NL300894I2 - cenegermin - Google Patents
cenegermin Download PDFInfo
- Publication number
- NL300894I2 NL300894I2 NL300894C NL300894C NL300894I2 NL 300894 I2 NL300894 I2 NL 300894I2 NL 300894 C NL300894 C NL 300894C NL 300894 C NL300894 C NL 300894C NL 300894 I2 NL300894 I2 NL 300894I2
- Authority
- NL
- Netherlands
- Prior art keywords
- ngf
- biologically active
- preparation
- beta
- proform
- Prior art date
Links
- 229950004206 cenegermin Drugs 0.000 title 1
- 108091004359 cenegermin Proteins 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 3
- 102100023995 Beta-nerve growth factor Human genes 0.000 abstract 1
- 101710129634 Beta-nerve growth factor Proteins 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000003297 denaturating effect Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 210000001236 prokaryotic cell Anatomy 0.000 abstract 1
- 238000004153 renaturation Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98119077A EP0994188B1 (de) | 1998-10-09 | 1998-10-09 | Verfahren zur Gewinnung von aktivem Beta-NGF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL300894I2 true NL300894I2 (nl) | 2018-02-01 |
Family
ID=8232766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL300894C NL300894I2 (nl) | 1998-10-09 | 2017-09-28 | cenegermin |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8318671B1 (nl) |
| EP (1) | EP0994188B1 (nl) |
| JP (2) | JP4634611B2 (nl) |
| KR (1) | KR100593831B1 (nl) |
| AT (1) | ATE257514T1 (nl) |
| AU (1) | AU765810B2 (nl) |
| BR (1) | BR9914393B1 (nl) |
| CA (1) | CA2346257C (nl) |
| DE (1) | DE59810555D1 (nl) |
| ES (1) | ES2213861T3 (nl) |
| FR (1) | FR17C0007I2 (nl) |
| NL (1) | NL300894I2 (nl) |
| WO (1) | WO2000022119A1 (nl) |
| ZA (1) | ZA200102780B (nl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0994188B1 (de) | 1998-10-09 | 2004-01-07 | Scil proteins GmbH | Verfahren zur Gewinnung von aktivem Beta-NGF |
| WO2004056385A2 (en) | 2002-12-20 | 2004-07-08 | Neuronicon Aps | Modulation of activity of neurotrophins |
| EP3225251B1 (en) | 2006-12-21 | 2020-02-12 | H. Lundbeck A/S | Modulation of activity of proneurotrophins |
| PT2907521T (pt) | 2011-12-19 | 2018-02-22 | Wacker Chemie Ag | Mutantes prongf inovadores e utilizações dos mesmos na produção de beta-ngf |
| CN103880943A (zh) * | 2014-01-20 | 2014-06-25 | 厦门北大之路生物工程有限公司 | 一种rhNGF成熟肽的制备方法 |
| CN106519024A (zh) * | 2015-09-15 | 2017-03-22 | 三生国健药业（上海）股份有限公司 | 一种用于去除单克隆抗体中异构体的复性液及复性方法 |
| EP3406259A1 (en) | 2017-05-24 | 2018-11-28 | Dompé farmaceutici S.p.A. | Neurotrophins for use in the treatment of hearing loss |
| CN108467428A (zh) * | 2018-03-26 | 2018-08-31 | 江苏中新医药有限公司 | 一种清除rhNGF中N端截短及异常变异体的方法 |
| WO2019207106A1 (en) | 2018-04-27 | 2019-10-31 | Chiesi Farmaceutici Spa | Production of nerve growth factor (ngf) and of muteins thereof |
| CN113226350B (zh) | 2018-09-17 | 2024-09-10 | 奇斯药制品公司 | 皮肤病治疗剂 |
| CN110093394B (zh) * | 2019-05-10 | 2023-10-03 | 重庆科润生物医药研发有限公司 | 一种蛋白包涵体及重组人β-神经生长因子的制备方法 |
| US20220401517A1 (en) | 2019-09-17 | 2022-12-22 | Chiesi Farmaceutici S.P.A. | Agent for use in treatment or prevention of ophthalmic disorders |
| IL302317A (en) | 2020-10-28 | 2023-06-01 | Dompe Farm Spa | Pharmaceutical packaging including polypropylene containers and aqueous formulations of NGF packed in them |
| EP4039269A1 (en) | 2021-02-05 | 2022-08-10 | Dompe' Farmaceutici S.P.A. | Ngf isoform for use in the treatment of ocular pathologies |
| IL307622A (en) | 2021-04-13 | 2023-12-01 | Domp? Farm S P A | Treatment of neuropathic corneal pain with ngf |
| EP4311554A1 (en) | 2022-07-29 | 2024-01-31 | Dompé farmaceutici S.p.a. | Combination for use in ophthalmology |
| EP4316505A1 (en) | 2022-08-05 | 2024-02-07 | Dompé farmaceutici S.p.a. | Intranasal administration of ngf for the treatment of sensorineural hearing loss |
| EP4342485A1 (en) | 2022-09-23 | 2024-03-27 | Dompe' Farmaceutici S.P.A. | Ngf for the treatment of spasticity |
| EP4497431A1 (en) | 2023-07-27 | 2025-01-29 | Dompé farmaceutici S.p.A. | Pharmaceutical formulation comprising nerve growth factor |
| EP4623927A1 (en) | 2024-03-27 | 2025-10-01 | Dompe' Farmaceutici SpA | Ngf for use in the prevention or treatment of motor impairment caused by neonatal hypoxic-ischemic encephalopathy |
| EP4659759A1 (en) | 2024-06-04 | 2025-12-10 | Dompé farmaceutici SpA | Administration of ngf for the treatment of niemann-pick type c disease |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169762A (en) * | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
| US5453363A (en) | 1985-10-23 | 1995-09-26 | Boehringer Mannheim Gmbh | Process for the activation of t-PA or Ing after genetic expression in prokaryotes |
| US5683894A (en) | 1988-04-29 | 1997-11-04 | University Of California | Recombinant nerve growth factor |
| US5606031A (en) | 1990-04-06 | 1997-02-25 | Lile; Jack | Production and purification of biologically active recombinant neurotrophic protein in bacteria |
| US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
| DE4139000A1 (de) * | 1991-11-27 | 1993-06-03 | Boehringer Mannheim Gmbh | Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf |
| DE4405179A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
| WO1996008562A1 (de) * | 1994-09-12 | 1996-03-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Berlin | Biologisch aktive, von neurotrophinen abgeleitete moleküle |
| US5935824A (en) * | 1996-01-31 | 1999-08-10 | Technologene, Inc. | Protein expression system |
| DE59711375D1 (de) | 1996-06-11 | 2004-04-08 | Roche Diagnostics Gmbh | Verfahren zur aktivierung von denaturiertem protein |
| EP0994188B1 (de) | 1998-10-09 | 2004-01-07 | Scil proteins GmbH | Verfahren zur Gewinnung von aktivem Beta-NGF |
-
1998
- 1998-10-09 EP EP98119077A patent/EP0994188B1/de not_active Expired - Lifetime
- 1998-10-09 ES ES98119077T patent/ES2213861T3/es not_active Expired - Lifetime
- 1998-10-09 AT AT98119077T patent/ATE257514T1/de active
- 1998-10-09 DE DE59810555T patent/DE59810555D1/de not_active Expired - Lifetime
-
1999
- 1999-10-11 US US09/807,096 patent/US8318671B1/en not_active Expired - Fee Related
- 1999-10-11 AU AU10348/00A patent/AU765810B2/en not_active Expired
- 1999-10-11 CA CA002346257A patent/CA2346257C/en not_active Expired - Lifetime
- 1999-10-11 JP JP2000576009A patent/JP4634611B2/ja not_active Expired - Lifetime
- 1999-10-11 WO PCT/EP1999/007613 patent/WO2000022119A1/de not_active Ceased
- 1999-10-11 BR BRPI9914393A patent/BR9914393B1/pt not_active IP Right Cessation
- 1999-10-11 KR KR1020017004512A patent/KR100593831B1/ko not_active Expired - Lifetime
-
2001
- 2001-04-04 ZA ZA200102780A patent/ZA200102780B/en unknown
-
2010
- 2010-04-22 US US12/765,229 patent/US8501439B2/en not_active Expired - Fee Related
- 2010-09-06 JP JP2010199387A patent/JP5275306B2/ja not_active Expired - Lifetime
-
2017
- 2017-09-27 FR FR17C0007C patent/FR17C0007I2/fr active Active
- 2017-09-28 NL NL300894C patent/NL300894I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5275306B2 (ja) | 2013-08-28 |
| FR17C0007I2 (fr) | 2018-11-09 |
| FR17C0007I1 (fr) | 2017-11-17 |
| JP2010280717A (ja) | 2010-12-16 |
| US8501439B2 (en) | 2013-08-06 |
| US20100203589A1 (en) | 2010-08-12 |
| EP0994188A1 (de) | 2000-04-19 |
| DE59810555D1 (de) | 2004-02-12 |
| AU1034800A (en) | 2000-05-01 |
| CA2346257A1 (en) | 2000-04-20 |
| KR100593831B1 (ko) | 2006-06-28 |
| CA2346257C (en) | 2005-03-01 |
| ATE257514T1 (de) | 2004-01-15 |
| ES2213861T3 (es) | 2004-09-01 |
| BR9914393A (pt) | 2001-06-26 |
| JP2002527062A (ja) | 2002-08-27 |
| EP0994188B1 (de) | 2004-01-07 |
| WO2000022119A1 (de) | 2000-04-20 |
| ZA200102780B (en) | 2002-07-04 |
| JP4634611B2 (ja) | 2011-02-16 |
| KR20010083900A (ko) | 2001-09-03 |
| AU765810B2 (en) | 2003-10-02 |
| US8318671B1 (en) | 2012-11-27 |
| BR9914393B1 (pt) | 2021-06-22 |
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