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EA200001129A2 - Способ получения 4-карбоксиамино-2-замещенного-1,2,3,4-тетрагидрохинолина - Google Patents

Способ получения 4-карбоксиамино-2-замещенного-1,2,3,4-тетрагидрохинолина

Info

Publication number
EA200001129A2
EA200001129A2 EA200001129A EA200001129A EA200001129A2 EA 200001129 A2 EA200001129 A2 EA 200001129A2 EA 200001129 A EA200001129 A EA 200001129A EA 200001129 A EA200001129 A EA 200001129A EA 200001129 A2 EA200001129 A2 EA 200001129A2
Authority
EA
Eurasian Patent Office
Prior art keywords
tetrahydrochinoline
carboxyamino
substitute
obtaining
ppsec
Prior art date
Application number
EA200001129A
Other languages
English (en)
Other versions
EA003668B1 (ru
EA200001129A3 (ru
Inventor
Дэвид Бернс Дэймон
Роберт Вэйн Даггер
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200001129A2 publication Critical patent/EA200001129A2/ru
Publication of EA200001129A3 publication Critical patent/EA200001129A3/ru
Publication of EA003668B1 publication Critical patent/EA003668B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Описываются способы получения ингибиторов ППСЭХ.
EA200001129A 1999-11-30 2000-11-29 Способ получения 4-карбоксиамино-2-замещенного-1, 2, 3, 4-тетрагидрохинолина EA003668B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (3)

Publication Number Publication Date
EA200001129A2 true EA200001129A2 (ru) 2001-06-25
EA200001129A3 EA200001129A3 (ru) 2001-10-22
EA003668B1 EA003668B1 (ru) 2003-08-28

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001129A EA003668B1 (ru) 1999-11-30 2000-11-29 Способ получения 4-карбоксиамино-2-замещенного-1, 2, 3, 4-тетрагидрохинолина

Country Status (44)

Country Link
US (1) US6313142B1 (ru)
EP (1) EP1125929B1 (ru)
JP (1) JP3579345B2 (ru)
KR (1) KR100408177B1 (ru)
CN (1) CN1173953C (ru)
AP (1) AP2000002011A0 (ru)
AR (1) AR029775A1 (ru)
AT (1) ATE315028T1 (ru)
AU (1) AU784694B2 (ru)
BG (1) BG105009A (ru)
BR (1) BR0005636A (ru)
CA (1) CA2327029C (ru)
CO (1) CO5261552A1 (ru)
CY (1) CY1104989T1 (ru)
CZ (1) CZ20004407A3 (ru)
DE (1) DE60025317T2 (ru)
DK (1) DK1125929T3 (ru)
DZ (1) DZ3079A1 (ru)
EA (1) EA003668B1 (ru)
EE (1) EE200000659A (ru)
ES (1) ES2254109T3 (ru)
GE (1) GEP20022798B (ru)
GT (1) GT200000190A (ru)
HN (1) HN2000000203A (ru)
HR (1) HRP20000804A2 (ru)
HU (1) HUP0004747A3 (ru)
ID (1) ID28489A (ru)
IL (1) IL139849A (ru)
IS (1) IS5715A (ru)
MA (1) MA25223A1 (ru)
NO (1) NO20006039L (ru)
NZ (1) NZ508509A (ru)
OA (1) OA11494A (ru)
PA (1) PA8503801A1 (ru)
PE (1) PE20010913A1 (ru)
PL (1) PL344208A1 (ru)
SG (1) SG102603A1 (ru)
SK (1) SK17792000A3 (ru)
TN (1) TNSN00230A1 (ru)
TW (1) TW591016B (ru)
UA (1) UA65615C2 (ru)
UY (1) UY26451A1 (ru)
YU (1) YU71500A (ru)
ZA (1) ZA200006947B (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
WO2003053368A2 (en) * 2001-12-19 2003-07-03 Atherogenics, Inc. Chalcone derivatives and their use to treat diseases
US7202247B2 (en) 2001-12-19 2007-04-10 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
AU2003230916A1 (en) * 2002-04-11 2003-10-27 Roar Holding Llc Ex vivo method for determination of cetp activity and efficacy of heart disease treatment
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7211672B2 (en) * 2002-10-04 2007-05-01 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
US20040181075A1 (en) * 2002-12-19 2004-09-16 Weingarten M. David Process of making chalcone derivatives
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
MXPA05005813A (es) 2002-12-20 2005-12-12 Pfizer Prod Inc Formas de dosificacion que comprenden un inhibidor de la cetp y un inhibidor de la hmg-coa reductasa.
JP2006523218A (ja) * 2003-03-04 2006-10-12 高砂香料工業株式会社 光学活性アミン類の製造方法
AU2004222436A1 (en) * 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of S-(2-(((1- (2-ethylbutyl) cyclohexyl)carbonyl) amino) phenyl)-2-methylpropanethioate
NZ542852A (en) * 2003-03-17 2008-09-26 Japan Tobacco Inc Pharmaceutical compositions of CETP inhibitors
TWI494102B (zh) * 2003-05-02 2015-08-01 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
CN1863778A (zh) * 2003-10-08 2006-11-15 伊莱利利公司 用于治疗血脂异常的化合物及方法
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
EA200700119A1 (ru) * 2004-06-24 2007-10-26 Эли Лилли Энд Компани Соединения и способы лечения дислипидемии
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
WO2006091674A1 (en) * 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
EP2134169A2 (en) 2007-03-09 2009-12-23 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
TW202409008A (zh) 2022-07-05 2024-03-01 荷蘭商新阿姆斯特丹製藥公司 奧比特拉(obicetrapib)鹽及彼等之製造方法與中間體

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7870M (ru) * 1968-11-08 1970-04-27
US3971789A (en) 1972-10-21 1976-07-27 John Wyeth & Brother Limited O-(4-Quinolylamino)benzamides
GB8432091D0 (en) 1984-12-19 1985-01-30 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
US4839368A (en) 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
GB8804444D0 (en) 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5231102A (en) 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US6140342A (en) 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
DE60025317D1 (de) 2006-03-30
ZA200006947B (en) 2002-05-27
ES2254109T3 (es) 2006-06-16
DZ3079A1 (fr) 2004-10-24
BG105009A (en) 2001-11-30
SG102603A1 (en) 2004-03-26
EA003668B1 (ru) 2003-08-28
UY26451A1 (es) 2001-06-29
AR029775A1 (es) 2003-07-16
IS5715A (is) 2001-05-31
PA8503801A1 (es) 2002-07-30
SK17792000A3 (sk) 2002-10-08
CY1104989T1 (el) 2010-03-03
EA200001129A3 (ru) 2001-10-22
PE20010913A1 (es) 2001-09-10
UA65615C2 (ru) 2004-04-15
DK1125929T3 (da) 2006-04-03
HRP20000804A2 (en) 2001-06-30
JP3579345B2 (ja) 2004-10-20
PL344208A1 (en) 2001-06-04
US6313142B1 (en) 2001-11-06
MA25223A1 (fr) 2001-07-02
AU784694B2 (en) 2006-06-01
GEP20022798B (en) 2002-09-25
TW591016B (en) 2004-06-11
TNSN00230A1 (fr) 2005-11-10
CO5261552A1 (es) 2003-03-31
NO20006039D0 (no) 2000-11-29
CA2327029A1 (en) 2001-05-30
YU71500A (sh) 2003-02-28
CA2327029C (en) 2005-08-09
EE200000659A (et) 2001-08-15
HU0004747D0 (ru) 2001-02-28
IL139849A (en) 2006-10-31
CN1302800A (zh) 2001-07-11
KR20010052012A (ko) 2001-06-25
EP1125929B1 (en) 2006-01-04
AU7178900A (en) 2001-05-31
KR100408177B1 (ko) 2003-12-01
IL139849A0 (en) 2002-02-10
ID28489A (id) 2001-05-31
CZ20004407A3 (cs) 2002-06-12
CN1173953C (zh) 2004-11-03
OA11494A (en) 2004-05-07
AP2000002011A0 (en) 2000-12-31
HUP0004747A2 (hu) 2001-10-28
NO20006039L (no) 2001-05-31
HN2000000203A (es) 2001-06-13
HUP0004747A3 (en) 2002-12-28
ATE315028T1 (de) 2006-02-15
GT200000190A (es) 2002-04-27
BR0005636A (pt) 2001-07-17
EP1125929A1 (en) 2001-08-22
JP2001163859A (ja) 2001-06-19
DE60025317T2 (de) 2006-08-03
HK1038007A1 (en) 2002-03-01
NZ508509A (en) 2001-06-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM