DK1272488T3 - Tri-aryl-substitueret ethan-PDE4-inhibitorer - Google Patents

Tri-aryl-substitueret ethan-PDE4-inhibitorer

Info

Publication number: DK1272488T3
Authority: DK; Denmark
Prior art keywords: tri; aryl; pde4 inhibitors; substituted ethane; ethane
Prior art date: 2000-03-23

Application number

DK01914905T

Other languages

English (en)

Inventor

Richard Friesen

Yves Ducharme

Bernard Cote

Marc Blouin

Daniel Guay

Pierre Hamel

Mario Girard

Richard Frenette

Evelyn Martins

Sebastien Laliberte

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-23

Filing date

2001-03-19

Publication date

2006-07-17

2001-03-19 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

2006-07-17 Application granted granted Critical

2006-07-17 Publication of DK1272488T3 publication Critical patent/DK1272488T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Immunology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Otolaryngology (AREA)

DK01914905T 2000-03-23 2001-03-19 Tri-aryl-substitueret ethan-PDE4-inhibitorer DK1272488T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US19166800P	2000-03-23	2000-03-23

Publications (1)

Publication Number	Publication Date
DK1272488T3 true DK1272488T3 (da)	2006-07-17

Family

ID=22706424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01914905T DK1272488T3 (da)	2000-03-23	2001-03-19	Tri-aryl-substitueret ethan-PDE4-inhibitorer

Country Status (16)

Country	Link
US (2)	US6399636B2 (da)
EP (1)	EP1272488B1 (da)
JP (1)	JP4944337B2 (da)
AR (1)	AR029240A1 (da)
AT (1)	ATE321043T1 (da)
AU (2)	AU4217201A (da)
CA (1)	CA2403423C (da)
DE (1)	DE60118165T2 (da)
DK (1)	DK1272488T3 (da)
ES (1)	ES2258521T3 (da)
JO (1)	JO2212B1 (da)
MY (1)	MY123585A (da)
PE (1)	PE20011115A1 (da)
PT (1)	PT1272488E (da)
TW (1)	TW575572B (da)
WO (1)	WO2001070738A2 (da)

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DE4328352A1 (de) *	1993-08-24	1995-03-02	Hoechst Ag	Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
MY123585A (en) *	2000-03-23	2006-05-31	Merck Canada Inc	Tri-aryl-substituted-ethane pde4 inhibitors.
US6639077B2 (en) *	2000-03-23	2003-10-28	Merck Frosst Canada & Co.	Tri-aryl-substituted-ethane PDE4 inhibitors
US6699890B2 (en)	2000-12-22	2004-03-02	Memory Pharmaceuticals Corp.	Phosphodiesterase 4 inhibitors
US7153871B2 (en)	2001-01-22	2006-12-26	Memory Pharmaceuticals Corporation	Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
US7205320B2 (en)	2001-01-22	2007-04-17	Memory Pharmaceuticals Corp.	Phosphodiesterase 4 inhibitors
JP2004535437A (ja) *	2001-06-22	2004-11-25	メルク　エンド　カムパニー　インコーポレーテッド	チロシンキナーゼ阻害剤
NZ532279A (en) *	2001-09-19	2006-02-24	Altana Pharma Ag	Combination of a PDE inhibitor and a leukotriene receptor antagonist
JP2005538972A (ja) *	2002-07-02	2005-12-22	メルクフロストカナダアンドカンパニー	ジアリール置換エタンピリドンｐｄｅ４阻害剤
JP2006502995A (ja)	2002-07-19	2006-01-26	メモリー・ファーマシューティカルズ・コーポレイション	ホスホジエステラーゼ４阻害剤としての６−アミノ−１ｈ−インダゾール及び４−アミノベンゾフラン化合物
EP1539697A1 (en)	2002-07-19	2005-06-15	Memory Pharmaceutical Corporation	Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
US6872724B2 (en)	2002-07-24	2005-03-29	Merck & Co., Inc.	Polymorphs with tyrosine kinase activity
AU2003288901A1 (en) *	2002-09-06	2004-03-29	Merck And Co., Inc.	Treatment of rheumatoid arthritis by inhibition of pde4
US20060069115A1 (en) *	2002-11-15	2006-03-30	Scolnick Edward M	Use of pde4 inhibitors as adjunct therapy for psychiatric disorders
MXPA05005345A (es)	2002-11-19	2005-08-26	Memory Pharm Corp	Inhibidores de fosfodiesterasa 4.
US20060040981A1 (en) *	2002-11-22	2006-02-23	Daniel Dube	Use of phosphodiesterase-4 inhibitors as enhancers of cognition
DE60330187D1 (de)	2002-12-30	2009-12-31	Celgene Corp	Fluoralkoxy-substituierte 1, 3-dihydro-isoindolyl-verbindungen und ihre pharmazeutischen verwendungen
CN1761466A (zh) *	2003-03-17	2006-04-19	协和发酵工业株式会社	慢性皮肤疾病的治疗及/或预防剂
CN1913882A (zh) *	2004-02-06	2007-02-14	Meda制药有限及两合公司	用抗胆碱能药单独或联合抗组胺药、磷酸二酯酶4抑制剂或皮质类固醇来治疗鼻炎
BRPI0713768A2 (pt)	2006-07-05	2012-10-30	Nycomed Gmbh	combinação de inibidores de reductase de hmg-coa com inibidores de fosfodiesterase 4 para o tratamento de doenças pulmonares inflamatórias
US20150119399A1 (en)	2012-01-10	2015-04-30	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
AU2021280418A1 (en) *	2020-05-28	2023-02-02	Giiant Pharma Inc.	Gut microbiota bioactivated PDE4 inhibitor precursors

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GB9212673D0 (en)	1992-06-15	1992-07-29	Celltech Ltd	Chemical compounds
GB9212693D0 (en)	1992-06-15	1992-07-29	Celltech Ltd	Chemical compounds
ATE144248T1 (de)	1992-07-01	1996-11-15	Hoechst Ag	3,4,5-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
GB9222253D0 (en)	1992-10-23	1992-12-09	Celltech Ltd	Chemical compounds
US5622977A (en)	1992-12-23	1997-04-22	Celltech Therapeutics Limited	Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
GB9226830D0 (en)	1992-12-23	1993-02-17	Celltech Ltd	Chemical compounds
DE4306152A1 (de)	1993-02-27	1994-09-01	Hoechst Ag	Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial
GB9304920D0 (en)	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
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DE4318756A1 (de)	1993-06-05	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9326699D0 (en)	1993-12-22	1994-03-02	Celltech Ltd	Chemical compounds
GB9326173D0 (en)	1993-12-22	1994-02-23	Celltech Ltd	Chemical compounds and process
WO1995017399A1 (en)	1993-12-22	1995-06-29	Celltech Therapeutics Limited	Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors
US5786354A (en)	1994-06-21	1998-07-28	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives and processes for their preparation
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GB9412571D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9412573D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9412672D0 (en)	1994-06-23	1994-08-10	Celltech Ltd	Chemical compounds
EP0765867A1 (de)	1995-09-27	1997-04-02	Hoechst Aktiengesellschaft	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
EP0873310A1 (en) *	1995-12-15	1998-10-28	Merck Frosst Canada Inc.	Diphenyl pyridyl ethane derivatives as pde iv inhibitors
GB9603723D0 (en)	1996-02-22	1996-04-24	Merck & Co Inc	Diphenyl pyridyl derivatives as pde iv inhibitors
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GB9526246D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526243D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526245D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
DE19622370A1 (de)	1996-06-04	1997-12-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9625184D0 (en)	1996-12-04	1997-01-22	Celltech Therapeutics Ltd	Chemical compounds
PL334059A1 (en)	1996-12-11	2000-01-31	Basf Ag	Ketone benzamides useful as calpain inhibitors
SK284468B6 (sk)	1998-04-01	2005-04-01	Janssen Pharmaceutica N. V.	Pyridínový derivát, spôsob jeho prípravy a použitie, kompozícia s jeho obsahom a spôsob jej prípravy
MY123585A (en) *	2000-03-23	2006-05-31	Merck Canada Inc	Tri-aryl-substituted-ethane pde4 inhibitors.

2001
- 2001-03-13 MY MYPI20011169A patent/MY123585A/en unknown
- 2001-03-16 US US09/810,119 patent/US6399636B2/en not_active Expired - Fee Related
- 2001-03-19 DK DK01914905T patent/DK1272488T3/da active
- 2001-03-19 AU AU4217201A patent/AU4217201A/xx active Pending
- 2001-03-19 JP JP2001568939A patent/JP4944337B2/ja not_active Expired - Fee Related
- 2001-03-19 AU AU2001242172A patent/AU2001242172B2/en not_active Ceased
- 2001-03-19 ES ES01914905T patent/ES2258521T3/es not_active Expired - Lifetime
- 2001-03-19 AT AT01914905T patent/ATE321043T1/de active
- 2001-03-19 PT PT01914905T patent/PT1272488E/pt unknown
- 2001-03-19 CA CA2403423A patent/CA2403423C/en not_active Expired - Fee Related
- 2001-03-19 DE DE60118165T patent/DE60118165T2/de not_active Expired - Lifetime
- 2001-03-19 EP EP01914905A patent/EP1272488B1/en not_active Expired - Lifetime
- 2001-03-19 WO PCT/CA2001/000365 patent/WO2001070738A2/en not_active Ceased
- 2001-03-20 PE PE2001000258A patent/PE20011115A1/es not_active Application Discontinuation
- 2001-03-21 TW TW90106613A patent/TW575572B/zh not_active IP Right Cessation
- 2001-03-21 JO JO200136A patent/JO2212B1/en active
- 2001-03-22 AR ARP010101343A patent/AR029240A1/es unknown
2002
- 2002-03-20 US US10/102,552 patent/US6841564B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
TW575572B (en)	2004-02-11
US20020013347A1 (en)	2002-01-31
EP1272488A2 (en)	2003-01-08
US6841564B2 (en)	2005-01-11
AR029240A1 (es)	2003-06-18
CA2403423C (en)	2010-05-25
JP2003528099A (ja)	2003-09-24
JP4944337B2 (ja)	2012-05-30
ES2258521T3 (es)	2006-09-01
DE60118165D1 (en)	2006-05-11
CA2403423A1 (en)	2001-09-27
US20020173661A1 (en)	2002-11-21
ATE321043T1 (de)	2006-04-15
DE60118165T2 (de)	2006-12-14
WO2001070738A2 (en)	2001-09-27
MY123585A (en)	2006-05-31
AU4217201A (en)	2001-10-03
EP1272488B1 (en)	2006-03-22
WO2001070738A3 (en)	2002-08-01
JO2212B1 (en)	2004-10-07
PT1272488E (pt)	2006-07-31
PE20011115A1 (es)	2001-10-29
AU2001242172B2 (en)	2005-01-27
US6399636B2 (en)	2002-06-04

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CY2012007I2 (el)	2014-07-02	Πεπτιδομιμητικοι αναστολεις πρωτεασης
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DE60143309D1 (de)	2010-12-02	Ukturen
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DE60118868D1 (de)	2006-05-24	Turbomaschinenleitschaufel
DE10196064T1 (de)	2003-03-13	Halbleiterfotodektionsgerät
NO20025786L (no)	2003-02-12	Protaseinhibitorer
PT1339695E (pt)	2006-08-31	Inibidores da farnesiltransferase