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NO20014234L - Pyrazol-3-on-derivater som faktor-Xa-inhibitorer - Google Patents

Pyrazol-3-on-derivater som faktor-Xa-inhibitorer

Info

Publication number
NO20014234L
NO20014234L NO20014234A NO20014234A NO20014234L NO 20014234 L NO20014234 L NO 20014234L NO 20014234 A NO20014234 A NO 20014234A NO 20014234 A NO20014234 A NO 20014234A NO 20014234 L NO20014234 L NO 20014234L
Authority
NO
Norway
Prior art keywords
pyrazol
inhibitors
derivatives
factor
prophylaxis
Prior art date
Application number
NO20014234A
Other languages
English (en)
Other versions
NO20014234D0 (no
Inventor
Dieter Dorsch
Horst Juraszyk
Werner Mederski
Christos Tsaklakidis
Hanns Wurziger
Sabine Bernotat-Danielowski
Guido Melzer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20014234D0 publication Critical patent/NO20014234D0/no
Publication of NO20014234L publication Critical patent/NO20014234L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye forbindelser med formel (I) R'-^N^o N-ti / \¿ R3 (I) hvor R1, R2, R3, R4, x og Y har de i patentkrav l angitte betydninger, er inhibitorer for koagulasjonsfaktoren Xa og kan anvendes til profylakse og/eller terapi av tromboemboliske sykdommer.
NO20014234A 1999-03-03 2001-08-31 Pyrazol-3-on-derivater som faktor-Xa-inhibitorer NO20014234L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19909237A DE19909237A1 (de) 1999-03-03 1999-03-03 Pyrazol-3-on-derivate
PCT/EP2000/001695 WO2000051989A1 (de) 1999-03-03 2000-02-29 Pyrazol-3-on-derivate als faktor xa inhibitoren

Publications (2)

Publication Number Publication Date
NO20014234D0 NO20014234D0 (no) 2001-08-31
NO20014234L true NO20014234L (no) 2001-10-24

Family

ID=7899522

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014234A NO20014234L (no) 1999-03-03 2001-08-31 Pyrazol-3-on-derivater som faktor-Xa-inhibitorer

Country Status (17)

Country Link
EP (1) EP1157010A1 (no)
JP (1) JP2002538143A (no)
KR (1) KR20010102428A (no)
CN (1) CN1342148A (no)
AU (1) AU2916500A (no)
BR (1) BR0008608A (no)
CA (1) CA2364908A1 (no)
CZ (1) CZ20013164A3 (no)
DE (1) DE19909237A1 (no)
HU (1) HUP0200242A3 (no)
MX (1) MXPA01008844A (no)
NO (1) NO20014234L (no)
PL (1) PL350941A1 (no)
RU (1) RU2001126566A (no)
SK (1) SK12152001A3 (no)
WO (1) WO2000051989A1 (no)
ZA (1) ZA200108064B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455525B1 (en) 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
WO2005012255A1 (ja) * 2003-08-01 2005-02-10 Mitsubishi Pharma Corporation 炎症性関節疾患の治療剤
DE102008020113A1 (de) 2008-04-23 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Substituierte Dihydropyrazolone und ihre Verwendung
DE102005019712A1 (de) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
DE102006050516A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
DE102006050513A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substitiuierte Dihydropyrazolone und ihre Verwendung
DE102006050515A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dipyridiyl-dihydropyrazolone und ihre Verwendung
DE102007044032A1 (de) 2007-09-14 2009-03-19 Bayer Healthcare Ag Substituierte heterocyclische Verbindungen und ihre Verwendung
DE102007048447A1 (de) 2007-10-10 2009-04-16 Bayer Healthcare Ag Substituierte Dihydropyrazolthione und ihre Verwendung
DE102010044131A1 (de) 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
JP3994453B2 (ja) * 1995-10-13 2007-10-17 日産化学工業株式会社 ピラゾロン類

Also Published As

Publication number Publication date
JP2002538143A (ja) 2002-11-12
HUP0200242A3 (en) 2002-12-28
BR0008608A (pt) 2002-01-02
PL350941A1 (en) 2003-02-24
EP1157010A1 (de) 2001-11-28
WO2000051989A1 (de) 2000-09-08
MXPA01008844A (es) 2002-05-14
SK12152001A3 (sk) 2002-03-05
DE19909237A1 (de) 2000-09-07
CN1342148A (zh) 2002-03-27
AU2916500A (en) 2000-09-21
CZ20013164A3 (cs) 2001-12-12
HUP0200242A2 (hu) 2002-11-28
NO20014234D0 (no) 2001-08-31
CA2364908A1 (en) 2000-09-08
RU2001126566A (ru) 2004-02-27
ZA200108064B (en) 2003-01-02
KR20010102428A (ko) 2001-11-15

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application