NL8100210A - Microbiologisch verkregen polypeptide met de aminozuurvolgorde van het proinsuline van primaten, dna en plasmiden, die deze volgorde coderen, microoerganismen die deze genetische informatie bevatten en het maken daarvan. - Google Patents

Microbiologisch verkregen polypeptide met de aminozuurvolgorde van het proinsuline van primaten, dna en plasmiden, die deze volgorde coderen, microoerganismen die deze genetische informatie bevatten en het maken daarvan. Download PDF

Info

Publication number: NL8100210A
Authority: NL; Netherlands
Prior art keywords: plasmid; polypeptide; amino acid; primate; proinsulin
Prior art date: 1980-01-19

Application number

NL8100210A

Other languages

English (en)

Dutch (nl)

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-01-19

Filing date

1981-01-16

Publication date

1981-08-17

1981-01-16 Application filed by Hoechst Ag filed Critical Hoechst Ag

1981-08-17 Publication of NL8100210A publication Critical patent/NL8100210A/nl

Links

239000013612 plasmid Substances 0.000 title claims abstract description 28
229920001184 polypeptide Polymers 0.000 title claims abstract description 13
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 13
108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 13
241000288906 Primates Species 0.000 title claims abstract description 12
244000005700 microbiome Species 0.000 title claims abstract description 11
230000002068 genetic effect Effects 0.000 title claims abstract description 8
108010076181 Proinsulin Proteins 0.000 title claims abstract 4
150000001413 amino acids Chemical class 0.000 title description 3
238000000034 method Methods 0.000 claims abstract description 12
230000015572 biosynthetic process Effects 0.000 claims abstract description 8
108020004999 messenger RNA Proteins 0.000 claims abstract description 5
125000003275 alpha amino acid group Chemical group 0.000 claims abstract 5
239000002299 complementary DNA Substances 0.000 claims abstract 5
108090000623 proteins and genes Proteins 0.000 claims description 18
210000002966 serum Anatomy 0.000 claims description 10
108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 7
AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 claims description 5
241000588724 Escherichia coli Species 0.000 claims description 4
244000309466 calf Species 0.000 claims description 4
210000000496 pancreas Anatomy 0.000 claims description 3
239000006166 lysate Substances 0.000 claims description 2
VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 1
108010075254 C-Peptide Proteins 0.000 claims 1
229910052792 caesium Inorganic materials 0.000 claims 1
TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 claims 1
210000004153 islets of langerhan Anatomy 0.000 claims 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 40
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 25
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FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
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KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
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239000005556 hormone Substances 0.000 description 4
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125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 4
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UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 3
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
102000053602 DNA Human genes 0.000 description 2
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241000282560 Macaca mulatta Species 0.000 description 2
108091028043 Nucleic acid sequence Proteins 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
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ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
229930024421 Adenine Natural products 0.000 description 1
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
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WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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239000003242 anti bacterial agent Substances 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
238000000376 autoradiography Methods 0.000 description 1
210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
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239000003814 drug Substances 0.000 description 1
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210000002919 epithelial cell Anatomy 0.000 description 1
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HJRIWDYVYNNCFY-UHFFFAOYSA-M potassium;dimethylarsinate Chemical compound [K+].C[As](C)([O-])=O HJRIWDYVYNNCFY-UHFFFAOYSA-M 0.000 description 1
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108010066381 preproinsulin Proteins 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

NL8100210A 1980-01-19 1981-01-16 Microbiologisch verkregen polypeptide met de aminozuurvolgorde van het proinsuline van primaten, dna en plasmiden, die deze volgorde coderen, microoerganismen die deze genetische informatie bevatten en het maken daarvan. NL8100210A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3001928		1980-01-19
DE19803001928 DE3001928A1 (de)	1980-01-19	1980-01-19	Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus

Publications (1)

Publication Number	Publication Date
NL8100210A true NL8100210A (nl)	1981-08-17

Family

ID=6092503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8100210A NL8100210A (nl)	1980-01-19	1981-01-16	Microbiologisch verkregen polypeptide met de aminozuurvolgorde van het proinsuline van primaten, dna en plasmiden, die deze volgorde coderen, microoerganismen die deze genetische informatie bevatten en het maken daarvan.

Country Status (14)

Country	Link
EP (1)	EP0032675B1 (sv)
JP (1)	JPS56104897A (sv)
AT (1)	ATE5151T1 (sv)
AU (1)	AU545665B2 (sv)
BE (1)	BE887129A (sv)
CA (1)	CA1192153A (sv)
DE (2)	DE3001928A1 (sv)
ES (3)	ES498451A0 (sv)
FR (1)	FR2479851A1 (sv)
GB (1)	GB2067574B (sv)
IT (1)	IT1136557B (sv)
NL (1)	NL8100210A (sv)
SE (1)	SE8100241L (sv)
ZA (1)	ZA81292B (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ199391A (en) *	1981-01-02	1985-12-13	Genentech Inc	Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
ZA824218B (en) *	1981-06-29	1983-04-27	Cetus Corp	Plasmid for producing human insulin
EP0090433A1 (en) *	1982-03-31	1983-10-05	Genetics Institute, Inc.	Creation of DNA sequences encoding modified proinsulin precursors
DE3380357D1 (en) *	1982-06-11	1989-09-14	Hoechst Ag	Process for the preparation of obligate methylotrophic, foreign dna expressing bacteria, and appropriate plasmids and host organisms therefor
US6511474B1 (en)	2000-07-12	2003-01-28	Corpak, Inc.	Bolus for non-occluding high flow enteral feeding tube
US7976518B2 (en)	2005-01-13	2011-07-12	Corpak Medsystems, Inc.	Tubing assembly and signal generator placement control device and method for use with catheter guidance systems
WO2013036772A1 (en)	2011-09-08	2013-03-14	Corpak Medsystems, Inc.	Apparatus and method used with guidance system for feeding and suctioning

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4082613A (en) *	1976-04-23	1978-04-04	The Regents Of The University Of Minnesota	Process for the production of insulin by genetically transformed fungal cells
NZ187300A (en) *	1977-05-27	1982-08-17	Univ California	Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
GB2008123B (en) *	1977-11-08	1982-09-08	Genentech Inc	Method of means for microbial polypeptide expression
US4411994A (en) *	1978-06-08	1983-10-25	The President And Fellows Of Harvard College	Protein synthesis
GR71912B (sv) *	1978-08-11	1983-08-16	Univ California
GR70279B (sv) *	1979-09-12	1982-09-03	Univ California

1980
- 1980-01-19 DE DE19803001928 patent/DE3001928A1/de not_active Withdrawn
1981
- 1981-01-08 DE DE8181100069T patent/DE3161251D1/de not_active Expired
- 1981-01-08 AT AT81100069T patent/ATE5151T1/de not_active IP Right Cessation
- 1981-01-08 EP EP81100069A patent/EP0032675B1/de not_active Expired
- 1981-01-13 ES ES498451A patent/ES498451A0/es active Granted
- 1981-01-16 ZA ZA00810292A patent/ZA81292B/xx unknown
- 1981-01-16 AU AU66280/81A patent/AU545665B2/en not_active Expired
- 1981-01-16 CA CA000368743A patent/CA1192153A/en not_active Expired
- 1981-01-16 NL NL8100210A patent/NL8100210A/nl not_active Application Discontinuation
- 1981-01-16 IT IT8119180A patent/IT1136557B/it active
- 1981-01-16 SE SE8100241A patent/SE8100241L/sv not_active Application Discontinuation
- 1981-01-19 BE BE0/203523A patent/BE887129A/fr not_active IP Right Cessation
- 1981-01-19 GB GB8101531A patent/GB2067574B/en not_active Expired
- 1981-01-19 JP JP524081A patent/JPS56104897A/ja active Pending
- 1981-01-19 FR FR8100869A patent/FR2479851A1/fr not_active Withdrawn
- 1981-02-03 ES ES499054A patent/ES499054A0/es active Granted
- 1981-02-03 ES ES499053A patent/ES8203101A1/es not_active Expired

Also Published As

Publication number	Publication date
CA1192153A (en)	1985-08-20
ES499053A0 (es)	1982-02-16
JPS56104897A (en)	1981-08-20
ES8200722A1 (es)	1981-11-01
BE887129A (fr)	1981-07-20
DE3001928A1 (de)	1981-08-06
GB2067574B (en)	1983-10-19
SE8100241L (sv)	1981-07-20
ES8205427A1 (es)	1982-06-01
DE3161251D1 (en)	1984-01-19
GB2067574A (en)	1981-07-30
ES8203101A1 (es)	1982-02-16
JPS642584A (en)	1989-01-06
EP0032675A2 (de)	1981-07-29
IT8119180A0 (it)	1981-01-16
AU6628081A (en)	1981-07-30
EP0032675B1 (de)	1983-10-26
IT1136557B (it)	1986-09-03
AU545665B2 (en)	1985-07-25
ES499054A0 (es)	1982-06-01
ES498451A0 (es)	1981-11-01
ZA81292B (en)	1982-02-24
ATE5151T1 (de)	1983-11-15
FR2479851A1 (fr)	1981-10-09
EP0032675A3 (en)	1981-11-11

Publication	Publication Date	Title
US4431740A (en)	1984-02-14	DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes
US4440859A (en)	1984-04-03	Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
EP0068646B1 (en)	1985-09-18	Process for expressing the bovine growth hormone gene, and plasmid for use therein
JP2530801B2 (ja)	1996-09-04	組換えｄｎａ分子
US4652525A (en)	1987-03-24	Recombinant bacterial plasmids containing the coding sequences of insulin genes
CS250655B2 (en)	1987-05-14	Method of microorganisme's viable culture's cultivation with means content for asexual regeneration
JPH0659218B2 (ja)	1994-08-10	Ｄｎａ導入ベクタ−
JPH08196275A (ja)	1996-08-06	新規ポリペプチドをコードする遺伝子（ｉ）
NL8100718A (nl)	1981-09-16	Microbiologisch gevormd polypeptide met de aminozuur-volgorde van menselijk interferon, dna en plasmiden, die deze volgorde coderen, microoerganismen, die deze genetische informaties bevatten en werkwijze voor het maken daarvan.
JPH0376580A (ja)	1991-04-02	大腸菌発現ベクターとそれを利用した抗ウイルス性タンパク質の製造方法
KR870000501B1 (ko)	1987-03-12	사람의 프로인슐린의 아미노산 배열을 함유하는 단백질의 제조방법
NL8100210A (nl)	1981-08-17	Microbiologisch verkregen polypeptide met de aminozuurvolgorde van het proinsuline van primaten, dna en plasmiden, die deze volgorde coderen, microoerganismen die deze genetische informatie bevatten en het maken daarvan.
US5552302A (en)	1996-09-03	Methods and compositions for production of human recombinant placental ribonuclease inhibitor
EP0252894A2 (fr)	1988-01-13	Polypeptides hybrides comprenant la somatocrinine et l'alpha1-antitrypsine, méthode pour leur production à partir de clones bactériens et leur utilisation pour la production de somatocrinine
CN114908097B (zh)	2023-01-13	一种Dox调控的记录猪组织分化与器官发生的谱系示踪技术
EP0198745A1 (fr)	1986-10-22	Procédé de préparation microbiologique de la sérum-albumine humaine
JPS58501121A (ja)	1983-07-14	ヒト　カルシトニン前駆体ポリ蛋白質構造遺伝子
NL8100719A (nl)	1981-09-16	Microbiologisch bereid polypeptide met de aminozuur-orde van menselijk interferon, dna en plasmiden, die voor deze volgorde coderen, microoerganismen, die deze genetische informatie bevatten en werkwijze voor het maken daarvan.
RU2354702C2 (ru)	2009-05-10	РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pHINS11, КОДИРУЮЩАЯ ГИБРИДНЫЙ БЕЛОК-ПРЕДШЕСТВЕННИК ИНСУЛИНА ЧЕЛОВЕКА, КЛЕТКА Escherichia coli, ТРАНСФОРМИРОВАННАЯ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК pHINS11, ШТАММ БАКТЕРИЙ Escherichia coli JM109/pHINS11 - ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА-ПРЕДШЕСТВЕННИКА ИНСУЛИНА ЧЕЛОВЕКА И СПОСОБ ПОЛУЧЕНИЯ ИНСУЛИНА ЧЕЛОВЕКА
JPS60260598A (ja)	1985-12-23	ポリペプチドの製造方法
HUT52154A (en)	1990-06-28	Recombinant interleukin-2 hybrid proteins.
CA1156166A (en)	1983-11-01	Recombinant bacterial plasmids containing the coding sequences of insulin genes
JPH012584A (ja)	1989-01-06	Ｄｎａおよびプラスミド並びにそれらを含有する微生物
JPH05508539A (ja)	1993-12-02	安定および生体活性改変ソマトトロピン類
WO2003018742A2 (en)	2003-03-06	Recombinant l-asparaginase erwinia caratovora

Legal Events

Date	Code	Title	Description
1985-01-01	A85	Still pending on 85-01-01
1986-09-01	BV	The patent application has lapsed