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NO20015651L - Nye farmasöytiske kombinasjoner for NOS inhibitorer - Google Patents

Nye farmasöytiske kombinasjoner for NOS inhibitorer

Info

Publication number
NO20015651L
NO20015651L NO20015651A NO20015651A NO20015651L NO 20015651 L NO20015651 L NO 20015651L NO 20015651 A NO20015651 A NO 20015651A NO 20015651 A NO20015651 A NO 20015651A NO 20015651 L NO20015651 L NO 20015651L
Authority
NO
Norway
Prior art keywords
disorders
sleep
inhibitors
nos
nos inhibitors
Prior art date
Application number
NO20015651A
Other languages
English (en)
Other versions
NO20015651D0 (no
Inventor
Mario David Saltarelli
Iii John Adams Lowe
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20015651D0 publication Critical patent/NO20015651D0/no
Publication of NO20015651L publication Critical patent/NO20015651L/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Det beskrives nye farmasøytiske anvendelser av forbindelser som oppviser aktivitet som nitrogenoksydsyntase- (NOS) inhibitorer. Nærmere bestemt beskrives anvendelsen av NOS-inhibitorer, særlig selektive neuronale NOS-inhibitorer (nNOS), alene eller i kombinasjon med et annet virkestoff, særlig enten en SSRI- eller en NK-1-reseptorantagonist, til behandlingen av forstyrrelser eller tilstander hvor behandlingen kan bevirkes eller lettes ved endring av døgnrytmer. Eksempler på slike forstyrrelser og tilstander er blindhet, fedme, årstids-affektive forstyrrelser, bipolare forstyrrelser, jet lag, døgnrytmeforstyrrelser av søvn, søvnløshet, parasomnier, REM-søvnforstyrrelser, hypersomni, søvn/våken cyklusforstyrrelser, narkolepsi og søvnforstyrrelser assosiert med skiftarbeid eller uregelmessige arbeidstider; nattlig enurese og restless-legs syndrom.
NO20015651A 1999-05-21 2001-11-20 Nye farmasöytiske kombinasjoner for NOS inhibitorer NO20015651L (no)

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PCT/IB2000/000295 WO2000071107A2 (en) 1999-05-21 2000-03-16 New pharmaceutical combinations for nos inhibitors

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DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
DOP2002000467A (es) * 2001-10-10 2003-04-15 Pfizer Prod Inc 2-amino-6 (fenilo sustituido en las posiciones 2,4,5)-piridinas
US6803470B2 (en) * 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
JP2009513491A (ja) * 2003-06-24 2009-04-02 ノイロサーチ アクティーゼルスカブ 新規な８−アザ−ビシクロ［３．２．１］オクタン誘導体、及びモノアミン神経伝達物質の再取り込み阻害剤としてのその使用
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
CN101678019B (zh) 2007-06-08 2016-03-30 詹森药业有限公司 哌啶/哌嗪衍生物
JP5443342B2 (ja) 2007-06-08 2014-03-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペリジン／ピペラジン誘導体
ES2483898T3 (es) 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Derivados de piperidina/piperazina
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
WO2009147170A2 (en) 2008-06-05 2009-12-10 Janssen Pharmaceutica Nv Drug combinations comprising a dgat inhibitor and a ppar-agonist
US8889674B2 (en) 2009-03-05 2014-11-18 Shionogi & Co., Ltd. Piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonism
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
WO2020252383A2 (en) * 2019-06-14 2020-12-17 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9)
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)

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GT200000071A (es) 2001-11-08
PE20010157A1 (es) 2001-02-16
MA26732A1 (fr) 2004-12-20
KR20020010916A (ko) 2002-02-06
WO2000071107A8 (en) 2002-01-24
HUP0301287A3 (en) 2005-03-29
BR0010820A (pt) 2002-03-05
JP2003523941A (ja) 2003-08-12
HRP20010862A2 (en) 2003-06-30
HUP0301287A2 (hu) 2003-08-28
NO20015651D0 (no) 2001-11-20
DZ3041A1 (fr) 2004-03-27
CA2374668A1 (en) 2000-11-30
OA11943A (en) 2006-04-12
PL358538A1 (en) 2004-08-09
ZA200109555B (en) 2004-04-07
TR200103351T2 (tr) 2002-06-21
AU2935300A (en) 2000-12-12
IS6126A (is) 2001-10-26
PA8494601A1 (es) 2002-08-29
CO5160295A1 (es) 2002-05-30
EA200101110A1 (ru) 2002-08-29
EP1178784A1 (en) 2002-02-13
IL145955A0 (en) 2002-07-25
WO2000071107A2 (en) 2000-11-30
HN2000000045A (es) 2001-03-02
TNSN00106A1 (fr) 2005-11-10
CN1617743A (zh) 2005-05-18
AP2001002326A0 (en) 2001-12-31
EE200100611A (et) 2003-02-17
BG106208A (en) 2002-09-30
AR022640A1 (es) 2002-09-04
MXPA01011978A (es) 2002-05-06
SK16602001A3 (sk) 2003-03-04
UY26148A1 (es) 2000-12-29

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