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AU2003218629A1 - A building block forming a c-c or a c-hetero atom bond uponreaction - Google Patents

A building block forming a c-c or a c-hetero atom bond uponreaction

Info

Publication number
AU2003218629A1
AU2003218629A1 AU2003218629A AU2003218629A AU2003218629A1 AU 2003218629 A1 AU2003218629 A1 AU 2003218629A1 AU 2003218629 A AU2003218629 A AU 2003218629A AU 2003218629 A AU2003218629 A AU 2003218629A AU 2003218629 A1 AU2003218629 A1 AU 2003218629A1
Authority
AU
Australia
Prior art keywords
uponreaction
building block
hetero atom
block forming
atom bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003218629A
Inventor
Jakob Felding
Michael Anders Godskesen
Alex Haahr Gouliaev
Kim Birkebaerd Jensen
Mikkel Dybro Lundorf
Henrik Pedersen
Christian Sams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuevolution AS
Original Assignee
Nuevolution AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuevolution AS filed Critical Nuevolution AS
Publication of AU2003218629A1 publication Critical patent/AU2003218629A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1068Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU2003218629A 2002-03-15 2003-03-14 A building block forming a c-c or a c-hetero atom bond uponreaction Abandoned AU2003218629A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US36405602P 2002-03-15 2002-03-15
DKPA20020415 2002-03-15
US60/364,056 2002-03-15
DKPA200200415 2002-03-15
US43442302P 2002-12-19 2002-12-19
US60/434,423 2002-12-19
DKPA200201950 2002-12-19
DKPA200201950 2002-12-19
PCT/DK2003/000176 WO2003078446A2 (en) 2002-03-15 2003-03-14 A building block forming a c-c or a c-hetero atom bond upon reaction

Publications (1)

Publication Number Publication Date
AU2003218629A1 true AU2003218629A1 (en) 2003-09-29

Family

ID=28046589

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003218629A Abandoned AU2003218629A1 (en) 2002-03-15 2003-03-14 A building block forming a c-c or a c-hetero atom bond uponreaction

Country Status (4)

Country Link
US (1) US20050247001A1 (en)
EP (1) EP1487850A2 (en)
AU (1) AU2003218629A1 (en)
WO (1) WO2003078446A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2332896A3 (en) 2001-03-19 2012-09-26 President and Fellows of Harvard College Evolving new molecular function
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
DE60324778D1 (en) 2002-03-15 2009-01-02 Nuevolution As AN IMPROVED METHOD FOR SYNTHESIS OF MATTRESS-RELATED MOLECULES
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
CA2495881C (en) 2002-08-19 2014-07-08 The President And Fellows Of Harvard College Evolving new molecular function
CN1720331B (en) 2002-10-30 2013-01-02 纽韦卢森公司 Method for synthesizing bifunctional complexes
AU2003291964A1 (en) 2002-12-19 2004-07-14 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (en) 2003-02-21 2005-11-23 Nuevolution A/S Method for producing second-generation library
DE602004019764D1 (en) 2003-03-20 2009-04-16 Nuevolution As LIGATION-RELATED CODING OF SMALL MOLECULES
DK1670939T3 (en) 2003-09-18 2010-03-01 Nuevolution As Method for obtaining structural information on a coded molecule and method for selecting compounds
BRPI0417830B1 (en) 2003-12-17 2021-02-17 Praecis Pharmaceuticals Inc methods for synthesizing a molecule comprising a functional portion operably linked to a coding oligonucleotide
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
US7704925B2 (en) 2004-03-22 2010-04-27 Nuevolution A/S Ligational encoding using building block oligonucleotides
EP2368868A1 (en) 2005-10-28 2011-09-28 Praecis Pharmaceuticals Inc. Methods for identifying compounds of interest using encoded libraries
DK3018206T3 (en) * 2005-12-01 2021-11-15 Nuevolution As ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
DK3211126T3 (en) 2009-02-13 2020-12-21 X Chem Inc METHODS FOR FORMING AND SCREENING DNA-CODED LIBRARIES
EP2558577B1 (en) 2010-04-16 2018-12-12 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
EP3351631B1 (en) 2011-09-07 2020-11-04 X-Chem, Inc. Methods for tagging dna-encoded libraries
DK3392338T3 (en) 2012-07-13 2021-02-01 X Chem Inc DNA-CODED LIBRARIES WITH CODING OLIGONUCLEOTID BINDS WHICH CANNOT BE READ BY POLYMERASES
CN115820806A (en) 2016-06-16 2023-03-21 哈斯达克科学公司 Combinatorial synthesis of oligonucleotide-guided and documented encoded probe molecules
WO2018204420A1 (en) * 2017-05-02 2018-11-08 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
DK3853234T3 (en) 2018-09-18 2025-07-21 Nikang Therapeutics Inc FUSIONED TRICYCLIC RING DERIVATIVES AS SRC HOMOLOGY 2-PHOSPHATASE INHIBITORS

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3763281A (en) * 1970-06-26 1973-10-02 Stauffer Chemical Co Ureidoalkylphosphonates
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5770358A (en) * 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE246702T1 (en) * 1993-04-12 2003-08-15 Univ Northwestern METHOD FOR PREPARING OLIGONUCLEOTIDES
US5681943A (en) * 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US5473060A (en) * 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
US5571903A (en) * 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
US6165778A (en) * 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
US5503805A (en) * 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5843650A (en) * 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5830658A (en) * 1995-05-31 1998-11-03 Lynx Therapeutics, Inc. Convergent synthesis of branched and multiply connected macromolecular structures
US5780613A (en) * 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
ATE332368T1 (en) * 1997-01-21 2006-07-15 Gen Hospital Corp SELECTION OF PROTEINS USING RNA-PROTEIN FUSIONS
ES2209145T5 (en) * 1997-05-28 2009-10-30 Crescendo Biologics Ltd. RIBOSOME COMPLEXES AS SELECTION PARTICLES FOR IN VITRO DEVELOPMENT AND PROTEIN EVOLUTION.
GB9815163D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds
EP1073730A1 (en) * 1998-04-17 2001-02-07 Whitehead For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
KR20020033743A (en) * 1999-07-27 2002-05-07 추후기재 Peptide acceptor ligation methods
US6593088B1 (en) * 1999-08-27 2003-07-15 Japan Science And Technology Corporation Reversible photocoupling nucleic acid and phosphoroamidite
EP2332896A3 (en) * 2001-03-19 2012-09-26 President and Fellows of Harvard College Evolving new molecular function

Also Published As

Publication number Publication date
EP1487850A2 (en) 2004-12-22
WO2003078446A2 (en) 2003-09-25
US20050247001A1 (en) 2005-11-10
WO2003078446A3 (en) 2003-12-31

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase