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NO178858C - Analogifremgangsmåte for fremstilling av substituerte 4-fenyl-4-piperidinkarboksamider med både lokal anestetisk og analgetisk effekt - Google Patents

Analogifremgangsmåte for fremstilling av substituerte 4-fenyl-4-piperidinkarboksamider med både lokal anestetisk og analgetisk effekt

Info

Publication number
NO178858C
NO178858C NO922380A NO922380A NO178858C NO 178858 C NO178858 C NO 178858C NO 922380 A NO922380 A NO 922380A NO 922380 A NO922380 A NO 922380A NO 178858 C NO178858 C NO 178858C
Authority
NO
Norway
Prior art keywords
piperidinecarboxamides
phenyl
local anesthetic
analgesic effect
analogous process
Prior art date
Application number
NO922380A
Other languages
English (en)
Norwegian (no)
Other versions
NO178858B (no
NO922380D0 (no
NO922380L (no
Inventor
Anna-Lena Ask
Rune Sandberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO922380D0 publication Critical patent/NO922380D0/no
Publication of NO922380L publication Critical patent/NO922380L/no
Publication of NO178858B publication Critical patent/NO178858B/no
Publication of NO178858C publication Critical patent/NO178858C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO922380A 1989-12-21 1992-06-17 Analogifremgangsmåte for fremstilling av substituerte 4-fenyl-4-piperidinkarboksamider med både lokal anestetisk og analgetisk effekt NO178858C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8904298A SE8904298D0 (sv) 1989-12-21 1989-12-21 New compounds
PCT/SE1990/000818 WO1991009845A1 (fr) 1989-12-21 1990-12-17 4-phenyle-4-piperidinecarboxamides substitues avec effet anesthesique et analgesique local et procedes pour leur preparation

Publications (4)

Publication Number Publication Date
NO922380D0 NO922380D0 (no) 1992-06-17
NO922380L NO922380L (no) 1992-06-17
NO178858B NO178858B (no) 1996-03-11
NO178858C true NO178858C (no) 1996-06-19

Family

ID=20377821

Family Applications (1)

Application Number Title Priority Date Filing Date
NO922380A NO178858C (no) 1989-12-21 1992-06-17 Analogifremgangsmåte for fremstilling av substituerte 4-fenyl-4-piperidinkarboksamider med både lokal anestetisk og analgetisk effekt

Country Status (40)

Country Link
US (2) US5227389A (fr)
EP (1) EP0506778B1 (fr)
JP (1) JP2656152B2 (fr)
KR (1) KR0179382B1 (fr)
CN (1) CN1037841C (fr)
AT (1) ATE138650T1 (fr)
AU (1) AU647068B2 (fr)
BG (1) BG60912B1 (fr)
BR (1) BR1100379A (fr)
CA (1) CA2069608C (fr)
CZ (1) CZ278035B6 (fr)
DE (1) DE69027221T2 (fr)
DK (1) DK0506778T3 (fr)
DZ (1) DZ1468A1 (fr)
EG (1) EG19361A (fr)
ES (1) ES2087280T3 (fr)
FI (1) FI100881B (fr)
HK (1) HK22997A (fr)
HR (1) HRP920591B1 (fr)
HU (1) HU213110B (fr)
IE (1) IE74855B1 (fr)
IL (1) IL96636A (fr)
IS (1) IS1664B (fr)
LT (1) LT4005B (fr)
LV (2) LV10949B (fr)
NO (1) NO178858C (fr)
NZ (1) NZ236293A (fr)
PL (1) PL163591B1 (fr)
PT (1) PT96303B (fr)
RO (1) RO112864B1 (fr)
RU (1) RU2039043C1 (fr)
SA (1) SA91110209B1 (fr)
SE (1) SE8904298D0 (fr)
SG (1) SG46413A1 (fr)
SI (1) SI9012346B (fr)
SK (1) SK278283B6 (fr)
UA (1) UA26403A (fr)
WO (1) WO1991009845A1 (fr)
YU (1) YU48086B (fr)
ZA (1) ZA909903B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3916092B2 (ja) * 1993-09-17 2007-05-16 杏林製薬株式会社 イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) * 1994-02-11 1994-02-11 Astra Ab New compounds
SE9404438D0 (sv) * 1994-12-21 1994-12-21 Astra Ab New process
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
GB9600235D0 (en) * 1996-01-05 1996-03-06 Pfizer Ltd Therapeutic agents
DE19642591A1 (de) * 1996-10-15 1998-04-16 Basf Ag Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
RU2125878C1 (ru) * 1996-12-26 1999-02-10 Новокузнецкий научно-исследовательский химико-фармацевтический институт Анальгетическое средство
RU2117481C1 (ru) * 1997-07-15 1998-08-20 Государственный научно-исследовательский институт органической химии и технологии Анальгетическое средство и способ его приготовления
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US20020102291A1 (en) * 1997-12-15 2002-08-01 Noven Pharmaceuticals, Inc. Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
SE9803240D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
SE9803239D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab Composition for the treatment of acute pain
ES2340147T3 (es) * 2001-04-12 2010-05-31 Pharmacopeia, Llc Piperidinas de arilo y biarilo usadas como antagonistas de mch.
RU2203041C1 (ru) * 2001-12-27 2003-04-27 Закрытое акционерное общество "Брынцалов-А" Спазмолитические таблетки бралангин
ES2356306T3 (es) * 2002-02-08 2011-04-06 Ono Pharmaceutical Co., Ltd. Compuestos y fármacos derivados de piperidina que contienen los compuestos como principio activo.
US7645771B2 (en) * 2002-12-13 2010-01-12 Smithkline Beecham Corp. CCR5 antagonists as therapeutic agents
CL2007002958A1 (es) * 2006-10-12 2008-05-09 Epix Delaware Inc Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
JP2011506466A (ja) 2007-12-11 2011-03-03 株式会社サイトパスファインダー カルボキサミド化合物ならびにケモカイン受容体アゴニストとしてのそれらの使用
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
WO2020152212A1 (fr) 2019-01-22 2020-07-30 Icm (Institut Du Cerveau Et De La Moelle Épinière) Anesthésique local pour le traitement de symptômes neurologiques résultant de dysfonctionnements cérébraux

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE96980C1 (fr)
US2486796A (en) * 1943-06-25 1949-11-01 Ciba Pharm Prod Inc Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) * 1964-10-20 1967-08-01 Aldrich Chem Co Inc N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) * 1967-06-26 1970-11-10 Janssen Pharm 4-aryl-4-aminoalkoxy-piperidines
CH498836A (de) * 1968-12-20 1970-11-15 Geigy Ag J R Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) * 1968-12-30 1973-06-05 Ciba Geigy Corp Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) * 1971-10-21 1973-06-01 Synthelabo 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) * 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

Also Published As

Publication number Publication date
DE69027221D1 (de) 1996-07-04
AU647068B2 (en) 1994-03-17
BG60912B1 (bg) 1996-06-28
WO1991009845A1 (fr) 1991-07-11
HRP920591A2 (en) 1997-08-31
DK0506778T3 (da) 1996-10-07
KR0179382B1 (ko) 1999-03-20
SI9012346B (sl) 1999-08-31
IS3659A7 (is) 1991-06-22
LV5766B4 (lv) 1997-06-20
LV5766A4 (lv) 1996-12-20
JPH05502869A (ja) 1993-05-20
RU2039043C1 (ru) 1995-07-09
PL163591B1 (pl) 1994-04-29
NO178858B (no) 1996-03-11
BR1100379A (pt) 1999-12-07
UA26403A (uk) 1999-08-30
HU213110B (en) 1997-02-28
DZ1468A1 (fr) 2004-09-13
YU234690A (sh) 1993-10-20
CA2069608A1 (fr) 1991-06-22
BG96513A (bg) 1993-12-24
HK22997A (en) 1997-02-27
KR927003531A (ko) 1992-12-18
SE8904298D0 (sv) 1989-12-21
NZ236293A (en) 1992-10-28
AU6978391A (en) 1991-07-24
DE69027221T2 (de) 1996-10-10
LV10949A (lv) 1995-12-20
IS1664B (is) 1997-07-04
FI922806L (fi) 1992-06-17
RO112864B1 (ro) 1998-01-30
FI922806A0 (fi) 1992-06-17
ES2087280T3 (es) 1996-07-16
PT96303A (pt) 1991-09-30
SA91110209B1 (ar) 2004-05-08
NO922380D0 (no) 1992-06-17
PT96303B (pt) 1998-07-31
SK658190A3 (en) 1996-08-07
NO922380L (no) 1992-06-17
US5360805A (en) 1994-11-01
ZA909903B (en) 1991-08-28
FI100881B (fi) 1998-03-13
JP2656152B2 (ja) 1997-09-24
CZ658190A3 (en) 1993-01-13
IL96636A (en) 1994-11-28
PL288409A1 (en) 1991-12-02
CA2069608C (fr) 2001-07-10
LV10949B (en) 1996-06-20
CN1037841C (zh) 1998-03-25
ATE138650T1 (de) 1996-06-15
HRP920591B1 (en) 1998-12-31
SG46413A1 (en) 1998-02-20
HU9202044D0 (en) 1992-09-28
CN1053605A (zh) 1991-08-07
IE74855B1 (en) 1997-08-13
CZ278035B6 (en) 1993-07-14
EG19361A (en) 1994-12-30
EP0506778B1 (fr) 1996-05-29
US5227389A (en) 1993-07-13
HUT64518A (en) 1994-01-28
IL96636A0 (en) 1991-09-16
SK278283B6 (en) 1996-08-07
LT4005B (en) 1996-07-25
EP0506778A1 (fr) 1992-10-07
SI9012346A (sl) 1998-08-31
IE904534A1 (en) 1991-07-03
YU48086B (sh) 1997-01-08
LTIP1731A (en) 1995-07-25

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