NO20030393L - Effektiv ligand-mediert Ullmann-kobling av aniliner og azoler - Google Patents
Effektiv ligand-mediert Ullmann-kobling av aniliner og azolerInfo
- Publication number
- NO20030393L NO20030393L NO20030393A NO20030393A NO20030393L NO 20030393 L NO20030393 L NO 20030393L NO 20030393 A NO20030393 A NO 20030393A NO 20030393 A NO20030393 A NO 20030393A NO 20030393 L NO20030393 L NO 20030393L
- Authority
- NO
- Norway
- Prior art keywords
- azoles
- anilines
- ullmann coupling
- efficient ligand
- mediated ullmann
- Prior art date
Links
- 238000006887 Ullmann reaction Methods 0.000 title abstract 2
- 150000001448 anilines Chemical class 0.000 title abstract 2
- 150000003851 azoles Chemical class 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 229940123583 Factor Xa inhibitor Drugs 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- -1 phenyl-substituted azoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Executing Machine-Instructions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22093200P | 2000-07-26 | 2000-07-26 | |
| PCT/US2001/023541 WO2002008199A2 (fr) | 2000-07-26 | 2001-07-26 | Couplage ullmann entre anilines et azoles par médiation ligandaire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20030393D0 NO20030393D0 (no) | 2003-01-24 |
| NO20030393L true NO20030393L (no) | 2003-03-24 |
Family
ID=22825611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030393A NO20030393L (no) | 2000-07-26 | 2003-01-24 | Effektiv ligand-mediert Ullmann-kobling av aniliner og azoler |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6541639B2 (fr) |
| EP (1) | EP1307431B1 (fr) |
| JP (1) | JP2004504384A (fr) |
| KR (1) | KR20030060872A (fr) |
| CN (1) | CN1444565A (fr) |
| AT (1) | ATE307804T1 (fr) |
| AU (1) | AU2001280813A1 (fr) |
| BR (1) | BR0112746A (fr) |
| CA (1) | CA2417426A1 (fr) |
| DE (1) | DE60114424T2 (fr) |
| EC (1) | ECSP034453A (fr) |
| ES (1) | ES2251501T3 (fr) |
| HU (1) | HUP0301699A3 (fr) |
| IL (1) | IL153547A0 (fr) |
| IS (1) | IS6695A (fr) |
| MX (1) | MXPA03000686A (fr) |
| NO (1) | NO20030393L (fr) |
| NZ (1) | NZ523271A (fr) |
| PL (1) | PL361233A1 (fr) |
| RU (1) | RU2003103706A (fr) |
| WO (1) | WO2002008199A2 (fr) |
| ZA (1) | ZA200300039B (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2275395B1 (fr) * | 2001-04-24 | 2016-11-09 | Massachusetts Institute of Technology (MIT) | Formation de liaisons carbone-carbone catalysées au cuivre |
| CN100525763C (zh) * | 2002-03-05 | 2009-08-12 | 特兰斯泰克制药公司 | 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物 |
| AU2003255620A1 (en) * | 2002-05-31 | 2003-12-19 | Rhodia Chimie | Method of forming a carbon-carbon or carbon-heteroatom linkage |
| CN1684944A (zh) | 2002-08-02 | 2005-10-19 | 麻省理工学院 | 铜催化形成碳－杂原子和碳－碳键的方法 |
| US20040067995A1 (en) * | 2002-10-02 | 2004-04-08 | Wong Pancras C. | Novel combination of a factor Xa inhibitor and clopidogrel |
| BRPI0410436A (pt) * | 2003-05-20 | 2006-05-30 | Transtech Pharma Inc | antagonistas de rage como agentes para amiloidose reversa e doenças associadas com a mesma |
| US20090012300A1 (en) * | 2004-07-16 | 2009-01-08 | Mathilda Maria Henrica Lambers | Process for the Preparation of an (Hetero) Arylamine |
| MX394214B (es) | 2007-03-12 | 2025-03-24 | Intra Cellular Therapies Inc | Sintesis de gamma-carbolinas fusionadas con heterociclo substituido. |
| US8580833B2 (en) | 2009-09-30 | 2013-11-12 | Transtech Pharma, Inc. | Substituted imidazole derivatives and methods of use thereof |
| WO2013155506A1 (fr) | 2012-04-14 | 2013-10-17 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et nouveaux procédés |
| DK2968320T3 (da) | 2013-03-15 | 2021-02-01 | Intra Cellular Therapies Inc | Organiske forbindelser |
| AU2014360452C1 (en) | 2013-12-03 | 2019-05-16 | Intra-Cellular Therapies, Inc. | Novel methods |
| JP2017509677A (ja) | 2014-04-04 | 2017-04-06 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| MX365969B (es) | 2014-04-04 | 2019-06-21 | Intra Cellular Therapies Inc | Gamma-carbolinas fusionadas con heterociclos sustituidas con deuterio. |
| WO2015171951A1 (fr) * | 2014-05-07 | 2015-11-12 | The Regents Of The University Of Colorado, A Body Corporate | Composés 2-(4-aryl-1h-imidazol-1-yl)aniline |
| ES2863471T3 (es) | 2016-01-26 | 2021-10-11 | Intra Cellular Therapies Inc | Compuestos de piridopirroloquinoxalina, sus composiciones y usos |
| RU2733975C2 (ru) | 2016-03-25 | 2020-10-08 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
| WO2017172811A1 (fr) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Nouveaux co-cristaux |
| EP3436083A4 (fr) | 2016-03-28 | 2019-11-27 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et méthodes |
| WO2017172784A1 (fr) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Nouveaux sels et cristaux |
| JP7013454B2 (ja) | 2016-10-12 | 2022-02-15 | イントラ－セルラー・セラピーズ・インコーポレイテッド | アモルファス固体分散体 |
| US10906906B2 (en) | 2016-12-29 | 2021-02-02 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
| KR102398194B1 (ko) | 2017-03-24 | 2022-05-18 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 조성물 및 방법 |
| CN111093664B (zh) | 2017-07-26 | 2023-06-02 | 细胞内治疗公司 | 有机化合物 |
| JP7223742B2 (ja) | 2017-07-26 | 2023-02-16 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| TWI827583B (zh) | 2018-03-08 | 2024-01-01 | 美商英塞特公司 | 作為ＰＩ３Ｋ-γ抑制劑之胺基吡嗪二醇化合物 |
| MX2020009928A (es) | 2018-03-23 | 2021-01-08 | Intra Cellular Therapies Inc | Compuestos organicos. |
| MX2020013116A (es) | 2018-06-06 | 2021-05-12 | Intra Cellular Therapies Inc | Sales y cristales novedosos. |
| MX2020013335A (es) | 2018-06-08 | 2021-05-27 | Intra Cellular Therapies Inc | Metodos novedosos. |
| KR102778034B1 (ko) | 2018-06-11 | 2025-03-12 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
| WO2020010003A1 (fr) | 2018-07-02 | 2020-01-09 | Incyte Corporation | DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| EP3843738A4 (fr) | 2018-08-31 | 2022-06-01 | Intra-Cellular Therapies, Inc. | Nouvelles méthodes |
| JP7457000B2 (ja) | 2018-08-31 | 2024-03-27 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規方法 |
| WO2020113094A1 (fr) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Composés pyrrole et pyrazole et leurs procédés d'utilisation |
| EP3898581B1 (fr) | 2018-12-17 | 2025-08-27 | Intra-Cellular Therapies, Inc. | Synthèse de gamma-carbolines fusionnées à hétérocycles substitués |
| JP7520012B2 (ja) | 2018-12-17 | 2024-07-22 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 置換複素環縮合γ－カルボリンの合成 |
| US20210000822A1 (en) | 2019-07-07 | 2021-01-07 | Intra-Cellular Therapies, Inc. | Novel methods |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6372658A (ja) | 1986-09-17 | 1988-04-02 | Sumitomo Chem Co Ltd | ニトロジフエニルアミン類の製造方法 |
| US5705697A (en) | 1997-01-30 | 1998-01-06 | Xerox Corporation | Arylamine processes |
| ZA985247B (en) | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
-
2001
- 2001-07-25 US US09/912,950 patent/US6541639B2/en not_active Expired - Fee Related
- 2001-07-26 PL PL36123301A patent/PL361233A1/xx not_active Application Discontinuation
- 2001-07-26 BR BR0112746-2A patent/BR0112746A/pt not_active IP Right Cessation
- 2001-07-26 RU RU2003103706/04A patent/RU2003103706A/ru not_active Application Discontinuation
- 2001-07-26 EP EP01959231A patent/EP1307431B1/fr not_active Expired - Lifetime
- 2001-07-26 HU HU0301699A patent/HUP0301699A3/hu unknown
- 2001-07-26 JP JP2002514105A patent/JP2004504384A/ja active Pending
- 2001-07-26 ES ES01959231T patent/ES2251501T3/es not_active Expired - Lifetime
- 2001-07-26 MX MXPA03000686A patent/MXPA03000686A/es unknown
- 2001-07-26 AU AU2001280813A patent/AU2001280813A1/en not_active Abandoned
- 2001-07-26 DE DE60114424T patent/DE60114424T2/de not_active Expired - Fee Related
- 2001-07-26 CA CA002417426A patent/CA2417426A1/fr not_active Abandoned
- 2001-07-26 AT AT01959231T patent/ATE307804T1/de not_active IP Right Cessation
- 2001-07-26 KR KR10-2003-7001155A patent/KR20030060872A/ko not_active Withdrawn
- 2001-07-26 WO PCT/US2001/023541 patent/WO2002008199A2/fr not_active Ceased
- 2001-07-26 NZ NZ523271A patent/NZ523271A/en unknown
- 2001-07-26 IL IL15354701A patent/IL153547A0/xx unknown
- 2001-07-26 CN CN01813378A patent/CN1444565A/zh active Pending
-
2003
- 2003-01-02 ZA ZA200300039A patent/ZA200300039B/en unknown
- 2003-01-22 IS IS6695A patent/IS6695A/is unknown
- 2003-01-24 NO NO20030393A patent/NO20030393L/no not_active Application Discontinuation
- 2003-01-24 EC EC2003004453A patent/ECSP034453A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1444565A (zh) | 2003-09-24 |
| IS6695A (is) | 2003-01-22 |
| WO2002008199A2 (fr) | 2002-01-31 |
| WO2002008199A3 (fr) | 2002-06-13 |
| ZA200300039B (en) | 2004-04-02 |
| CA2417426A1 (fr) | 2002-01-31 |
| US20020099225A1 (en) | 2002-07-25 |
| HUP0301699A2 (hu) | 2003-12-29 |
| AU2001280813A1 (en) | 2002-02-05 |
| MXPA03000686A (es) | 2003-06-06 |
| NO20030393D0 (no) | 2003-01-24 |
| NZ523271A (en) | 2005-01-28 |
| PL361233A1 (en) | 2004-10-04 |
| ECSP034453A (es) | 2003-03-31 |
| ES2251501T3 (es) | 2006-05-01 |
| KR20030060872A (ko) | 2003-07-16 |
| EP1307431B1 (fr) | 2005-10-26 |
| DE60114424D1 (de) | 2005-12-01 |
| HUP0301699A3 (en) | 2004-03-29 |
| IL153547A0 (en) | 2003-07-06 |
| JP2004504384A (ja) | 2004-02-12 |
| ATE307804T1 (de) | 2005-11-15 |
| BR0112746A (pt) | 2003-09-09 |
| DE60114424T2 (de) | 2006-07-27 |
| EP1307431A2 (fr) | 2003-05-07 |
| RU2003103706A (ru) | 2004-08-10 |
| US6541639B2 (en) | 2003-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |