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NO20015651L - New pharmaceutical combinations for NOS inhibitors - Google Patents

New pharmaceutical combinations for NOS inhibitors

Info

Publication number
NO20015651L
NO20015651L NO20015651A NO20015651A NO20015651L NO 20015651 L NO20015651 L NO 20015651L NO 20015651 A NO20015651 A NO 20015651A NO 20015651 A NO20015651 A NO 20015651A NO 20015651 L NO20015651 L NO 20015651L
Authority
NO
Norway
Prior art keywords
disorders
sleep
inhibitors
nos
nos inhibitors
Prior art date
Application number
NO20015651A
Other languages
Norwegian (no)
Other versions
NO20015651D0 (en
Inventor
Mario David Saltarelli
Iii John Adams Lowe
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20015651D0 publication Critical patent/NO20015651D0/en
Publication of NO20015651L publication Critical patent/NO20015651L/en

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Det beskrives nye farmasøytiske anvendelser av forbindelser som oppviser aktivitet som nitrogenoksydsyntase- (NOS) inhibitorer. Nærmere bestemt beskrives anvendelsen av NOS-inhibitorer, særlig selektive neuronale NOS-inhibitorer (nNOS), alene eller i kombinasjon med et annet virkestoff, særlig enten en SSRI- eller en NK-1-reseptorantagonist, til behandlingen av forstyrrelser eller tilstander hvor behandlingen kan bevirkes eller lettes ved endring av døgnrytmer. Eksempler på slike forstyrrelser og tilstander er blindhet, fedme, årstids-affektive forstyrrelser, bipolare forstyrrelser, jet lag, døgnrytmeforstyrrelser av søvn, søvnløshet, parasomnier, REM-søvnforstyrrelser, hypersomni, søvn/våken cyklusforstyrrelser, narkolepsi og søvnforstyrrelser assosiert med skiftarbeid eller uregelmessige arbeidstider; nattlig enurese og restless-legs syndrom.New pharmaceutical uses of compounds which exhibit activity as nitric oxide synthase (NOS) inhibitors are described. More specifically, the use of NOS inhibitors, in particular selective neuronal NOS inhibitors (nNOS), alone or in combination with another active substance, in particular either an SSRI or an NK-1 receptor antagonist, is described for the treatment of disorders or conditions where the treatment may caused or facilitated by changing circadian rhythms. Examples of such disorders and conditions are blindness, obesity, seasonal affective disorders, bipolar disorders, jet lag, circadian rhythm disturbances of sleep, insomnia, parasomnias, REM sleep disorders, hypersomnia, sleep / wake cycle disorders and sleep disorders or narcotic disorders. ; nocturnal enuresis and restless-legs syndrome.

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DE10001785A1 (en) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma Use of NK-1 receptor antagonists for treatment of restless legs syndrome
GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
DOP2002000467A (en) * 2001-10-10 2003-04-15 Pfizer Prod Inc 2-AMINO-6 (PHENYL REPLACED IN POSITIONS 2,4,5) -PIRIDINES
US6803470B2 (en) * 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
JP2009513491A (en) * 2003-06-24 2009-04-02 ノイロサーチ アクティーゼルスカブ Novel 8-aza-bicyclo [3.2.1] octane derivatives and their use as monoamine neurotransmitter reuptake inhibitors
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
CN101678019B (en) 2007-06-08 2016-03-30 詹森药业有限公司 Piperidine/piperazine derivatives
JP5443342B2 (en) 2007-06-08 2014-03-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Piperidine / piperazine derivatives
ES2483898T3 (en) 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Piperidine / Piperazine Derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine/Piperazine derivatives
WO2009147170A2 (en) 2008-06-05 2009-12-10 Janssen Pharmaceutica Nv Drug combinations comprising a dgat inhibitor and a ppar-agonist
US8889674B2 (en) 2009-03-05 2014-11-18 Shionogi & Co., Ltd. Piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonism
JP6440625B2 (en) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー Methods and compositions for treating schizophrenia
WO2020252383A2 (en) * 2019-06-14 2020-12-17 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9)
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