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NO169711B - Analogifremgangsmaate ved fremstilling av terapeutisk aktive etylendiaminmonoamid-derivater - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive etylendiaminmonoamid-derivater Download PDF

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Publication number
NO169711B
NO169711B NO853390A NO853390A NO169711B NO 169711 B NO169711 B NO 169711B NO 853390 A NO853390 A NO 853390A NO 853390 A NO853390 A NO 853390A NO 169711 B NO169711 B NO 169711B
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arm
locking
hooks
rod
drawer
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NO853390A
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NO169711C (no
NO853390L (no
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Rene Imhof
Emilio Kyburz
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Hoffmann La Roche
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Priority claimed from CH4132/84A external-priority patent/CH661043A5/de
Priority claimed from CH2404/85A external-priority patent/CH664755A5/de
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO853390L publication Critical patent/NO853390L/no
Publication of NO169711B publication Critical patent/NO169711B/no
Publication of NO169711C publication Critical patent/NO169711C/no

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07ORGANIC CHEMISTRY
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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Description

Hurtigkopling, særlig for tilkopling av en
gravemaskinskuffe til en gravearm.
Foreliggende oppfinnelse angår en hurtigkopling og er spesielt beregnet for hurtig å kunne tilkople en gravemaskinskuffe til en gravearm av den art der det tilnærmet parallelt med gravearmen forløper en aksialt bevegbar stang, f.eks. stempelstangen til en hydraulisk sylinder som skal bevirke en svingning av skuffen.
Normalt er en gravemaskinskuffe utstyrt med "ører hvortil gravearm og den aksialt bevegbare stang tilkoples skuffen ved hjelp av bolter. Dette er en sikker og robust konstruksjon. Imidlertid kan det ved slikt graveutstyr ofte være ønskelig å montere skuffen med åpningen rettet motsatt vei, det vil si forandre gravemaskinen fra en forgraver til en bakgraver eller omvendt. På det tidligere kjente utstyr må da boltene som sammenbinder skuffens"ører med gravearm og den aksialt forskyvbare stang tas ut. Deretter kan gravearm og stang fjernes fra skuffen og denne dreies l80° i forhold til gravemaskinen.
Deretter settes arm og stang på plass og boltene skyves inn og låses. Denne måte å snu skuffen på er temmelig tidskrevende og kan ved enkelte arbeider der det er bruk for hyppig å kunne skifte fra for-til bakgraver, gi seg kraftig utslag i arbeidsomkostningene.
Ved en tidligere kjent konstruksjon er den aksialt forskyvbare stang forsynt med et sviveledd ved den ende som er forbundet
er
med skuffen. Denne ende forbundet med skuffen omtrent midt på skuffens ene side, og begge de hosliggende hjørner er forsynt med hull for tilkopling til gravearmen. I dette tilfelle er det for omskifting til ny graveretning nok å slå løs bolten for gravearmen og dreie skuffen l80° og feste gravearmen i det andre hull. Ved denne konstruksjon sparer man halve arbeidet ved skifting til ny graveretning. Imidlertid må allikevel gravemaskinkjøreren ned å slå ut den ene bolten, og man få i tillegg til dette en mere komplisert konstruksjon.
Foreliggende oppfinnelse tar sikte på å fremskaffe en hurtigkopling som-muliggjør en meget rask tilkopling av en grave-maskinskuff e til en gravearm og som således vil sette ned arbeidsomkostningene ved slike arbeider der det kreves hyppig skifting fra for- til bakgraver.
Hurtigkoplingen ifølge oppfinnelsen er karakterisert ved to i forhold til hverandre sammenhengslede låsearmer på hvilke det --er anordnet utad rettede haker, hvilke armer er dreibart opphengt i gravearmens og den aksialt forskyvbare stangs ytterende på en slik måte at hakene kan beveges fra hverandre ved en aksial bevegelse av gravearm og/eller stang, for låsing av hakene under kantene i en åpning i skuffen.
Ved en foretrukket utførelsesform er den ene låsearms ender leddbart forbundet med gravearmens og den aksialt forskyvbare stangs ytterender og den andre låsearm er leddbart forbundet med- den første låsearm. •
Ved en annen utførelsesform er de to låsearmer omtrent ved midten leddbart forbundet med hverandre til en saks og gravearmen og den aksialt forskyvbare stang er leddbart forbundet med hver sin arm og den frie ende av saksarmene er tildannet til utad åpne haker. De to låsearmene kan fastgjøres til hverandre i den stilling der hakene ligger i låsestilling i skuffens åpning. En hensiktsmessig låsing av låsearmen i forhold til hverandre er ved hjelp av en løs-tagbar bolt som skyves inn i hull<*>i låsearmene, hvilke hull korres-ponderer med hverandre i koplingens låsestilling i skuffen. ;Foruten at det ved hjelp av konstruksjonen ifølge oppfinnelsen blir lettere å skifte skuffens graveretning, så vil man på samme enkle måte kunne skifte fra en skuffetype^ til en annen. Ved enkelte arbeider kan det være aktuelt, relativt ofte å skifte skuffe-type, f.eks. fra en bred masseskuffe til en noe smalere graveskuffe. ;Oppfinnelsen skal i det følgende forklares nærmere ved hjelp av tegningen som viser to forskjellige utførelsesformer for oppfinnelsen. ;Fig. 1 viser i perspektiv hurtigkoplingen idet den er på vei inn i åpningen i gravemaskinskuffen. Det samme er vist i fig. 2, men her sett rett fra siden. ;I fig. 3 er hurtigkoplingen på plass i skuffen. ;Fig. 4 viser en annen utførelsesform for hurtigkoplingen ;idet den føres inn i skuffens åpning. ;I det første eksempel (fig. 1,2 og 3) er gravearmen 1 og én aksialet forskyvbar stang 2 ved sine ender leddbart forbundet med endene av en første låsearm 3* Denne låsearm har en hake 4 hvis
åpning vender mot gravearmen 1. Til armen 3 er det leddbart forbundet ved punktet 5 en annen låsearm 6 med hake 7- Denne hakes åpning vender mot den aksialt forskyvbare stang 2. Armen 3 er mellom sine oppheng-ningspunkter i gravearm og stang forsynt med et hull 8 som i koplingens låsestilling (fig. 3) stemmer overens med et hull 9 i den annen
arm 6. I Senne stilling kan armene 3 og 6 låses til hverandre ved
hjelp av en bolt eller pinne 10, som for lettvint å kunne trekkes ut og inn ér forsynt med et håndtak 11. Armenes 3 og 6 utad åpne haker 4 og 7 samvirker med en åpning 12 i skuffens 13 øvre del. Denne åpning
12 begrenses langs to motstående kanter av partier 14 og 15 hvis form
stemmer overens med hakenes 4°g 7 åpninger. Disse partiene som på
to motstående kanter begrenser åpningen 12 i skuffen 13 bør ha en avrundet form og utgjøres i eksemplet av rør.
I fig. 4 er det vist en annen utførelsesform for!<k>o<p>lingen, idet to armer 16 og 17 er omtrent vei midten sammenleddet til en saks hvis to'øvre armpar er leddbart forbundet til gravearmen 1 og den aksialt bevegbare stang 2. De nedre frie endene på armene 16 og 17 er tildanjiet til haker med utad vendende åpninger. Koplingen føres
inn i skuffeås åpning slik at hakene hviler mot kantene 14 og 15 og ved å føre gravearm 1 og stang 2 ytterligere nedover Vil hakene
■ I i
presses utover og gå i inngrep med kantene 14 og 15 når armene 16 og 17 er parallelle slik at det kan skyves inn en bolt i åpningene 18 og 19.
For å få mulighet for større svingning av skuffen med en be-stemt forlengelse av staget 2, så kan låsearmen 6 være forsynt med et ekstra hull 20, slik at staget 2 kan hengsles i hullet 8 og hullet 20 låses sammen med hullene i enden av arnen 3 i innretningens låsestill-r ing med skuffen. Dermed forkortes avstanden mellom opphengningspunkt-
et for gravearmen 1 og det forlengbare stag og den nevnte virkning opp-nås.
På grunn av de spesielle forhold som en graveskuffe utsettes
for vil det oppstå stor slitasje ved koplingens innfesting i skuffen,
og det kan derfor være hensiktsmessig å anordne utskiftbare bolter som forløper på tvers av skuffen og sette koplingen fast til disse isteden-for til åpningens kanter.

Claims (3)

1. Hurtigkopling, særlig for tilkopling av en gravemaskinskuffe til en gravearm (l) av den art der det parallellt med gravearmen for-løper en aksialt bevegbar stang (2), f.eks. stempelstangen til en hydraulisk sylinder som kan bevirke en svingning av skuffen, karakt-
r i s e r t ved to i forhold til hverandre sammenhengslede låsearmer (3,6 og 16,17) på hvilke det er anordnet utad rettede haker (4,7), hvilke låsearmer (3,6 og 16,17) er dreibart opphengt i armens (1) og den aksialt forskyvbare stangs (2) ytterende på en slik måte at hakene (4,7) kan beveges fra hverandre ved eh aksial bevegelse av gravearmen (1) og/eller stangen (2), for fastlåsing av hakene (4i7) under kantene (14,15) i en åpning (12) i skuffen (13).
2. Hurtigkopling ifølge krav 1, karakterisert ved at den ene låsearms (3) ender er leddbart forbundet med gravearmens (1) og den aksialt forskyvbare stangs (2) ytterende og at den andre låsearmen (6) er leddbart forbundet med den første låsearm (3).
3. Hurtigkopling ifølge krav 1, karakterisert ved at de to låsearmer (16,17) omtrent ved midten er leddet sammen til en saks og at gravearmen (1) og den aksialt forskyvbare stang (2) er leddbart forbundet med hver sin arm (16,17) og ftt de frie ender av armene (16,17) er tildannet til utad åpne haker. 4« Hurtigkopling ifølge krav 1, 2 eller 3, karakter! se-r t ved at de to lasea»er kan fastgjøres «iu „ inge ,ed hakene I låsestilling i skuffen ^ ' Sl" stU1" 5- Hurtigkopling ifølre krav I t «t d. to lasearaer i lIsestiUinTlr \ ' 1P av en gjenno-gaende bolt (lo" U-
NO853390A 1984-08-29 1985-08-28 Analogifremgangsmaate ved fremstilling av terapeutisk aktive etylendiaminmonoamid-derivater NO169711C (no)

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Application Number Priority Date Filing Date Title
CH4132/84A CH661043A5 (en) 1984-08-29 1984-08-29 Ethylenediamine monoamide derivatives
CH2404/85A CH664755A5 (de) 1985-06-05 1985-06-05 Aethylendiaminmonoamid-derivat.

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NO853390L NO853390L (no) 1986-03-03
NO169711B true NO169711B (no) 1992-04-21
NO169711C NO169711C (no) 1992-07-29

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Publication number Priority date Publication date Assignee Title
US5204482A (en) * 1988-07-28 1993-04-20 Hoffman-Laroche Inc. Compounds for treating and preventing cognitive diseases and depression and methods of making same
EP0352581A3 (de) * 1988-07-28 1990-07-04 F. Hoffmann-La Roche Ag Aethylendiaminmonoamid-Derivate
CA2245055C (en) * 1989-02-28 2003-03-25 F. Hoffmann-La Roche Ag Amidation of pyridines
EP0451790A1 (de) * 1990-04-12 1991-10-16 Hoechst Aktiengesellschaft 3,5-disubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu deren Herstellung, diese enthaltende Mittel und ihre Verwendung
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AU4663685A (en) 1986-03-06
DE3530046C2 (de) 1997-12-04
GB2163746A (en) 1986-03-05
BG60401B1 (en) 1995-02-28
ES8705372A1 (es) 1987-05-01
FR2569694A1 (fr) 1986-03-07
JPH07300417A (ja) 1995-11-14
LU86049A1 (de) 1986-09-11
SE464083B (sv) 1991-03-04
IE58788B1 (en) 1993-11-17
KR870002078A (ko) 1987-03-30
PT81041B (pt) 1988-01-22
ATA251585A (de) 1990-05-15
ES546482A0 (es) 1987-05-01
DE3530046A1 (de) 1986-03-13
DK162888B (da) 1991-12-23
PT81041A (en) 1985-09-01
NO169711C (no) 1992-07-29
JPS6160657A (ja) 1986-03-28
FI83511C (fi) 1991-07-25
GB8521358D0 (en) 1985-10-02
BG96645A (bg) 1993-12-24
KR920007269B1 (ko) 1992-08-29
SE8504014L (sv) 1986-03-01
DK162888C (da) 1992-05-11
HU197309B (en) 1989-03-28
NL8502374A (nl) 1986-03-17
SE8504014D0 (sv) 1985-08-28
FR2569694B1 (fr) 1991-05-03
CA1261335A (en) 1989-09-26
JPH0825879B2 (ja) 1996-03-13
FI853140A0 (fi) 1985-08-15
AR244209A1 (es) 1993-10-29
HUT38317A (en) 1986-05-28
PH22813A (en) 1988-12-27
IL76176A0 (en) 1985-12-31
GR852071B (no) 1985-12-24
IT1190385B (it) 1988-02-16
ES552399A0 (es) 1987-11-01
MC1696A1 (fr) 1986-07-18
AU582381B2 (en) 1989-03-23
JPH0764817B2 (ja) 1995-07-12
NL193583C (nl) 2000-03-02
IT8521865A0 (it) 1985-08-05
FI83511B (fi) 1991-04-15
DK391485D0 (da) 1985-08-28
NZ213193A (en) 1989-10-27
BE903110A (fr) 1986-02-24
IE852118L (en) 1986-02-28
ES8800158A1 (es) 1987-11-01
FI853140L (fi) 1986-03-01
GB2163746B (en) 1988-06-22
US4764522A (en) 1988-08-16
AT391694B (de) 1990-11-12
NL193583B (nl) 1999-11-01
IL76176A (en) 1989-02-28
NO853390L (no) 1986-03-03
DK391485A (da) 1986-03-01

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