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NO992770L - Nye heterocyklisk substituerte benzamider og deres anvendelse ved bekjempelse av sykdommer - Google Patents

Nye heterocyklisk substituerte benzamider og deres anvendelse ved bekjempelse av sykdommer

Info

Publication number
NO992770L
NO992770L NO992770A NO992770A NO992770L NO 992770 L NO992770 L NO 992770L NO 992770 A NO992770 A NO 992770A NO 992770 A NO992770 A NO 992770A NO 992770 L NO992770 L NO 992770L
Authority
NO
Norway
Prior art keywords
heterocyclic substituted
substituted benzamides
novel heterocyclic
combating diseases
diseases
Prior art date
Application number
NO992770A
Other languages
English (en)
Other versions
NO992770D0 (no
Inventor
Wilfried Lubisch
Ller Achim M
Hans-J Rg Treiber
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO992770D0 publication Critical patent/NO992770D0/no
Publication of NO992770L publication Critical patent/NO992770L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Heterocyklisk substituerte benzamider med formel l er beskrevet, hvor R1, R2, R3, R4, R5, X, m og n har betydningene gitt i beskrivelsen. De nye forbindelser er nyttige for kontroll av sykdommer.
NO992770A 1996-12-09 1999-06-08 Nye heterocyklisk substituerte benzamider og deres anvendelse ved bekjempelse av sykdommer NO992770L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19650975A DE19650975A1 (de) 1996-12-09 1996-12-09 Neue heterocyclisch substituierte Benzamide und deren Anwendung
PCT/EP1997/006653 WO1998025899A1 (de) 1996-12-09 1997-11-28 Neue heterocyclisch substituierte benzamide und deren anwendung bei der bekämpfung von krankheiten

Publications (2)

Publication Number Publication Date
NO992770D0 NO992770D0 (no) 1999-06-08
NO992770L true NO992770L (no) 1999-06-08

Family

ID=7814035

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992770A NO992770L (no) 1996-12-09 1999-06-08 Nye heterocyklisk substituerte benzamider og deres anvendelse ved bekjempelse av sykdommer

Country Status (24)

Country Link
US (2) US6172072B1 (no)
EP (1) EP0946509A1 (no)
JP (1) JP2001505889A (no)
KR (1) KR20000057445A (no)
CN (1) CN1239949A (no)
AR (1) AR010339A1 (no)
AU (1) AU742732B2 (no)
BG (1) BG63388B1 (no)
BR (1) BR9713884A (no)
CA (1) CA2273988A1 (no)
CO (1) CO4910161A1 (no)
CZ (1) CZ292391B6 (no)
DE (1) DE19650975A1 (no)
HR (1) HRP970671A2 (no)
HU (1) HUP0000496A3 (no)
ID (1) ID22490A (no)
IL (1) IL129358A0 (no)
NO (1) NO992770L (no)
NZ (1) NZ335066A (no)
SK (1) SK56699A3 (no)
TR (1) TR199901282T2 (no)
TW (1) TW420666B (no)
WO (1) WO1998025899A1 (no)
ZA (1) ZA9710979B (no)

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* Cited by examiner, † Cited by third party
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JP2002512240A (ja) * 1998-04-20 2002-04-23 ビーエーエスエフ アクチェンゲゼルシャフト 複素環式置換基を有する新規アミド、その製造方法およびその使用
CA2389685C (fr) * 1999-11-05 2011-07-12 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R) Nouveaux composes heterocycliques et leur application a titre de medicaments
FR2800737B1 (fr) * 1999-11-05 2006-06-30 Sod Conseils Rech Applic Nouveaux composes heterocycliques et leur application a titre de medicaments
GB0031302D0 (en) 2000-12-21 2001-01-31 Glaxo Group Ltd Napthalene derivatives
KR100962972B1 (ko) 2002-07-26 2010-06-09 주식회사유한양행 1-페닐피페리딘-3-온 유도체 및 그의 제조방법
CA2505098A1 (en) 2002-11-12 2004-05-27 Merck & Co., Inc. Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
CA2536313A1 (en) * 2003-08-22 2005-03-03 Takeda Pharmaceutical Company Limited Fused pyrimidine derivative and use thereof
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
FR2863268B1 (fr) * 2003-12-09 2006-02-24 Sod Conseils Rech Applic Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments
RU2390520C2 (ru) * 2003-12-22 2010-05-27 Адзиномото Ко., Инк. Новые производные фенилаланина
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
US20070010537A1 (en) * 2004-08-20 2007-01-11 Kazumasa Hamamura Fused pyramidine derivative and use thereof
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7834023B2 (en) * 2006-09-20 2010-11-16 Portola Pharmaceuticals, Inc. Substituted dihydroquinazolines as platelet ADP receptor inhibitors
JP5295976B2 (ja) 2006-12-29 2013-09-18 アボット ゲーエムベーハー ウント カンパニー カーゲー カルボキサミド化合物およびカルパイン阻害剤としてのこれらの使用
ES2576643T3 (es) 2007-03-09 2016-07-08 Second Genome, Inc. Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos
TWI453019B (zh) 2007-12-28 2014-09-21 Abbvie Deutschland 甲醯胺化合物
TWI519530B (zh) 2009-02-20 2016-02-01 艾伯維德國有限及兩合公司 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途
US8236798B2 (en) 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
US9051304B2 (en) 2009-12-22 2015-06-09 AbbVie Deutschland GmbH & Co. KG Carboxamide compounds and their use as calpain inhibitors V
US8598211B2 (en) 2009-12-22 2013-12-03 Abbvie Inc. Carboxamide compounds and their use as calpain inhibitors IV
CN103599588B (zh) 2010-04-30 2017-04-26 雅培心脏血管系统股份有限公司 呈现迅速膨胀和收缩的改进型球囊导管
US9062027B2 (en) 2010-12-09 2015-06-23 AbbVie Deutschland GmbH & Co. KG Carboxamide compounds and their use as calpain inhibitors V
JP2015512427A (ja) 2012-04-03 2015-04-27 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー カルボキサミド化合物およびそれのカルパイン阻害薬ｖとしての使用
WO2017156071A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
WO2018064119A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

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GB8524663D0 (en) * 1985-10-07 1985-11-13 Fujisawa Pharmaceutical Co Quinazoline derivatives
DE3717828A1 (de) * 1987-05-27 1988-12-15 Hoechst Ag Siliziumhaltige benzoesaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz
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EP0473551A1 (de) * 1990-08-31 1992-03-04 Ciba-Geigy Ag 3-Aryluracil-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Unkrautbekämpfungsmittel
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US5541290A (en) 1993-06-24 1996-07-30 Harbeson; Scott L. Optically pure calpain inhibitor compounds

Also Published As

Publication number Publication date
CA2273988A1 (en) 1998-06-18
US6172072B1 (en) 2001-01-09
CN1239949A (zh) 1999-12-29
AU5558098A (en) 1998-07-03
CZ174399A3 (cs) 1999-08-11
SK56699A3 (en) 1999-10-08
NZ335066A (en) 2000-03-27
NO992770D0 (no) 1999-06-08
HUP0000496A2 (hu) 2000-09-28
JP2001505889A (ja) 2001-05-08
KR20000057445A (ko) 2000-09-15
TR199901282T2 (xx) 1999-10-21
BG103399A (en) 2000-01-31
TW420666B (en) 2001-02-01
AU742732B2 (en) 2002-01-10
WO1998025899A1 (de) 1998-06-18
US6436949B1 (en) 2002-08-20
CZ292391B6 (cs) 2003-09-17
AR010339A1 (es) 2000-06-07
DE19650975A1 (de) 1998-06-10
HUP0000496A3 (en) 2002-11-28
EP0946509A1 (de) 1999-10-06
HRP970671A2 (en) 1998-10-31
IL129358A0 (en) 2000-02-17
BG63388B1 (bg) 2001-12-29
ZA9710979B (en) 1999-06-18
CO4910161A1 (es) 2000-04-24
ID22490A (id) 1999-10-21
BR9713884A (pt) 2000-02-29

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