EE200300195A - Pürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid - Google Patents

Pürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid

Info

Publication number: EE200300195A
Authority: EE; Estonia
Prior art keywords: pyrimidine; metalloproteinase inhibitors; trione metalloproteinase; trione; inhibitors
Prior art date: 2000-10-26

Application number

EEP200300195A

Other languages

English (en)

Inventor

Carl Noe Mark

Alan Reiter Lawrence

James Wythes Martin

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-26

Filing date

2001-10-17

Publication date

2003-10-15

2001-10-17 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2003-10-15 Publication of EE200300195A publication Critical patent/EE200300195A/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Dental Preparations (AREA)
Plural Heterocyclic Compounds (AREA)

EEP200300195A 2000-10-26 2001-10-17 Pürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid EE200300195A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24331400P	2000-10-26	2000-10-26
PCT/IB2001/001953 WO2002034726A2 (en)	2000-10-26	2001-10-17	Pyrimidine-2,4,6-trione metalloproteinase inhibitors

Publications (1)

Publication Number	Publication Date
EE200300195A true EE200300195A (et)	2003-10-15

Family

ID=36950891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300195A EE200300195A (et)	2000-10-26	2001-10-17	Pürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid

Country Status (36)

Country	Link
US (2)	US6706723B2 (et)
EP (1)	EP1332136A2 (et)
JP (1)	JP2004512327A (et)
KR (1)	KR20030061825A (et)
CN (1)	CN1714084A (et)
AP (1)	AP2001002319A0 (et)
AR (1)	AR035362A1 (et)
AU (1)	AU2002210800A1 (et)
BG (1)	BG107651A (et)
BR (1)	BR0114917A (et)
CA (1)	CA2425280A1 (et)
CR (1)	CR6939A (et)
CZ (1)	CZ20031069A3 (et)
EA (1)	EA200300409A1 (et)
EC (1)	ECSP034568A (et)
EE (1)	EE200300195A (et)
GT (1)	GT200100214A (et)
HN (1)	HN2001000243A (et)
HR (1)	HRP20030331A2 (et)
HU (1)	HUP0302337A3 (et)
IL (1)	IL154946A0 (et)
IS (1)	IS6749A (et)
MA (1)	MA26956A1 (et)
MX (1)	MXPA03003734A (et)
NO (1)	NO20031852L (et)
NZ (1)	NZ524774A (et)
OA (1)	OA12528A (et)
PA (1)	PA8531501A1 (et)
PE (1)	PE20020585A1 (et)
PL (1)	PL362919A1 (et)
SK (1)	SK4872003A3 (et)
SV (1)	SV2003000704A (et)
TN (1)	TNSN01150A1 (et)
UY (1)	UY26981A1 (et)
WO (1)	WO2002034726A2 (et)
ZA (1)	ZA200302192B (et)

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EP1368323B1 (en)	2001-02-14	2010-06-30	Warner-Lambert Company LLC	Pyrimidine matrix metalloproteinase inhibitors
DOP2002000333A (es)	2001-02-14	2002-09-30	Warner Lambert Co	Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
WO2002064578A1 (en)	2001-02-14	2002-08-22	Warner-Lambert Company Llc	Benzo thiadiazine matrix metalloproteinase inhibitors
DOP2002000332A (es)	2001-02-14	2002-08-30	Warner Lambert Co	Inhibidores de piridina de metaloproteinasas de la matriz
PA8539501A1 (es)	2001-02-14	2002-09-30	Warner Lambert Co	Compuestos triazolo como inhibidores de mmp
US6924276B2 (en)	2001-09-10	2005-08-02	Warner-Lambert Company	Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
US6962922B2 (en)	2001-10-12	2005-11-08	Warner-Lambert Company Llc	Alkynylated quinazoline compounds
EP1434585A1 (en)	2001-10-12	2004-07-07	Warner-Lambert Company LLC	Alkyne matrix metalloproteinase inhibitors
US7294624B2 (en) *	2001-12-20	2007-11-13	Bristol Myers Squibb Company	Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases
US6936620B2 (en)	2001-12-20	2005-08-30	Bristol Myers Squibb Company	Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases
US6894057B2 (en)	2002-03-08	2005-05-17	Warner-Lambert Company	Oxo-azabicyclic compounds
EP1501834B1 (en)	2002-04-26	2005-09-07	Pfizer Products Inc.	Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors
WO2003090751A1 (en) *	2002-04-26	2003-11-06	Pfizer Products Inc.	Pyrimidine-2, 4, 6-trione metallo-proteinase inhibitors
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EP1537098A1 (en)	2002-08-13	2005-06-08	Warner-Lambert Company LLC	Monocyclic derivatives as matrix metalloproteinase inhibitors
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AU2003250470A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidinone fused bicyclic metalloproteinase inhibitors
BR0313384A (pt)	2002-08-13	2005-07-12	Warner Lambert Co	Derivados de cromona como inibidores de metaloproteinases de matriz
JP2006504665A (ja)	2002-08-13	2006-02-09	ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー	マトリックスメタロプロテイナーゼ阻害剤としてのアザイソキノリン誘導体
WO2004014909A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
GB0223249D0 (en) *	2002-10-08	2002-11-13	Amersham Plc	Improved imaging agents
WO2004084903A1 (en) *	2003-03-27	2004-10-07	F. Hoffmann-La Roche Ag	Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis
WO2004084902A1 (en) *	2003-03-28	2004-10-07	F. Hoffmann-La Roche Ag	Use of a trioxopyrimidine for the treatment of chronic wounds
WO2004089294A2 (en)	2003-04-04	2004-10-21	Incyte Corporation	Compositions, methods and kits relating to her-2 cleavage
JP4584981B2 (ja) *	2004-04-01	2010-11-24	ユニベルシテ・ド・リエージュ	気管支炎症疾患の処置および予防のためのトリオキソピリミジンの使用
CA2568640C (en)	2004-06-04	2011-08-09	Teva Pharmaceutical Industries Ltd.	Pharmaceutical composition containing irbesartan
TW200806648A (en) *	2005-11-29	2008-02-01	Sankyo Co	Acid addition salts of dihydropyridine derivatives
TW200736245A (en) *	2005-11-29	2007-10-01	Sankyo Co	Acid addition salts of optically active dihydropyridine derivatives
EP2427438B1 (en) *	2009-05-05	2016-10-12	Cambria Pharmaceuticals, Inc.	Pyrimidine-2,4,6-triones for use in the treatment of amyotrophic lateral sclerosis
RU2400233C1 (ru)	2009-07-07	2010-09-27	Общество с ограниченной ответственностью "Вирфарм"	Способ лечения заболеваний печени различного генеза
KR101301533B1 (ko) *	2010-02-09	2013-09-04	한미사이언스 주식회사	암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체
HUE036408T2 (hu)	2011-03-14	2018-07-30	Boehringer Ingelheim Int	A leukotrién-termelés benzodioxán inhibitorai
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JP6080226B2 (ja)	2012-03-06	2017-02-15	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	他の活性物質と組み合わせたロイコトリエン産生阻害用ベンゾジオキサン
JP6080227B2 (ja)	2012-03-06	2017-02-15	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ロイコトリエン生成を阻害するためのベンゾジオキサン
WO2014014874A1 (en)	2012-07-17	2014-01-23	Boehringer Ingelheim International Gmbh	Pyrazole derivatives which inhibit leukotriene production
US9433623B2 (en) *	2012-09-14	2016-09-06	Elizabeth LEVINA	Medicinal drug with activity against gram positive bacteria, mycobacteria and fungi
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JP6353899B2 (ja)	2013-07-15	2018-07-04	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ロイコトリエン生成の阻害剤
US9573957B2 (en)	2013-07-15	2017-02-21	Boehringer Ingelheim International Gmbh	Inhibitors of leukotriene production
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CZ20031069A3 (cs) *	2000-10-26	2004-05-12	Pfizeráproductsáinc	Pyrimidin@@Ź@Ź@@trionové inhibitory metaloproteinasy

2001
- 2001-10-17 CZ CZ20031069A patent/CZ20031069A3/cs unknown
- 2001-10-17 AP APAP/P/2001/002319A patent/AP2001002319A0/en unknown
- 2001-10-17 JP JP2002537717A patent/JP2004512327A/ja not_active Withdrawn
- 2001-10-17 EP EP01978707A patent/EP1332136A2/en not_active Withdrawn
- 2001-10-17 PL PL01362919A patent/PL362919A1/xx not_active Application Discontinuation
- 2001-10-17 EA EA200300409A patent/EA200300409A1/ru unknown
- 2001-10-17 WO PCT/IB2001/001953 patent/WO2002034726A2/en not_active Ceased
- 2001-10-17 MX MXPA03003734A patent/MXPA03003734A/es unknown
- 2001-10-17 CN CNA018180841A patent/CN1714084A/zh active Pending
- 2001-10-17 SK SK487-2003A patent/SK4872003A3/sk unknown
- 2001-10-17 HU HU0302337A patent/HUP0302337A3/hu unknown
- 2001-10-17 NZ NZ524774A patent/NZ524774A/en unknown
- 2001-10-17 KR KR10-2003-7005756A patent/KR20030061825A/ko not_active Ceased
- 2001-10-17 CA CA002425280A patent/CA2425280A1/en not_active Abandoned
- 2001-10-17 IL IL15494601A patent/IL154946A0/xx unknown
- 2001-10-17 AU AU2002210800A patent/AU2002210800A1/en not_active Abandoned
- 2001-10-17 OA OA1200300122A patent/OA12528A/en unknown
- 2001-10-17 EE EEP200300195A patent/EE200300195A/et unknown
- 2001-10-17 BR BR0114917-2A patent/BR0114917A/pt not_active IP Right Cessation
- 2001-10-17 HR HR20030331A patent/HRP20030331A2/hr not_active Application Discontinuation
- 2001-10-23 UY UY26981A patent/UY26981A1/es not_active Application Discontinuation
- 2001-10-24 HN HN2001000243A patent/HN2001000243A/es unknown
- 2001-10-24 PE PE2001001051A patent/PE20020585A1/es not_active Application Discontinuation
- 2001-10-24 AR ARP010104976A patent/AR035362A1/es unknown
- 2001-10-25 SV SV2001000704A patent/SV2003000704A/es unknown
- 2001-10-25 US US10/032,837 patent/US6706723B2/en not_active Expired - Fee Related
- 2001-10-25 GT GT200100214A patent/GT200100214A/es unknown
- 2001-10-25 TN TNTNSN01150A patent/TNSN01150A1/fr unknown
- 2001-10-26 PA PA20018531501A patent/PA8531501A1/es unknown
2003
- 2003-03-17 IS IS6749A patent/IS6749A/is unknown
- 2003-03-19 ZA ZA200302192A patent/ZA200302192B/en unknown
- 2003-03-20 BG BG107651A patent/BG107651A/bg unknown
- 2003-03-26 CR CR6939A patent/CR6939A/es not_active Application Discontinuation
- 2003-04-21 MA MA27114A patent/MA26956A1/fr unknown
- 2003-04-24 NO NO20031852A patent/NO20031852L/no not_active Application Discontinuation
- 2003-04-25 EC EC2003004568A patent/ECSP034568A/es unknown
2004
- 2004-02-13 US US10/778,990 patent/US20050107414A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HUP0302337A3 (en)	2004-01-28
CR6939A (es)	2003-11-25
CZ20031069A3 (cs)	2004-05-12
WO2002034726A3 (en)	2002-10-17
BG107651A (bg)	2003-12-31
US20050107414A1 (en)	2005-05-19
PA8531501A1 (es)	2003-06-30
AP2001002319A0 (en)	2001-12-31
HRP20030331A2 (en)	2003-06-30
SK4872003A3 (en)	2004-08-03
NZ524774A (en)	2004-09-24
UY26981A1 (es)	2002-06-20
TNSN01150A1 (fr)	2005-11-10
KR20030061825A (ko)	2003-07-22
MXPA03003734A (es)	2003-07-28
MA26956A1 (fr)	2004-12-20
WO2002034726A9 (en)	2003-03-06
IS6749A (is)	2003-03-17
JP2004512327A (ja)	2004-04-22
PL362919A1 (en)	2004-11-02
SV2003000704A (es)	2003-01-13
AR035362A1 (es)	2004-05-12
AU2002210800A1 (en)	2002-05-06
NO20031852D0 (no)	2003-04-24
PE20020585A1 (es)	2002-07-06
HN2001000243A (es)	2002-11-07
US6706723B2 (en)	2004-03-16
HUP0302337A2 (hu)	2003-10-28
GT200100214A (es)	2002-07-03
US20020132822A1 (en)	2002-09-19
EA200300409A1 (ru)	2003-08-28
ECSP034568A (es)	2003-06-25
EP1332136A2 (en)	2003-08-06
IL154946A0 (en)	2003-10-31
NO20031852L (no)	2003-06-23
ZA200302192B (en)	2004-05-05
OA12528A (en)	2006-06-02
CN1714084A (zh)	2005-12-28
WO2002034726A2 (en)	2002-05-02
CA2425280A1 (en)	2002-05-02
BR0114917A (pt)	2003-07-01

Publication	Publication Date	Title
EE200300195A (et)	2003-10-15	Pürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid
NO20031853L (no)	2003-06-23	Spiro-pyrimidin-2,4,6-trion metalloproteinaseinhibitorer
NO20020662D0 (no)	2002-02-11	Pyrimidin-2,4,6-trion metalloproteinase inhibitorer
DK1303496T3 (da)	2007-12-27	Pyrimidinderivater
CY2015035I1 (el)	2016-04-13	Ενωσεις πυριμιδινης
NO20024127D0 (no)	2002-08-29	Pyrimidin-forbindelser
MA26881A1 (fr)	2004-12-20	5-alkyl-pyrido [2,3-d]pyrimidines inhibitrices de tyrosine-kinases.
DE60002193D1 (de)	2003-05-22	Metalloprotease inhibitoren
AU2003219410A8 (en)	2003-11-10	Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors
ATE433451T1 (de)	2009-06-15	Xanthin-phosphodiesteras-v-inhibitoren
ATE308544T1 (de)	2005-11-15	N-substituiete heteroaryloxy-aryl-spiro- pyrimidine-2,4,6-trion metalloproteinase inhibitoren
MA25996A1 (fr)	2003-12-31	Inhibiteurs de phosphodiesterase 4.
DK1272488T3 (da)	2006-07-17	Tri-aryl-substitueret ethan-PDE4-inhibitorer
NO20014243L (no)	2001-10-17	Dihetero-substituerte metalloproteaseinhibitorer
NO20032291D0 (no)	2003-05-21	Pyrimidinderivater
ATE277912T1 (de)	2004-10-15	Pyrimidine-2,4,6-trione als matrixmetalloproteinase-hemmer
AR028075A1 (es)	2003-04-23	Inhibidores de la peptido-desformilasa
ITNO20000008A0 (it)	2000-10-24	Progetto anubi
FI20002561A0 (fi)	2000-11-22	Haketusterä