NL301217I2 - tirzepatide en farmaceutisch aanvaardbare zouten daarvan - Google Patents

tirzepatide en farmaceutisch aanvaardbare zouten daarvan

Info

Publication number: NL301217I2
Authority: NL; Netherlands
Prior art keywords: tirzepatide; pharmaceutically acceptable; acceptable salts; salts; pharmaceutically
Prior art date: 2015-01-09

Application number

NL301217C

Other languages

English (en)

Other versions

NL301217I1 (nl

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-01-09

Filing date

2023-02-07

Publication date

2023-04-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55315708&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL301217(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2023-02-07 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2023-02-15 Publication of NL301217I1 publication Critical patent/NL301217I1/nl

2023-04-04 Publication of NL301217I2 publication Critical patent/NL301217I2/nl

Links

150000003839 salts Chemical class 0.000 title 1
BTSOGEDATSQOAF-SMAAHMJQSA-N tirzepatide Chemical compound CC[C@H](C)[C@@H](C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@H](C(O)=O)NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)C(N[C@@H](C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(NCC(NCC(N(CCC1)[C@@H]1C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](C)C(N(CCC1)[C@@H]1C(N(CCC1)[C@@H]1C(N(CCC1)[C@@H]1C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC(C(C)(C)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@H](CC(C=C1)=CC=C1O)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](CC1=CC=CC=C1)NC([C@H]([C@@H](C)O)NC(CNC([C@H](CCC(O)=O)NC(C(C)(C)NC([C@H](CC(C=C1)=CC=C1O)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O BTSOGEDATSQOAF-SMAAHMJQSA-N 0.000 title 1
229940121512 tirzepatide Drugs 0.000 title 1
108091004331 tirzepatide Proteins 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Child & Adolescent Psychology (AREA)

NL301217C 2015-01-09 2023-02-07 tirzepatide en farmaceutisch aanvaardbare zouten daarvan NL301217I2 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201562101488P	2015-01-09	2015-01-09
PCT/US2016/012124 WO2016111971A1 (en)	2015-01-09	2016-01-05	Gip and glp-1 co-agonist compounds

Publications (2)

Publication Number	Publication Date
NL301217I1 NL301217I1 (nl)	2023-02-15
NL301217I2 true NL301217I2 (nl)	2023-04-04

Family

ID=55315708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL301217C NL301217I2 (nl)	2015-01-09	2023-02-07	tirzepatide en farmaceutisch aanvaardbare zouten daarvan

Country Status (46)

Country	Link
US (1)	US9474780B2 (nl)
EP (2)	EP3242887B1 (nl)
JP (3)	JP6219534B2 (nl)
KR (5)	KR20240135032A (nl)
CN (2)	CN112608377B (nl)
AR (2)	AR103242A1 (nl)
AU (1)	AU2016205435B2 (nl)
CA (1)	CA2973352C (nl)
CL (1)	CL2017001760A1 (nl)
CO (1)	CO2017006737A2 (nl)
CR (1)	CR20170310A (nl)
CY (2)	CY1122028T1 (nl)
DK (1)	DK3242887T3 (nl)
DO (1)	DOP2017000153A (nl)
EA (3)	EA202090392A3 (nl)
EC (1)	ECSP17043648A (nl)
ES (1)	ES2747928T3 (nl)
FI (1)	FIC20230005I1 (nl)
FR (1)	FR23C1006I2 (nl)
HR (1)	HRP20191614T1 (nl)
HU (2)	HUE045860T2 (nl)
IL (4)	IL281545B2 (nl)
JO (2)	JOP20200119A1 (nl)
LT (2)	LT3242887T (nl)
LU (1)	LUC00296I2 (nl)
MA (2)	MA41315B1 (nl)
MD (1)	MD3242887T2 (nl)
ME (1)	ME03494B (nl)
MX (2)	MX382753B (nl)
MY (1)	MY193616A (nl)
NL (1)	NL301217I2 (nl)
NO (1)	NO2023005I1 (nl)
NZ (3)	NZ732000A (nl)
PE (1)	PE20170954A1 (nl)
PH (1)	PH12017501252B1 (nl)
PL (1)	PL3242887T3 (nl)
PT (1)	PT3242887T (nl)
RS (1)	RS59146B1 (nl)
SG (1)	SG11201705603YA (nl)
SI (1)	SI3242887T1 (nl)
SV (1)	SV2017005453A (nl)
TN (1)	TN2017000198A1 (nl)
TW (1)	TWI582109B (nl)
UA (1)	UA118239C2 (nl)
WO (1)	WO2016111971A1 (nl)
ZA (1)	ZA201703930B (nl)

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AR119471A1 (es)	2019-08-01	2021-12-22	Lilly Co Eli	Compuestos agonistas de gipr
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TW202228762A (zh)	2020-01-30	2022-08-01	美商美國禮來大藥廠	提派肽(tirzepatide)之治療用途
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AU2021229621B2 (en)	2020-03-06	2023-08-31	Sanofi	Peptides as selective GIP receptor agonists
CN113493503B (zh) *	2020-04-08	2022-08-05	浙江道尔生物科技有限公司	一种肠促胰岛素类似物及其制备方法和用途
TW202216746A (zh) *	2020-06-22	2022-05-01	印度商太陽製藥工業有限公司	長效型ｇｌｐ－１／ｇｉｐ雙重促效劑
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KR20230083294A (ko) *	2020-09-30	2023-06-09	베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드	폴리펩타이드 접합체 및 사용 방법
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JP2024508745A (ja) *	2021-02-17	2024-02-28	イーライリリーアンドカンパニー	Ｇｉｐ／ｇｌｐ１デュアルアゴニスト治療方法
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US20240209056A1 (en) *	2021-03-25	2024-06-27	Brightgene Bio-Medical Technology Co., Ltd.	Gip and glp-1 dual receptor agonist, pharmaceutical composition, and use
US12215133B2 (en)	2021-03-25	2025-02-04	Brightgene Bio-Medical Technology Co., Ltd.	GIP and GLP-1 dual receptor agonist, pharmaceutical composition, and use
AU2022269659B2 (en)	2021-05-07	2025-04-10	Eli Lilly And Company	Erodible tablet
MX2023013492A (es)	2021-05-13	2024-02-29	Carmot Therapeutics Inc	Moduladores de los receptores acoplados a proteinas g.
CN118307645A (zh) *	2021-05-28	2024-07-09	广东众生睿创生物科技有限公司	多肽的制备及其应用
CN117440964A (zh) *	2021-06-01	2024-01-23	南京知和医药科技有限公司	一种glp-1r和gipr双重靶向激动作用的多肽衍生物及其制备方法和用途
JP2024522196A (ja)	2021-06-09	2024-06-11	ザスクリプスリサーチインスティテュート	長時間作用型デュアルｇｉｐ／ｇｌｐ－１ペプチドコンジュゲートおよび使用方法
TW202302624A (zh) *	2021-06-18	2023-01-16	大陸商廣東眾生睿創生物科技有限公司	含內醯胺橋的多肽化合物
WO2023031455A1 (en)	2021-09-06	2023-03-09	Sanofi Sa	New peptides as potent and selective gip receptor agonists
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US20250000948A1 (en)	2021-11-15	2025-01-02	Adocia	Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4180060A1 (en)	2021-11-15	2023-05-17	Adocia	Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4299057A1 (en)	2022-06-30	2024-01-03	Adocia	Solid compositions comprising a peptide or a protein and an acylated amino acid
WO2023089594A1 (en)	2021-11-22	2023-05-25	Sun Pharmaceutical Industries Limited	Process for the preparation of tirzepatide or pharmaceutically acceptable salt thereof
TW202330584A (zh)	2022-01-20	2023-08-01	丹麥商諾佛儂迪克股份有限公司	前藥及其用途
JP2025512980A (ja) *	2022-04-07	2025-04-22	広東衆生睿創生物科技有限公司	糖尿病、肥満症およびその関連疾患を治療および／または予防するための医薬品の調製における、ポリペプチドの医薬的使用
CN116947978A (zh) *	2022-04-19	2023-10-27	北京惠之衡生物科技有限公司	一种glp-1和gip受体共激动多肽衍生物及其盐和制剂
EP4299052A1 (en)	2022-06-30	2024-01-03	Adocia	Solid compositions comprising a peptide or a protein and a permeation enhancer
CN119421702A (zh)	2022-06-30	2025-02-11	伊莱利利公司	替尔泊肽组合物和用途
EP4299071A1 (en)	2022-07-01	2024-01-03	Adocia	Compositions comprising a peptide or a protein and an acylated amino acid
PE20251259A1 (es) *	2022-07-13	2025-05-06	Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd	Agonista dual de glp-1/gip, metodo de preparacion y uso del mismo
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JP6545766B2 (ja)	2019-07-17
KR20210145311A (ko)	2021-12-01
PH12017501252B1 (en)	2023-06-16
ES2747928T3 (es)	2020-03-12
CL2017001760A1 (es)	2018-03-16
MA41315A (fr)	2017-11-15
CY2023003I2 (el)	2023-06-09
JP6754867B2 (ja)	2020-09-16
HUS2300006I1 (hu)	2023-02-28
DOP2017000153A (es)	2017-07-15
NZ771547A (en)	2024-12-20
FR23C1006I1 (fr)	2023-03-24
EA201892057A1 (ru)	2019-02-28
EA201791281A1 (ru)	2017-11-30
JP2017507124A (ja)	2017-03-16
LTC3242887I2 (nl)	2024-10-10
AR131857A2 (es)	2025-05-07
MX2021005835A (es)	2021-07-15
MY193616A (en)	2022-10-20
AR103242A1 (es)	2017-04-26
AU2016205435A1 (en)	2017-06-08
CN112608377A (zh)	2021-04-06
IL276492B (en)	2021-04-29
EP3242887B1 (en)	2019-08-14
IL320236A (en)	2025-06-01
EA035055B1 (ru)	2020-04-22
MX382753B (es)	2025-03-13
CN107207576B (zh)	2020-11-24
KR102330764B1 (ko)	2021-11-25
US9474780B2 (en)	2016-10-25
TW201636362A (zh)	2016-10-16
JOP20200119A1 (ar)	2017-06-16
SV2017005453A (es)	2018-08-27
UA118239C2 (uk)	2018-12-10
MA41315B1 (fr)	2019-11-29
NZ755618A (en)	2024-12-20
JP2019203000A (ja)	2019-11-28
HRP20191614T1 (hr)	2019-12-13
KR20190026967A (ko)	2019-03-13
IL281545B1 (en)	2025-05-01
NZ748274A (en)	2022-03-25
RS59146B1 (sr)	2019-09-30
AU2016205435B2 (en)	2018-03-29
EA031591B1 (ru)	2019-01-31
JO3575B1 (ar)	2020-07-05
TWI582109B (zh)	2017-05-11
LTPA2023504I1 (nl)	2023-02-27
IL276492A (en)	2020-09-30
CN107207576A (zh)	2017-09-26
LT3242887T (lt)	2019-11-11
MD3242887T2 (ro)	2019-11-30
LUC00296I2 (nl)	2025-09-22
CY2023003I1 (el)	2023-03-24
IL252499B (en)	2020-08-31
ZA201703930B (en)	2019-06-26
MX2017008927A (es)	2017-10-11
IL281545A (en)	2021-05-31
JP2018052933A (ja)	2018-04-05
KR101957620B1 (ko)	2019-03-13
PH12017501252A1 (en)	2017-10-30
EA202090392A3 (ru)	2020-08-31
CA2973352C (en)	2019-03-26
KR20240135032A (ko)	2024-09-10
ECSP17043648A (es)	2017-11-30
IL281545B2 (en)	2025-09-01
TN2017000198A1 (en)	2018-10-19
KR20170092661A (ko)	2017-08-11
ME03494B (me)	2020-01-20
CN112608377B (zh)	2024-02-13
SI3242887T1 (sl)	2019-10-30
JP6219534B2 (ja)	2017-10-25
CA2973352A1 (en)	2016-07-14
EP3597662A1 (en)	2020-01-22
HUE045860T2 (hu)	2020-01-28
PT3242887T (pt)	2019-10-29
BR112017010596A2 (pt)	2018-03-06
CO2017006737A2 (es)	2017-09-29
US20160199438A1 (en)	2016-07-14
FR23C1006I2 (fr)	2024-01-05
CY1122028T1 (el)	2020-10-14
DK3242887T3 (da)	2019-09-02
SG11201705603YA (en)	2017-08-30
NZ732000A (en)	2018-11-30
PL3242887T3 (pl)	2020-02-28
PE20170954A1 (es)	2017-07-13
NL301217I1 (nl)	2023-02-15
EA202090392A2 (ru)	2020-05-31
WO2016111971A1 (en)	2016-07-14
NZ771043A (en)	2024-12-20
MA50422A (fr)	2020-08-26
EP3242887A1 (en)	2017-11-15
NO2023005I1 (no)	2023-02-02
KR20230023822A (ko)	2023-02-17
CR20170310A (es)	2017-08-17
FIC20230005I1 (fi)	2023-02-02
IL252499A0 (en)	2017-07-31

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