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MX2020013116A - Sales y cristales novedosos. - Google Patents

Sales y cristales novedosos.

Info

Publication number
MX2020013116A
MX2020013116A MX2020013116A MX2020013116A MX2020013116A MX 2020013116 A MX2020013116 A MX 2020013116A MX 2020013116 A MX2020013116 A MX 2020013116A MX 2020013116 A MX2020013116 A MX 2020013116A MX 2020013116 A MX2020013116 A MX 2020013116A
Authority
MX
Mexico
Prior art keywords
crystals
novel salts
novel
7hpyrido
quinoxalin
Prior art date
Application number
MX2020013116A
Other languages
English (en)
Inventor
Peng Li
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of MX2020013116A publication Critical patent/MX2020013116A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La divulgación proporciona una nueva forma de sal de bis-tosilato farmacéuticamente aceptable, nueva, estable, de 1-(4-fluorofenil)-4-((6bR,10aS)-3-metil-2,3,6b,9,10,10a-hexahidro -1H,7Hpirido[3',4':4,5]pirrolo[1,2,3-de]quinoxalin-8-il)-butan-1- ona, junto con métodos para preparar y usar la misma, y composiciones farmacéuticas que la comprende.
MX2020013116A 2018-06-06 2019-06-06 Sales y cristales novedosos. MX2020013116A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862681534P 2018-06-06 2018-06-06
PCT/US2019/035845 WO2019236889A1 (en) 2018-06-06 2019-06-06 Novel salts and crystals

Publications (1)

Publication Number Publication Date
MX2020013116A true MX2020013116A (es) 2021-05-12

Family

ID=68769581

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020013116A MX2020013116A (es) 2018-06-06 2019-06-06 Sales y cristales novedosos.

Country Status (11)

Country Link
US (2) US20200157100A1 (es)
EP (1) EP3628007B1 (es)
JP (1) JP7476115B2 (es)
KR (1) KR102888393B1 (es)
CN (1) CN112384218B (es)
AU (1) AU2019280850C1 (es)
BR (1) BR112020024885A2 (es)
CA (1) CA3102848A1 (es)
IL (2) IL279195B2 (es)
MX (1) MX2020013116A (es)
WO (1) WO2019236889A1 (es)

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IL304026B2 (en) 2017-03-24 2024-11-01 Intra Cellular Therapies Inc A pharmaceutical preparation containing 1-(4-fluoro-phenyl)-4-((Sa10,Rb6)-3-D2-2,2-methyl-2, 3, a10, 10, 9, b6- hexahydro-H7, H1- Pyrido[3',4',:4,5]pyrrolo[3,2,1-de]quioxalin-8-yl)-butan-1-one and its uses
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EP3765021A4 (en) 2018-03-16 2022-03-09 Intra-Cellular Therapies, Inc. NOVEL PROCESSES
CA3240552A1 (en) * 2018-06-11 2019-12-19 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
BR112021003655A2 (pt) 2018-08-31 2021-05-18 Intra-Cellular Therapies, Inc. métodos novos
CN118873536A (zh) 2018-08-31 2024-11-01 细胞内治疗公司 新方法
BR112022000231A2 (pt) 2019-07-07 2022-02-22 Intra Cellular Therapies Inc Novos métodos
EP4034119A4 (en) 2019-09-25 2023-10-18 Intra-Cellular Therapies, Inc. NOVEL METHODS
WO2021119334A1 (en) 2019-12-11 2021-06-17 Intra-Cellular Therapies, Inc. Organic compound
US20230312573A1 (en) * 2020-09-04 2023-10-05 Intra-Cellular Therapies, Inc. Novel salts, crystals, and co-crystals
CN115120593A (zh) * 2021-03-26 2022-09-30 上海博志研新药物技术有限公司 卢美哌隆药用盐、制备方法、含其的药物组合物及应用
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
WO2025240804A1 (en) 2024-05-16 2025-11-20 Intra-Cellular Therapies, Inc. Novel compositions, devices and methods

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Also Published As

Publication number Publication date
EP3628007A4 (en) 2020-05-20
CN112384218B (zh) 2024-04-26
KR20210018440A (ko) 2021-02-17
AU2019280850A1 (en) 2021-01-07
KR102888393B1 (ko) 2025-11-18
CA3102848A1 (en) 2019-12-12
IL321985A (en) 2025-09-01
IL279195B1 (en) 2025-08-01
EP3628007B1 (en) 2023-05-03
BR112020024885A2 (pt) 2021-03-09
JP7476115B2 (ja) 2024-04-30
CN112384218A (zh) 2021-02-19
AU2019280850C1 (en) 2025-02-13
EP3628007A1 (en) 2020-04-01
AU2019280850B2 (en) 2024-08-08
US20220281867A1 (en) 2022-09-08
WO2019236889A1 (en) 2019-12-12
JP2021527043A (ja) 2021-10-11
IL279195A (en) 2021-01-31
US12195464B2 (en) 2025-01-14
US20200157100A1 (en) 2020-05-21
IL279195B2 (en) 2025-12-01

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