter
AR028075A1 (es)	2003-04-23	Inhibidores de la peptido-desformilasa
NO20032328L (no)	2003-07-02	Proteaseinhibitorer
FI20002561A0 (fi)	2000-11-22	Haketusterä
ITNO20000008A0 (it)	2000-10-24	Progetto anubi

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